Title Breakthrough Articles from Nucleic Acid Research Degree of recognition International Media name/outlet Breakthrough highlights Nucleic Acid Research Media type Web Country/Territory Netherlands Date 10/11/2020 Description NAR’s Breakthrough Articles present high-impact studies answering long-standing questions in the field of nucleic acids research and/or opening up new areas and mechanistic hypotheses for investigation. These articles are chosen by the Editors on the recommendation of Editorial Board Members and Referees. Articles are accompanied by a brief synopsis explaining the findings of the paper and where they fit in the broader context of nucleic acids research. They represent the very best papers published at NAR.
Genome-wide mapping of SARS-CoV-2 RNA structures identifies therapeutically-relevant elements
Ilaria Manfredonia, Chandran Nithin, Almudena Ponce-Salvatierra, Pritha Ghosh, Tomasz K Wirecki, Tycho Marinus, Natacha S Ogando, Eric J Snijder, Martijn J van Hemert, Janusz M Bujnicki, and Danny Incarnato
Multiple outbreaks of severe acute respiratory syndromes caused by coronaviruses over the past 18 years, the latest leading to (as of this writing) nearly one million deaths across the world, have demonstrated the pressing need for new therapeutically-relevant and durable druggable targets for the treatment of coronavirus infections. This paper describes the characterization of the SARS-CoV-2 RNA genome structure using a variety of experimental and computational methods.
Producer/Author Nucleic Acid Research URL www.narbreakthrough.com Persons Danny Incarnato