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  • 2021

    Genetic analyses of the QT interval and its components in over 250K individuals identifies new loci and pathways affecting ventricular depolarization and repolarization

    Young, W. J., Lahrouchi, N., Isaacs, A., Duong, T., Foco, L., Ahmed, F., Brody, J. A., Salman, R., Noordam, R., Benjamins, J-W., Haessler, J., Lyytikäinen, L-P., Repetto, L., Concas, M. P., Berg, M. E. V. D., Weiss, S., Baldassari, A. R., Bartz, T. M., Cook, J. P., Evans, D. S. & 146 others, Freudling, R., Hines, O., Isaksen, J. L., Lin, H., Mei, H., Moscati, A., Müller-Nurasyid, M., Nursyifa, C., Qian, Y., Richmond, A., Roselli, C., Ryan, K. A., Tarazona-Santos, E., Thériault, S., Duijvenboden, S. V., Warren, H. R., Yao, J., Raza, D., Aeschbacher, S., Ahlberg, G., Alonso, A., Andreasen, L., Bis, J. C., Boerwinkle, E., Campbell, A., Catamo, E., Cocca, M., Cutler, M. J., Darbar, D., Grandi, A. D., Luca, A. D., Ding, J., Ellervik, C., Ellinor, P. T., Felix, S. B., Froguel, P., Fuchsberger, C., Gögele, M., Graff, C., Graff, M., Guo, X., Hansen, T., Heckbert, S. R., Huang, P. L., Huikuri, H. V., Hutri-Kähönen, N., Ikram, M. A., Jackson, R. D., Junttila, J., Kavousi, M., Kors, J. A., Leal, T. P., Lemaitre, R. N., Lin, H. J., Lind, L., Linneberg, A., Liu, S., MacFarlane, P. W., Mangino, M., Meitinger, T., Mezzavilla, M., Mishra, P. P., Mitchell, R. N., Mononen, N., Montasser, M. E., Morrison, A. C., Nauck, M., Nauffal, V., Navarro, P., Nikus, K., Pare, G., Patton, K. K., Pelliccione, G., Pittman, A., Porteous, D. J., Pramstaller, P. P., Preuss, M. H., Raitakari, O. T., Reiner, A. P., Ribeiro, A. L. P., Rice, K. M., Risch, L., Schlessinger, D., Schotten, U., Schurmann, C., Shen, X., Shoemaker, M. B., Sinagra, G., Sinner, M. F., Soliman, E. Z., Stoll, M., Strauch, K., Tarasov, K., Taylor, K. D., Tinker, A., Trompet, S., Uitterlinden, A., Völker, U., Völzke, H., Waldenberger, M., Weng, L-C., Whitsel, E. A., Wilson, J. G., Avery, C. L., Conen, D., Correa, A., Cucca, F., Dörr, M., Gharib, S. A., Girotto, G., Grarup, N., Hayward, C., Jamshidi, Y., Järvelin, M-R., Jukema, J. W., Kääb, S., Kähönen, M., Kanters, J. K., Kooperberg, C., Lehtimäki, T., Lima-Costa, M. F., Liu, Y., Loos, R. J. F., Lubitz, S. A., Mook-Kanamori, D. O., Morris, A. P., O’Connell, J. R., Olesen, M. S., Orini, M., Padmanabhan, S., Pattaro, C., Peters, A., Psaty, B. M., Rotter, J. I., Stricker, B., Harst, P. V. D., Duijn, C. M. V., Verweij, N., Wilson, J. F., Arking, D. E., Ramirez, J., Lambiase, P. D., Sotoodehnia, N., Mifsud, B., Newton-Cheh, C. & Munroe, P. B., 4-Nov-2021, MedRxiv.

    Research output: Working paperPreprintAcademic

  • Genetic Risk Score to Identify Risk of Venous Thromboembolism in Patients With Cardiometabolic Disease

    Marston, N. A., Melloni, G. E. M., Gurmu, Y., Bonaca, M. P., Kamanu, F. K., Roselli, C., Lee, C., Cavallari, I., Giugliano, R. P., Scirica, B. M., Bhatt, D. L., Steg, P. G., Cohen, M., Storey, R. F., Keech, A. C., Raz, I., Mosenzon, O., Braunwald, E., Lubitz, S. A., Ellinor, P. T. & 2 others, Sabatine, M. S. & Ruff, C. T., Feb-2021, In: Circulation-Genomic and precision medicine. 14, 1, p. 82-87 6 p., e003006.

    Research output: Contribution to journalArticleAcademicpeer-review

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    1 Citation (Scopus)
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  • 2020

    Genetic risk and atrial fibrillation in patients with heart failure

    Kloosterman, M., Santema, B. T., Roselli, C., Nelson, C. P., Koekemoer, A., Romaine, S. P. R., Van Gelder, I. C., Lam, C. S. P., Artola, V. A., Lang, C. C., Ng, L. L., Metra, M., Anker, S., Filippatos, G., Dickstein, K., Ponikowski, P., van der Harst, P., van der Meer, P., van Veldhuisen, D. J., Benjamin, E. J. & 3 others, Voors, A. A., Samani, N. J. & Rienstra, M., 9-Jan-2020, (E-pub ahead of print) In: European Journal of Heart Failure. 22, 3, p. 519-527 9 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
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    2 Citations (Scopus)
    28 Downloads (Pure)
  • Genetics of Atrial Fibrillation in 2020 GWAS, Genome Sequencing, Polygenic Risk, and Beyond

    Roselli, C., Rienstra, M. & Ellinor, P. T., 19-Jun-2020, In: Circulation research. 127, 1, p. 21-33 13 p.

    Research output: Contribution to journalArticleAcademicpeer-review

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    20 Citations (Scopus)
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  • Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure

    Regeneron Genetics Ctr, Shah, S., Henry, A., Roselli, C., Lin, H., Sveinbjornsson, G., Fatemifar, G., Hedman, A. K., Wilk, J. B., Morley, M. P., Chaffin, M. D., Helgadottir, A., Verweij, N., Dehghan, A., Almgren, P., Andersson, C., Aragam, K. G., Arnlov, J., Backman, J. D., Biggs, M. L. & 31 others, Bloom, H. L., Brandimarto, J., Brown, M. R., Buckbinder, L., Carey, D. J., Chasman, D. I., Chen, X., Chen, X., Chung, J., Chutkow, W., Cook, J. P., Delgado, G. E., Denaxas, S., Doney, A. S., Doerr, M., Dudley, S. C., Dunn, M. E., Engstrom, G., Esko, T., Felix, S. B., Finan, C., Ford, I., Ghanbari, M., Ghasemi, S., Giedraitis, V., Giulianini, F., Gottdiener, J. S., van der Harst, P., Voors, A. A., Zhao, J. H. & Asselbergs, F. W., 9-Jan-2020, In: Nature Communications. 11, 1, 12 p., 163.

    Research output: Contribution to journalArticleAcademicpeer-review

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    76 Citations (Scopus)
    61 Downloads (Pure)
  • Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction

    Ntalla, I., Weng, L-C., Cartwright, J. H., Hall, A. W., Sveinbjornsson, G., Tucker, N. R., Choi, S. H., Chaffin, M. D., Roselli, C., Barnes, M. R., Mifsud, B., Warren, H. R., Hayward, C., Marten, J., Cranley, J. J., Concas, M. P., Gasparini, P., Boutin, T., Kolcic, I., Polasek, O. & 167 others, Rudan, I., Araujo, N. M., Lima-Costa, M. F., Ribeiro, A. L. P., Souza, R. P., Tarazona-Santos, E., Giedraitis, V., Ingelsson, E., Mahajan, A., Morris, A. P., Del Greco M, F., Foco, L., Gögele, M., Hicks, A. A., Cook, J. P., Lind, L., Lindgren, C. M., Sundström, J., Nelson, C. P., Riaz, M. B., Samani, N. J., Sinagra, G., Ulivi, S., Kähönen, M., Mishra, P. P., Mononen, N., Nikus, K., Caulfield, M. J., Dominiczak, A., Padmanabhan, S., Montasser, M. E., O'Connell, J. R., Ryan, K., Shuldiner, A. R., Aeschbacher, S., Conen, D., Risch, L., Thériault, S., Hutri-Kähönen, N., Lehtimäki, T., Lyytikäinen, L-P., Raitakari, O. T., Barnes, C. L. K., Campbell, H., Joshi, P. K., Wilson, J. F., Isaacs, A., Kors, J. A., van Duijn, C. M., Huang, P. L., Gudnason, V., Harris, T. B., Launer, L. J., Smith, A. V., Bottinger, E. P., Loos, R. J. F., Nadkarni, G. N., Preuss, M. H., Correa, A., Mei, H., Wilson, J., Meitinger, T., Müller-Nurasyid, M., Peters, A., Waldenberger, M., Mangino, M., Spector, T. D., Rienstra, M., van de Vegte, Y. J., van der Harst, P., Verweij, N., Kääb, S., Schramm, K., Sinner, M. F., Strauch, K., Cutler, M. J., Fatkin, D., London, B., Olesen, M., Roden, D. M., Benjamin Shoemaker, M., Gustav Smith, J., Biggs, M. L., Bis, J. C., Brody, J. A., Psaty, B. M., Rice, K., Sotoodehnia, N., De Grandi, A., Fuchsberger, C., Pattaro, C., Pramstaller, P. P., Ford, I., Wouter Jukema, J., Macfarlane, P. W., Trompet, S., Dörr, M., Felix, S. B., Völker, U., Weiss, S., Havulinna, A. S., Jula, A., Sääksjärvi, K., Salomaa, V., Guo, X., Heckbert, S. R., Lin, H. J., Rotter, J. I., Taylor, K. D., Yao, J., de Mutsert, R., Maan, A. C., Mook-Kanamori, D. O., Noordam, R., Cucca, F., Ding, J., Lakatta, E. G., Qian, Y., Tarasov, K. V., Levy, D., Lin, H., Newton-Cheh, C. H., Lunetta, K. L., Murray, A. D., Porteous, D. J., Smith, B. H., Stricker, B. H., Uitterlinden, A., van den Berg, M. E., Haessler, J., Jackson, R. D., Kooperberg, C., Peters, U., Reiner, A. P., Whitsel, E. A., Alonso, A., Arking, D. E., Boerwinkle, E., Ehret, G. B., Soliman, E. Z., Avery, C. L., Gogarten, S. M., Kerr, K. F., Laurie, C. C., Seyerle, A. A., Stilp, A., Assa, S., Abdullah Said, M., Yldau van der Ende, M., Lambiase, P. D., Orini, M., Ramirez, J., Van Duijvenboden, S., Arnar, D. O., Gudbjartsson, D. F., Holm, H., Sulem, P., Thorleifsson, G., Thorolfsdottir, R. B., Thorsteinsdottir, U., Benjamin, E. J., Tinker, A., Stefansson, K., Ellinor, P. T., Jamshidi, Y., Lubitz, S. A. & Munroe, P. B., 21-May-2020, In: Nature Communications. 11, 1, 12 p., 2542.

    Research output: Contribution to journalArticleAcademicpeer-review

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    9 Citations (Scopus)
    43 Downloads (Pure)
  • Predicting Benefit From Evolocumab Therapy in Patients With Atherosclerotic Disease Using a Genetic Risk Score Results From the FOURIER Trial

    Marston, N. A., Kamanu, F. K., Nordio, F., Gurmu, Y., Roselli, C., Sever, P. S., Pedersen, T. R., Keech, A. C., Wang, H., Pineda, A. L., Giugliano, R. P., Lubitz, S. A., Ellinor, P. T., Sabatine, M. S. & Ruff, C. T., 25-Feb-2020, In: Circulation. 141, 8, p. 616-623 8 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    44 Citations (Scopus)
  • The Effect of PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) Inhibition on the Risk of Venous Thromboembolism

    Marston, N. A., Gurmu, Y., Melloni, G. E. M., Bonaca, M., Gencer, B., Sever, P. S., Pedersen, T. R., Keech, A. C., Roselli, C., Lubitz, S. A., Ellinor, P. T., O'Donoghue, M. L., Giugliano, R. P., Ruff, C. T. & Sabatine, M. S., 19-May-2020, In: Circulation. 141, 20, p. 1600-1607 8 p.

    Research output: Contribution to journalArticleAcademicpeer-review

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    21 Citations (Scopus)
  • Transcriptional and Cellular Diversity of the Human Heart

    Tucker, N. R., Chaffin, M., Fleming, S. J., Hall, A. W., Parsons, V. A., Bedi, K. C., Akkad, A-D., Herndon, C. N., Arduini, A., Papangeli, I., Roselli, C., Aguet, F., Choi, S. H., Ardlie, K. G., Babadi, M., Margulies, K. B., Stegmann, C. M. & Ellinor, P. T., 4-Aug-2020, In: Circulation. 142, 5, p. 466-482 17 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
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    59 Citations (Scopus)
    1 Downloads (Pure)
  • 2019

    Assessment of the Relationship Between Genetic Determinants of Thyroid Function and Atrial Fibrillation A Mendelian Randomization Study

    Ellervik, C., Roselli, C., Christophersen, I. E., Alonso, A., Pietzner, M., Sitlani, C. M., Trompet, S., Arking, D. E., Geelhoed, B., Guo, X., Kleber, M. E., Lin, H. J., Lin, H., Macfarlane, P., Selvin, E., Shaffer, C., Smith, A., Verweij, N., Weiss, S., Cappola, A. R. & 26 others, Dorr, M., Gudnason, V., Heckbert, S., Mooijaart, S., Marz, W., Psaty, B. M., Ridker, P. M., Roden, D., Stott, D. J., Volzke, H., Benjamin, E. J., Delgado, G., Ellinor, P., Homuth, G., Kottgen, A., Jukema, J. W., Lubitz, S. A., Mora, S., Rienstra, M., Rotter, J., Shoemaker, M. B., Sotoodehnia, N., Taylor, K. D., van der Harst, P., Albert, C. M. & Chasman, D., 23-Jan-2019, In: Jama cardiology. 4, 2, p. 144-152 9 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    29 Citations (Scopus)
  • Genetic risk prediction of atrial fibrillation in a contemporary heart failure cohort

    Kloosterman, M., Santema, B. T., Roselli, C., Koekemoer, A. L., Romaine, S. P. R., Nelson, C. P., Van Gelder, I. C., Lam, C. S. P., Van der Harst, P., Sama, I. E., Van Veldhuisen, D. J., Voors, A. A., Samani, N. J. & Rienstra, M., May-2019, In: European Journal of Heart Failure. 21, p. 494-495 2 p.

    Research output: Contribution to journalMeeting AbstractAcademic

  • Publisher Correction: Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

    AFGen Consortium, Jul-2019, In: Nature Genetics. 51, p. 1187-1194

    Research output: Contribution to journalArticleAcademicpeer-review

    2 Citations (Scopus)