Additional file 13 of Distinct cell type-specific protein signatures in GRN and MAPT genetic subtypes of frontotemporal dementia

  • Peter Heutink (Contributor)
  • Pim van Nierop (Contributor)
  • Kevin Menden (Contributor)
  • John C. van Swieten (Contributor)
  • Patrizia Rizzu (Contributor)
  • Christine de Veij Mestdagh (Contributor)
  • Andrea B. Ganz (Contributor)
  • Iryna Paliukhovich (Contributor)
  • Ka Wan Li (Contributor)
  • Henne Holstege (Contributor)
  • Ronald E. van Kesteren (Contributor)
  • August B. Smit (Contributor)
  • Merel O Mol (Contributor)
  • van Rooij (Contributor)
  • Frank T.W. Koopmans (Contributor)
  • Shamiram Melhem (Contributor)
  • Suzanne S. M. Miedema (Contributor)
  • David C. Hondius (Contributor)

    Dataset

    Description

    Additional file 13 Overview of unique proteins detected and quantified within temporal cortical tissues for AD and unique proteins detected and quantified within temporal cortical tissues for both AD and the FTD-MAPT subtype. Proteins were selected using quality filtering on peptide level (q ≤10-3 in at least 50% of samples per group, i.e. NDC or AD). For every protein, the raw fold change and raw p-value are given for the statistical comparison between NDC and AD, and NDC and FTD-MAPT. In addition, columns are included which note whether a protein has passed statistical multiple testing comparison (q < 0.05) and whether differential protein expression is in a similar direction in AD and FTD-MAPT.
    Date made available7-Jul-2022
    Publisherfigshare Academic Research System

    Keywords on Datasets

    • Frontotemporal dementia
    • GRN
    • MAPT
    • Human brain proteomics
    • Cell type enrichment

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