Description
Aim: In vivo evaluation of microglia activation and neuroinflammation is considered a potential tool in the management of several neurological and psychiatric disorders. [11C]PK11195 has been widely used for this purpose in PET imaging. However, it possesses a low sensitivity and poor signal-to-noise ratio. For that reason, [11C]CB184 was evaluated as a potential more sensitive PET tracer, using a rat model of herpes encephalitis. Materials and methods: Male Wistar rats were intranasal inoculated with HSV-1 (HSE) or PBS (control). At either day 6 or 7 after inoculation, [11C]CB184 PET scans were acquired, followed by ex vivo biodistribution. Arterial blood sampling of [11C]CB184 and [11C]PK11195 scans was performed for pharmacokinetic modelling. Differences between control and HSE groups were explored using volumes of interest and voxel-based analysis. Results: The ex vivo uptake of [11C]CB184 in HSE rats, as compared with control, was significantly increased (pPeriod | 19-Oct-2014 |
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Event title | 28th Annual Congress of the European Association of Nuclear Medicine (EANM) |
Event type | Conference |
Conference number | 28 |
Location | Hamburg, Germany |
Related content
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Research output
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Evaluation of [C-11]CB184 for imaging and quantification of TSPO overexpression in a rat model of herpes encephalitis
Research output: Contribution to journal › Article › Academic › peer-review