Bart Eggen

2024

An anti-aging vaccine: BCG turns back the clock on remyelination failure

Kotah, J. M. & Eggen, B. J. L., 10-Sept-2024, In: Immunity. 57, 9, p. 2005-2007 3 p.

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

ATP5PO levels regulate enteric nervous system development in zebrafish, linking Hirschsprung disease to Down Syndrome

Kuil, L. E., Chauhan, R. K., de Graaf, B. M., Cheng, W. W., Kakiailatu, N. J. M., Lasabuda, R., Verhaeghe, C., Windster, J. D., Schriemer, D., Azmani, Z., Brooks, A. S., Edie, S., Reeves, R. H., Eggen, B. J. L., Shepherd, I. T., Burns, A. J., Hofstra, R. M. W., Melotte, V., Brosens, E. & Alves, M. M., Mar-2024, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1870, 3, 10 p., 166991.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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80 Downloads (Pure)

Brain organoid models for studying the function of iPSC-derived microglia in neurodegeneration and brain tumours

Sabogal-Guaqueta, A. M., Mitchell-Garcia, T., Hunneman, J., Voshart, D., Thiruvalluvan, A., Foijer, F., Kruyt, F., Trombetta-Lima, M., Eggen, B. J. L., Boddeke, E., Barazzuol, L. & Dolga, A. M., Dec-2024, In: Neurobiology of Disease. 203, 16 p., 106742.

Research output: Contribution to journal › Review article › peer-review

Open Access

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Calorie restriction increases the sensitivity of progeroid Ercc1^Δ/− mice to acute (neuro)inflammation

Reitsema, V. A., Schreuder, L., Gerrits, E., Eggen, B. J. L., Goris, M., Laman, J. D., de Rooij, S. E., Wesseling, E. M., Bouma, H. R. & Henning, R. H., 17-Sept-2024, (E-pub ahead of print) In: GeroScience. 12 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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10 Downloads (Pure)

Cellular senescence in brain aging and neurodegeneration

Melo Dos Santos, L. S., Trombetta-Lima, M., Eggen, B. & Demaria, M., Jan-2024, In: Ageing Research Reviews. 93, 12 p., 102141.

Research output: Contribution to journal › Review article › peer-review

Open Access

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15 Citations (Scopus)

164 Downloads (Pure)

Early amyloid-induced changes in microglia gene expression in male APP/PS1 mice

Oshima, T., Kater, M. S. J., Huffels, C. F. M., Wesseling, E. M., Middeldorp, J., Hol, E. M., Verheijen, M. H. G., Smit, A. B., Boddeke, E. W. G. M. & Eggen, B. J. L., Mar-2024, In: Journal of Neuroscience Research. 102, 3, 14 p., e25295.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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31 Downloads (Pure)

Glioblastoma and its treatment are associated with extensive accelerated brain aging

Ainslie, A. P., Klaver, M., Voshart, D. C., Gerrits, E., den Dunnen, W. F. A., Eggen, B. J. L., Bergink, S. & Barazzuol, L., Mar-2024, In: Aging Cell. 23, 3, 14 p., e14066.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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4 Citations (Scopus)

50 Downloads (Pure)

Identification of clinical disease trajectories in neurodegenerative disorders with natural language processing

Mekkes, N. J., Groot, M., Hoekstra, E., de Boer, A., Dagkesamanskaia, E., Bouwman, S., Wehrens, S. M. T., Herbert, M. K., Wever, D. D., Rozemuller, A., Eggen, B. J. L., Huitinga, I. & Holtman, I. R., Apr-2024, In: Nature Medicine. 30, 4, p. 1143-1153 11 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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6 Citations (Scopus)

42 Downloads (Pure)

Radiotherapy induces persistent innate immune reprogramming of microglia into a primed state

Voshart, D. C., Oshima, T., Jiang, Y., van der Linden, G. P., Ainslie, A. P., Reali Nazario, L., van Buuren-Broek, F., Scholma, A. C., van Weering, H. R. J., Brouwer, N., Sewdihal, J., Brouwer, U., Coppes, R. P., Holtman, I. R., Eggen, B. J. L., Kooistra, S. M. & Barazzuol, L., 27-Feb-2024, 2 ed. 17 p. (Cell reports)

Research output: Book/Report › Report › Academic › peer-review

Open Access

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2 Citations (Scopus)

108 Downloads (Pure)

Sex-dependent APOE4 neutrophil–microglia interactions drive cognitive impairment in Alzheimer’s disease

Rosenzweig, N., Kleemann, K. L., Rust, T., Carpenter, M., Grucci, M., Aronchik, M., Brouwer, N., Valenbreder, I., Cooper-Hohn, J., Iyer, M., Krishnan, R. K., Sivanathan, K. N., Brandão, W., Yahya, T., Durao, A., Yin, Z., Chadarevian, J. P., Properzi, M. J., Nowarski, R. & Davtyan, H. & 6 others, Weiner, H. L., Blurton-Jones, M., Yang, H. S., Eggen, B. J. L., Sperling, R. A. & Butovsky, O., 2024, (Accepted/In press) In: Nature Medicine.

Research output: Contribution to journal › Article › Academic › peer-review

6 Citations (Scopus)

Single-Nucleus RNA-Seq Characterizes the Cell Types Along the Neuronal Lineage in the Adult Human Subependymal Zone and Reveals Reduced Oligodendrocyte Progenitor Abundance with Age

Puvogel, S., Alsema, A., North, H. F., Webster, M. J., Weickert, C. S. & Eggen, B. J. L., Mar-2024, In: Eneuro. 11, 3, 19 p., ENEURO.0246-23.2024.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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2 Citations (Scopus)

25 Downloads (Pure)

Spatially resolved gene signatures of white matter lesion progression in multiple sclerosis

Alsema, A. M., Wijering, M. H. C., Miedema, A., Kotah, J. M., Koster, M., Rijnsburger, M., van Weering, H. R. J., de Vries, H. E., Baron, W., Kooistra, S. M. & Eggen, B. J. L., 5-Nov-2024, (E-pub ahead of print) In: Nature neuroscience.

Research output: Contribution to journal › Article › Academic › peer-review

The role of microglia in early neurodevelopment and the effects of maternal immune activation

Mastenbroek, L. J. M., Kooistra, S. M., Eggen, B. J. L. & Prins, J. R., 11-Jul-2024, In: Seminars in immunopathology. 46, 1-2, 14 p., 1.

Research output: Contribution to journal › Review article › peer-review

Open Access

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3 Citations (Scopus)

19 Downloads (Pure)

2023

APOE4 impairs the microglial response in Alzheimer’s disease by inducing TGFβ-mediated checkpoints

Yin, Z., Rosenzweig, N., Kleemann, K. L., Zhang, X., Brandão, W., Margeta, M. A., Schroeder, C., Sivanathan, K. N., Silveira, S., Gauthier, C., Mallah, D., Pitts, K. M., Durao, A., Herron, S., Shorey, H., Cheng, Y., Barry, J. L., Krishnan, R. K., Wakelin, S. & Rhee, J. & 23 others, Yung, A., Aronchik, M., Wang, C., Jain, N., Bao, X., Gerrits, E., Brouwer, N., Deik, A., Tenen, D. G., Ikezu, T., Santander, N. G., McKinsey, G. L., Baufeld, C., Sheppard, D., Krasemann, S., Nowarski, R., Eggen, B. J. L., Clish, C., Tanzi, R. E., Madore, C., Arnold, T. D., Holtzman, D. M. & Butovsky, O., Nov-2023, In: Nature Immunology. 24, 11, p. 1839-1853 15 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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41 Citations (Scopus)

455 Downloads (Pure)

Characterizing microglial gene expression in a model of secondary progressive multiple sclerosis

Vainchtein, I. D., Alsema, A. M., Dubbelaar, M. L., Grit, C., Vinet, J., van Weering, H. R. J., Al-Izki, S., Biagini, G., Brouwer, N., Amor, S., Baker, D., Eggen, B. J. L., Boddeke, E. W. G. M. & Kooistra, S. M., Mar-2023, In: Glia. 71, 03, 588 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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4 Citations (Scopus)

105 Downloads (Pure)

Cold Mechanical Isolation of Placental Macrophages as a Method to Limit Procedure-Induced Activation of Macrophages

Eskandar, S., Bezemer, R. E., Eggen, B. J. L. & Prins, J. R., 15-Dec-2023, In: Journal of Immunology. 211, 12, p. 1868-1876 9 p., ji2300379.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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1 Citation (Scopus)

33 Downloads (Pure)

Failure to repair endogenous DNA damage in β-cells causes adult-onset diabetes in mice

Yousefzadeh, M. J., Huerta Guevara, A. P., Postmus, A. C., Flores, R. R., Sano, T., Jurdzinski, A., Angelini, L., McGowan, S. J., O'Kelly, R. D., Wade, E. A., Gonzalez-Espada, L. V., Henessy-Wack, D., Howard, S., Rozgaja, T. A., Trussoni, C. E., LaRusso, N. F., Eggen, B. J. L., Jonker, J. W., Robbins, P. D. & Niedernhofer, L. J. & 1 others, Kruit, J. K., Oct-2023, In: Aging Biology. 1, 1, 10 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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53 Downloads (Pure)

How the cGAS-STING system links inflammation and cognitive decline

Eggen, B. J. L., 10-Aug-2023, In: Nature. 620, p. 280-282 3 p.

Research output: Contribution to journal › Letter › Academic

Open Access

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1 Citation (Scopus)

59 Downloads (Pure)

Microglia morphotyping in the adult mouse CNS using hierarchical clustering on principal components reveals regional heterogeneity but no sexual dimorphism

van Weering, H. R. J., Nijboer, T. W., Brummer, M. L., Boddeke, E. W. G. M. & Eggen, B. J. L., Oct-2023, In: Glia. 71, 10, p. 2356-2371 16 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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9 Citations (Scopus)

119 Downloads (Pure)

Microglia Transcriptional Profiling in Major Depressive Disorder Shows Inhibition of Cortical Gray Matter Microglia

Scheepstra, K. W. F., Mizee, M. R., van Scheppingen, J., Adelia, A., Wever, D. D., Mason, M. R. J., Dubbelaar, M. L., Hsiao, C. C., Eggen, B. J. L., Hamann, J. & Huitinga, I., 15-Oct-2023, In: Biological Psychiatry. 94, 8, p. 619-629 11 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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15 Citations (Scopus)

42 Downloads (Pure)

Pathological ultrastructural alterations of myelinated axons in normal appearing white matter in progressive multiple sclerosis

Oost, W., Huitema, A. J., Kats, K., Giepmans, B. N. G., Kooistra, S. M., Eggen, B. J. L. & Baron, W., 20-Jun-2023, In: Acta Neuropathologica Communications. 11, 17 p., 100.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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6 Citations (Scopus)

110 Downloads (Pure)

Prevention of microgliosis halts early memory loss in a mouse model of Alzheimer's disease

Kater, M. S. J., Huffels, C. F. M., Oshima, T., Renckens, N. S., Middeldorp, J., Boddeke, E. W. G. M., Smit, A. B., Eggen, B. J. L., Hol, E. M. & Verheijen, M. H. G., Jan-2023, In: Brain, Behavior, and Immunity. 107, p. 225-241 17 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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10 Citations (Scopus)

141 Downloads (Pure)

Species-specific metabolic reprogramming in human and mouse microglia during inflammatory pathway induction

Sabogal-Guáqueta, A. M., Marmolejo-Garza, A., Trombetta-Lima, M., Oun, A., Hunneman, J., Chen, T., Koistinaho, J., Lehtonen, S., Kortholt, A., Wolters, J. C., Bakker, B. M., Eggen, B. J. L., Boddeke, E. & Dolga, A., 13-Oct-2023, In: Nature Communications. 14, 1, 24 p., 6454.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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22 Citations (Scopus)

97 Downloads (Pure)

The Netherlands Neurogenetics Database (NND)

Holtman, I. R. (Developer), Swertz, M. A. (Developer), Rozenmuller, A. (Developer), Hamann, J. (Developer), Boddeke, E. W. G. M. (Developer), Eggen, B. (Developer) & Huitinga, I. (Developer), 1-Sept-2023

Research output: Non-textual form › Data set/Database › Academic

Open Access

2022

An emerging role for microglia in stress-effects on memory

Sanguino-Gomez, J., Buurstede, J. C., Abiega, O., Fitzsimons, C. P., Lucassen, P. J., Eggen, B. J. L., Lesuis, S. L., Meijer, O. C. & Krugers, H. J., May-2022, In: European Journal of Neuroscience. 55, 9-10, p. 2491-2518 28 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

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22 Citations (Scopus)

194 Downloads (Pure)

Brain macrophages acquire distinct transcriptomes in multiple sclerosis lesions and normal appearing white matter

Miedema, A., Gerrits, E., Brouwer, N., Jiang, Q., Kracht, L., Meijer, M., Nutma, E., Peferoen-Baert, R., Pijnacker, A. T. E., Wesseling, E. M., Wijering, M. H. C., Gabius, H.-J., Amor, S., Eggen, B. J. L. & Kooistra, S. M., 28-Jan-2022, In: Acta Neuropathologica Communications. 10, 1, 18 p., 8.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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35 Citations (Scopus)

168 Downloads (Pure)

Distinct gene expression in demyelinated white and grey matter areas of patients with multiple sclerosis

van Wageningen, T. A., Gerrits, E., Brouwer, N., Breve, J. J. P., Geurts, J. J. G., Eggen, B. J. L., Boddeke, H. W. G. M. & van Dam, A.-M., 1-Mar-2022, In: Brain Communications. 4, 2, 16 p., 005.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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12 Citations (Scopus)

132 Downloads (Pure)

Early-life stress lastingly impacts microglial transcriptome and function under basal and immune-challenged conditions

Reemst, K., Kracht, L., Kotah, J. M., Rahimian, R., van Irsen, A. A. S., Congrains Sotomayor, G., Verboon, L. N., Brouwer, N., Simard, S., Turecki, G., Mechawar, N., Kooistra, S. M., Eggen, B. J. L. & Korosi, A., 8-Dec-2022, In: Translational Psychiatry. 12, 1, 13 p., 507.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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22 Citations (Scopus)

159 Downloads (Pure)

Epigenetic regulation of innate immune memory in microglia

Zhang, X., Kracht, L., Lerario, A. M., Dubbelaar, M. L., Brouwer, N., Wesseling, E. M., Boddeke, E. W. G. M., Eggen, B. J. L. & Kooistra, S. M., 14-May-2022, In: Journal of neuroinflammation. 19, 1, 19 p., 111.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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32 Citations (Scopus)

140 Downloads (Pure)

Microglia states and nomenclature: A field at its crossroads

Paolicelli, R. C., Sierra, A., Stevens, B., Tremblay, M. E., Aguzzi, A., Ajami, B., Amit, I., Audinat, E., Bechmann, I., Bennett, M., Bennett, F., Bessis, A., Biber, K., Bilbo, S., Blurton-Jones, M., Boddeke, E., Brites, D., Brône, B., Brown, G. C. & Butovsky, O. & 76 others, Carson, M. J., Castellano, B., Colonna, M., Cowley, S. A., Cunningham, C., Davalos, D., De Jager, P. L., de Strooper, B., Denes, A., Eggen, B. J. L., Eyo, U., Galea, E., Garel, S., Ginhoux, F., Glass, C. K., Gokce, O., Gomez-Nicola, D., González, B., Gordon, S., Graeber, M. B., Greenhalgh, A. D., Gressens, P., Greter, M., Gutmann, D. H., Haass, C., Heneka, M. T., Heppner, F. L., Hong, S., Hume, D. A., Jung, S., Kettenmann, H., Kipnis, J., Koyama, R., Lemke, G., Lynch, M., Majewska, A., Malcangio, M., Malm, T., Mancuso, R., Masuda, T., Matteoli, M., McColl, B. W., Miron, V. E., Molofsky, A. V., Monje, M., Mracsko, E., Nadjar, A., Neher, J. J., Neniskyte, U., Neumann, H., Noda, M., Peng, B., Peri, F., Perry, V. H., Popovich, P. G., Pridans, C., Priller, J., Prinz, M., Ragozzino, D., Ransohoff, R. M., Salter, M. W., Schaefer, A., Schafer, D. P., Schwartz, M., Simons, M., Smith, C. J., Streit, W. J., Tay, T. L., Tsai, L. H., Verkhratsky, A., von Bernhardi, R., Wake, H., Wittamer, V., Wolf, S. A., Wu, L. J. & Wyss-Coray, T., 2-Nov-2022, In: Neuron. 110, 21, p. 3458-3483 26 p.

Research output: Contribution to journal › Review article › peer-review

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649 Citations (Scopus)

146 Downloads (Pure)

Natural language processing and modeling of clinical disease trajectories across brain disorders

Netherlands Neurogenetics Database Consortium, 7-Oct-2022, MedRxiv.

Research output: Working paper › Preprint › Academic

Open Access

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102 Downloads (Pure)

Neurovascular dysfunction in GRN-associated frontotemporal dementia identified by single-nucleus RNA sequencing of human cerebral cortex

Brainbank Neuro-CEB Neuropathology, Gerrits, E., Giannini, L. A. A., Brouwer, N., Melhem, S., Seilhean, D., Le Ber, I., Kamermans, A., Kooij, G., de Vries, H. E., Boddeke, E. W. G. M., Seelaar, H., van Swieten, J. C. & Eggen, B. J. L., Aug-2022, In: Nature neuroscience. 25, 8, p. 1034-1048 34 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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30 Citations (Scopus)

701 Downloads (Pure)

Single-nucleus RNA sequencing of midbrain blood-brain barrier cells in schizophrenia reveals subtle transcriptional changes with overall preservation of cellular proportions and phenotypes

Puvogel, S., Alsema, A., Kracht, L., Webster, M. J., Weickert, C. S., Sommer, I. E. C. & Eggen, B. J. L., Nov-2022, In: Molecular Psychiatry. 27, p. 4731–4740 10 p.

Research output: Contribution to journal › Article › Academic › peer-review

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10 Citations (Scopus)

72 Downloads (Pure)

Transcriptomic and epigenomic landscapes of Alzheimer's disease evidence mitochondrial-related pathways

Marmolejo-Garza, A., Medeiros-Furquim, T., Rao, R., Eggen, B. J. L., Boddeke, E. & Dolga, A. M., Oct-2022, In: Biochimica et Biophysica Acta - Molecular Cell Research. 1869, 10, 119326.

Research output: Contribution to journal › Review article › peer-review

Open Access

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18 Citations (Scopus)

134 Downloads (Pure)

Transcriptomic changes in autophagy-related genes are inversely correlated with inflammation and are associated with multiple sclerosis lesion pathology

Misrielal, C., Alsema, A. M., Wijering, M. H. C., Miedema, A., Mauthe, M., Reggiori, F. & Eggen, B. J. L., Nov-2022, In: Brain, Behavior, and Immunity - Health. 25, p. 100510 10 p., 100510.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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3 Citations (Scopus)

115 Downloads (Pure)

2021

Distinct amyloid-beta and tau-associated microglia profiles in Alzheimer's disease

Gerrits, E., Brouwer, N., Kooistra, S. M., Woodbury, M. E., Vermeiren, Y., Lambourne, M., Mulder, J., Kummer, M., Moller, T., Biber, K., den Dunnen, W. F. A., De Deyn, P. P., Eggen, B. J. L. & Boddeke, E. W. G. M., 20-Feb-2021, In: Acta Neuropathologica. 16 p.

Research output: Contribution to journal › Article › Academic › peer-review

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166 Citations (Scopus)

232 Downloads (Pure)

Exploring reported genes of microglia RNA-sequencing data: Uses and considerations

van Wageningen, T. A., Gerrits, E., Bonson, S. P., Huitinga, I., Eggen, B. J. L. & van Dam, A.-M., Dec-2021, In: Glia. 69, 12, p. 2933-2946 14 p.

Research output: Contribution to journal › Article › Academic › peer-review

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3 Citations (Scopus)

72 Downloads (Pure)

Human fetal microglia acquire homeostatic immune-sensing properties early in development

Kracht, L., Borggrewe, M., Eskandar, S., Brouwer, N., Lopes, S. C. D. S., Laman, J., Scherjon, S., Prins, J., Kooistra, S. & Eggen, B., Jul-2021, In: Glia. 69, p. E248-E249 2 p.

Research output: Contribution to journal › Meeting Abstract › Academic

Identification of distinct and age-dependent p16High microglia subtypes

Talma, N., Gerrits, E., Wang, B., Eggen, B. J. L. & Demaria, M., Oct-2021, In: Aging Cell. 20, 10, 13 p., e13450.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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18 Citations (Scopus)

101 Downloads (Pure)

Increased insulin sensitivity and diminished pancreatic beta-cell function in DNA repair deficient Ercc1(d/-) mice

Huerta Guevara, A. P., McGowan, S. J., Kazantzis, M., Stallons, T. R., Sano, T., Mulder, N. L., Jurdzinski, A., van Dijk, T. H., Eggen, B. J. L., Jonker, J. W., Niedernhofer, L. J. & Kruit, J. K., Apr-2021, In: Metabolism: Clinical and Experimental. 117, p. 1-9 9 p., 154711.

Research output: Contribution to journal › Article › Academic › peer-review

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9 Citations (Scopus)

83 Downloads (Pure)

Intrinsic DNA damage repair deficiency results in progressive microglia loss and replacement

Zhang, X., Heng, Y., Kooistra, S. M., van Weering, H. R. J., Brummer, M. L., Gerrits, E., Wesseling, E. M., Brouwer, N., Nijboer, T. W., Dubbelaar, M. L., Boddeke, E. W. G. M. & Eggen, B. J. L., Mar-2021, In: Glia. 3, p. 1-17 17 p., 23925.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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13 Citations (Scopus)

119 Downloads (Pure)

Lipids, beta-secretase 1, and Alzheimer disease

Villamil-Ortiz, J., Eggen, B. J. L. & Cardona-Gómez, G. P., 1-Jan-2021, Factors Affecting Neurological Aging: Genetics, Neurology, Behavior, and Diet. Martin, C. R., Preedy, V. R. & Rajendram, R. (eds.). Elsevier, p. 289-299 11 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

2 Citations (Scopus)

P16-expressing microglial cells with distinct transcriptional profiles accumulate in the aging brain

Talma, N., Gerrits, E., Wang, B., Eggen, B. J. & Demaria, M., Jul-2021, In: Glia. 69, p. E262-E263 2 p.

Research output: Contribution to journal › Meeting Abstract › Academic

Regionally diverse astrocyte subtypes and their heterogeneous response to EAE

Borggrewe, M., Grit, C., Vainchtein, I. D., Brouwer, N., Wesseling, E. M., Laman, J. D., Eggen, B. J. L., Kooistra, S. M. & Boddeke, E. W. G. M., May-2021, In: Glia. 69, 5, p. 1140-1154 15 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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29 Citations (Scopus)

165 Downloads (Pure)

Systemic administration of beta-glucan induces immune training in microglia

Heng, Y., Zhang, X., Borggrewe, M., van Weering, H. R. J., Brummer, M. L., Nijboer, T. W., Joosten, L. A. B., Netea, M. G., Boddeke, E. W. G. M., Laman, J. D. & Eggen, B. J. L., 22-Feb-2021, In: Journal of neuroinflammation. 18, 1, 15 p., 57.

Research output: Contribution to journal › Article › Academic › peer-review

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26 Citations (Scopus)

99 Downloads (Pure)

The effects of postmortem delay on mouse and human microglia gene expression

Heng, Y., Dubbelaar, M. L., Marie, S. K. N., Boddeke, E. W. G. M. & Eggen, B. J. L., Apr-2021, In: Glia. 69, 4, p. 1053-1060 8 p.

Research output: Contribution to journal › Article › Academic › peer-review

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7 Citations (Scopus)

97 Downloads (Pure)

Transcriptional profiling of macaque microglia reveals an evolutionary preserved gene expression program

Dubbelaar, M. L., Misrielal, C., Bajramovic, J. J., Burm, S. M., Zuiderwijk-Sick, E. A., Brouwer, N., Grit, C., Kooistra, S. M., Shinjo, S. M. O., Marie, S. K. N., Boddeke, H. W. G. M. & Eggen, B. J. L., Aug-2021, In: Brain, behavior, & immunity - health. 15, 8 p., 100265.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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4 Citations (Scopus)

98 Downloads (Pure)

Type I interferon-activated microglia are critical for neuromyelitis optica pathology

Wlodarczyk, A., Khorooshi, R., Marczynska, J., Holtman, I. R., Burton, M., Jensen, K. N., Blaabjerg, M., Meyer, M., Thomassen, M., Eggen, B. J. L., Asgari, N. & Owens, T., Apr-2021, In: Glia. 69, 4, p. 943-953 11 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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11 Citations (Scopus)

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VISTA regulates microglia homeostasis and myelin phagocytosis, and is associated with MS lesion pathology

Borggrewe, M., Kooistra, S. M., Wesseling, E. M., Gierschek, F. L., Brummer, M. L., Nowak, E. C., Medeiros-furquim, T., Otto, T. A., Lee, S. W., Noelle, R. J., Eggen, B. J. L. & Laman, J. D., 18-May-2021, In: Acta Neuropathologica Communications. 9, 1, p. 91-109 18 p., 91.

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9 Citations (Scopus)

112 Downloads (Pure)

2020

Autophagy in Multiple Sclerosis: Two Sides of the Same Coin

Misrielal, C., Mauthe, M., Reggiori, F. & Eggen, B. J. L., 20-Nov-2020, In: Frontiers in cellular neuroscience. 14, 15 p., 603710.

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35 Citations (Scopus)

141 Downloads (Pure)

Bart Eggen

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