Personal profile
Research interests
I am a hematopathologist at the University Medical Center Groningen and a principal investigator in the SALL (stem cells, aging, leukemia and lymphoma) program of the CRCG (Cancer Research Center Groningen). My main research interest involves malignant lymphoma, in particular Hodgkin lymphoma, with a strong focus on interactions between tumor cells and the microenvironment. In my PhD thesis "Classical Hodgkin lymphoma: population based studies on HLA and EBV (2007)" and follow-up studies, I discovered that the HLA system is intricately involved in Hodgkin lymphoma susceptibility, pathogenesis and prognosis and published these findings in the Lancet, Journal of Clinical Oncology and Blood. I secured three Dutch Cancer Society grants to do functional follow-up studies on these findings. Fruitful international collaborations involve the Interlymph consortium on genome wide association studies, the Lymphoma group of the EORTC and various groups in the UK, Canada and the US. My areas of expertise are: immunology, tumor cell biology, association studies and molecular diagnostics in pathology.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 2 Zero Hunger -
SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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Intra-erythrocyte creatine, plasma creatine and long-term outcomes in stable kidney transplant recipients: Results from the TransplantLines Biobank and Cohort study
TransplantLines Investigators, Doorenbos, C. S. E., Post, A., van der Veen, Y., Franssen, C. F. M., Eisenga, M. F., Dullaart, R. P. F., Navis, G., Wu, Q., Gonzalez-Delgado, J. M., Connelly, M. A. & Bakker, S. J. L., Feb-2026, In: Clinical Nutrition Open Science. 65, 17 p., 100606.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile -
Overlapping macrophage immune profiles in polymyalgia rheumatica and giant cell arteritis
Zhang, A., Jiemy, W. F., van Sleen, Y., Xu, S., Sandovici, M., Abdulahad, W. H., Diepstra, A., Hein, S., Graver, J. C., Heeringa, P., Dasgupta, B., Brouwer, E. & van der Geest, K. S. M., Feb-2026, In: Rheumatology (Oxford, England). 65, 2, 6 p., keaf629.Research output: Contribution to journal › Article › Academic › peer-review
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Atezolizumab Consolidation in Patients with High Risk Diffuse Large B-cell Lymphoma in Complete Remission after R-CHOP
Nijland, M., Issa, D. E., Bult, J. A. A., Deeren, D., Velders, G. A., Nijziel, M. R., Sandberg, Y., Vergote, V. K., Oosterveld, M., Fijnheer, R., Brouwer, R., Boersma, R., Wu, K., Nieuwenhuizen, L., Vermaat, J. S., van Kampen, R. J. W., Terpstra, W. E., Snauwaert, S., van der Poel, M. W. & de Jongh, E. & 22 others, , 10-Jul-2025, In: Blood Advances. 9, 14, p. 3530–3539 10 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile3 Citations (Scopus)25 Downloads (Pure) -
Dynamics of circulating tumour DNA in relapsed/refractory diffuse large B-cell lymphoma patients
Zhong, Y., Bult, J., Veltmaat, N., de Jesus, F. M., Sillje, L., Kluiver, J., van den Berg, A., Plattel, W., Diepstra, A. & Nijland, M., 18-Dec-2025, (E-pub ahead of print) In: British Journal of Haematology.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile14 Downloads (Pure) -
GM-CSF drives IL-6 production by macrophages in polymyalgia rheumatica
Jiemy, W. F., Zhang, A., Abdulahad, W. H., Reitsema, R. D., van Sleen, Y., Sandovici, M., Alegria, G. C., Cornec, D., Devauchelle-Pensec, V., Hemon, P., Quéré, B., Boukhlal, S., Roozendaal, C., Kwee, T. C., Dasgupta, B., Diepstra, A., Heeringa, P., Brouwer, E. & van der Geest, K. S. M., May-2025, In: Annals of the Rheumatic Diseases. 84, 5, p. 833-843 11 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile4 Citations (Scopus)20 Downloads (Pure)
Activities
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TOX as a novel biomarker in T cell large granular lymphocytic leukemia
Diepstra, A. (Speaker)
23-Jan-2025Activity: Talk and presentation › Academic presentation › Academic
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A unifying pathogenetic framework for classic Hodgkin lymphoma
Diepstra, A. (Speaker)
6-Feb-2025Activity: Talk and presentation › Academic presentation › Academic
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Active projects at the UMC Groningen
Diepstra, A. (Speaker)
26-Jun-2024Activity: Talk and presentation › Academic presentation › Academic
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Moleculaire tumor board hematologie
Diepstra, A. (Speaker)
27-Nov-2024Activity: Talk and presentation › Academic presentation › Academic
Datasets
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Supplementary Material for: MicroRNA High Throughput Loss-of-Function Screening Reveals an Oncogenic Role for miR-21-5p in Hodgkin Lymphoma
Niu, F. (Contributor), Yuan, Y. (Contributor), Sarkis Azkanaz, M. (Contributor), Diepstra, A. (Contributor), Bystrykh, L. (Contributor), Visser, L. (Contributor), Dzikiewicz-Krawczyk, A. (Contributor), Osinga, J. (Contributor), Rutgers, B. (Contributor), Kok, K. (Contributor), Koerts, J. (Contributor), Terpstra, M. (Contributor), Kluiver, J. (Contributor), van den Berg, A. (Contributor), Nolte, I. M. (Contributor) & de Jong, D. (Contributor), figshare Academic Research System, 5-Sept-2018
DOI: 10.6084/m9.figshare.7047695.v1
Dataset
Press/Media
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Whodunit? Het speurwerk van de patholoog bij lymfeklierkanker
07/08/2024
1 item of Media coverage
Press/Media: Expert Comment › Popular
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Serum TARC Levels Increased Years Prior to Hodgkin Lymphoma Diagnosis
16/01/2024
1 Media contribution
Press/Media: Research › Academic
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Serumspiegels TARC-eiwit al jaren voor diagnose Hodgkin lymfoom verhoogd
01/12/2023
1 Media contribution
Press/Media: Research › Professional
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Hodgkin lymphoma can be diagnosed much earlier
19/10/2023
1 item of Media coverage
Press/Media: Research › Academic
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Video Interview for the Video Journal of Haematological Oncology on TARC in Hodgkin lymphoma
26/10/2022
1 Media contribution
Press/Media: Expert Comment › Academic
Prizes
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Appointment Coordinating Committee Member International Interlymph Consortium
Diepstra, A. (Recipient), 24-Nov-2022
Prize: Appointment › Academic
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Expert in Lymphoma
Diepstra, A. (Recipient), 8-Dec-2021
Prize: National/international honour › Academic
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Translational research Transplant-BRAVE trial
Diepstra, A. (Recipient), 2020
Prize: National/international honour › Academic
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