Dataset: Ovalbumin-containing core-shell implants suitable to obtain a delayed IgG1 antibody response in support of a biphasic pulsatile release profile in mice

  • Katie Amssoms (Creator)
  • Philip Born (Creator)
  • Max Beugeling (Creator)
  • Ben De Clerck (Creator)
  • Ellen Van Gulck (Creator)
  • Wouter Hinrichs (Creator)
  • Erik Frijlink (Creator)
  • Niels Grasmeijer (Creator)
  • Guenter Kraus (Creator)
  • Roger Sutmuller (Creator)
  • Kenny Simmen (Creator)
  • Lieven Baert (Creator)



Vaccination is one of the most effective and efficient ways to control the spread of more than thirty infectious diseases.
In this study we investigated whether a core-shell based implant, containing ovalbumin as core material and poly(DL-lactic-co-glycolic acid) of various monomer ratios as shell material can be used to obtain such a booster release. An in vitro release study showed that the lag time after which the ovalbumin was released from the core-shell implant increased with increasing lactic to glycolic acid ratio of the polymer and ranged from 3–6 weeks. Fluorescence spectroscopy showed minimal differences between native ovalbumin and ovalbumin from core-shell implants that were incubated until just before the observed in vitro release. In addition, mice immunized with a subcutaneous inserted core-shell implant containing ovalbumin showed an ovalbumin-specific IgG1 antibody response after a lag time of 4 or 6–8 weeks.
Date made available17-Aug-2018
PublisherUniversity of Groningen

Keywords on Datasets

  • biogradable polymer
  • biphasic pulsatile release
  • implant
  • poly(lactic-co-glycolic acid)
  • prime-boost
  • single-injection
  • antigen
  • vaccine

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