Research output per year
Research output per year
Personal profile
Research interests
Single cell sequencing, genome instability, structural variations, ageing, stem cells, cancer, immunology
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Dive into the research topics where Diana Spierings is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Single-cell chromosome and bulk transcriptome analysis as a diagnostic tool to differentiate between localized and metastatic pheochromocytoma and sympathetic paraganglioma
Berends, A. M. A., Wardenaar, R., van den Bos, H., Tijhuis, A. E., Links, T. P., Feelders, R. A., Hofland, L. J., Kruijff, S., Pacak, K., Spierings, D. C. J., Kerstens, M. N. & Foijer, F., 3-May-2025, (E-pub ahead of print) In: Oncogene. 1122.Research output: Contribution to journal › Article › Academic › peer-review
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CDK4 is co-amplified with either TP53 promoter gene fusions or MDM2 through distinct mechanisms in osteosarcoma
Saba, K. H., Difilippo, V., Styring, E., Nilsson, J., Magnusson, L., van den Bos, H., Wardenaar, R., Spierings, D. C. J., Foijer, F., Nathrath, M., Haglund de Flon, F., Baumhoer, D. & Nord, K. H., 25-Sept-2024, In: npj Genomic Medicine. 9, 1, 12 p., 42.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile2 Citations (Scopus)60 Downloads (Pure) -
Centrosome amplification primes ovarian cancer cells for apoptosis and potentiates the response to chemotherapy
Edwards, F., Fantozzi, G., Simon, A. Y., Morretton, J.-P., Herbette, A., Tijhuis, A. E., Wardenaar, R., Foulane, S., Gemble, S., Spierings, D. C. J., Foijer, F., Mariani, O., Vincent-Salomon, A., Roman-Roman, S., Sastre-Garau, X., Goundiam, O. & Basto, R., 2024, In: PLOS BIOLOGY. 22, 9, 30 p., e3002759.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile4 Citations (Scopus)53 Downloads (Pure) -
Chromosomal instability in aneuploid acute lymphoblastic leukemia associates with disease progression
Molina, O., Ortega-Sabater, C., Thampi, N., Fernández-Fuentes, N., Guerrero-Murillo, M., Martínez-Moreno, A., Vinyoles, M., Velasco-Hernández, T., Bueno, C., Trincado, J. L., Granada, I., Campos, D., Giménez, C., Boer, J. M., den Boer, M. L., Calvo, G. F., Camós, M., Fuster, J. L., Velasco, P. & Ballerini, P. & 6 others, , 1-Jan-2024, In: EMBO Molecular Medicine. 16, 1, p. 64-92 29 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile3 Citations (Scopus)100 Downloads (Pure) -
Chronic spindle assembly checkpoint activation causes myelosuppression and gastrointestinal atrophy
Karbon, G., Schuler, F., Braun, V. Z., Eichin, F., Haschka, M., Drach, M., Sotillo, R., Geley, S., Spierings, D. C., Tijhuis, A. E., Foijer, F. & Villunger, A., 28-May-2024, In: Embo Reports. 25, p. 2743-2772 30 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile71 Downloads (Pure)
Activities
- 1 Academic presentation
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Dutch Hematology congress
Spierings, D. (Speaker)
24-Jan-2018 → 26-Jan-2018Activity: Talk and presentation › Academic presentation › Academic
Datasets
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Data from: Direct chromosome-length haplotyping by single-cell sequencing
Lansdorp, P. M. (Contributor), Sanders, A. D. (Contributor), Wietmarschen ,van, N. (Creator), Falconer, E. (Creator), Hills, M. (Creator), Spierings, D. (Contributor), Bevova, M. (Creator) & Guryev, V. (Contributor), ZENODO, 26-Nov-2016
Dataset
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Single cell whole genome sequencing of high hyperdiploid acute lymphoblastic leukemia
Woodward, E. (Contributor), Yang, M. (Contributor), Moura-Castro, L. H. (Contributor), van den Bos, H. (Contributor), Gunnarsson, R. (Contributor), Arvidsson, L. O. (Contributor), Spierings, D. C. J. (Contributor), Castor, A. (Contributor), Duployez, N. (Contributor), Zaliova, M. (Contributor), Zuna, J. (Contributor), Johansson, B. (Contributor), Foijer, F. (Contributor) & Paulsson, K. (Contributor), National Bioinformatics Infrastructure Sweden, 22-Feb-2022
DOI: 10.17044/scilifelab.19160954.v1, https://scilifelab.figshare.com/articles/dataset/Single_cell_whole_genome_sequencing_of_high_hyperdiploid_acute_lymphoblastic_leukemia/19160954/1
Dataset
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Additional file 3 of Replication stress generates distinctive landscapes of DNA copy number alterations and chromosome scale losses
Shaikh, N. (Contributor), Mazzagatti, A. (Contributor), De Angelis, S. (Contributor), Johnson, S. C. (Contributor), Bakker, B. (Contributor), Spierings, D. (Contributor), Wardenaar, R. (Contributor), Maniati, E. (Contributor), Wang, J. (Contributor), Boemo, M. A. (Contributor), Foijer, F. (Contributor) & McClelland, S. E. (Contributor), figshare Academic Research System, 20-Oct-2022
DOI: 10.6084/m9.figshare.21376242.v1, https://springernature.figshare.com/articles/dataset/Additional_file_3_of_Replication_stress_generates_distinctive_landscapes_of_DNA_copy_number_alterations_and_chromosome_scale_losses/21376242/1
Dataset
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Additional file 11 of InvertypeR: Bayesian inversion genotyping with Strand-seq data
Hanlon, V. C. T. (Creator), Mattsson, C.-A. (Creator), Spierings, D. C. J. (Creator), Guryev, V. (Creator) & Lansdorp, P. M. (Creator), figshare, 31-Jul-2021
DOI: 10.6084/m9.figshare.15087431, https://springernature.figshare.com/articles/dataset/Additional_file_11_of_InvertypeR_Bayesian_inversion_genotyping_with_Strand-seq_data/15087431
Dataset
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Additional file 4: Table S1. of Single-cell sequencing reveals karyotype heterogeneity in murine and human malignancies
Bakker, B. (Creator), Taudt, A. (Creator), Belderbos, M. E. (Creator), Porubský, D. (Creator), Spierings, D. C. J. (Creator), de Jong, T. V. (Contributor), Halsema, N. (Creator), Kazemier, H. G. (Creator), Hoekstra-Wakker, K. (Creator), Bradley, A. (Creator), de Bont, E. S. J. M. (Contributor), van den Berg, A. (Contributor), Guryev, V. (Creator), Lansdorp, P. M. (Creator), Colomé-Tatché, M. (Contributor) & Foijer, F. (Creator), figshare, 31-May-2016
DOI: 10.6084/m9.figshare.c.3601100_d7
Dataset
Press/Media
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Death receptors in normal and malignant tissues
14/03/2004
1 Media contribution
Press/Media: Expert Comment › Professional