Chemical and Pharmaceutical Biology

Research output

Research output per year 1988 2016 2017 2018 2019 2020 2021 2022 2023 2024

• 179 Article
• 51 Thesis fully internal (DIV)
• 34 Review article
• 12 Chapter
• 28 More
  • 6 Meeting Abstract
  • 4 Patent
  • 4 Preprint
  • 2 Conference contribution
  • 2 Comment/Letter to the editor
  • 2 Erratum
  • 2 Digital or Visual Products
  • 2 Other contribution
  • 1 Book
  • 1 Report
  • 1 Editorial
  • 1 Letter

Research output per year

Research output per year

Search results

• 2023

  A guidebook for sustainability in laboratories

  Freese, T., Kat, R., Lanooij, S. D., Böllersen, T. C., Roo, C. M. D., Elzinga, N., Beatty, M., Setz, B., Weber, R. R., Malta, I., Gandek, T. B., Fodran, P., Pollice, R. & Lerch, M. M., 1-Dec-2023, Chemical education. 70 p.

  Research output: Book/Report › Book › Academic

  File
  2 Downloads (Pure)

• Allosteric Inhibitors of Macrophage Migration Inhibitory Factor (MIF) Interfere with Apoptosis-Inducing Factor (AIF) Co-Localization to Prevent Parthanatos

  Chen, D., Osipyan, A., Adriana, J., Kader, M., Gureev, M., Knol, C. W. J., Sigmund, M. C., Xiao, Z., van der Wouden, P. E., Cool, R. H., Poelarends, G. J. & Dekker, F. J., 13-Jul-2023, In: Journal of Medicinal Chemistry. 66, 13, p. 8767-8781 15 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  4 Downloads (Pure)

• An Optimized System for the Study of Rieske Oxygenase-catalyzed Hydroxylation Reactions In vitro

  Runda, M. E., Kremser, B., Özgen, F. & Schmidt, S., 21-Aug-2023, In: ChemCatChem. 15, 16, 11 p., e202300371.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  8 Downloads (Pure)

• Biocatalytic Cascade Synthesis of Enantioenriched Epoxides and Triols from Biomass-Derived Synthons Driven by Specifically Designed Enzymes

  Grandi, E., Crotti, M., Sigmund, M-C., Xu, G., Tepper, P. G. & Poelarends, G. J., 2-Jun-2023, In: Chemistry. 29, 31, 8 p., e202300697.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  1 Citation (Scopus)

  8 Downloads (Pure)

• Challenge accepted: harnessing the power of light to drive photobiocatalytic reactions

  Özgen, F., 2023, [Groningen]: University of Groningen. 318 p.

  Research output: Thesis › Thesis fully internal (DIV)

  Open Access

  File
  103 Downloads (Pure)

• Cover Feature: Rieske Oxygenases and Other Ferredoxin-Dependent Enzymes: Electron Transfer Principles and Catalytic Capabilities

  Runda, M. E., de Kok, N. A. W. & Schmidt, S., 1-Aug-2023

  Research output: Non-textual form › Digital or Visual Products › Academic

• Design and synthesis of ligands targeting MIF family enzymes and their application in medicinal chemistry

  Osipyan, A., 2023, [Groningen]: University of Groningen. 135 p.

  Research output: Thesis › Thesis fully internal (DIV)

  Open Access

  File
  69 Downloads (Pure)

• Discovery of highly potent HDAC8 PROTACs with anti-tumor activity

  Zhao, C., Chen, D., Suo, F., Setroikromo, R., Quax, W. J. & Dekker, F., Jul-2023, In: Bioorganic Chemistry. 136, 16 p., 106546.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  4 Citations (Scopus)

  42 Downloads (Pure)

• Emerging opportunities to target gene transcription and DNA repair in drug discovery

  Chen, D., 2023, [Groningen]: University of Groningen. 335 p.

  Research output: Thesis › Thesis fully internal (DIV)

  Open Access

  File
  137 Downloads (Pure)

• Enhancing biocatalytical N-N bond formation with the actinobacterial piperazate synthase KtzT

  Schröder, S., Maier, A., Schmidt, S., Mügge, C. & Tischler, D., 15-Jan-2024, In: Molecular catalysis. 553, 11 p., 113733.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  1 Downloads (Pure)

• Enzymatic Oxy- and Amino-Functionalization in Biocatalytic Cascade Synthesis: Recent Advances and Future Perspectives

  Grandi, E., Özgen, F. F., Schmidt, S. & Poelarends, G. J., 27-Nov-2023, In: Angewandte Chemie (International ed. in English). 62, 48, 27 p., e202309012.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  25 Downloads (Pure)

• Exciting Enzymes: Current State and Future Perspective of Photobiocatalysis

  Alphand, V., van Berkel, W. J. H., Jurkaš, V., Kara, S., Kourist, R., Kroutil, W., Mascia, F., Nowaczyk, M. M., Paul, C. E., Schmidt, S., Spasic, J., Tamagnini, P. & Winkler, C. K., Jul-2023, In: ChemPhotoChem. 7, 7, 9 p., e202200325.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  2 Citations (Scopus)

  6 Downloads (Pure)

• Exploiting the catalytic power of enzymes for oxy- and amino-functionalization reactions

  Grandi, E., 2023, [Groningen]: University of Groningen. 222 p.

  Research output: Thesis › Thesis fully internal (DIV)

  Open Access

  File
  234 Downloads (Pure)

• Exploring the genetics of asthma: from gene variants to targeted treatments

  Elhusseini, Z., 2023, [Groningen]: University of Groningen. 142 p.

  Research output: Thesis › Thesis fully internal (DIV)

  Open Access

  File
  80 Downloads (Pure)

• First-in-Class Selective Inhibitors of the Lysine Acetyltransferase KAT8

  Fiorentino, F., Sementilli, S., Menna, M., Turrisi, F., Tomassi, S., Pellegrini, F. R., Iuzzolino, A., D’Acunzo, F., Feoli, A., Wapenaar, H., Taraglio, S., Fraschetti, C., Del Bufalo, D., Sbardella, G., Dekker, F. J., Paiardini, A., Trisciuoglio, D., Mai, A. & Rotili, D., 8-May-2023, In: Journal of Medicinal Chemistry. 66, 10, p. 6591–6616 26 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  15 Downloads (Pure)

• Genome sequencing and molecular networking analysis of the wild fungusAnthostomella pineareveal its ability to produce a diverse range of secondary metabolites

  Iacovelli, R., He, T., Allen, J. L., Hackl, T. & Haslinger, K., 20-Oct-2023, (Submitted) BioRxiv, 57 p.

  Research output: Working paper › Preprint › Academic

  File
  3 Downloads (Pure)

• Genomic and metabolomic analysis of the endophytic fungus Fusarium sp. VM-40 isolated from the medicinal plant Vinca minor

  He, T., Li, X., Iacovelli, R., Hackl, T. & Haslinger, K., 27-Jun-2023, In: Journal of fungi (Basel, Switzerland). 9, 7, 26 p., 704.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  12 Downloads (Pure)

• Histone Deacetylase 3-Directed PROTACs Have Anti-inflammatory Potential by Blocking Polarization of M0-like into M1-like Macrophages

  Zhao, C., Chen, S., Chen, D., Río-Bergé, C., Zhang, J., Ettema, P., Daemen, T. & Dekker, F. J., 16-Oct-2023, In: Angewandte Chemie (International ed. in English). 62, 42, 11 p., e202310059.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  2 Downloads (Pure)

• Identification and Characterization of a Small Molecule that Activates Thiosulfate Sulfurtransferase and Stimulates Mitochondrial Respiration

  Al-Dahmani, Z. M., Hadian, M., Ruiz-Moreno, A. J., Maria, S-G. A., Batista, F. A., Zhang, R., Luo, Y., Sadremomtaz, A., van der Straat, R., Spoor, M., Dolga, A. M., Dekker, F. J., S S, A. D., van Goor, H. & Groves, M. R., Nov-2023, In: Protein Science. 32, 11, 18 p., e4794.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

• Light-driven bioprocesses

  Runda, M. E. & Schmidt, S., 17-Apr-2023, (E-pub ahead of print) In: Physical Sciences Reviews. 34 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  17 Downloads (Pure)

• Membrane Adaptations and Cellular Responses of Sulfolobus acidocaldarius to the Allylamine Terbinafine

  Rao, A., de Kok, N. A. W. & Driessen, A. J. M., 15-Apr-2023, In: International Journal of Molecular Sciences. 24, 8, 16 p., 7328.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  1 Citation (Scopus)

  13 Downloads (Pure)

• MIBiG 3.0: a community-driven effort to annotate experimentally validated biosynthetic gene clusters

  MiBIG 3.0, 2023, In: Nucleic Acids Research. 51, D1, p. D603-D610 7 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  33 Citations (Scopus)

  18 Downloads (Pure)

• Novel inhibitors of histone deacetylase (hdac), and methods, compositions and uses related thereto

  Zwinderman, R. H. & Dekker, F. J., 26-Jan-2023, Patent No. WO2023003468, 22-Jul-2022, Priority date 23-Jul-2021

  Research output: Patent

  Open Access

  File
  33 Downloads (Pure)

• Peroxygenases and oxygenases within the tautomerase superfamily: Investigation, Engineering and the Application in an Enzymatic Cascade

  Sigmund, M., 2023, [Groningen]: University of Groningen. 201 p.

  Research output: Thesis › Thesis fully internal (DIV)

  Open Access

  File
  64 Downloads (Pure)

• Protocol of the Double-Click Seq Method to Evaluate the Deposition Bias of Chromatin Proteins

  van der Wouden, P. E., Zwinderman, M. R. H., Chen, D., Borghesan, M. & Dekker, F. J., Jun-2023, In: Current Protocols. 3, 6, 17 p., e805.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  6 Downloads (Pure)

• Rational Design in Photopharmacology with Molecular Photoswitches

  Kobauri, P., Dekker, F. J., Szymanski, W. & Feringa, B. L., 24-Jul-2023, In: Angewandte Chemie - International Edition. 62, 30, e202300681.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File
  9 Citations (Scopus)

  61 Downloads (Pure)

• Rieske Oxygenases and other Ferredoxin‐dependent Enzymes: Electron Transfer Principles and Catalytic Capabilities

  Runda, M. E., De kok, N. A. W. & Schmidt, S., 1-Aug-2023, In: ChemBioChem. 24, 15, 23 p., e202300078.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  1 Citation (Scopus)

  9 Downloads (Pure)

• Structural characterization and extended substrate scope analysis of two Mg²⁺-dependent O-methyltransferases from bacteria

  Sokolova, N., Zhang, L., Deravi, S., Oerlemans, R., Groves, M. R. & Haslinger, K., 29-Jan-2023, (Submitted) BioRxiv, 17 p.

  Research output: Working paper › Preprint › Academic

  File
  23 Downloads (Pure)

• Structural Characterization and Extended Substrate Scope Analysis of Two Mg²⁺-Dependent O-Methyltransferases from Bacteria**

  Sokolova, N., Zhang, L., Deravi, S., Oerlemans, R., Groves, M. R. & Haslinger, K., 2-May-2023, In: ChemBioChem. 24, 9, 11 p., e202300076.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  2 Citations (Scopus)

  13 Downloads (Pure)

• Substituted thiophene compounds as d-dopachrome tautomerase inhibitors

  Xiao, Z. & Dekker, F. J., 9-Mar-2023, Patent No. WO2023031246, 31-Aug-2022, Priority date 1-Sept-2021

  Research output: Patent

  Open Access

  File
  4 Downloads (Pure)

• Tailored photoenzymatic systems for selective reduction of aliphatic and aromatic nitro compounds fueled by light

  Luján, A. P., Bhat, M. F., Tsaturyan, S., van Merkerk, R., Fu, H. & Poelarends, G. J., 6-Sept-2023, In: Nature Communications. 14, 1, 10 p., 5442.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  6 Downloads (Pure)

• Tapping into abiological reaction chemistries in biocatalysis

  de Kok, N. & Schmidt, S., 16-Mar-2023, In: Chem Catalysis. 3, 3, 100493.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
• 2022

  4-Iodopyrimidine labeling reveals nuclear translocation and nuclease activity for both MIF and MIF2

  Xiao, Z., Chen, D., Mulder, F., Song, S., van der Wouden, P. E., Cool, R. H., Melgert, B. N., Poelarends, G. J. & Dekker, F. J., 3-Jan-2022, In: Chemistry. 28, 1, e202103030.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  3 Citations (Scopus)

  93 Downloads (Pure)

• Artemisinin-Type Drugs in Tumor Cell Death: Mechanisms, Combination Treatment with Biologics and Nanoparticle Delivery

  Zhou, X., Suo, F., Haslinger, K. & Quax, W. J., 10-Feb-2022, In: Pharmaceutics. 14, 2, 27 p., 395.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File
  5 Citations (Scopus)

  112 Downloads (Pure)

• Chemo‐ and Enantioselective Photoenzymatic Ketone Reductions Using a Promiscuous Flavin‐dependent Nitroreductase

  Luján, A. P., Bhat, M. F., Saravanan, T. & Poelarends, G. J., 22-Apr-2022, In: ChemCatChem. 14, 6 p., e202200043.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  4 Citations (Scopus)

  53 Downloads (Pure)

• Chemoenzymatic Asymmetric Synthesis of Complex Heterocycles: Dihydrobenzoxazinones and Dihydroquinoxalinones

  Bhat, F., Prats Lujan, A., Saifuddin, M. & Poelarends, G., 6-Sept-2022, In: ACS Catalysis. 12, p. 11421–11427 7 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  3 Citations (Scopus)

  29 Downloads (Pure)

• Controlling the virulence of Pseudomonas aeruginosa through inhibiting the synthesis of pyoverdine

  Wibowo, J., 2022, [Groningen]: University of Groningen. 169 p.

  Research output: Thesis › Thesis fully internal (DIV)

  Open Access

  File
  397 Downloads (Pure)

• Cover Feature: The Synthesis of Chiral γ-Lactones by Merging Decatungstate Photocatalysis with Biocatalysis (ChemCatChem 19/2022)

  Özgen, F. F., Jorea, A., Capaldo, L., Kourist, R., Ravelli, D. & Schmidt, S., Oct-2022

  Research output: Non-textual form › Digital or Visual Products › Academic

• Design and Directed Evolution of Enzymes for Iminium Biocatalysis

  Xu, G., 2022, [Groningen]: University of Groningen. 234 p.

  Research output: Thesis › Thesis fully internal (DIV)

  Open Access

  File
  271 Downloads (Pure)

• Designing biocatalysts for non-natural carboligations

  Kunzendorf, A., 2022, [Groningen]: University of Groningen. 268 p.

  Research output: Thesis › Thesis fully internal (DIV)

  Open Access

  File
  142 Downloads (Pure)

• Development and application of CRISPR-based genetic tools in Bacillus species and Bacillus phages

  Song, Y., He, S., Jopkiewicz, A., Setroikromo, R., van Merkerk, R. & Quax, W. J., Oct-2022, In: Journal of Applied Microbiology. 133, 4, p. 2280-2298 19 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File
  1 Citation (Scopus)

  82 Downloads (Pure)

• Dihydroartemisinin-Transferrin Adducts Enhance TRAIL-Induced Apoptosis in Triple-Negative Breast Cancer in a P53-Independent and ROS-Dependent Manner

  Zhou, X., Soto-Gamez, A., Nijdam, F., Setroikromo, R. & Quax, W. J., 3-Jan-2022, In: Frontiers in Oncology. 11, 789336.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  7 Citations (Scopus)

  31 Downloads (Pure)

• Discovery of chromene compounds as inhibitors of PvdQ acylase of Pseudomonas aeruginosa

  Vogel, J. G. T., Wibowo, J. P., Fan, H., Setroikromo, R., Wang, K., Dömling, A., Dekker, F. J. & Quax, W. J., 27-Oct-2022, In: Microbes and infection. 24, 7 p., 105017.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  1 Citation (Scopus)

  21 Downloads (Pure)

• Enantiocomplementary Michael Additions of Acetaldehyde to Aliphatic Nitroalkenes Catalyzed by Proline‐Based Carboligases

  Kunzendorf, A., Saifuddin, M. & Poelarends, G. J., 18-Mar-2022, In: ChemBioChem. 23, 6, 5 p., 202100644.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  1 Citation (Scopus)

  34 Downloads (Pure)

• Engineering a plant polyketide synthase for the biosynthesis of methylated flavonoids

  Peng, B., Zhang, L., He, S., Oerlemans, R., Quax, W. J., Groves, M. R. & Haslinger, K., 2-Oct-2022, (Submitted) BioRxiv, 27 p.

  Research output: Working paper › Preprint › Academic

  File
  17 Downloads (Pure)

• Enhanced extrinsic apoptosis of therapy-induced senescent cancer cells using a death receptor 5 (DR5) selective agonist

  Soto-Gamez, A., Wang, Y., Zhou, X., Seras, L., Quax, W. & Demaria, M., 28-Jan-2022, In: Cancer letters. 525, p. 67-75 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  9 Citations (Scopus)

  106 Downloads (Pure)

• Enhancing the Peroxygenase Activity of a Cofactor‐Independent Peroxyzyme by Directed Evolution Enabling Gram‐Scale Epoxide Synthesis

  Sigmund, M., Xu, G., Grandi, E. & Poelarends, G. J., 21-Oct-2022, In: Chemistry. 28, 59, 8 p., e202201651.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  2 Citations (Scopus)

  38 Downloads (Pure)

• Enzyme-Mediated Quenching of the Pseudomonas Quinolone Signal (PQS): A Comparison between Naturally Occurring and Engineered PQS-Cleaving Dioxygenases

  Arranz San Martín, A., Vogel, J., Wullich, S. C., Quax, W. J. & Fetzner, S., 21-Jan-2022, In: Biomolecules. 12, 2, 12 p., 170.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  4 Citations (Scopus)

  21 Downloads (Pure)

• Erratum to: Nonribosomal peptide synthetases and their biotechnological potential in Penicillium rubens(Journal of Industrial Microbiology and Biotechnology DOI: 10.1093/jimb/kuab045)

  Iacovelli, R., Bovenberg, R. A. L. & Driessen, A. J. M., 1-May-2022, In: Journal of Industrial Microbiology and Biotechnology. 49, 3, 1 p., kuac005.

  Research output: Contribution to journal › Erratum

  Open Access

  File
  8 Downloads (Pure)

• Expanding the repertoire of Rieske oxygenases for O-demethylations

  Schmidt, S., 18-Aug-2022, In: Chem Catalysis. 2, 8, p. 1843-1845 3 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  1 Citation (Scopus)

  143 Downloads (Pure)