Research output per year
Research output per year
- 1 - 50 out of 159 results
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2024
AI is a viable alternative to high throughput screening: a 318-target study
The Atomwise AIMS Program, Wallach, I., Bernard, D., Nguyen, K., Ho, G., Morrison, A., Stecula, A., Rosnik, A., Garaeva, A. A., Borowska, A. & Slotboom, D. J., 2-Apr-2024, In: Scientific Reports. 14, 1, 16 p., 7526.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile25 Citations (Scopus)67 Downloads (Pure) -
Author Correction: Identification of inhibitors targeting the energy-coupling factor (ECF) transporters
Diamanti, E., Souza, P. C. T., Setyawati, I., Bousis, S., Monjas, L., Swier, L. J. Y. M., Shams, A., Tsarenko, A., Stanek, W. K., Jäger, M., Marrink, S. J., Slotboom, D. J. & Hirsch, A. K. H., 9-Jan-2024, In: Communications biology. 7, 1 p., 70.Research output: Contribution to journal › Erratum
Open AccessFile33 Downloads (Pure) -
Bidirectional ATP-driven transport of cobalamin by the mycobacterial ABC transporter BacA
Nijland, M., Lefebvre, S. N., Thangaratnarajah, C. & Slotboom, D. J., 23-Mar-2024, In: Nature Communications. 15, 1, 9 p., 2626.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile1 Citation (Scopus)57 Downloads (Pure) -
Chemiosmotic nutrient transport in synthetic cells powered by electrogenic antiport coupled to decarboxylation
Patiño-Ruiz, M. F., Anshari, Z. R., Gaastra, B., Slotboom, D. J. & Poolman, B., 12-Sept-2024, In: Nature Communications. 15, 1, 19 p., 7976.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile27 Downloads (Pure) -
Cobalamin decyanation by the membrane transporter BtuM
Martínez Felices, J. M., Barreto, Y. B., Thangaratnarajah, C., Whittaker, J. J., Alencar, A. M., Guskov, A. & Slotboom, D. J., 8-Aug-2024, In: Structure. 32, 13 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile8 Downloads (Pure) -
Expression and characterization of pantothenate energy-coupling factor transporters as an anti-infective drug target
Shams, A., Bousis, S., Diamanti, E., Elgaher, W. A. M., Zeimetz, L., Haupenthal, J., Slotboom, D. J. & Hirsch, A. K. H., Nov-2024, In: Protein Science. 33, 11, 11 p., e5195.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile2 Downloads (Pure) -
Fitness landscape of substrate-adaptive mutations in evolved amino acid-polyamine-organocation transporters
Karapanagioti, F., Atlason, Ú. Á., Slotboom, D. J., Poolman, B. & Obermaier, S., 25-Jun-2024, In: eLife. 13, 24 p., RP93971.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile39 Downloads (Pure) -
Hit optimization by dynamic combinatorial chemistry on Streptococcus pneumoniae energy-coupling factor transporter ECF-PanT.
Exapicheidou, I. A., Shams, A., Ibrahim, H., Tsarenko, A., Backenköhler, M., Hamed, M. M., Diamanti, E., Volkamer, A., Slotboom, D. J. & Hirsch, A. K. H., 2024, In: Chemical communications (Cambridge, England). 60, p. 870–873 4 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile2 Citations (Scopus)33 Downloads (Pure) -
Structural basis of the obligatory exchange mode of human neutral amino acid transporter ASCT2
Borowska, A. M., Chiariello, M. G., Garaeva, A. A., Rheinberger, J., Marrink, S. J., Paulino, C. & Slotboom, D. J., Dec-2024, In: Nature Communications. 15, 1, 16 p., 6570.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile12 Downloads (Pure) -
The S-component fold: a link between bacterial transporters and receptors
Partipilo, M. & Jan Slotboom, D., 21-May-2024, In: Communications biology. 7, 1, 10 p., 610.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile1 Citation (Scopus)33 Downloads (Pure) -
2023
A Hitchhiker’s Guide to Supplying Enzymatic Reducing Power into Synthetic Cells
Partipilo, M., Claassens, N. J. & Slotboom, D. J., Apr-2023, In: ACS Synthetic Biology. 12, p. 947-962 16 p., 3c00070.Research output: Contribution to journal › Review article › peer-review
Open AccessFile6 Citations (Scopus)107 Downloads (Pure) -
Biochemical and structural insight into the chemical resistance and cofactor specificity of the formate dehydrogenase from Starkeya novella
Partipilo, M., Whittaker, J. J., Pontillo, N., Coenradij, J., Herrmann, A., Guskov, A. & Slotboom, D. J., Sept-2023, In: The FEBS Journal. 290, 17, p. 4238-4255 18 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile2 Citations (Scopus)71 Downloads (Pure) -
Expulsion mechanism of the substrate-translocating subunit in ECF transporters
Thangaratnarajah, C., Nijland, M., Borges-Araújo, L., Jeucken, A., Rheinberger, J., Marrink, S. J., Souza, P. C. T., Paulino, C. & Slotboom, D. J., 25-Jul-2023, In: Nature Communications. 14, 1, 14 p., 4484.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile7 Citations (Scopus)82 Downloads (Pure) -
Identification of inhibitors targeting the energy-coupling factor (ECF) transporters
Diamanti, E., Souza, P. C. T., Setyawati, I., Bousis, S., Gómez, L. M., Swier, L. J. Y. M., Shams, A., Tsarenko, A., Stanek, W. K., Jäger, M., Marrink, S. J., Slotboom, D. J. & Hirsch, A. K. H., 20-Nov-2023, In: Communications biology. 6, 1, 9 p., 1182.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile6 Citations (Scopus)35 Downloads (Pure) -
Minimal Out-of-Equilibrium Metabolism for Synthetic Cells: A Membrane Perspective
Bailoni, E., Partipilo, M., Coenradij, J., Grundel, D. A. J., Slotboom, D. J. & Poolman, B., 2023, In: ACS Synthetic Biology. 12, 25 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile19 Citations (Scopus)195 Downloads (Pure) -
Mutation in glutamate transporter homologue GltTk provides insights into pathologic mechanism of episodic ataxia 6
Colucci, E., Anshari, Z., Patiño-Ruiz, M., Nemchinova, M., Whittaker, J., Slotboom, D. & Guskov, A., 31-Mar-2023, In: Nature Communications. 14, 10 p., 1799.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile4 Citations (Scopus)88 Downloads (Pure) -
The linkage-type and the exchange molecule affect the protein-labeling efficiency of iminoboronate probes
van der Zouwen, A. J., Jeucken, A., van der Pol, E., Boerema, G., Slotboom, D. J. & Witte, M. D., 2023, In: Organic & Biomolecular Chemistry. 21, p. 9173-9181 9 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile38 Downloads (Pure) -
2022
A conserved sequence motif in the E. coli soluble FAD-containing pyridine nucleotide transhydrogenase is important for reaction efficiency
Partipilo, M., Yang, G., Mascotti, L., Slotboom, D. & Fraaije, M., Sept-2022, In: The Journal of Biological Chemistry. 298, 9, 13 p., 102304.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile1 Citation (Scopus)81 Downloads (Pure) -
Biparatopic sybodies neutralize SARS-CoV-2 variants of concern and mitigate drug resistance
Walter, J. D., Scherer, M., Hutter, C. A. J., Garaeva, A. A., Zimmermann, I., Wyss, M., Rheinberger, J., Ruedin, Y., Earp, J. C., Egloff, P., Sorgenfrei, M., Hürlimann, L. M., Gonda, I., Meier, G., Remm, S., Thavarasah, S., van Geest, G., Bruggmann, R., Zimmer, G. & Slotboom, D. J. & 3 others, , 5-Apr-2022, In: Embo Reports. 23, 4, 19 p., e54199.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile29 Citations (Scopus)179 Downloads (Pure) -
Correction to: On the Role of a Conserved Methionine in the Na+-Coupling Mechanism of a Neurotransmitter Transporter Homolog (Neurochemical Research, (2022), 47, 1, (163-175), 10.1007/s11064-021-03253-w)
Zhou, W., Trinco, G., Slotboom, D. J., Forrest, L. R. & Faraldo-Gómez, J. D., Jan-2022, In: NEUROCHEMICAL RESEARCH. 47, 1, p. 176 1 p.Research output: Contribution to journal › Erratum
Open AccessFile42 Downloads (Pure) -
High-speed atomic force microscopy reveals a three-state elevator mechanism in the citrate transporter CitS
Maity, S., Trinco, G., Buzón, P., Anshari, Z. R., Kodera, N., Ngo, K. X., Ando, T., Slotboom, D. J. & Roos, W. H., 8-Feb-2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 6, 9 p., e2113927119.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile8 Citations (Scopus)132 Downloads (Pure) -
Membrane transport of cobalamin
Nijland, M., Martínez Felices, J. M., Slotboom, D. J. & Thangaratnarajah, C., 22-Mar-2022, Vitamins and Hormones. Litwack, G. (ed.). ACADEMIC PRESS INC ELSEVIER SCIENCE, p. 121-148 28 p. (Vitamins and Hormones; vol. 119).Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review
9 Citations (Scopus) -
On the Role of a Conserved Methionine in the Na+-Coupling Mechanism of a Neurotransmitter Transporter Homolog
Zhou, W., Trinco, G., Slotboom, D. J., Forrest, L. R. & Faraldo-Gómez, J. D., Jan-2022, In: NEUROCHEMICAL RESEARCH. 47, 1, p. 163-175 13 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile3 Citations (Scopus)84 Downloads (Pure) -
2021
Iminoboronates as Dual-Purpose Linkers in Chemical Probe Development
van der Zouwen, A. J. N., Jeucken, A., Steneker, R., Hohmann, K. F., Lohse, J., Slotboom, D. J. & Witte, M., 15-Feb-2021, In: Chemistry. 27, 10, p. 3292-3296 5 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile9 Citations (Scopus)84 Downloads (Pure) -
Insights into the bilayer-mediated toppling mechanism of a folate-specific ECF transporter by cryo-EM
Thangaratnarajah, C., Rheinberger, J., Paulino, C. & Slotboom, D. J., 24-Aug-2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 34, 9 p., e2105014118.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile9 Citations (Scopus)213 Downloads (Pure) -
Kinetic mechanism of Na+-coupled aspartate transport catalyzed by GltTk
Trinco, G., Arkhipova, V., Garaeva, A., Hutter, C. A. J., Seeger, M. A., Guskov, A. & Slotboom, D., 17-Jun-2021, In: Communications biology. 4, 11 p., 751.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile9 Citations (Scopus)84 Downloads (Pure) -
Minimal Pathway for the Regeneration of Redox Cofactors
Partipilo, M., Ewins, E. J., Frallicciardi, J., Robinson, T., Poolman, B. & Slotboom, D. J., 27-Dec-2021, In: JACS Au. 1, 12, p. 2280-2293 14 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile19 Citations (Scopus)162 Downloads (Pure) -
Rational design of ASCT2 inhibitors using an integrated experimental-computational approach
Garibsingh, R.-A. A., Ndaru, E., Garaeva, A. A., Shi, Y., Zielewicz, L., Zakrepine, P., Bonomi, M., Slotboom, D. J., Paulino, C., Grewer, C. & Schlessinger, A., 14-Sept-2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 37, 10 p., e2104093118.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile38 Citations (Scopus)83 Downloads (Pure) -
Structural Aspects of Photopharmacology: Insight into the Binding of Photoswitchable and Photocaged Inhibitors to the Glutamate Transporter Homologue
Arkhipova, V., Fu, H., Hoorens, M., Trinco, G., Lameijer, L., Marin, E., Feringa, B. L., Poelarends, G., Szymanski, W., Slotboom, D. & Guskov, A., Mar-2021, In: Journal of the American Chemical Society. 143, 3, p. 1513-1520 8 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile25 Citations (Scopus)159 Downloads (Pure) -
2020
A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds
Rempel, S., Gati, C., Nijland, M., Thangaratnarajah, C., Karyolaimos, A., Gier, J.-W. L. D., Guskov, A. & Slotboom, D., 16-Apr-2020, In: Nature. 580, 7803, p. 409-412 4 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile68 Citations (Scopus)233 Downloads (Pure) -
An ECF-type transporter scavenges heme to overcome iron-limitation in Staphylococcus lugdunensis
Jochim, A., Adolf, L., Belikova, D., Schilling, N. A., Setyawati, I., Chin, D., Meyers, S., Verhamme, P., Heinrichs, D. E., Slotboom, D. J. & Heilbronner, S., Jun-2020, In: eLife. 9, 20 p., e57322.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile17 Citations (Scopus)139 Downloads (Pure) -
Bacterial multi-solute transporters
Slotboom, D. J., Ettema, T. W., Nijland, M. & Thangaratnarajah, C., Dec-2020, In: FEBS Letters. 594, 23, p. 3898-3907 10 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile14 Citations (Scopus)127 Downloads (Pure) -
Elevator-type mechanisms of membrane transport
Garaeva, A. A. & Slotboom, D. J., Jun-2020, In: Biochemical Society Transactions. 48, 3, p. 1227-1241 15 p., BST20200290.Research output: Contribution to journal › Review article › peer-review
Open AccessFile67 Citations (Scopus)201 Downloads (Pure) -
Highly potent bispecific sybodies neutralize SARS-CoV-2
Walter, J. D., Hutter, C. A., Garaeva, A. A., Scherer, M., Zimmermann, I., Wyss, M., Rheinberger, J., Ruedin, Y., Earp, J. C., Egloff, P., Sorgenfrei, M., Hürlimann, L. M., Gonda, I., Meier, G., Remme, S., Thavarasah, S., van der Geest, G., Bruggman, R., Zimmer, G. & Slotboom, D. & 3 others, , Nov-2020, BioRxiv.Research output: Working paper › Academic
File152 Downloads (Pure) -
In vitro reconstitution of dynamically interacting integral membrane subunits of energy-coupling factor transporters
Setyawati, I., Stanek, W. K., Dosz-Majsnerowska, M., Ziel-Swier, L., Pardon, E., Steyaert, J., Guskov, A. & Slotboom, D., 22-Dec-2020, In: eLife. 9, p. 1-21 21 p., e64389.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile15 Citations (Scopus)99 Downloads (Pure) -
Membrane mediated toppling mechanism of the folate energy coupling factor transporter
Faustino, I., Abdizadeh, H., Souza, P. C. T., Jeucken, A., Stanek, W. K., Guskov, A., Slotboom, D. & Marrink, S., 1-Dec-2020, In: Nature Communications. 11, 1, 10 p., 1763.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile20 Citations (Scopus)201 Downloads (Pure) -
Molecular insight into a new low affinity xylan binding module from the xylanolytic gut symbiont Roseburia intestinalis
Leth, M. L., Ejby, M., Madland, E., Kitaoku, Y., Slotboom, D. J., Guskov, A., Aachmann, F. L. & Abou Hachem, M., 1-May-2020, In: The FEBS Journal. 287, 10, p. 2105-2117 13 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile9 Citations (Scopus)109 Downloads (Pure) -
Structural and Functional Characterization of NadR from Lactococcus lactis
Stetsenko, A., Singh, R., Jähme, M., Guskov, A. & Slotboom, D., 22-Apr-2020, In: Molecules. 25, 8, 14 p., 1940.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile4 Citations (Scopus)126 Downloads (Pure) -
Structural and functional diversity calls for a new classification of ABC transporters
Thomas, C., Aller, S. G., Beis, K., Carpenter, E. P., Chang, G., Chen, L., Dassa, E., Dean, M., Duong Van Hoa, F., Ekiert, D., Ford, R., Gaudet, R., Gong, X., Holland, I. B., Huang, Y., Kahne, D. K., Kato, H., Koronakis, V., Koth, C. M. & Lee, Y. & 23 others, , Dec-2020, In: FEBS Letters. 594, 23, p. 3767-3775 9 p., 1873-3468.13935.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile177 Citations (Scopus)123 Downloads (Pure) -
Structural ensemble of a glutamate transporter homologue in lipid nanodisc environment
Arkhipova, V., Guskov, A. & Slotboom, D., 21-Feb-2020, In: Nature Communications. 11, 1, 9 p., 998.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile48 Citations (Scopus)178 Downloads (Pure) -
2019
A one-gate elevator mechanism for the human neutral amino acid transporter ASCT2
Garaeva, A. A., Guskov, A., Slotboom, D. J. & Paulino, C., 31-Jul-2019, In: Nature Communications. 10, 8 p., 3427.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile68 Citations (Scopus)328 Downloads (Pure) -
Binding and transport of D-aspartate by the glutamate transporter homologue GltTk
Arkhipova, V. I., Trinco, G., Thijs, E., Jensen, S., Slotboom, D. & Guskov, A., 1-May-2019, In: eLife. 8, 12 p., e45286.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile20 Citations (Scopus)361 Downloads (Pure) -
ECF-Type ATP-Binding Cassette Transporters
Rempel, S., Stanek, W. K. & Slotboom, D. J., Jun-2019, In: Annual Review of Biochemistry. 88, p. 551-576 26 p., annurev-biochem-013118-111705.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile58 Citations (Scopus)218 Downloads (Pure) -
Energy-Coupling Factor Transporters as Novel Antimicrobial Targets
Bousis, S., Setyawati, I., Diamanti, E., Slotboom, D. J. & Hirsch, A. K. H., Feb-2019, In: Advanced Therapeutics. 2, 2, 17 p., 1800066.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile22 Citations (Scopus)154 Downloads (Pure) -
Models to determine the kinetic mechanisms of ion-coupled transporters
Lolkema, J. S. & Slotboom, D. J., 10-Jan-2019, In: The Journal of General Physiology. 151, 3, p. 369-380 11 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile6 Citations (Scopus)259 Downloads (Pure) -
Two binding proteins of the ABC transporter that confers growth of Bifidobacterium animalis subsp. lactis ATCC27673 on β-mannan possess distinct manno-oligosaccharide binding profiles
Ejby, M., Guskov, A., Pichler, M. J., Zanten, G. C., Schoof, E., Saburi, W., Slotboom, D. J. & Abou Hachem, M., Jul-2019, In: Molecular Microbiology. 112, 1, p. 114-130 17 p., 14257.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile23 Citations (Scopus)156 Downloads (Pure) -
2018
Cryo-EM structure of the human neutral amino acid transporter ASCT2
Garaeva, A., Oostergetel, G., Gati, C., Guskov, A., Batista Paulino, C. & Slotboom, D., 5-Jun-2018, In: Nature Structural & Molecular Biology. 25, p. 515-521 7 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile106 Citations (Scopus)189 Downloads (Pure) -
Cysteine-mediated decyanation of vitamin B12 by the predicted membrane transporter BtuM
Rempel, S., Colucci, E., Gier, J.-W. D., Guskov, A. & Slotboom, D., 2-Aug-2018, In: Nature Communications. 9, 1, 8 p., 3038.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile29 Citations (Scopus)394 Downloads (Pure) -
Functional and structural characterization of an ECF-type ABC transporter for vitamin B12
Luís da Silva Santos Guimarães, J. A., Rempel, S., Mous, S. T. M., Tambascia Pereira, C., ter Beek, J., Gier, J.-W. D., Guskov, A. & Slotboom, D., 2018, In: eLife. 7, 16 p., e35828.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile35 Citations (Scopus)379 Downloads (Pure) -
Glutamate Transporter Inhibitors with Photo-Controlled Activity
Hoorens, M. W. H., Fu, H., Duurkens, R. H., Trinco, G., Arkhipova, V., Feringa, B. L., Poelarends, G. J., Slotboom, D. J. & Szymanski, W., Jun-2018, In: Advanced Therapeutics. 1, 2, 7 p., 1800028.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile15 Citations (Scopus)240 Downloads (Pure)