Research output per year
Research output per year
Personal profile
Research interests
PhD project: The role of the microbiome in disease-associated mental and behavioral problems - The case of phenylketonuria (PKU)
I’m interested in the link between the microbiome, brain and behaviour. I study this link under a pathological condition called phenylketonuria (PKU), which is a metabolic disorder in which there is an inability to convert phenylalanine into tyrosine. This can lead to behavioural changes as deficits in learning and memory, increase in depression- and anxiety-like behaviours and sleep loss. I want to examine to what extend these behavioural problems are related to the microbial communities present in the gut in PKU mice.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Phenylketonuria in a microbial world: Gut-microbiome-brain interactions shaping behavior in PKU
van der Goot, E., 2023, [Groningen]: University of Groningen. 225 p.Research output: Thesis › Thesis fully internal (DIV)
Open AccessFile465 Downloads (Pure) -
Gut-microbiome composition in response to phenylketonuria depends on dietary phenylalanine in BTBR Pahenu2 mice
van der Goot, E., Vink, S. N., van Vliet, D., van Spronsen, F. J., Falcao Salles, J. & van der Zee, E. A., 4-Jan-2022, In: Frontiers in nutrition. 8, 16 p., 735366.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile7 Citations (Scopus)123 Downloads (Pure) -
The increasing importance of LNAA supplementation in phenylketonuria at higher plasma phenylalanine concentrations
van Vliet, D., van der Goot, E., van Ginkel, W. G., van Faassen, H. J. R., de Blaauw, P., Kema, I. P., Heiner-Fokkema, M. R., van der Zee, E. A. & van Spronsen, F. J., Jan-2022, In: Molecular Genetics and Metabolism. 135, 1, p. 27-34 8 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile6 Citations (Scopus)240 Downloads (Pure) -
Correlations of blood and brain biochemistry in phenylketonuria: Results from the Pah-enu2 PKU mouse
Dijkstra, A. M., van Vliet, N., van Vliet, D., Romani, C., Huijbregts, S. C. J., van der Goot, E., Hovens, I. B., van der Zee, E. A., Kema, I. P., Heiner-Fokkema, M. R. & van Spronsen, F. J., Nov-2021, In: Molecular Genetics and Metabolism. 134, 3, p. 250-256 7 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile8 Citations (Scopus)73 Downloads (Pure) -
A microbial community ecology perspective on the gut-microbiome-brain axis
van der Goot, E., van Spronsen, F. J., Falcão Salles, J. & van der Zee, E. A., 2-Sept-2020, In: Frontiers in endocrinology. 11, p. 611 611.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile6 Citations (Scopus)122 Downloads (Pure)
Projects
- 1 Finished
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AL-II: The role of the microbiome in disease–associated mental and behavioral problems: The case of phenylketonuria (PKU)
van der Zee, E. (PI), Falcao Salles, J. (PI), van Spronsen, F. (PI) & van der Goot, E. (PhD student)
01/07/2017 → 01/08/2023
Project: Research
Activities
- 2 Professional or public presentation
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36th E.S.PKU Conference 2022
van der Goot, E. (Invited speaker)
28-Oct-2022Activity: Talk and presentation › Professional or public presentation › Professional
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33rd E.S.PKU Conference 2019
Goot, van der, E. (Speaker)
2-Nov-2019Activity: Talk and presentation › Professional or public presentation › Professional
Datasets
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Supplementary data for: Phenylketonuria in a microbial world, chapter 4
van der Goot, E. (Contributor) & Falcao-Salles, J. (Contributor), DataverseNL, 11-May-2023
DOI: 10.34894/4bi6ds
Dataset
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Supplementary data for: Phenylketonuria in a microbial world, chapter 7
van der Goot, E. (Creator) & Van Spronsen, F. J. (Contributor), DataverseNL, 11-May-2023
DOI: 10.34894/pvjn4j
Dataset
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Supplementary data for: Phenylketonuria in a microbial world, chapter 3
van der Goot, E. (Creator) & Van Der Zee, E. A. (Contributor), DataverseNL, 11-May-2023
DOI: 10.34894/8xfinu
Dataset
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Replication Data for: Long-term dietary intervention with low Phe and/or a specific nutrient combination improve certain aspects of brain functioning in Phenylketonuria (PKU)
Bruinenberg, V. (Contributor), Vliet ,van, D. (Contributor), van der Goot, E. (Contributor), Vries, de, M. (Contributor), Counotte, D. S. (Contributor), Kuhn, M. (Contributor), van Spronsen, F. (Contributor) & van der Zee, E. (Contributor), University of Groningen, 5-Mar-2019
DOI: 10.34894/kn3ezu
Dataset
Press/Media
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Balancing behavior and the microbiome: Meet Els van der Goot
van der Goot, E., Falcao Salles, J. & van der Zee, E.
15/04/2019
1 Media contribution
Press/Media: Research › Professional