Personal profile
Biosketch
My ultimate fascination is how the genome shapes and affects the ability of organisms to adapt to a changing world. I have been investigating the causes and consequences of genomic variation within and among species for at least 20 years, using a combination of experimentation, genomic approaches, and bioinformatics. My scientific expertise further includes evolutionary biology, ecological interactions, ecological and evolutionary genomics, genetics & heredity, and entomology.
Research interests
In my research, I use state-of-the-art technologies and analyses, and employ these to fundamental questions in evolutionary ecology, and in applied research. Rather than trying to minimize the genetic variation in our genomics experiments to facilitate the analyses, my strategy is actually to exploit, quantify and characterize genomic variation to gain fundamental knowledge on ecological traits and evolutionary processes.
In my research, I focus on Drosophila, as this genetically tractable model system with well-studied ecological drivers is ideal for addressing the molecular mechanisms of evolutionary adaptation. In this system, I map the complex gene networks that coordinate ecologically relevant traits and reveal how genomes change during evolution. My research aims are to unravel the molecular principles of evolutionary innovation, and to study functional diversification and interference of gene regulatory networks. For applied research, I will continue to work together with my commercial partners for co-creation of knowledge for biological control, insect mass-rearing and in developing insects as mini-livestock for feed.
Teaching
I am programme director for the MSc Ecology and Evolution since 2017.
Education/Academic qualification
Entomology, PhD (cum laude), Ecology of Drosophila aggregation pheromone: A multitrophic approach, Wageningen University & Research
Award Date: 1-Oct-2001
Biology (Ecology and Evolution), MSc (cum laude), Leiden University
Award Date: 31-Aug-1996
External positions
Board member NLSEB, Dutch Society for Evolutionary Biology (NLSEB)
2021 → …
Steering group member Origins Center, Origins Center
2020 → …
Chair of the section Entomology Day of the Netherlands Entomological Society, Nederlandse Entomologische Vereniging
2015 → 2022
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 2 Zero Hunger
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SDG 8 Decent Work and Economic Growth
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SDG 12 Responsible Consumption and Production
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SDG 13 Climate Action
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SDG 15 Life on Land
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
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Leveraging advances in RNAi and CRISPR for improved biological pest control
Faber, N. R., Ashok, K., Venkatesan, T., Wertheim, B. & Bulgarella, M., Feb-2026, In: Current opinion in insect science. 73, 8 p., 101453.Research output: Contribution to journal › Review article › peer-review
Open Access9 Citations (Scopus) -
Prevalence and distribution of two polycipiviruses in wild black garden ants (Lasius niger L.) in the Netherlands
Manfredonia, I., Chioso, L., Mateescu, I., Konu, M., Brons, J. K., Deelman-Driessen, C., Viljakainen, L., Wertheim, B. & Lequime, S., Jul-2026, In: Journal of Invertebrate Pathology. 217, 8 p., 108611.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile -
Sociability is a Multidimensional Trait in Drosophila melanogaster
Bailly, T. P. M., Lamers, S. J. C., Sarma, A., Jansen, A. C. M., Freerks, K., van Dijk, M., Etienne, R. S., Wertheim, B. & Billeter, J.-C., 3-Apr-2026, (E-pub ahead of print) In: Behavior Genetics. 17 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile -
Exploring matrine and oxymatrine as potential bioinsecticide to control Drosophila suzukii (Diptera: Drosophilidae)
Brilinger, D., Fiedler, M., Arioli, C. J., Werner, S. S., Wertheim, B. & Boff, M. I. C., Feb-2025, In: Neotropical Entomology. 54, 1, 9 p., 14.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile6 Citations (Scopus)41 Downloads (Pure) -
Footprints of worldwide adaptation in structured populations of Drosophila melanogaster through the expanded DEST 2.0 genomic resource
Nunez, J. C. B., Coronado-Zamora, M., Gautier, M., Kapun, M., Steindl, S., Ometto, L., Hoedjes, K., Wertheim, B., P Kohlmeier, P. & et al., 18-Aug-2025, In: Molecular Biology and Evolution. 42, 8, 28 p., msaf132.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile3 Citations (Scopus)11 Downloads (Pure)
Projects
- 11 Finished
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INSECTFEED: Insects as sustainable feed for a circular economy - Interdisciplinary approach to value chain development
Beukeboom, L. (PI), Wertheim, B. (PI), Falcao Salles, J. (PI), Voulgari Kokota, A. (Postdoc), Vogel, M. (PhD student) & van der Bruggen, M. (PhD student)
06/01/2020 → 06/02/2024
Project: Research
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Neurogenetic dissection of a sexual conflict in Drosophila melanogaster
Billeter, J.-C. (PI), Wertheim, B. (PI) & Doubovetzky, N. (PhD student)
01/05/2019 → 01/05/2023
Project: Research
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CINCHRON: Circadian light entrainment in Nasonia
Hut, R. (PI), Beukeboom, L. (PI), Wertheim, B. (PI) & van Hasselt, Y. (PhD student)
01/04/2019 → 01/06/2022
Project: Research
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AL-II: Eco-evolutionary dynamics in the winter moth, Operophtera brumata: The mechanism of adaptation to changing ecological conditions due to climate change
Wertheim, B. (PI), Hut, R. (PI), Visser, M. (PI) & van Dis, N. E. (PhD student)
01/09/2018 → 01/12/2023
Project: Research
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AL-II: How species of malaria vector mosquitoes emerged and evolved in the Anopheles gambiae complex in face of widespread introgressive hybridization: Theoretical and empirical approaches
Wertheim, B. (PI), Fontaine, M. (PI), van Doorn, S. (PI) & Amaya Romero, J. E. (PI)
01/09/2017 → 01/06/2023
Project: Research
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Protix
Beukeboom, L. (Visiting researcher) & Wertheim, B. (Visiting researcher)
Aug-2023Activity: Visiting an external institution › Professional
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Winter moth (Operophtera brumata) adaptation to climate change: plasticity in embryonic response to temperature
van Dis, N. E. (Speaker), Risse, J. E. (Contributor), van der Zee, M. (Contributor), Pijl, A. S. (Contributor), Hut, R. (Contributor), Visser, M. (Contributor) & Wertheim, B. (Contributor)
18-Jul-2022Activity: Talk and presentation › Academic presentation › Academic
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Genomic basis of rapid adaptation to climate change in the winter moth
van Dis, N. E. (Speaker), Risse, J. E. (Contributor), Pijl, A. S. (Contributor), Hut, R. (Contributor), Visser, M. (Contributor) & Wertheim, B. (Contributor)
28-Jun-2022Activity: Talk and presentation › Academic presentation › Academic
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Dutch Society for Evolutionary Biology (NLSEB) (External organisation)
Wertheim, B. (Chair)
2022 → …Activity: Membership › Academic
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Seasonal reproductive biology of Drosophila suzukii
Wertheim, B. (Speaker)
25-Oct-2022Activity: Talk and presentation › Academic presentation › Academic
Datasets
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Additional file 4: of Regulatory and sequence evolution in response to selection for improved associative learning ability in Nasonia vitripennis
Kraaijeveld, K. (Contributor), Oostra, V. (Contributor), Liefting, M. (Contributor), Wertheim, B. (Contributor), De Meijer, E. (Contributor) & Ellers, J. (Contributor), University of Groningen, 10-Dec-2018
DOI: 10.6084/m9.figshare.7446863.v1
Dataset
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Additional file 3: of Regulatory and sequence evolution in response to selection for improved associative learning ability in Nasonia vitripennis
Kraaijeveld, K. (Contributor), Oostra, V. (Contributor), Liefting, M. (Contributor), Wertheim, B. (Contributor), De Meijer, E. (Contributor) & Ellers, J. (Contributor), University of Groningen, 10-Dec-2018
DOI: 10.6084/m9.figshare.7446854.v1
Dataset
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Replication Data for: Seasonal morphotypes of Drosophila suzukii differ in key life history traits during and after a period of cold exposure
Aurore Panel, A. (Contributor), Pen, I. (Contributor), Pannebakker, B. (Contributor), Helsen, H. (Contributor) & Wertheim, B. (Contributor), University of Groningen, 23-Aug-2020
DOI: 10.34894/trjayh, https://doi.org/10.34894/trjayh
Dataset
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Replication Data for: Studying foraging behavior to improve bait sprays application to control Drosophila suzukii
Escobedo Quevedo, K. (Creator), Lankheet, M. (Creator), Pen, I. (Creator), Trienens, M. (Creator), Helsen, H. (Creator) & Wertheim, B. (Creator), DataverseNL, 7-May-2024
DOI: 10.34894/y8r63p
Dataset
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Replication Data for: Resident group size modulates oviposition site selection in Drosophila melanogaster
Verschut, T. (Creator), Ng, R. (Creator), Doubovetzky, N. P. (Creator), Le Calvez, G. (Creator), Sneep, R. (Creator), Minnaard, A. (Creator), Su, C. Y. (Creator), Carlsson, M. A. (Creator), Wertheim, B. (Creator) & Billeter, J. C. (Creator), DataverseNL, 8-Feb-2023
DOI: 10.34894/ygefct
Dataset
Press/Media
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Nieuwe leerstoelhouder Laboratorium voor Entomologie voor Bregje Wertheim
22/08/2024
2 items of Media coverage
Press/Media: Research › Popular
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Bregje en Judith onderzoeken hoe vliegen hét nieuwe veevoer kunnen zijn. Moeten we dan ook rekening houden met het welzijn van een insect?
Wertheim, B. & Borgman, J.
02/07/2024 → 08/07/2024
2 items of Media coverage
Press/Media: Research › Popular
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Editorial: Diet, nutrition and insect responses to environmental change
van Dis, N., Wertheim, B. & Visser, M.
15/06/2024
1 item of Media coverage
Press/Media: Research › Popular
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Even over evolutie: het is niet altijd de sterkste
07/06/2023
1 Media contribution
Press/Media: Public Engagement Activities › Popular
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Waar komen al die fruitvliegjes ineens vandaan?
13/07/2022
1 Media contribution
Press/Media: Expert Comment › Popular
Prizes
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NWO Vidi Research Fellowship
Wertheim, B. (Recipient), Jul-2009
Prize: Fellowship awarded competitively › Academic
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Rosalind Franklin Fellowship
Wertheim, B. (Recipient), 2008
Prize: Fellowship awarded competitively › Academic