Research output per year
Research output per year
Nijenborgh7, Gebouw 5172, ruimte 0836
9747 AG Groningen
Netherlands
The group of Minnaard is active in organic chemistry, specifically in organic synthesis, focussing on the ability to chemically prepare complex molecules, based on in-house developed catalysis methodology. Parts of his work are carried out in close collaboration with other groups in chemistry (Codée, Bickelhaupt), biology (Gilleron, CNRS Toulouse, and Yamasaki, Osaka University), and medicine (Moody, Harvard Med School, Seshadri, U. Washington).
By working together with leading groups in tuberculosis research, the group makes fundamental discoveries in the immunology of this disease and unravels how tuberculosis bacteria survive in macrophages. The research spans the entire chain from fundamental science to novel diagnostics and antibiotics to combat TB. The fundamental research is funded by NWO, and the NIH. The more applied research is funded by the Gates Foundation and industry. With the planned launch of a novel diagnostic test for TB worldwide by Minnaard’s initiated UG spin-off company, its mission is on its way to being accomplished.
With the development of highly selective catalysis recently also in photoredox catalysis and electrosynthesis, Minnaard’s group has joined the new and rapidly growing community that studies the selective modification of complex molecules. Minnaard holds the world record in selective oxidation of hydroxyl groups (one out of 27 hydroxyl groups in the molecule) and has recently demonstrated the selective modification of currently used aminoglycoside antibiotics (in just 2 steps!) in such a way that bacterial resistance is circumvented. This novel synthesis methodology is also the basis for the total synthesis of extremely complex molecules, in particular complex glycolipids. By showing that these compounds can be chemically prepared, the field is pushed forward.
Four years ago, the Minnaard group was the first worldwide to show that photoredox catalysis can be applied successfully on unprotected carbohydrates (2018), and this year (2022) they renewed this claim for electrochemical oxidation of secondary alcohols in unprotected carbohydrates. These findings catch significant attention, and boosts the application of carbohydrates as renewable starting materials (in the context of ARC-CBBC). The group applies readily available carbohydrates as renewable starting materials for the pharma and coating industry.
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research output: Contribution to journal › Article › Academic › peer-review
Research output: Contribution to journal › Erratum
Research output: Contribution to journal › Article › Academic › peer-review
Research output: Contribution to journal › Article › Academic › peer-review
Research output: Contribution to journal › Article › Academic › peer-review
Minnaard, A. (Member)
Activity: Membership › Academic
Minnaard, A. (Member)
Activity: Membership › Academic
Minnaard, A. (Peer reviewer)
Activity: Peer-review and editorial work › Editorial work › Academic
Minnaard, A. (Editorial board member)
Activity: Peer-review and editorial work › Editorial work › Academic
Eisink, N. (Contributor), Witte, M. (Contributor) & Minnaard, A. J. (Contributor), University of Groningen, 17-Feb-2016
DOI: 10.5517/ccdc.csd.cc1kt0yb
Dataset
Holt, J. (Contributor), Maj, A. M. (Contributor), Schudde, E. (Contributor), Pietrusiewicz, K. M. (Contributor), Sieroñ, L. (Contributor), Wieczorek, W. (Contributor), Jerphagnon, T. (Contributor), Arends, I. W. C. E. (Contributor), Hanefeld, U. (Contributor) & Minnaard, A. (Contributor), University of Groningen, 10-Feb-2009
DOI: 10.5517/ccs566b
Dataset
Kortmann, F. (Contributor), Chang, M.-C. (Contributor), Otten, E. (Contributor), Couzijn, E. P. A. (Contributor), Lutz, M. (Contributor) & Minnaard, A. (Contributor), University of Groningen, 21-Jun-2013
DOI: 10.5517/cc10rxwk
Dataset
Jerphagnon, T. (Contributor), Gayet, A. (Contributor), Berthiol, F. (Contributor), Ritleng, V. (Contributor), Mrsic, N. (Contributor), Meetsma, A. (Contributor), Pfeffer, M. (Contributor), Minnaard, A. (Contributor), Feringa, B. L. (Contributor) & De Vries, J. G. (Contributor), University of Groningen, 15-Jan-2010
DOI: 10.5517/cctnmrt
Dataset
Rudolph, A. (Contributor), Bos, P. (Contributor), Meetsma, A. (Contributor), Minnaard, A. (Contributor) & Feringa, B. L. (Contributor), University of Groningen, 9-Mar-2011
DOI: 10.5517/ccwdttw
Dataset
El Aidy, S., Minnaard, A. & Bunt, D.
18/01/2023
1 item of Media coverage
Press/Media: Public Engagement Activities › Popular
28/11/2016
1 item of Media coverage
Press/Media: Public Engagement Activities › Popular