Bettien van Hemel

2025

Genome-Wide DNA Methylation and Copy Number Alterations in Gastrointestinal Stromal Tumors

Kleijn, T. G., Ameline, B., Bleckman, R. F., Kooistra, W., van den Broek, E., Diercks, G. F. H., van Hemel, B. M., Timmer, B., Timens, W., Kats-Ugurlu, G., van Kempen, L. C., van Etten, B., Schuuring, E., Suurmeijer, A. J. H., de Haan, J. J., Baumhoer, D., Reyners, A. K. L. & Cleven, A. H. G., Mar-2025, In: Genes Chromosomes & Cancer. 64, 3, 10 p., e70046.

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Trends in the Incidence, Organization of Care, and Surgical Treatment of Medullary Thyroid Cancer: A Population-Based Study

Jager, E. C., Metman, M. J. H., Timmenga, I. A. C., Zandee, W. T., Jansen, L., van Hemel, B. M., Lodewijk, L., Vriens, M. R., van den Broek, M. F. M., Engelsman, A. F., Dreijerink, K. M. A., Netea-Maier, R. T., van Ginhoven, T. M., Peeters, R. P., de Heus, E., Links, T. P. & Kruijff, S., 16-Jan-2025, In: Thyroid. p. 87-96 10 p.

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Validation of the International Medullary Thyroid Cancer Grading System and Identification of EZH2 as a Prognostic and Potential Therapeutic Marker in Medullary Thyroid Cancer

Jager, E. C., van Hemel, B. M., Rutgers, B., Zandee, W. T., Jansen, L., Kruijff, S. & Links, T. P., 21-Feb-2025, In: Cancers. 17, 5, 15 p., 737.

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2024

Een snelgroeiende zwelling in de hals

Translated title of the contribution: A rapidly enlarging neck massLin, J. F., Links, T. P., Broekman, K. E., van Hemel, B., Vister, J., Verbeek, H. H. G., Brouwers, A. H. & Kruijff, S., 10-Jun-2024, In: Nederlands Tijdschrift voor Geneeskunde. 168, D7899.

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Expression of integrin α_vβ₃ in medullary thyroid carcinoma

de Vries, L. H., Lodewijk, L., Pijnappel, E. W., van Diest, P. J., Schepers, A., Bonenkamp, H. J., van Engen-van Grunsven, I. A. C. H., Kruijff, S., van Hemel, B. M., Links, T. P., Nieveen van Dijkum, E. J. M., Eeden, S. V., van Leeuwaarde, R. S., Valk, G. D., Keizer, B. D., Borel Rinkes, I. H. M. & Vriens, M. R., 2024, In: Future oncology. 20, 27, p. 2015-2022 8 p.

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Head-to-head comparison of [11C]methionine PET, [11C]choline PET, and 4-dimensional CT as second-line scans for detection of parathyroid adenomas in primary hyperparathyroidism

Noltes, M. E., Kruijff, S., Appelman, A. P. A., Jansen, L., Zandee, W. T., Links, T. P., van Hemel, B. M., Schouw, H. M., Dierckx, R. A. J. O., Francken, A. B., Kelder, W., van der Hoorn, A. & Brouwers, A. H., Jul-2024, In: European Journal of Nuclear Medicine and Molecular Imaging. 51, 9, p. 1050–1059 10 p.

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8 Citations (Scopus)

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Methylation Analysis to Detect CIN3+ in High-Risk Human Papillomavirus-Positive Self-Samples From the Population-Based Cervical Cancer Screening Program

de Waard, J., Bhattacharya, A., de Boer, M. T., van Hemel, B. M., Esajas, M. D., Vermeulen, K. M., de Bock, G. H., Schuuring, E. & Wisman, G. B. A., Aug-2024, In: Modern Pathology. 37, 8, 7 p., 100528.

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4 Citations (Scopus)

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MET-receptor targeted fluorescent imaging and spectroscopy to detect multifocal papillary thyroid cancer

Metman, M. J. H., Jonker, P. K. C., Sondorp, L. H. J., van Hemel, B. M., Sywak, M. S., Gill, A. J., Jansen, L., van Diest, P. J., van Ginhoven, T. M., Löwik, C. W. G. M., Nguyen, A. H., Robinson, D. J., van Dam, G. M., Links, T. P., Coppes, R. P., Fehrmann, R. S. N. & Kruijff, S., Jul-2024, In: European Journal of Nuclear Medicine and Molecular Imaging. 51, p. 2384–2394 11 p.

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5 Citations (Scopus)

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2023

European experience with the Afirma Gene Expression Classifier for indeterminate thyroid nodules: A clinical utility study in the Netherlands

Lončar, I., van Velsen, E. F. S., Massolt, E. T., van Kemenade, F. J., van Engen-van Grunsven, A. C. H., van Hemel, B. M., van Nederveen, F. H., Netea-Maier, R., Links, T. P., Peeters, R. P. & van Ginhoven, T. M., Sept-2023, In: Head and Neck. 45, 9, p. 2227-2236 10 p.

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3 Citations (Scopus)

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Identification of a methylation panel as an alternative triage to detect CIN3+ in hrHPV-positive self-samples from the population-based cervical cancer screening programme

de Waard, J., Bhattacharya, A., de Boer, M. T., van Hemel, B. M., Esajas, M. D., Vermeulen, K. M., de Bock, G. H., Schuuring, E. & Wisman, G. B. A., 15-Jun-2023, In: Clinical Epigenetics. 15, 11 p., 103.

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8 Citations (Scopus)

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SCC Antigen Concentrations in Fine-Needle Aspiration Samples to Detect Cervical Lymph Node Metastases: A Prospective Analysis

van Schaik, J. E., Muller Kobold, A. C., van der Laan, B. F. A. M., van der Vegt, B., van Hemel, B. M. & Plaat, B. E. C., Mar-2023, In: Otolaryngology - Head and Neck Surgery. 168, 3, p. 407-412 6 p., 01945998221102870.

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2 Citations (Scopus)

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Towards in vivo characterization of thyroid nodules suspicious for malignancy using multispectral optoacoustic tomography

Noltes, M. E., Bader, M., Metman, M. J. H., Vonk, J., Steinkamp, P. J., Kukačka, J., Westerlaan, H. E., Dierckx, R. A. J. O., van Hemel, B. M., Brouwers, A. H., van Dam, G. M., Jüstel, D., Ntziachristos, V. & Kruijff, S., Jul-2023, In: European Journal of Nuclear Medicine and Molecular Imaging. 50, p. 2736-2750 15 p.

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10 Citations (Scopus)

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2022

Intraoperative MET-receptor targeted fluorescent imaging and spectroscopy for lymph node detection in papillary thyroid cancer: novel diagnostic tools for more selective central lymph node compartment dissection

Jonker, P. K. C., Metman, M. J. H., Sondorp, L. H. J., Sywak, M. S., Gill, A. J., Jansen, L., Links, T. P., van Diest, P. J., van Ginhoven, T. M., Löwik, C. W. G. M., Nguyen, A. H., Coppes, R. P., Robinson, D. J., van Dam, G. M., van Hemel, B. M., Fehrmann, R. S. N. & Kruijff, S., Aug-2022, In: European Journal of Nuclear Medicine and Molecular Imaging. 49, p. 3557-3570 14 p.

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11 Citations (Scopus)

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2021

Association of homozygous variants of STING1 with outcome in human cervical cancer

Lubbers, J. M., Koopman, B., de Klerk-Sluis, J. M., van Rooij, N., Plat, A., Pijper, H., Koopman, T., van Hemel, B. M., Hollema, H., Wisman, B., Nijman, H. W. & de Bruyn, M., Jan-2021, In: Cancer science. 112, 1, p. 61-71 11 p.

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12 Citations (Scopus)

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2020

Feasibility of endometrial sampling by vaginal tampons in women with Lynch syndrome

Woolderink, J. M., De Bock, G. H., van Hemel, B. M., Geuken, E., Hollema, H., Werner, N. & Mourits, M. J., 17-Mar-2020, In: BMC Women's Health. 20, 1, 7 p., 54.

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6 Citations (Scopus)

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The IGF2 methylation score for adrenocortical cancer: an ENSAT validation study

Creemers, S. G., Feelders, R. A., Valdes, N., Ronchi, C. L., Volante, M., van Hemel, B. M., Luconi, M., Ettaieb, M. H. T., Mannelli, M., Chiara, M. D., Fassnacht, M., Papotti, M., Kerstens, M. N., Nesi, G., Haak, H. R., van Kemenade, F. J. & Hofland, L. J., Oct-2020, In: Endocrine-Related cancer. 27, 10, p. 541-550 10 p.

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4 Citations (Scopus)

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2019

Squamous cell carcinoma antigen concentration in fine needle aspiration samples: A new method to detect cervical lymph node metastases of head and neck squamous cell carcinoma

van Schaik, J. E., Muller Kobold, A. C., van der Laan, B. F. A. M., van der Vegt, B., van Hemel, B. M. & Plaat, B. E. C., Aug-2019, In: Head and Neck: Journal of the Sciences and Specialties of the Head and Neck. 41, 8, p. 2561-2565 5 p.

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6 Citations (Scopus)

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2018

Increased Global DNA Hypomethylation in Distant Metastatic and Dedifferentiated Thyroid Cancer

Hesselink, E. N. K., Zafon, C., Villalmanzo, N., Iglesias, C., van Hemel, B. M., Hesselink, M. S. K., Montero-Conde, C., Buj, R., Mauricio, D., Peinado, M. A., Puig-Domingo, M., Riesco-Eizaguirre, G., Reverter, J. L., Robledo, M., Links, T. P. & Jorda, M., Feb-2018, In: Journal of Clinical Endocrinology and Metabolism. 103, 2, p. 397-406 10 p.

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22 Citations (Scopus)

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Rapid BRAF mutation tests in patients with advanced melanoma: Comparison of immunohistochemistry, Droplet Digital PCR, and the Idylla Mutation Platform

Bisschop, C., Ter Elst, A., Bosman, L. J., Platteel, I., Jalving, M., van den Berg, A., Diepstra, A., van Hemel, B., Diercks, G. F. H., Hospers, G. A. P. & Schuuring, E., Apr-2018, In: Melanoma Research. 28, 2, p. 96-104 9 p.

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45 Citations (Scopus)

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SSTR2A expression in medullary thyroid carcinoma is correlated with longer survival

de Vries, L. H., Lodewijk, L., Willems, S. M., Dreijerink, K. M. A., de Keizer, B., van Diest, P. J., Schepers, A., Bonenkamp, H. J., van Engen-van Grunsven, I. A. C. H., Kruijff, S., van Hemel, B. M., Links, T. P., van Dijkum, E. J. M. N., van Eeden, S., Valk, G. D., Rinkes, I. H. M. B. & Vriens, M. R., Dec-2018, In: Endocrine. 62, 3, p. 639-647 9 p.

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15 Citations (Scopus)

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Suitability of the Cellient (TM) cell block method for diagnosing soft tissue and bone tumors

Song, W., van Hemel, B. M. & Suurmeijer, A. J. H., Apr-2018, In: Diagnostic Cytopathology. 46, 4, p. 299-305 7 p.

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3 Citations (Scopus)

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The theranostic target prostate-specific membrane antigen is expressed in medullary thyroid cancer

Lodewijk, L., Willems, S. M., Dreijerink, K. M. A., de Keizer, B., van Diest, P. J., Schepers, A., Morreau, H., Bonenkamp, H. J., Van Engen-van Grunsven, I. A. C. H., Kruijff, S., van Hemel, B. M., Links, T. P., van Dijkum, E. N., van Eeden, S., Valk, G. D., Rinkes, I. H. M. B. & Vriens, M. R., Nov-2018, In: Human Pathology. 81, p. 245-254 10 p.

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13 Citations (Scopus)

2017

Expression of HIF-1 alpha in medullary thyroid cancer identifies a subgroup with poor prognosis

Lodewijk, L., van Diest, P., van der Groep, P., ter Hoeve, N., Schepers, A., Morreau, J., Bonenkamp, J., van Engen-van Grunsven, A., Kruijff, S., van Hemel, B., Links, T., van Dijkum, E. N., van Eeden, S., Valk, G., Rinkes, I. B. & Vriens, M., 2017, In: Oncotarget. 8, 17, p. 28650-28659 10 p.

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22 Citations (Scopus)

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2016

Immunological response to quadrivalent HPV vaccine in treatment of recurrent respiratory papillomatosis

Gi, R. E. A. T. P., San Giorgi, M. R. M., Pawlita, M., Michel, A., van Hemel, B. M., Schuuring, E. M. D., Heuvel , van den, E., van der Laan, B. F. A. M. & Dikkers, F. G., Oct-2016, In: European Archives of Oto-Rhino-Laryngology. 273, 10, p. 3231-3236 6 p.

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37 Citations (Scopus)

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2015

Assessment of hypoxic subvolumes in laryngeal cancer with F-18-fluoroazomycinarabinoside (F-18-FAZA)-PET/CT scanning and immunohistochemistry

Bruine de Bruin, L., Bollineni, V. R., Wachters, J. E., Schuuring, E., van Hemel, B. M., van der Wal, J. E., Slagter-Menkema, L., de Bock, G. H., Steenbakkers, R. J. H. M., Langendijk, J. A., Pruim, J., van der Laan, B. F. A. M. & Halmos, G. B., Oct-2015, In: Radiotherapy and Oncology. 117, 1, p. 106-112 7 p.

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14 Citations (Scopus)

Clinical course of recurrent respiratory papillomatosis: Comparison between aggressiveness of human papillomavirus-6 and human papillomavirus-11

Tjon Pian Gi, R. E. A., San Giorgi, M. R. M., Slagter-Menkema, L., van Hemel, B. M., van der Laan, B. F. A. M., van den Heuvel, E. R., Dikkers, F. G. & Schuuring, E. M. D., Nov-2015, In: Head and Neck: Journal of the Sciences and Specialties of the Head and Neck. 37, 11, p. 1625-1632 8 p.

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62 Citations (Scopus)

2014

Clinical Validation of the Cervista HPV HR Test According to the International Guidelines for Human Papillomavirus Test Requirements for Cervical Cancer Screening

Boers, A., Wang, R., Slagter-Menkema, L., van Hemel, B. M., Ghyssaert, H., van der Zee, A. G. J., Schuurs-Wisman, G. B. A. & Schuuring, E., Dec-2014, In: Journal of Clinical Microbiology. 52, 12, p. 4391-4393 3 p.

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20 Citations (Scopus)

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Comparing the Cervista HPV HR Test and Hybrid Capture 2 Assay in a Dutch Screening Population: Improved Specificity of the Cervista HPV HR Test by Changing the Cut-Off

Boers, A., Slagter-Menkema, L., van Hemel, B. M., Belinson, J. L., Ruitenbeek, T., Buikema, H. J., Klip, H., Ghyssaert, H., van der Zee, A. G. J., de Bock, G. H., Wisman, G. B. A. & Schuuring, E., 22-Jul-2014, In: PLoS ONE. 9, 7, 9 p., 101930.

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11 Citations (Scopus)

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2013

Application of the ThinPrep Imaging System in Urine Cytology A Prospective Study

van Hemel, B. M., Haarsma, J. G., Ruitenbeek, T., Groen, H. & Suurmeijer, A. J. H., Aug-2013, In: Cancer cytopathology. 121, 8, p. 410-414 5 p.

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11 Citations (Scopus)

Effective Application of the Methanol-Based PreservCyt (TM) Fixative and the Cellient (TM) Automated Cell Block Processor to Diagnostic Cytopathology, Immunocytochemistry, and Molecular Biology

van Hemel, B. M. & Suurmeijer, A. J. H., Aug-2013, In: Diagnostic Cytopathology. 41, 8, p. 734-741 8 p.

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41 Citations (Scopus)

Is human papillomavirus involved in laryngeal neuroendocrine carcinoma?

Halmos, G. B., van der Laan, T. P., van Hemel, B. M., Dikkers, F. G., Slagter-Menkema, L., van der Laan, B. F. A. M. & Schuuring, E., Feb-2013, In: European Archives of Oto-Rhino-Laryngology. 270, 2, p. 719-725 7 p.

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26 Citations (Scopus)

The importance of multimodality therapy in the treatment of sinonasal neuroendocrine carcinoma

van der Laan, T. P., Bijl, H. P., van Hemel, B. M., Plaat, B. E. C., Wedman, J., van der Laan, B. F. A. M. & Halmos, G., Sept-2013, In: European Archives of Oto-Rhino-Laryngology. 270, 9, p. 2565-2568 4 p.

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37 Citations (Scopus)

2012

Narrow band imaging is a new technique in visualization of recurrent respiratory papillomatosis

Tjon Pian Gi, R. E. A., Halmos, G. B., van Hemel, B. M., van den Heuvel, E. R., van der Laan, B. F. A. M., Plaat, B. E. C. & Dikkers, F. G., Aug-2012, In: Laryngoscope. 122, 8, p. 1826-1830 5 p.

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49 Citations (Scopus)

Neuroendocrine carcinoma of the larynx - an extraordinary malignancy with high recurrence rates and long survival: Our experience in 11 patients

van der Laan, T. P., van der Laan, B. F. A. M., Plaat, B. E. C., Wedman, J., Van Hemel, B. M. & Halmos, G. B., Feb-2012, In: Clinical Otolaryngology. 37, 1, p. 63-66 4 p.

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14 Citations (Scopus)

2011

Detection of cervical neoplasia by DNA methylation analysis in cervico-vaginal lavages, a feasibility study

Eijsink, J. J. H., Yang, N., Lendvai, A., Klip, H. G., Volders, H. H., Buikema, H. J., van Hemel, B. M., Voll, M., Bennink, H. J. T. C., Schuuring, E., Wisman, G. B. A. & van der Zee, A. G. J., Feb-2011, In: Gynecologic Oncology. 120, 2, p. 280-283 4 p.

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51 Citations (Scopus)

2010

Diagnostic Value and Cost Considerations of Routine Fine-Needle Aspirations in the Follow-Up of Thyroid Nodules with Benign Readings

van Roosmalen, J., van Hemel, B., Suurmeijer, A., Groen, H., Ruitenbeek, T., Links, T. P. & Plukker, J. T. M., Dec-2010, In: Thyroid. 20, 12, p. 1359-1365 7 p.

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11 Citations (Scopus)

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Procedure-related, false-positive cytology results during EUS-guided FNA in patients with esophageal cancer

van Hemel, B. M., Lamprou, A. A., Weersma, R., Plukker, J. T. M., Suurmeijer, A. J. H. & van Dullemen, H. M., Jun-2010, In: Gastrointestinal endoscopy. 71, 7, p. 1130-1133 4 p.

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14 Citations (Scopus)

Size of sentinel-node metastasis and chances of non-sentinel-node involvement and survival in early stage vulvar cancer: results from GROINSS-V, a multicentre observational study

Oonk, M. H., van Hemel, B. M., Hollema, H., de Hullu, J. A., Ansink, A. C., Vergote, I., Verheijen, R. H., Maggioni, A., Gaarenstroom, K. N., Baldwin, P. J., van Dorst, E. B., van der Velden, J., Hermans, R. H., van der Putten, H. W., Drouin, P., Runnebaum, I. B., Sluiter, W. J. & van der Zee, A. G., Jul-2010, In: Lancet Oncology. 11, 7, p. 646-652 7 p.

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