Activity: Talk and presentation › Academic presentation › Academic
Description
Neoplastic progression is the result of a dynamic interplay between transformed cells and the microenvironment. The early stages of tumour growth can be regarded as wounds that fail to heal, with evidence of continued fibroblast activation, matrix remodelling, angiogenesis and recruitment of inflammatory cells. This eventually culminates into a protumourigenic microenvironment. Elucidating the contribution of stromal cells to early tumour development not only advance our understanding tumour biology but may also provide avenues for prevention strategies. With lessons learned from cutaneous squamous cell carcinoma, I will highlight the importance of mouse models of de novo oral squamous cell carcinomas to dissect the complex stromal interactions and to understand the contribution of the tumour microenvironment to neoplastic progression.
Period
25-Feb-2022
Event title
Oral Potentially Malignant Disorders (OPMD): State of the art and roadmap for research