Research output per year
Research output per year
- 34 results
Search results
-
2025
CBX7 inhibitors affect H3K9 methyltransferase-regulated gene repression in leukemic cells
de Groot, A. P., Nguyen, H., Pouw, J. S., Weersing, E., Dethmers-Ausema, A. & de Haan, G., Feb-2025, In: Experimental Hematology. 142, 104691.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile7 Downloads (Pure) -
2024
CD61 identifies a superior population of aged murine HSCs and is required to preserve quiescence and self-renewal
Skinder, N., Sanz Fernández, I., Dethmers-Ausema, A., Weersing, E. & de Haan, G., 9-Jan-2024, In: -. 8, 1, p. 99-111 13 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile1 Citation (Scopus)77 Downloads (Pure) -
2022
3-Deazaadenosine alleviates senescence to promote cellular fitness and cell therapy efficiency in mice
Guerrero, A., Innes, A. J., Roux, P. F., Buisman, S. C., Jung, J., Ortet, L., Moiseeva, V., Wagner, V., Robinson, L., Ausema, A., Potapova, A., Perdiguero, E., Weersing, E., Aarts, M., Martin, N., Wuestefeld, T., Muñoz-Cánoves, P., de Haan, G., Bischof, O. & Gil, J., Sept-2022, In: Nature Aging. 2, 9, p. 851-866 16 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile7 Citations (Scopus)472 Downloads (Pure) -
2021
Persistent expression of microRNA-125a targets is required to induce murine hematopoietic stem cell repopulating activity
Luinenburg, D. G., Dinitzen, A. B., Svendsen, A. F., Cengiz, R., Ausema, A., Weersing, E., Bystrykh, L. & de Haan, G., Feb-2021, In: Experimental Hematology. 94, p. 47-59.e5 18 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile2 Citations (Scopus)135 Downloads (Pure) -
2020
Correction: Quantitative distribution of patient-derived leukemia clones in murine xenografts revealed by cellular barcodes
Jacobs, S., Ausema, A., Zwart, E., Weersing, E., Kingma, M. J., El Menshawi, Y. A. S., de Haan, G., Bystrykh, L. V. & Belderbos, M. E., 1-Jul-2020, In: Leukemia. 34, 7, p. 1974 1 p.Research output: Contribution to journal › Erratum
Open AccessFile77 Downloads (Pure) -
Detection of chemotherapy-resistant patient-derived acute lymphoblastic leukemia clones in murine xenografts using cellular barcodes
Jacobs, S., Ausema, A., Zwart, E., Weersing, E., de Haan, G., Bystrykh, L. V. & Belderbos, M. E., Nov-2020, In: Experimental Hematology. 91, p. 46-54 9 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile7 Citations (Scopus)87 Downloads (Pure) -
Donor-to-Donor Heterogeneity in the Clonal Dynamics of Transplanted Human Cord Blood Stem Cells in Murine Xenografts
Belderbos, M., Jacobs, S., Koster, T., Ausema, B., Weersing, E., Zwart, E., Haan, de, G. & Bystrykh, L., Jan-2020, In: Biology of Blood and Marrow Transplantation. 26, 1, p. 16-25 10 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile17 Citations (Scopus)65 Downloads (Pure) -
Quantitative distribution of patient-derived leukemia clones in murine xenografts revealed by cellular barcodes.
Jacobs, S., Ausema, B., Zwart, E., Weersing, E., Kingma, M., El Menshawi, Y., Haan, de, G., Bystrykh, L. & Belderbos, M., 1-Jun-2020, In: Leukemia. 34, 6, p. 1669-1674 6 p.Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review
Open AccessFile5 Citations (Scopus)141 Downloads (Pure) -
2019
CBX7 Induces Self-Renewal of Human Normal and Malignant Hematopoietic Stem and Progenitor Cells by Canonical and Non-canonical Interactions
Jung, J., Buisman, S. C., Weersing, E., Dethmers-Ausema, A., Zwart, E., Schepers, H., Dekker, M. R., Lazare, S. S., Hammerl, F., Skokova, Y., Kooistra, S. M., Klauke, K., Poot, R. A., Bystrykh, L. V. & de Haan, G., 12-Feb-2019, In: Cell reports. 26, 7, p. 1906-1918.e8 21 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile26 Citations (Scopus)316 Downloads (Pure) -
MiR-125a enhances self-renewal, lifespan, and migration of murine hematopoietic stem and progenitor cell clones.
Wójtowicz, E., Broekhuis, M. J. C., Weersing, E., Dinitzen, A., Verovskaya, E., Ausema, B., Ritsema, M., Zwart, E., de Haan, G. & Bystrykh, L., 2019, In: Scientific Reports. 9, 13 p., 4785.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile11 Citations (Scopus)280 Downloads (Pure) -
2017
The role of CBX proteins in human benign and malignant hematopoiesis
Jung, J., Schepers, H., Lazare, S., Buisman, S., Weersing, E., Dethmers, B., Klauke, K., Bystrykh, L. & de Haan, G., Sept-2017, In: Oncology Research and Treatment. 40, p. 210-210 1 p.Research output: Contribution to journal › Meeting Abstract › Academic
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2016
Ectopic miR-125a Expression Induces Long-Term Repopulating Stem Cell Capacity in Mouse and Human Hematopoietic Progenitors
Wojtowicz, E. E., Lechman, E. R., Hermans, K. G., Schoof, E. M., Wienholds, E., Isserlin, R., van Veelen, P. A., Broekhuis, M. J. C., Janssen, G. M. C., Trotman-Grant, A., Dobson, S. M., Krivdova, G., Elzinga, J., Kennedy, J., Gan, O. I., Sinha, A., Ignatchenko, V., Kislinger, T., Dethmers-Ausema, B. & Weersing, E. & 8 others, , 1-Sept-2016, In: Cell stem cell. 19, 3, p. 383-396 14 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile48 Citations (Scopus)178 Downloads (Pure) -
MIR-125A CONFERS MULTI-LINEAGE LONG-TERM REPOPULATING STEM CELL ACTIVITY TO MURINE HEMATOPOIETIC PROGENITORS
Wojtowicz, E., van Veelen, P., Broekhuis, M., Weersing, E., Alemdehy, M. F., de Looper, H., Ritsema, M., Erkeland, S., Bystrykh, L. & de Haan, G., Sept-2016, In: Experimental Hematology. 44, 9, p. S98-S98 1 p.Research output: Contribution to journal › Meeting Abstract › Academic
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The role of CBX proteins in human benign and malignant hematopoiesis
Jung, J., Schepers, H., Lazare, S., Buisman, S., Weersing, E., Dethmers, B., Klauke, K., Bystrykh, L. & de Haan, G., Oct-2016, In: Oncology Research and Treatment. 39, p. 210-210 1 p.Research output: Contribution to journal › Meeting Abstract › Academic
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The Role of Cbx Proteins in Human Benign and Malignant Hematopoiesis
Jung, J., Schepers, H., Lazare, S., Buisman, S., Weersing, E., Dethmers, B., Klauke, K., Bystrykh, L. & De Haan, G., 2-Dec-2016, In: Blood. 128, 22, 5 p.Research output: Contribution to journal › Meeting Abstract › Academic
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The role of cbx proteins in human hematopoiesis
Jung, J., Schepers, H., Lazare, S., Buisman, S., Weersing, E., Dethmers-Ausema, B., Klauke, K., Bystrykh, L. & de Haan, G., Sept-2016, In: Experimental Hematology. 44, 9, p. S82-S82 1 p., 3083.Research output: Contribution to journal › Meeting Abstract › Academic
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2015
Tracing Dynamics and Clonal Heterogeneity of Cbx7-Induced Leukemic Stem Cells by Cellular Barcoding
Klauke, K., Broekhuis, M. J. C., Weersing, E., Dethmers-Ausema, A., Ritsema, M., Gonzalez, M. V., Zwart, E., Bystrykh, L. V. & de Haan, G., 13-Jan-2015, In: Stem Cell Reports. 4, 1, p. 74-89 16 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile14 Citations (Scopus)323 Downloads (Pure) -
2014
Asymmetry in skeletal distribution of mouse hematopoietic stem cell clones and their equilibration by mobilizing cytokines
Verovskaya, E., Broekhuis, M. J. C., Zwart, E., Weersing, E., Ritsema, M., Bosman, L. J., van Poele, T., de Haan, G. & Bystrykh, L. V., 10-Mar-2014, In: Journal of Experimental Medicine. 211, 3, p. 487-497 11 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile36 Citations (Scopus)337 Downloads (Pure) -
A systematic analysis of miRNA-125 family members reveals their similar role in the regulation of hematopoietic cell production
Wojtowicz, E., Walasek, M., Broekhuis, M., Weersing, E., Ritsema, M., Dethmers-Ausema, B., Bystrykh, L. & de Haan, G., Aug-2014, In: Experimental Hematology. 42, 8, p. S65 1 p.Research output: Contribution to journal › Meeting Abstract › Academic
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MicroRNA-125 family members exert a similar role in the regulation of murine hematopoiesis
Wojtowicz, E. E., Walasek, M. A., Broekhuis, M. J. C., Weersing, E., Ritsema, M., Ausema, A., Bystrykh, L. V. & de Haan, G., Oct-2014, In: Experimental Hematology. 42, 10, p. 909-918.e1 11 p.Research output: Contribution to journal › Article › Academic › peer-review
26 Citations (Scopus) -
Tracing dynamics and clonal heterogeneity of Cbx7 driven multi-lineage leukemias by cellular barcoding
Klauke, K., Broekhuis, M., Weersing, E., Zwart, E., Bystrykh, L. & de Haan, G., Aug-2014, In: Experimental Hematology. 42, 8, p. S43 1 p.Research output: Contribution to journal › Meeting Abstract › Academic
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2013
Polycomb Cbx family members mediate the balance between haematopoietic stem cell self-renewal and differentiation
Klauke, K., Radulovic, V., Broekhuis, M., Weersing, E., Zwart, E., Olthof, S., Ritsema, M., Bruggeman, S., Wu, X., Helin, K., Bystrykh, L. & de Haan, G., Apr-2013, In: Nature Cell Biology. 15, 4, p. 353-+ 22 p.Research output: Contribution to journal › Article › Academic › peer-review
197 Citations (Scopus) -
2012
Genetic screen identifies microRNA cluster 99b/let-7e/125a as a regulator of primitive hematopoietic cells
Gerrits, A., Walasek, M. A., Olthof, S., Weersing, E., Ritsema, M., Zwart, E., van Os, R., Bystrykh, L. V. & de Haan, G., 12-Jan-2012, In: Blood. 119, 2, p. 377-387 11 p.Research output: Contribution to journal › Article › Academic › peer-review
87 Citations (Scopus) -
2009
Expression Quantitative Trait Loci Are Highly Sensitive to Cellular Differentiation State
Gerrits, A., Li, Y., Tesson, B. M., Bystrykh, L. V., Weersing, E., Ausema, A., Dontje, B., Wang, X., Breitling, R., Jansen, R. C., de Haan, G. & Dethmers-Ausema, B., 16-Oct-2009, In: PLoS genetics. 5, 10, 8 p., 1000692.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile76 Citations (Scopus)348 Downloads (Pure) -
2006
Differential role for very late antigen-5 in mobilization and homing of hematopoietic stem cells
Wierenga, P. K., Weersing, E., Dontje, B., de Haan, G. & van Os, R., Dec-2006, In: Bone marrow transplantation. 38, 12, p. 789-797 9 p.Research output: Contribution to journal › Article › Academic › peer-review
16 Citations (Scopus) -
Fibroblast growth factor-1 and-2 preserve long-term repopulating ability of hematopoietic stem cells in serum-free cultures
Yeoh, J. S. G., van Os, R., Weersing, E., Ausema, A., Dontje, B., Vellenga, E. & de Haan, G., Jun-2006, In: STEM CELLS. 24, 6, p. 1564-1572 9 p.Research output: Contribution to journal › Article › Academic › peer-review
54 Citations (Scopus) -
The polycomb group gene Ezh2 prevents hematopoietic stem cell exhaustion
Kamminga, L., Bystrykh, L., Boer, A., Houwer, S., Douma, J., Weersing, E., Dontje, B. & de Haan, G., 1-Mar-2006, In: Blood. 107, 5, p. 2170-2179 10 p.Research output: Contribution to journal › Article › Academic › peer-review
312 Citations (Scopus) -
2005
Impaired hematopoietic stem cell functioning after serial transplantation and during normal aging
Kamminga, L., Van Os, R., Ausema, A., Noach, E., Weersing, E., Dontje, B., Vellenga, E. & De Haan, G., Jan-2005, In: STEM CELLS. 23, 1, p. 82-92 11 p.Research output: Contribution to journal › Article › Academic › peer-review
122 Citations (Scopus) -
Uncovering regulatory pathways that effect hematopoietic stem cell function using 'genetical genomics'
Bystrykh, L., Weersing, E., Dontje, B., Sutton, S., Pletcher, M. T., Wiltshire, T., Su, A. I., Vellenga, E., Wang, J., Manly, K. F., Lu, L., Chesler, E. J., Alberts, R., Jansen, R. C., Williams, R. W., Cooke, M., Pletcher, M., de Haan, G., Su, A. & Wang, J. & 3 others, , Mar-2005, In: Nature Genetics. 37, 3, p. 225 - 232 8 p.Research output: Contribution to journal › Article › Academic › peer-review
331 Citations (Scopus)238 Downloads (Pure) -
2003
Chemotherapy prior to autologous bone marrow transplantation impairs long-term engraftment in mice
Noach, E., Ausema, A., van Os, R., Akkerman, [. V., Koopal, S., Weersing, E., Dontje, B., Vellenga, E. & de Haan, G., Jun-2003, In: Experimental Hematology. 31, 6, p. 528-534 7 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile18 Citations (Scopus)388 Downloads (Pure) -
In vitro generation of long-term repopulating hematopoietic stem cells by fibroblast growth factor-1
de Haan, G., Weersing, E., Dontje, B., van Os, R., Bystrykh, L., Vellenga, E. & Miller, G., Feb-2003, In: Developmental Cell. 4, 2, p. 241-251 11 p.Research output: Contribution to journal › Article › Academic › peer-review
130 Citations (Scopus) -
2002
A genetic and genomic analysis identifies a cluster of genes associated with hematopoietic cell turnover
de Haan, G., Bystrykh, L., Weersing, E., Dontje, B., Geiger, H., Ivanova, N., Lemischka, I., Vellenga, E. & Van Zant, G., 15-Sept-2002, In: Blood. 100, 6, p. 2056-2062 7 p.Research output: Contribution to journal › Article › Academic › peer-review
58 Citations (Scopus) -
Growth factor treatment prior to low-dose total body irradiation increases donor cell engraftment after bone marrow transplantation in mice
Noach, E., Ausema, A., Dillingh, J., Dontje, B., Weersing, E., Akkerman, [. V., Vellenga, E. & Haan, G., 1-Jul-2002, In: Blood. 100, 1, p. 312-317 6 p.Research output: Contribution to journal › Article › Academic › peer-review
5 Citations (Scopus) -
2000
Autonomous behavior of hematopoietic stem cells
Kamminga, L., Akkerman, [. V., Weersing, E., Ausema, A., Dontje, B., Van Zant, G. & de Haan, G., Dec-2000, In: Experimental Hematology. 28, 12, p. 1451-1459 9 p.Research output: Contribution to journal › Article › Academic › peer-review
23 Citations (Scopus)