Anika Nagelkerke

Search results

• 2022

  Breaking through the barrier: Modelling and exploiting the physical microenvironment to enhance drug transport and efficacy

  Gładysz, M. Z., Stevanoska, M., Włodarczyk-Biegun, M. K. & Nagelkerke, A., May-2022, In: Advanced Drug Delivery Reviews. 184, 20 p., 114183.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

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  1 Citation (Scopus)

  28 Downloads (Pure)

• Development of an ex vivo model for non-alcoholic fatty liver disease using precision-cut liver slices

  Li, M., de Meijer, V., Olinga, P., Nagelkerke, A. & Geng, Y., Jul-2022, In: Journal of Hepatology. 77, p. S711-S711 1 p.

  Research output: Contribution to journal › Meeting Abstract › Academic

• Extracellular vesicles and soluble factors secreted by lung fibroblasts support alveolar organoid formation

  van der Koog, L., Nagelkerke, A. & Gosens, R., 9-May-2022, In: European Respiratory Journal. 8, Suppl. 8, 2

  Research output: Contribution to journal › Meeting Abstract › Academic

• Liposomes and Extracellular Vesicles as Drug Delivery Systems: A Comparison of Composition, Pharmacokinetics, and Functionalization

  van der Koog, L., Gandek, T. B. & Nagelkerke, A., 2-Mar-2022, In: Advanced healthcare materials. 11, 5, 32 p., e2100639.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

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  72 Citations (Scopus)

  126 Downloads (Pure)

• THIN MELT-ELECTROWRITTEN SCAFFOLDS AS A NOVEL ALTERNATIVE FOR POROUS INSERTS IN BLOOD-BRAIN BARRIER MODELS IN VITRO

  Gladysz, M., Kamperman, M., Nagelkerke, A. & Wlodarczyk-Biegun, M., 1-Apr-2022, p. S486.

  Research output: Contribution to conference › Abstract › Academic
• 2021

  Current developments in modelling the tumour microenvironment in vitro: Incorporation of biochemical and physical gradients

  Ahmed, M. A. M. & Nagelkerke, A., Nov-2021, In: Organs-on-a-Chip. 3, 100012.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

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  95 Downloads (Pure)

• Extracellular vesicles for tissue repair and regeneration: Evidence, challenges and opportunities

  Nagelkerke, A., Ojansivu, M., van der Koog, L., Whittaker, T. E., Cunnane, E. M., Silva, A. M., Dekker, N. & Stevens, M. M., Aug-2021, In: Advanced Drug Delivery Reviews. 175, 113775.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

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  52 Citations (Scopus)

  352 Downloads (Pure)

• High-Throughput Molecular Imaging via Deep-Learning-Enabled Raman Spectroscopy

  Horgan, C. C., Jensen, M., Nagelkerke, A., St-Pierre, J-P., Vercauteren, T., Stevens, M. M. & Bergholt, M. S., 7-Dec-2021, In: Analytical Chemistry. 93, 48, p. 15850-15860 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

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  16 Citations (Scopus)

  111 Downloads (Pure)

• IL-1β mediated nanoscale surface clustering of integrin α5β1 regulates the adhesion of mesenchymal stem cells

  Maynard, S. A., Pchelintseva, E., Zwi-Dantsis, L., Nagelkerke, A., Gopal, S., Korchev, Y. E., Shevchuk, A. & Stevens, M. M., 2021, In: Scientific Reports. 11, 1, 14 p., 6890 .

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

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  1 Citation (Scopus)

  13 Downloads (Pure)

• Image-guided Raman spectroscopy probe-tracking for tumor margin delineation

  Horgan, C. C., Bergholt, M. S., Thin, M. Z., Nagelkerke, A., Kennedy, R., Kalber, T. L., Stuckey, D. J. & Stevens, M. M., Mar-2021, In: Journal of Biomedical Optics. 26, 3, 15 p., 036002.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

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  8 Citations (Scopus)

  32 Downloads (Pure)

• Improving Breast Cancer Treatment Specificity Using Aptamers Obtained by 3D Cell-SELEX

  Nelissen, F. H. T., Peeters, W. J. M., Roelofs, T. P., Nagelkerke, A., Span, P. N. & Heus, H. A., 9-Apr-2021, In: Pharmaceuticals. 14, 4, 349.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

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  13 Citations (Scopus)

  52 Downloads (Pure)

• Integrated photodynamic Raman theranostic system for cancer diagnosis, treatment, and post-treatment molecular monitoring

  Horgan, C., Bergholt, M., Nagelkerke, A., Thin, M. Z., Pence, I., Kauscher, U., Kalber, T., Stuckey, D. & Stevens, M., 2021, In: Theranostics. 11, 4, p. 2006–2019

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

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  7 Citations (Scopus)

  13 Downloads (Pure)

• Multiplexing physical stimulation on single human induced pluripotent stem cell-derived cardiomyocytes for phenotype modulation

  Kit-Anan, W., Mazo, M. M., Wang, B. X., Leonardo, V., Pence, I. J., Gopal, S., Gelmi, A., Nagelkerke, A., Becce, M., Chiappini, C., Harding, S. E., Terracciano, C. M. & Stevens, M. M., 2021, In: Biofabrication. 13, 2, 025004.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  7 Citations (Scopus)

  3 Downloads (Pure)

• Single Particle Automated Raman Trapping Analysis of Breast Cancer Cell-Derived Extracellular Vesicles as Cancer Biomarkers

  Penders, J., Nagelkerke, A., Cunnane, E. M., Pedersen, S. V., Pence, I. J., Coombes, R. C. & Stevens, M. M., 23-Nov-2021, In: Acs Nano. 15, 11, p. 18192–18205 14 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

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  25 Citations (Scopus)

  70 Downloads (Pure)

• The gastrointestinal microbiota in colorectal cancer cell migration and invasion

  Henstra, C., van Praagh, J., Olinga, P. & Nagelkerke, A., 2021, In: Clinical & Experimental Metastasis. 38, p. 495–510

  Research output: Contribution to journal › Review article › peer-review

  Open Access

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  8 Citations (Scopus)

  176 Downloads (Pure)
• 2020

  Experimental artefacts can lead to misattribution of bioactivity from soluble mesenchymal stem cell paracrine factors to extracellular vesicles

  Whittaker, T. E., Nagelkerke, A., Nele, V., Kauscher, U. & Stevens, M. M., 26-Aug-2020, In: Journal of Extracellular Vesicles. 9, 1, p. 1807674

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

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  37 Citations (Scopus)

  22 Downloads (Pure)

• Gold Nanocluster Extracellular Vesicle Supraparticles: Self-Assembled Nanostructures for Three-Dimensional Uptake Visualization

  Kauscher, U., Penders, J., Nagelkerke, A., Holme, M. N., Nele, V., Massi, L., Gopal, S., Whittaker, T. E. & Stevens, M. M., 14-Apr-2020, In: Langmuir. 36, 14, p. 3912-3923 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

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  10 Citations (Scopus)

  264 Downloads (Pure)

• Molecular imaging of extracellular vesicles in vitro via Raman metabolic labelling

  Horgan, C. C., Nagelkerke, A., Whittaker, T. E., Nele, V., Massi, L., Kauscher, U., Penders, J., Bergholt, M. S., Hood, S. R. & Stevens, M. M., 2020, In: Journal of materials chemistry b. 8, 20, p. 4447-4459 13 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

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  12 Citations (Scopus)

  43 Downloads (Pure)

• Surface enhanced Raman scattering artificial nose for high dimensionality fingerprinting

  Kim, N., Thomas, M. R., Bergholt, M. S., Pence, I. J., Seong, H., Charchar, P., Todorova, N., Nagelkerke, A., Belessiotis-Richards, A., Payne, D. J., Gelmi, A., Yarovsky, I. & Stevens, M. M., 10-Jan-2020, In: Nature Communications. 11, 1, p. 1-12 207.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

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  75 Citations (Scopus)

  15 Downloads (Pure)

• Tunable Hybrid Matrices Drive Epithelial Morphogenesis and YAP Translocation

  Zhang, Y., Zegers, M., Nagelkerke, A., Rowan, A., Span, P. & Kouwer, P., 2020, In: Advanced science . 8, 2

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

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  9 Citations (Scopus)

  17 Downloads (Pure)
• 2018

  Interferon-Stimulated Genes Are Involved in Cross-resistance to Radiotherapy in Tamoxifen-Resistant Breast Cancer

  Post, A. E. M., Smid, M., Nagelkerke, A., Martens, J. W. M., Bussink, J., Sweep, F. C. G. J. & Span, P. N., 15-Jul-2018, In: Clinical Cancer Research. 24, 14, p. 3397-3408 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  59 Citations (Scopus)

• Single Particle Automated Raman Trapping Analysis

  Penders, J., Pence, I. J., Horgan, C. C., Bergholt, M. S., Wood, C. S., Najer, A., Kauscher, U., Nagelkerke, A. & Stevens, M. M., 15-Oct-2018, In: Nature Communications. 9, 1, 4256.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

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  27 Citations (Scopus)

  19 Downloads (Pure)
• 2016

  Staining Against Phospho-H2AX (γ-H2AX) as a Marker for DNA Damage and Genomic Instability in Cancer Tissues and Cells

  Nagelkerke, A. & Span, P. N., 22-Jun-2016, In: Advances in experimental medicine and biology. 899, p. 1-10 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  41 Citations (Scopus)
• 2015

  Hypoxic regulation of the PERK/ATF4/LAMP3-arm of the unfolded protein response in head and neck squamous cell carcinoma

  Nagelkerke, A., Sweep, F. C. G. J., Stegeman, H., Grénman, R., Kaanders, J. H. A. M., Bussink, J. & Span, P. N., Jun-2015, In: Head and Neck: Journal of the Sciences and Specialties of the Head and Neck. 37, 6, p. 896-905 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  22 Citations (Scopus)

• Poor prognosis of constitutive γ-H2AX expressing triple-negative breast cancers is associated with telomere length

  Nagelkerke, A., van Kuijk, S. J. A., Martens, J. W. M., Sweep, F. C. G. J., Hoogerbrugge, N., Bussink, J. & Span, P. N., 2015, In: Biomarkers in medicine. 9, 4, p. 383-90 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  5 Citations (Scopus)

• The mechanical microenvironment in cancer: How physics affects tumours

  Nagelkerke, A., Bussink, J., Rowan, A. E. & Span, P. N., Dec-2015, In: Seminars in cancer biology. 35, p. 62-70 9 p.

  Research output: Contribution to journal › Review article › peer-review
  89 Citations (Scopus)

• Therapeutic targeting of autophagy in cancer. Part I: molecular pathways controlling autophagy

  Nagelkerke, A., Sweep, F. C. G. J., Geurts-Moespot, A., Bussink, J. & Span, P. N., Apr-2015, In: Seminars in cancer biology. 31, p. 89-98 10 p.

  Research output: Contribution to journal › Review article › peer-review
  44 Citations (Scopus)

• Therapeutic targeting of autophagy in cancer. Part II: Pharmacological modulation of treatment-induced autophagy

  Nagelkerke, A., Bussink, J., Geurts-Moespot, A., Sweep, F. C. G. J. & Span, P. N., Apr-2015, In: Seminars in cancer biology. 31, p. 99-105 7 p.

  Research output: Contribution to journal › Review article › peer-review
  62 Citations (Scopus)
• 2014

  LAMP3 is involved in tamoxifen resistance in breast cancer cells through the modulation of autophagy

  Nagelkerke, A., Sieuwerts, A. M., Bussink, J., Sweep, F. C. G. J., Look, M. P., Foekens, J. A., Martens, J. W. M. & Span, P. N., Feb-2014, In: Endocrine-Related cancer. 21, 1, p. 101-12 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  66 Citations (Scopus)

• The unfolded protein response as a target for cancer therapy

  Nagelkerke, A., Bussink, J., Sweep, F. C. G. J. & Span, P. N., Dec-2014, In: Biochimica et biophysica acta. 1846, 2, p. 277-84 8 p.

  Research output: Contribution to journal › Review article › peer-review
  85 Citations (Scopus)
• 2013

  Generation of multicellular tumor spheroids of breast cancer cells: How to go three-dimensional

  Nagelkerke, A., Bussink, J., Sweep, F. C. G. J. & Span, P. N., 1-Jun-2013, In: Analytical Biochemistry. 437, 1, p. 17-9 3 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  52 Citations (Scopus)

• Hypoxia stimulates migration of breast cancer cells via the PERK/ATF4/LAMP3-arm of the unfolded protein response

  Nagelkerke, A., Bussink, J., Mujcic, H., Wouters, B. G., Lehmann, S., Sweep, F. C. G. J. & Span, P. N., 7-Jan-2013, In: Breast cancer research. 15, 1, R2.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

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  160 Citations (Scopus)

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• Hypoxic activation of the PERK/eIF2α arm of the unfolded protein response promotes metastasis through induction of LAMP3

  Mujcic, H., Nagelkerke, A., Rouschop, K. M. A., Chung, S., Chaudary, N., Span, P. N., Clarke, B., Milosevic, M., Sykes, J., Hill, R. P., Koritzinsky, M. & Wouters, B. G., 15-Nov-2013, In: Clinical Cancer Research. 19, 22, p. 6126-6137 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  51 Citations (Scopus)

• The PERK/ATF4/LAMP3-arm of the unfolded protein response affects radioresistance by interfering with the DNA damage response

  Nagelkerke, A., Bussink, J., van der Kogel, A. J., Sweep, F. C. G. J. & Span, P. N., Sept-2013, In: Radiotherapy and Oncology. 108, 3, p. 415-21 7 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  74 Citations (Scopus)
• 2012

  Kinetics and thiol requirements of iodothyronine 5'-deiodination are tissue-specific in common carp (Cyprinus carpio L.)

  Klaren, P. H. M., Geven, E. J. W., Nagelkerke, A. & Flik, G., 2012, In: Comparative biochemistry and physiology b-Biochemistry & molecular biology. 161, 3, p. 275-82 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  2 Citations (Scopus)
• 2011

  Constitutive expression of γ-H2AX has prognostic relevance in triple negative breast cancer

  Nagelkerke, A., van Kuijk, S. J. A., Sweep, F. C. G. J., Nagtegaal, I. D., Hoogerbrugge, N., Martens, J. W. M., Timmermans, M. A., van Laarhoven, H. W. M., Bussink, J. & Span, P. N., 2011, In: Radiotherapy and Oncology. 101, 1, p. 39-45 7 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

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  32 Citations (Scopus)

  7 Downloads (Pure)

• Hypoxic regulation and prognostic value of LAMP3 expression in breast cancer

  Nagelkerke, A., Mujcic, H., Bussink, J., Wouters, B. G., van Laarhoven, H. W. M., Sweep, F. C. G. J. & Span, P. N., 15-Aug-2011, In: Cancer. 117, 16, p. 3670-81 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  51 Citations (Scopus)
• 2010

  18S is an appropriate housekeeping gene for in vitro hypoxia experiments

  Nagelkerke, A., Mujcic, H., Wouters, B. & Span, P. N., 10-Aug-2010, In: British Journal of Cancer. 103, 4, p. 590; author reply 591-2

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

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  4 Citations (Scopus)

  9 Downloads (Pure)