Research output per year
Research output per year
Description
Interleukin-6 (IL-6) levels are upregulated in myocardial infarction. Recent data suggest a causal role of the IL-6 receptor (IL-6R) in coronary heart disease. We evaluated if IL-6R blockade by a monoclonal antibody (MR16-1) prevents the heart from adverse left ventricular remodeling in a mouse model of ischemia-reperfusion (I/R).
CJ57/BL6 mice underwent I/R injury (left coronary artery ligation for 45 minutes) or sham surgery, and thereafter received MR16-1 (2mg/mouse) 5 minutes before reperfusion and 0.5mg/mouse weekly during four weeks, or control IgG treatment. Cardiac Magnetic Resonance Imaging (CMR) and hemodynamic measurements were performed to determine cardiac function after four weeks.
CJ57/BL6 mice underwent I/R injury (left coronary artery ligation for 45 minutes) or sham surgery, and thereafter received MR16-1 (2mg/mouse) 5 minutes before reperfusion and 0.5mg/mouse weekly during four weeks, or control IgG treatment. Cardiac Magnetic Resonance Imaging (CMR) and hemodynamic measurements were performed to determine cardiac function after four weeks.
| Date made available | 18-Nov-2016 |
|---|---|
| Publisher | University of Groningen |
Keywords on Datasets
- Health
- Cardiology
- myocardial infarction
- cytokine concentrations
- Ischemia reperfusion model
Research output
- 1 Article
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Inhibition of Interleukin-6 Receptor in a Murine Model of Myocardial Ischemia-Reperfusion
Hartman, M. H. T., Vreeswijk-Baudoin, I., Groot, H. E., van de Kolk, K. W. A., de Boer, R. A., Leach, I. M., Vliegenthart, R., Sillje, H. H. W. & van der Harst, P., 9-Dec-2016, In: PLoS ONE. 11, 12, 11 p., e0167195.Research output: Contribution to journal › Article › Academic › peer-review
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