Life Course Epidemiology (LCE)

2025

A Large-Scale Genome-wide Association Study of Blood Pressure Accounting for Gene-Depressive Symptomatology Interactions in 564,680 Individuals from Diverse Populations

Lee, S., Miller, C. L., Bentley, A. R., Brown, M. R., Nagarajan, P., Noordam, R., Morrison, J., Schwander, K., Westerman, K., Kho, M., Kraja, A. T., de Vries, P. S., Ammous, F., Aschard, H., Bartz, T. M., Do, A., Dupont, C. T., Feitosa, M. F., Gudmundsdottir, V. & Guo, X. & 131 others, Harris, S. E., Hikino, K., Huang, Z., Lefevre, C., Lyytikäinen, L.-P., Milaneschi, Y., Nardone, G. G., Santin, A., Schmidt, H., Shen, B., Sofer, T., Sun, Q., Tan, Y. A., Tang, J., Thériault, S., van der Most, P. J., Ware, E. B., Weiss, S., Xing, W. Y., Yu, C., Zhao, W., Ansari, M. A. Y., Anugu, P., Attia, J. R., Bazzano, L. A., Bis, J. C., Breyer, M., Cade, B., Chen, G., Collins, S., Corley, J., Davies, G., Dörr, M., Du, J., Edwards, T. L., Faquih, T., Faul, J. D., Fohner, A. E., Fretts, A. M., Gangireddy, S., Gepner, A., Graff, M., Hofer, E., Homuth, G., Hood, M. M., Jie, X., Kähönen, M., Kardia, S. L., Karvonen-Gutierrez, C. A., Launer, L. J., Levy, D., Maheshwari, M., Martin, L. W., Matsuda, K., McNeil, J. J., Nolte, I. M., Okochi, T., Raffield, L. M., Raitakari, O. T., Risch, L., Risch, M., Roux, A. D., Ruiz-Narvaez, E. A., Russ, T. C., Saito, T., Schreiner, P. J., Scott, R. J., Shikany, J., Smith, J. A., Snieder, H., Spedicati, B., Tai, E. S., Taylor, A. M., Taylor, K. D., Tesolin, P., van Dam, R. M., Wang, R., Wenbin, W., Xie, T., Yao, J., Young, K. L., Zhang, R., Zonderman, A. B., Project, T. B. J., Study, L. C., Concas, M. P., Conen, D., Cox, S. R., Evans, M. K., Fox, E. R., Fuentes, L. D. L., Giri, A., Girotto, G., Grabe, H. J., Gu, C., Gudnason, V., Harlow, S. D., Holliday, E., Jost, J. B., Lacaze, P., Lee, S., Lehtimäki, T., Li, C., Liu, C.-T., Morrison, A. C., North, K. E., Penninx, B. W., Peyser, P. A., Province, M. M., Psaty, B. M., Redline, S., Rosendaal, F. R., Rotimi, C. N., Rotter, J. I., Schmidt, R., Sim, X., Terao, C., Weir, D. R., Zhu, X., Franceschini, N., O'Connell, J. R., Jaquish, C. E., Wang, H., Manning, A., Munroe, P. B., Rao, D. C., Chen, H., Gauderman, W. J., Bierut, L., Winkler, T. W. & Fornage, M., 17-Feb-2025, Research Square Company, 20 p. (Research Square).

Research output: Working paper › Preprint › Academic

Open Access

Development of an e-learning environment with a user-centered design process: an example in the education of epidemiology and medical statistics

Wieringa, T. H., van de Belt, H. A., Burgerhof, J. G. M., Groen, H., Postmus, D., Smidt, N., Nolte, I. M., Thio, C. H. L., la Bastide-van Gemert, S., Schroevers, M. J., Ranchor, A. V., Wardenaar, K. J., Hietkamp-Hoekstra, S. D., Nijmeijer, R., Tamasi, K., de Bock, G. H., Snieder, H. & El-Baz, N., 21-Mar-2025, ZENODO, 14 p.

Research output: Working paper › Preprint › Academic

Open Access

File

33 Downloads (Pure)

Robust inference and widespread genetic correlates from a large-scale genetic association study of human personality

Estonian Biobank Research Team, Schwaba, T., Clapp Sullivan, M. L., Akingbuwa, W. A., Ilves, K., Tanksley, P. T., Williams, C. M., Dragostinov, Y., Liao, W., Ackerman, L. S., Fealy, J. C. M., Hemani, G., de la Fuente, J., Gupta, P., Stein, M. B., Gelernter, J., Levey, D. F., Võsa, U., Ausmees, L. & Realo, A. & 32 others, Vaht, M., Allik, J., Esko, T., Mõttus, R., Vainik, U., Jonsdottir, G. A., Thorleifsson, G., Gunnarsson, Á. F., Bjornsdottir, G., Thorgeirsson, T. E., Stefansson, H., Stefansson, K., Cheesman, R., Qin, Q., Corfield, E. C., Ask, H., Torvik, F. A., Ystrom, E., Tesli, M., Boomsma, D. I., de Geus, E. J. C., Hottenga, J.-J., Melo, D. C., Snieder, H., Hartman, C. A., Xia, C., Campbell, A., Luciano, M., van der Most, P. J., Oldehinkel, A. J., Kretschmer, T. & Tucker-Drob, E. M., 19-May-2025, BioRxiv.

Research output: Working paper › Preprint › Academic

Open Access

2024

A Large-Scale Genome-Wide Gene-Sleep Interaction Study in 732,564 Participants Identifies Lipid Loci Explaining Sleep-Associated Lipid Disturbances

Million Veteran Program, Noordam, R., Wang, W., Nagarajan, P., Wang, H., Brown, M. R., Bentley, A. R., Hui, Q., Kraja, A. T., Morrison, J. L., O'Connel, J. R., Lee, S., Schwander, K., Bartz, T. M., de Las Fuentes, L., Feitosa, M. F., Guo, X., Hanfei, X., Harris, S. E. & Huang, Z. & 26 others, Kals, M., Lefevre, C., Mangino, M., Milaneschi, Y., van der Most, P., Pacheco, N. L., Palmer, N. D., Rao, V., Rauramaa, R., Sun, Q., Tabara, Y., Vojinovic, D., Wang, Y., Weiss, S., Zhu, W., Abu Yusuf Ansari, M., Aschard, H., Anugu, P., Assimes, T. L., Attia, J., Baker, L. D., Ballantyne, C., Chen, Z., Nolte, I. M., Snieder, H. & Triatin, R., 4-Sept-2024, 39 p. (medRxiv : the preprint server for health sciences).

Research output: Working paper › Preprint › Academic

Open Access

File

9 Downloads (Pure)

A Large-Scale Genome-Wide Study of Gene-Sleep Duration Interactions for Blood Pressure in 811,405 Individuals from Diverse Populations

Million Veteran Program, Nagarajan, P., Winkler, T. W., Bentley, A. R., Miller, C. L., Kraja, A. T., Schwander, K., Lee, S., Wang, W., Brown, M. R., Morrison, J. L., Giri, A., O'Connell, J. R., Bartz, T. M., de Las Fuentes, L., Gudmundsdottir, V., Guo, X., Harris, S. E., Huang, Z. & Kals, M. & 31 others, Kho, M., Lefevre, C., Luan, J., Lyytikäinen, L.-P., Mangino, M., Milaneschi, Y., Palmer, N. D., Rao, V., Rauramaa, R., Shen, B., Stadler, S., Sun, Q., Tang, J., Thériault, S., van der Graaf, A., van der Most, P. J., Wang, Y., Weiss, S., Westerman, K. E., Yang, Q., Yasuharu, T., Zhao, W., Zhu, W., Altschul, D., Ansari, M. A. Y., Argoty-Pantoja, A. D., Chen, Z., de Vries, P. S., Nolte, I. M., Penninx, B. W. & Snieder, H., 8-Mar-2024, MedRxiv, 28 p. (medRxiv : the preprint server for health sciences).

Research output: Working paper › Preprint › Academic

Open Access

A Large-Scale Genome-Wide Study of Gene-Sleep Duration Interactions for Blood Pressure in 811,405 Individuals from Diverse Populations

Wang, H., Nagarajan, P., Winkler, T., Bentley, A., Miller, C., Kraja, A., Schwander, K., Lee, S., Wang, W., Brown, M., Morrison, J., Giri, A., O'Connell, J., Bartz, T., Fuentes, L. D. L., Gudmundsdottir, V., Guo, X., Harris, S., Huang, Z. & Kals, M. & 142 others, Kho, M., Lefevre, C., Luan, J., Lyytikäinen, L.-P., Mangino, M., Milaneschi, Y., Palmer, N., Rao, V., Rauramaa, R., Shen, B., Stadler, S., Sun, Q., Tang, J., Thériault, S., van der Graaf, A., van der Most, P., Wang, Y., Weiss, S., Westerman, K., Yang, Q., Yasuharu, T., Zhao, W., Zhu, W., Altschul, D., Ansari, M. A. Y., Anugu, P., Argoty-Pantoja, A., Arzt, M., Aschard, H., Attia, J., Bazzano, L., Breyer, M., Brody, J., Cade, B., Chen, H.-H., Chen, Y.-D. I., Chen, Z., de Vries, P., Dimitrov, L., Do, A., Du, J., Dupont, C., Edwards, T., Evans, M., Faquih, T., Felix, S., Fisher-Hoch, S., Floyd, J., Graff, M., Gu, C. C., Gu, D., Hairston, K., Hanley, A., Heid, I., Heikkinen, S., Highland, H., Hood, M., Kähönen, M., Karvonen-Gutierrez, C., Kawaguchi, T., Kazuya, S., Tanika, K., Komulainen, P., Levy, D., Lin, H., Liu, P., Marques-Vidal, P., McCormick, J., Mei, H., Meigs, J., Menni, C., Nam, K., Nolte, I., Pacheco, N., Petty, L., Polikowsky, H., Province, M., Psaty, B., Raffield, L., Raitakari, O., Rich, S., Riha, R., Risch, L., Risch, M., Ruiz-Narvaez, E., Scott, R., Sitlani, C., Smith, J., Sofer, T., Teder-Laving, M., Völker, U., Vollenweider, P., Wang, G., van Dijk, K. W., Wilson, O., Xia, R., Yao, J., Young, K., Zhang, R., Zhu, X., Below, J., Böger, C., Conen, D., Cox, S., Dörr, M., Feitosa, M., Fox, E., Franceschini, N., Gharib, S., Gudnason, V., Harlow, S., He, J., Holliday, E., Kutalik, Z., Lakka, T., Lawlor, D., Lee, S., Lehtimäki, T., Li, C., Liu, C.-T., Mägi, R., Matsuda, F., Morrison, A., Penninx, B. W. J. H., Peyser, P., Rotter, J., Snieder, H., Spector, T., Wagenknecht, L., Wareham, N., Zonderman, A., North, K., Fornage, M., Hung, A., Manning, A., Gauderman, W., Chen, H., Munroe, P., Rao, D., van Heemst, D., Redline, S. & Noordam, R., 17-Jul-2024, Research Square Company, 18 p. (Research Square).

Research output: Working paper › Preprint › Academic

Open Access

File

59 Downloads (Pure)

Compositional changes of the lung extracellular matrix in acute respiratory distress syndrome

Fan, Y., Moser, J., Jongman, R., Borghuis, T., Vonk, J., Timens, W., van, M. M., Pillay, J. & Burgess, J., 15-Nov-2024, BioRxiv, 35 p.

Research output: Working paper › Preprint › Academic

Multi-ancestry polygenic risk scores for venous thromboembolism

Lifelines Cohort Study, INVENT Consortium, Jee, Y. H., Thibord, F., Dominguez, A., Sept, C., Boulier, K., Venkateswaran, V., Ding, Y., Cherlin, T., Verma, S. S., Faro, V. L., Bartz, T. M., Boland, A., Brody, J. A., Deleuze, J.-F., Emmerich, J., Germain, M., Johnson, A. D. & Kooperberg, C. & 17 others, Morange, P.-E., Pankratz, N., Psaty, B. M., Reiner, A. P., Smadja, D. M., Sitlani, C. M., Suchon, P., Tang, W., Trégouët, D.-A., Zöllner, S., Pasaniuc, B., Damrauer, S. M., Sanna, S., Snieder, H., Kabrhel, C., Smith, N. L. & Kraft, P., 10-Jan-2024, MedRxiv.

Research output: Working paper › Preprint › Academic

Open Access

File

27 Downloads (Pure)

Positive and negative affect, related mental health traits, and cognitive performance: shared genetic architecture and potential causality

Slaney, C., Mac Giollabhui, N., van der Most, P. J., Palacios, E. R., Snieder, H., Nivard, M., Hemani, G., Hartman, C. A. & Khandaker, G. M., 2-Nov-2024, MedRxiv, 26 p. (medRxiv : the preprint server for health sciences).

Research output: Working paper › Preprint › Academic

Role of Inflammation in Depressive and Anxiety Disorders, Affect, and Cognition: Genetic and Non-Genetic Findings in the Lifelines Cohort Study

Giollabhui, N. M., Slaney, C., Hemani, G., Foley, E., van der Most, P., Nolte, I., Snieder, H., Smith, G. D., Khandaker, G. & Hartman, C., 10-Aug-2024, Research Square Company.

Research output: Working paper › Preprint › Academic

Open Access

Role of Inflammation in Depressive and Anxiety Disorders, Affect, and Cognition: Genetic and Non-Genetic Findings in the Lifelines Cohort Study

Mac Giollabhui, N., Slaney, C., Hemani, G., Foley, E. M., van der Most, P. J., Nolte, I. M., Snieder, H., Smith, G. D., Khandaker, G. & Hartman, C., 19-Apr-2024, MedRxiv, (medRxiv : the preprint server for health sciences).

Research output: Working paper › Preprint › Academic

12 Downloads (Pure)

2023

Cohort profile: the ‘Biomarkers of heterogeneity in type 1 diabetes’ study – a prospective cohort study of clinical and metabolic phenotyping of individuals with long-standing type 1 diabetes

Mul, D., Varkevisser, R. D. M., Aanstoot, H.-J., Dekker, P., Birnie, E., Boersma, E., Boesten, L. S. M., Brugts, M. P., van Dijk, P. R., Duijvestijn, P. H. L. M., Dutta, S., Fransman, C., Gonera, R. K., Hoogenberg, K., Kooy, A., Latres, E., Loves, S., Nefs, G., Sas, T. & Verburg, F. A. J. & 6 others, Vollenbrock, C. E., Vosjan-Noeverman, M. J., de Vries-Velraeds, M. M. C., Veeze, H. J., Wolffenbuttel, B. H. R. & van der Klauw, M. M., 21-Aug-2023, MedRxiv.

Research output: Working paper › Preprint › Academic

Open Access

Understanding the genetic complexity of puberty timing across the allele frequency spectrum

ABCTB Investigators, Kentistou, K. A., Kaisinger, L. R., Stankovic, S., Vaudel, M., de Oliveira, E. M., Messina, A., Walters, R. G., Liu, X., Busch, A. S., Helgason, H., Thompson, D. J., Santon, F., Petricek, K. M., Zouaghi, Y., Huang-Doran, I., Gudbjartsson, D. F., Bratland, E., Lin, K. & Gardner, E. J. & 33 others, Zhao, Y., Jia, R., Terao, C., Riggan, M., Bolla, M. K., Yazdanpanah, M., Yazdanpanah, N., Bradfield, J. P., Broer, L., Campbell, A., Chasman, D. I., Cousminer, D. L., Franceschini, N., Franke, L. H., Girotto, G., He, C., Järvelin, M.-R., Joshi, P. K., Kamatani, Y., Karlsson, R., Luan, J., Lunetta, K. L., Mägi, R., Mangino, M., Smith, A. V., van der Most, P. J., Hübner, H., Nolte, I. M., Oldehinkel, A. J., Alizadeh, B. Z., Snieder, H., Perry, J. R. B. & Ong, K. K., 20-Jun-2023, MedRxiv.

Research output: Working paper › Preprint › Academic

2022

Towards overtreatment-free immunotherapy: Using genomic scars to select treatment beneficiaries in lung cancer

Donker, H., van Es, B., Tamminga, M., Lunter, G., van Kempen, L., Schuuring, E., Hiltermann, J. & Groen, H., 26-Sept-2022, BioRxiv, 26 p. (bioRxiv).

Research output: Working paper › Preprint › Academic

Open Access

File

33 Downloads (Pure)

2020

Determinants of SARS-CoV-2 receptor gene expression in upper and lower airways

Aliee, H., Massip, F., Qi, C., Stella de Biase, M., van Nijnatten, J. L., Kersten, E. T. G., Kermani, N. Z., Khuder, B., Vonk, J. M., Vermeulen, R. C. H., Neighbors, M., Tew, G. W., Grimbaldeston, M., Ten Hacken, N. H. T., Hu, S., Guo, Y., Zhang, X., Sun, K., Hiemstra, P. S. & Ponder, B. A. & 14 others, Makela, M. J., Malmstrom, K., Rintoul, R. C., Reyfman, P. A., Theis, F. J., Brandsma, C.-A., Adcock, I., Timens, W., Xu, C. J., van den Berge, M., Schwarz, R. F., Koppelman, G. H., Nawijn, M. C. & Faiz, A., 2-Sept-2020, 40 p. (medRxiv : the preprint server for health sciences).

Research output: Working paper › Preprint › Academic

Open Access

File

69 Downloads (Pure)

Implications of data-driven analyses for personalized therapy in psychosis: a systematic review of cluster- and trajectory-based modelling studies

Habtewold, T. D., Rodijk, L. H., Liemburg, E. J., Sidorenkov, G., Boezen, H. M., Bruggeman, R. & Alizadeh, B. Z., 2020, 45 p. (bioRxiv).

Research output: Working paper › Preprint › Academic

Life Course Epidemiology (LCE)

Research output

Search results