Groningen Biomolecular Sciences and Biotechnology Institute

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  • 2024

    Large conical nanopores and uses thereof in analyte sensing

    Maglia, G. (Inventor), Yelleswarapu, M. (Inventor), Wloka, C. (Inventor) & Straathof, S. (Inventor), 3-Oct-2024, Patent No. WO2024205413, 2-Apr-2024, Priority date 30-Mar-2023

    Research output: Patent

    Open Access
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    59 Downloads (Pure)

  • Method for the preparation of lactulose

    Toplak, A. (Inventor), Cabri, W. (Inventor), Nuijens, T. (Inventor), Ricci, A. (Inventor) & Janssen, D. B. (Inventor), 10-Oct-2024, Patent No. WO2024208687, 27-Mar-2024, Priority date 6-Apr-2023

    Research output: Patent

    Open Access
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    1 Downloads (Pure)

  • Nanobody-functionalized biological nanopores and means and methods related thereto

    Maglia, G. (Inventor), Zhang, X. (Inventor) & Kjems, J. (Inventor), 6-Jun-2024, Patent No. WO2024117910, 1-Dec-2023, Priority date 2-Dec-2022

    Research output: Patent

    Open Access
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    9 Downloads (Pure)

  • Nanopore-based analysis of proteins

    Maglia, G. (Inventor), Zhang, S. (Inventor) & Heron, A. (Inventor), 2-May-2024, Patent No. WO2024091124, 30-Oct-2023, Priority date 28-Oct-2022

    Research output: Patent

    Open Access
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    49 Downloads (Pure)

  • Nanopore systems and methods for single-molecule polymer profiling

    Maglia, G. (Inventor) & Sauciuc, A. (Inventor), 2-May-2024, Patent No. WO2024091123, 30-Oct-2023, Priority date 28-Oct-2022

    Research output: Patent

    Open Access
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    64 Downloads (Pure)

  • Thermostable subtilisin variants and their use

    Cabri, W. (Inventor), Halmschlag, B. S. (Inventor), Toplak, A. (Inventor), Janssen, D. B. (Inventor), Teixeira de Oliveira, E. F. (Inventor), Nuijens, T. (Inventor) & Wijma, H. J. (Inventor), 27-Jun-2024, Patent No. WO2024133313, 19-Dec-2023, Priority date 19-Dec-2022

    Research output: Patent

    Open Access
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    9 Downloads (Pure)

  • Variant flavoproteins comprising covalently tethered flavin cofactor, and means and methods related thereto.

    Fraaije, M. W. (Inventor) & Tong, Y. (Inventor), 27-Jun-2024, Patent No. WO2024136655, 21-Dec-2023, Priority date 21-Dec-2022

    Research output: Patent

    Open Access
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    62 Downloads (Pure)
  • 2022

    5-hydroxyindole and analogs thereof as stimulants of gut motility

    El Aidy, S. (Inventor) & Waclawiková, B. (Inventor), 13-Jan-2022, Patent No. WO2022010352, 9-Jul-2021, Priority date 10-Jul-2020

    Research output: Patent

    Open Access
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    30 Downloads (Pure)

  • Increased 2'-fl production by goats

    Haandrikman, A. J. (Inventor), Happe, R. P. (Inventor), Pellis, E. P. M. (Inventor), Benjamins, F. (Inventor), Dijkhuizen, L. (Inventor), Chatziioannou, A. C. (Inventor) & van Leeuwen, S. S. (Inventor), 16-Jun-2022, Patent No. WO2022123036, 10-Dec-2016, Priority date 11-Dec-2020

    Research output: Patent

    Open Access
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    114 Downloads (Pure)

  • Nanopore proteomics

    Lucas, F. L. R. (Inventor), Versloot, R. C. R. (Inventor) & Maglia, G. (Inventor), 24-Nov-2022, Patent No. WO2022245209, 18-May-2022, Priority date 18-May-2021

    Research output: Patent

    Open Access
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    76 Downloads (Pure)
  • 2021

    Artificial nanopores and uses and methods relating thereto

    Maglia, G. (Inventor) & Zhang, S. (Inventor), 27-May-2021, Patent No. WO2021101378, 19-Nov-2020, Priority date 19-Nov-2019

    Research output: Patent

    Open Access
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    43 Downloads (Pure)

  • Chemically-stabilized allosteric modulators of leucine-rich repeat kinase 2 (lrrk2)

    Kennedy, E. (Inventor), Kortholt, A. (Inventor) & Helton, L. G. (Inventor), 2-Sept-2021, Patent No. WO2021173802, 25-Feb-2021, Priority date 25-Feb-2020

    Research output: Patent

    Open Access
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    30 Downloads (Pure)

  • Engineered plyab nanopores and uses thereof.

    Maglia, G. (Inventor), Huang, G. (Inventor) & Soskine, M. (Inventor), 16-Sept-2021, Patent No. WO2021182957, 11-Mar-2021, Priority date 11-Mar-2020

    Research output: Patent

    Open Access
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    25 Downloads (Pure)

  • Leucine-rich repeat kinase 2 allosteric modulators

    Versees, W. (Inventor), Singh, R. K. (Inventor), Kortholt, A. (Inventor) & Gloeckner, C. J. (Inventor), 2-Sept-2021, Patent No. WO2021170540, 22-Feb-2021, Priority date 25-Feb-2020

    Research output: Patent

    Open Access
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    17 Downloads (Pure)

  • Means and methods for selective double diol oxidation.

    Fraaije, M. W. (Inventor), Trajkovic, M. (Inventor) & Martin, C. (Inventor), 15-Apr-2021, Patent No. WO2021071356, 7-Oct-2020, Priority date 8-Oct-2019

    Research output: Patent

    Open Access
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    57 Downloads (Pure)

  • Process for dyeing textiles

    Lončar, N. (Inventor), Konukoglu, F. (Inventor), Fraaije, M. (Inventor), Eryilmaz, J. (Inventor) & Tuncer, E. (Inventor), 28-Jan-2021, Patent No. WO2021013371, 31-Oct-2019, Priority date 22-Jul-2019

    Research output: Patent

    Open Access
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    43 Downloads (Pure)

  • Reversible photo-controlled frac nanopores, modified frac monomers, methods for preparing the same, and uses thereof

    Maglia, G. (Inventor), Mutter, N. L. (Inventor), Volaric, J. (Inventor), Feringa, B. L. (Inventor) & Szymanski, W. C. (Inventor), 3-Feb-2021, Patent No. EP3771687, 30-Jul-2019, Priority date 30-Jul-2019

    Research output: Patent

    Open Access
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    141 Downloads (Pure)
  • 2020

    Biological nanopores having tunable pore diameters and uses thereof as analytical tools

    Huang, K. (Inventor) & Maglia, G. (Inventor), 19-Mar-2020, Patent No. WO2020055246, 11-Sept-2019, Priority date 11-Sept-2018

    Research output: Patent

    Open Access
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    25 Downloads (Pure)

  • Genetically-modified bacteria and uses thereof

    Knight, J. (Inventor), Branneby, C. K. (Inventor), Dijkhuizen, L. (Inventor), Petrusma, M. (Inventor) & Fernández de las Heras, L. (Inventor), 13-Feb-2020, Patent No. WO2020030799, 9-Aug-2019, Priority date 9-Aug-2018

    Research output: Patent

    Open Access
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    30 Downloads (Pure)

  • Process and apparatus for dyeing textiles

    Lončar, N. (Inventor), Eryilmaz, J. (Inventor), Senel, E. (Inventor), Kaplan, G. (Inventor), Fraaije, M. (Inventor) & Cobanoglu, O. (Inventor), 23-Jan-2020, Patent No. WO2020015839, 20-Jul-2018, Priority date 20-Jul-2018

    Research output: Patent

    Open Access
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    28 Downloads (Pure)
  • 2019

    Mutant alcohol oxidases and use thereof in the conversion of diols and polyols

    Fraaije, M. W. (Inventor), Romero Guzman, E. (Inventor), Mattevi, A. (Inventor) & Nguyen, Q.-T. (Inventor), 7-Nov-2019, Patent No. WO2019212351, 3-May-2019, Priority date 3-May-2018

    Research output: Patent

    Open Access
  • 2018

    Antimicrobial peptides and admixtures thereof showing antimicrobial activity against gram-negative pathogens

    Kuipers, O. P. (Inventor) & Li, Q. (Inventor), 20-Dec-2018, Patent No. WO2018231058, Priority date 13-Jun-2017

    Research output: Patent

    Open Access

  • Biological nanopores for biopolymer sensing and sequencing based on frac actinoporin

    Maglia,, G. (Inventor), Wloka,, C. (Inventor), Mutter, N. L. (Inventor), Soskine,, M. (Inventor) & Huang,, G. (Inventor), 18-Jan-2018, Patent No. WO2018012963, Priority date 12-Jul-2016

    Research output: Patent

    Open Access

  • Branched alpha glucans

    Gangoiti Muñecas, J. (Inventor), van Leeuwen, S. S. (Inventor), Pijning, T. (Inventor), Dijkhuizen, L. (Inventor), Vafeiadi, C. (Inventor) & Duboux, S. (Inventor), 20-Sept-2018, Patent No. WO2018167032, Priority date 15-Mar-2017

    Research output: Patent

    Open Access

  • Eukaryotic cell comprising xylose isomerase

    Verhoeven, M. D. (Inventor), Lee, M. (Inventor), van den Broek, M. (Inventor), Janssen, D. B. (Inventor), Daran, J.-M. G. (Inventor), van Maris, A. J. A. (Inventor), Pronk, J. T. (Inventor), Bracher, J. M. (Inventor), De Waal, P. P. (Inventor) & de Bruijn, H. M. C. J. (Inventor), 26-Apr-2018, Patent No. WO2018073107, Priority date 19-Oct-2016

    Research output: Patent

    Open Access

  • Means and methods for reducing or avoiding antibiotic resistance and spread of virulence in human pathogens

    Domenech, A. (Inventor) & Veening, J.-W. (Inventor), 19-Apr-2018, Patent No. WO2018070874, Priority date 12-Oct-2016

    Research output: Patent

    Open Access

  • Prebiotic branched galacto-oligosaccharides (gos)

    Lammerts van Bueren-Brandt, A. (Inventor) & Dijkhuizen, L. (Inventor), 15-Mar-2018, Patent No. WO2018048305, Priority date 12-Sept-2016

    Research output: Patent

    Open Access
  • 2017

    Alpha glucans

    Dijkhuizen,, L. (Inventor), Gangoiti Muñecas,, J. (Inventor), van Leeuwen, S. S. (Inventor), Vafeiadi, C. (Inventor) & Duboux,, S. (Inventor), 7-Dec-2017, Patent No. WO2017207663, Priority date 2-Jun-2016

    Research output: Patent

    Open Access

  • Beta-glucosidase and uses thereof

    Wijma, H. J. (Inventor), Janssen, D. B. (Inventor) & van Leeuwen, J. G. E. (Inventor), 15-Jun-2017, Patent No. WO2017097897, Priority date 10-Dec-2015

    Research output: Patent

    Open Access

  • Branched alpha glucans

    Gangoiti Muñecas, J. (Inventor), van Leeuwen, S. S. (Inventor), Dijkhuizen, L. (Inventor), Vafeiadi, C. (Inventor) & Lamothe, L. (Inventor), 23-Mar-2017, Patent No. WO2017046040, Priority date 15-Sept-2015

    Research output: Patent

    Open Access

  • Mbth-like proteins in eukaryotic nrps-catalyzed processes

    Bovenberg, R. A. L. (Inventor), Muller, U. M. (Inventor), Driessen, A. J. M. (Inventor), Pohl, C. (Inventor) & Zwahlen, R. D. (Inventor), 19-Oct-2017, Patent No. WO2017178624, Priority date 14-Apr-2016

    Research output: Patent

    Open Access
  • 2016

    A CRISPR-CAS system for a filamentous fungal host cell

    Meijrink, B. (Inventor), Verwaal, R. (Inventor), Gielesen, B. E. M. (Inventor), Roubos, J. A. (Inventor), Nygård, Y. I. (Inventor), Bovenberg, R. (Inventor), Driessen, A. J. M. (Inventor) & Pohl, C. (Inventor), 14-Jul-2016, Patent No. WO2016110453, Priority date 6-Jan-2015

    Research output: Patent

    Open Access

  • Methods for the enzymatic modification of steviol glycosides, modified steviol glycosides obtainable thereby, and the use thereof as sweeteners

    te Poele, E. M. (Inventor), Dijkhuizen, L. (Inventor), Gerwig, G. J. (Inventor) & Kamerling, J. P. (Inventor), 15-Sept-2016, Patent No. WO2016144175, Priority date 10-Mar-2015, Priority No. EP20150158421 20150310

    Research output: Patent

    Open Access

  • Nanopores with internal protein adaptors

    Maglia, G. (Inventor), Soskine, M. (Inventor), Biesemans, A. (Inventor), Meervelt, V. (Inventor) & Poolman, B. (Inventor), 20-Oct-2016, Patent No. WO2016166232, Priority date 14-Apr-2015

    Research output: Patent

    Open Access

  • Peptide fragment condensation and cyclisation using a subtilisin variant with improved synthesis over hydrolysis ratio

    Quaedflieg, P. J. L. M. (Inventor), Nuijens, T. (Inventor), van der Laan, J. M. (Inventor), Janssen, D. B. (Inventor), Toplak, A. (Inventor) & Wu, B. (Inventor), 14-Apr-2016, Patent No. WO2016056913, Priority date 10-Oct-2014

    Research output: Patent

    Open Access
  • 2015

    Heat resistant microorganism

    Berendsen, E. M. (Inventor), Bennik, M. H. J. (Inventor) & Kuipers, O. P. (Inventor), 27-Aug-2015, Patent No. WO2015126251, Priority date 20-Feb-2014, Priority No. EP20140155913 20140220

    Research output: Patent

    Open Access

  • Process for production of an alkyl methacrylate

    Eastham, G. R. (Inventor), Johnson, D. W. (Inventor), Fraaije, M. (Inventor) & Winter, R. (Inventor), 16-Jul-2015, IPC No. C12P7/62, Patent No. AU20130366045(A1), Priority date 21-Dec-2012, Priority No. GB20120023271 20121221; WO2013GB53385 20131220

    Research output: Patent

  • Process for the production of methyl methacrylate

    Eastham, G. R. (Inventor), Johnson, D. W. (Inventor), Straathof, A. J. J. (Inventor), Fraaije, M. (Inventor) & Winter, R. (Inventor), 5-Feb-2015, IPC No. C12N9/02; C12P7/62, Patent No. MX2014014370 (A), Priority date 28-May-2012, Priority No. GB20120009425 20120528; WO2013GB51376 20130524

    Research output: Patent

  • Thermostable Alginate degrading enzymes and their methods of use

    Hreggvidsson, G. O. (Inventor), Jonsson Wheat, J. O. (Inventor), Bjornsdottir, B. (Inventor), Fridjonsson, O. H. (Inventor), Altenbuchner, J. (Inventor), Watzlawick, H. (Inventor), Dobruchowska, J. M. (Inventor) & Kamerling, J. P. (Inventor), 16-Jul-2015, Patent No. WO2015104723, Priority date 10-Jan-2014

    Research output: Patent

    Open Access
  • 2014

    Compounds and their use in therapy

    van Hell, A. (Inventor), Verheij, M. (Inventor), Marrink, S. J. (Inventor) & Koning, G. (Inventor), 20-Nov-2014, Patent No. WO2014184726, Priority date 15-May-2013

    Research output: Patent

    Open Access

  • Glucan branching enzymes and their methods of use

    Jonsson Wheat, J. O. (Inventor), Hreggvidsson, G. O. (Inventor), Fridjonsson, O. H. (Inventor), Dobruchowska, J. M. (Inventor), Kamerling, J. P. (Inventor) & Dijkhuizen, L. (Inventor), 2-Oct-2014, Patent No. Netherlands, Priority date 26-Mar-2013

    Research output: Patent

    Open Access

  • Improved means and methods for expressing recombinant proteins

    Poolman, B. (Inventor), Martinez Linares, D. (Inventor) & Gul, N. (Inventor), 29-Oct-2014, Patent No. EP2796556, Priority date 25-Apr-2013

    Research output: Patent

    Open Access

  • Improved penicillin production

    Scheckhuber, C. Q. (Inventor) & van der Klei, I. J. (Inventor), 3-Jan-2014, Patent No. WO2014003555, Priority date 27-Jun-2012

    Research output: Patent

    Open Access

  • Method for the production of primary amines

    Baldenius, K.-U. (Inventor), Ditrich, K. (Inventor), Breurer, M. (Inventor), Navickas, V. (Inventor), Janssen, D. (Inventor), Bartsch, S. (Inventor) & Crismaru, C. (Inventor), 20-Mar-2014, Patent No. WO2014041011, Priority date 11-Sept-2012

    Research output: Patent

    Open Access

  • Nanopore biosensors for detection of proteins and nucleic acids

    Maglia, G. (Inventor) & Soskine, M. (Inventor), 2-Oct-2014, Patent No. WO2014153625, Priority date 25-Mar-2013

    Research output: Patent

    Open Access

  • Polypeptides with permease activity

    Klaassen, P. (Inventor), De Waal, P. P. (Inventor), De Jong, R. M. (Inventor), Driessen, A. J. M. (Inventor), Nijland, J. G. (Inventor) & Shin, H. Y. (Inventor), 11-Dec-2014, Patent No. WO2014195522, Priority date 18-Dec-2013

    Research output: Patent

    Open Access

  • Polypeptides with permease activity

    Klaassen, P. (Inventor), De Waal, P. P. (Inventor), De Jong, R. M. (Inventor), Driessen, A. J. M. (Inventor), Nijland, J. G. (Inventor) & Shin, H. Y. (Inventor), 11-Dec-2014, Patent No. WO2014195520, Priority date 13-Dec-2013, Priority No. EP20130197988 20131218 ; EP20140160772 20140319 ; EP20140164270 20140410

    Research output: Patent

    Open Access

  • Polypetides with permease activity

    Klaassen, P. (Inventor), De Waal, P. P. (Inventor), De Jong, R. M. (Inventor), Driessen, A. J. M. (Inventor), Nijland, J. G. (Inventor) & Shin, H. Y. (Inventor), 11-Dec-2014, IPC No. C07K14/395, Patent No. WO2014195521, Priority date 11-Dec-2013

    Research output: Patent

    Open Access
  • 2013

    Increased production of membrane proteins

    Poolman, B. (Inventor), Linares, D. M. (Inventor) & Gul, N. (Inventor), 2013, Patent No. P100103EP00

    Research output: Patent

  • Methods for providing sialylated oligosaccharides

    Sallomons, E. (Inventor), Wilbrink, M. H. (Inventor), Sanders, P. (Inventor) & Kamerling, J. P. (Inventor), 13-Jun-2013, Patent No. WO2013085384, 6-Dec-2012, Priority date 7-Dec-2011

    Research output: Patent

    Open Access