Research output per year
Research output per year
Personal profile
Research interests
Single cell sequencing, genome instability, structural variations, ageing, stem cells, cancer, immunology
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Single-cell chromosome and bulk transcriptome analysis as a diagnostic tool to differentiate between localized and metastatic pheochromocytoma and sympathetic paraganglioma
Berends, A. M. A., Wardenaar, R., van den Bos, H., Tijhuis, A. E., Links, T. P., Feelders, R. A., Hofland, L. J., Kruijff, S., Pacak, K., Spierings, D. C. J., Kerstens, M. N. & Foijer, F., 4-Aug-2025, In: Oncogene. 44, p. 2547–2560 14 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile1 Citation (Scopus)2 Downloads (Pure) -
Spatiotemporal Immune Landscape and Long-term Immune Memory in POLE-Mutant Endometrial Cancer at the Single-Cell Level
Brummel, K., Requesens, M., van Rooij, N., Workel, H. H., Eggink, F. A., Plat, A., Wardenaar, R., Spierings, D. C. J., Foijer, F., Church, D. N., Bart, J., Nijman, H. W. & de Bruyn, M., 1-Dec-2025, In: Cancer immunology research. 13, 12, p. 1911-1924 14 p.Research output: Contribution to journal › Article › Academic › peer-review
1 Citation (Scopus) -
CDK4 is co-amplified with either TP53 promoter gene fusions or MDM2 through distinct mechanisms in osteosarcoma
Saba, K. H., Difilippo, V., Styring, E., Nilsson, J., Magnusson, L., van den Bos, H., Wardenaar, R., Spierings, D. C. J., Foijer, F., Nathrath, M., Haglund de Flon, F., Baumhoer, D. & Nord, K. H., 25-Sept-2024, In: npj Genomic Medicine. 9, 1, 12 p., 42.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile6 Citations (Scopus)92 Downloads (Pure) -
Centrosome amplification primes ovarian cancer cells for apoptosis and potentiates the response to chemotherapy
Edwards, F., Fantozzi, G., Simon, A. Y., Morretton, J.-P., Herbette, A., Tijhuis, A. E., Wardenaar, R., Foulane, S., Gemble, S., Spierings, D. C. J., Foijer, F., Mariani, O., Vincent-Salomon, A., Roman-Roman, S., Sastre-Garau, X., Goundiam, O. & Basto, R., 2024, In: PLOS BIOLOGY. 22, 9, 30 p., e3002759.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile5 Citations (Scopus)87 Downloads (Pure) -
Chromosomal instability in aneuploid acute lymphoblastic leukemia associates with disease progression
Molina, O., Ortega-Sabater, C., Thampi, N., Fernández-Fuentes, N., Guerrero-Murillo, M., Martínez-Moreno, A., Vinyoles, M., Velasco-Hernández, T., Bueno, C., Trincado, J. L., Granada, I., Campos, D., Giménez, C., Boer, J. M., den Boer, M. L., Calvo, G. F., Camós, M., Fuster, J. L., Velasco, P. & Ballerini, P. & 6 others, , 1-Jan-2024, In: EMBO Molecular Medicine. 16, 1, p. 64-92 29 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile4 Citations (Scopus)138 Downloads (Pure)
Activities
- 1 Academic presentation
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Dutch Hematology congress
Spierings, D. (Speaker)
24-Jan-2018 → 26-Jan-2018Activity: Talk and presentation › Academic presentation › Academic
Datasets
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Data: Direct chromosome-length haplotyping by single-cell sequencing
Lansdorp, P. (Creator), Sanders, A. D. (Creator), van Wietmarschen, N. (Creator), Falconer, E. (Creator), Hills, M. (Creator), Spierings, D. (Creator), Bevova, M. (Creator) & Guryev, V. (Creator), University of Groningen, 26-Nov-2016
DOI: 10.5281/zenodo.599901, https://zenodo.org/record/830278
Dataset
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Additional file 11 of InvertypeR: Bayesian inversion genotyping with Strand-seq data
Hanlon, V. C. T. (Creator), Mattsson, C.-A. (Creator), Spierings, D. C. J. (Creator), Guryev, V. (Creator) & Lansdorp, P. M. (Creator), figshare, 31-Jul-2021
DOI: 10.6084/m9.figshare.15087431, https://springernature.figshare.com/articles/dataset/Additional_file_11_of_InvertypeR_Bayesian_inversion_genotyping_with_Strand-seq_data/15087431
Dataset
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Data from: Direct chromosome-length haplotyping by single-cell sequencing
Lansdorp, P. M. (Contributor), Sanders, A. D. (Contributor), Wietmarschen ,van, N. (Creator), Falconer, E. (Creator), Hills, M. (Creator), Spierings, D. (Contributor), Bevova, M. (Creator) & Guryev, V. (Contributor), ZENODO, 26-Nov-2016
Dataset
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Single cell whole genome sequencing of high hyperdiploid acute lymphoblastic leukemia
Woodward, E. (Contributor), Yang, M. (Contributor), Moura-Castro, L. H. (Contributor), van den Bos, H. (Contributor), Gunnarsson, R. (Contributor), Arvidsson, L. O. (Contributor), Spierings, D. C. J. (Contributor), Castor, A. (Contributor), Duployez, N. (Contributor), Zaliova, M. (Contributor), Zuna, J. (Contributor), Johansson, B. (Contributor), Foijer, F. (Contributor) & Paulsson, K. (Contributor), National Bioinformatics Infrastructure Sweden, 22-Feb-2022
DOI: 10.17044/scilifelab.19160954.v1, https://scilifelab.figshare.com/articles/dataset/Single_cell_whole_genome_sequencing_of_high_hyperdiploid_acute_lymphoblastic_leukemia/19160954/1
Dataset
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Additional file 3 of Replication stress generates distinctive landscapes of DNA copy number alterations and chromosome scale losses
Shaikh, N. (Contributor), Mazzagatti, A. (Contributor), De Angelis, S. (Contributor), Johnson, S. C. (Contributor), Bakker, B. (Contributor), Spierings, D. (Contributor), Wardenaar, R. (Contributor), Maniati, E. (Contributor), Wang, J. (Contributor), Boemo, M. A. (Contributor), Foijer, F. (Contributor) & McClelland, S. E. (Contributor), figshare Academic Research System, 20-Oct-2022
DOI: 10.6084/m9.figshare.21376242.v1, https://springernature.figshare.com/articles/dataset/Additional_file_3_of_Replication_stress_generates_distinctive_landscapes_of_DNA_copy_number_alterations_and_chromosome_scale_losses/21376242/1
Dataset
Press/Media
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Death receptors in normal and malignant tissues
14/03/2004
1 Media contribution
Press/Media: Expert Comment › Professional