Erratum: Bronchoscopic Coil Treatment for Patients with Severe Emphysema: A Meta-Analysis

  • Juergen Hetzel (Contributor)
  • Wolfgang Gesierich (Contributor)
  • Sylvie Leroy (Contributor)
  • Gaëtan Deslée (Contributor)
  • William McNulty (Contributor)
  • Franz Stanzel (Contributor)
  • Christian Witt (Contributor)
  • Samuel V. Kemp (Contributor)
  • Jorine Hartman (Contributor)
  • Martin Hetzel (Contributor)
  • Romain Kessler (Contributor)
  • Pallav L. Shah (Contributor)
  • Felix J. F. Herth (Contributor)
  • Zaid Zoumot (Contributor)
  • Dirk Jan Slebos (Contributor)
  • Stefan Blaas (Contributor)
  • Karin Slebos-Klooster (Contributor)



Background: Bronchoscopic coil treatment has been shown to improve pulmonary function, exercise capacity, and quality of life in patients with severe emphysema. Objectives: To perform a meta-analysis of the results of four independent European clinical trials investigating this coil therapy for emphysema. Methods: Data on all patients included in the four European clinical trials were analyzed for efficacy and safety outcomes. Results: A total of 2,536 coils were placed during 259 procedures in 140 patients. A total of 37 chronic obstructive pulmonary disease exacerbations and 27 pneumonias were recorded as serious adverse events up to 1 year after treatment. The pneumothorax rate was 6.4%. Both 6 and 12 months after treatment, significant (all p < 0.001) improvements were observed for: forced expiratory volume in 1 s [+0.08 liters (±0.19) and +0.08 liters (±0.21)], residual volume [RV; -510 ml (±850) and -430 ml (±720)], 6-min walking distance [6MWD; +44.1 m (±69.8) and +38.1 m (±71.9)], and St. George's Respiratory Questionnaire score [SGRQ; -9.5 points (±14.3) and -7.7 points (±14.2)]. No differences in any outcome measures were observed between heterogeneous and homogeneous emphysema patients. Only a high baseline RV was found to be an independent predictor of successful treatment. Conclusions: Bronchoscopic coil treatment improves pulmonary function, 6MWD, and quality of life in patients with severe emphysema up to 1 year after treatment, independent of the distribution of the disease.
Date made available25-Jul-2017
PublisherUniversity of Groningen

Cite this