Keyphrases
Genetic Variability
100%
Attention Deficit Hyperactivity Disorder
100%
Methylphenidate
100%
Carboxylesterase 1 (CES1)
100%
High Dose
100%
Plasma Concentration
20%
Pharmacokinetics
13%
Pharmacokinetic Analysis
13%
Population Data
13%
DNA Variants
6%
Short-acting
6%
Simulated Population
6%
Central Compartment
6%
Volume of Distribution
6%
Quantitative PCR
6%
Clinical Effect
6%
Gene number
6%
Gene Copy number
6%
Equivalent Dose
6%
Scheduled Time
6%
Mean Absorption Time
6%
Elimination Clearance
6%
Metabolism
6%
Single nucleotide Polymorphism
6%
Adverse Effects
6%
Netherlands
6%
Genetic Variants
6%
Patient Needs
6%
Population Model
6%
Biochemistry, Genetics and Molecular Biology
Genetic Divergence
100%
Drug Megadose
100%
Carboxylesterase 1
100%
Pharmacokinetics
57%
Blood Level
42%
Enzyme
28%
Real-Time Polymerase Chain Reaction
14%
Population Model
14%
Metabolic Pathway
14%
Genotyping
14%
Single-Nucleotide Polymorphism
14%
Absorption
14%
Neuroscience
Methylphenidate
100%
Carboxylesterase
100%
Attention Deficit Hyperactivity Disorder
100%
Pharmacokinetics
26%
Single-Nucleotide Polymorphism
6%
Metabolic Pathway
6%
Real-Time Polymerase Chain Reaction
6%
Adverse Effect
6%
