Research output per year
Research output per year
Personal profile
Research interests
- Physiology and pathophysiology of the enterohepatic circulation in humans and experimental animals: hepatic and intestinal transport systems, mechanisms of bile formation and cholestasis, (patho)physiology of biliary lipid secretion, metabolic control by bile acids via newly identified signaling cascades
- Hepatic lipid metabolism in humans and experimental animals: lipoprotein assembly and secretion, causes and consequences of hepatic steatosis, interactions between carbohydrate and lipid metabolism, inborn errors of metabolism, inflammatory pathways, role of nuclear receptors (LXR, CHREBP)
- Regulation of cholesterol synthesis and trafficking: transcription factors and nuclear receptors (SREBP/PPAR/FXR/LXR) and transporter proteins, perinatal development, metabolic programming, application of stable isotope approaches
- Quantification of metabolic fluxes by stable isotope procedures
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Absence of gut microbiota reduces neonatal survival and exacerbates liver disease in Cyp2c70-deficient mice with a human-like bile acid composition
Sjöland, W., Wahlström, A., Makki, K., Schöler, M., Molinaro, A., Olsson, L., Greiner, T. U., Caesar, R., de Boer, J. F., Kuipers, F., Bäckhed, F. & Marschall, H-U., 14-Jul-2023, In: Clinical Science. 137, 13, p. 995-1011 17 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile8 Downloads (Pure) -
Activation of Liver X Receptors and Peroxisome Proliferator-Activated Receptors by Lipid Extracts of Brown Seaweeds: A Potential Application in Alzheimer's Disease?
Martens, N., Zhan, N., Voortman, G., Leijten, F. P. J., van Rheenen, C., van Leerdam, S., Geng, X., Huybrechts, M., Liu, H., Jonker, J. W., Kuipers, F., Lütjohann, D., Vanmierlo, T. & Mulder, M. T., 30-Jun-2023, In: Nutrients. 15, 13, 24 p., 3004.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile1 Citation (Scopus)35 Downloads (Pure) -
Adipocyte-specific FXR-deficiency protects adipose tissue from oxidative stress and insulin resistance and improves glucose homeostasis
Dehondt, H., Marino, A., Butruille, L., Mogilenko, D. A., Nzoussi Loubota, A. C., Chávez-Talavera, O., Dorchies, E., Vallez, E., Haas, J., Derudas, B., Bongiovanni, A., Tardivel, M., Kuipers, F., Lefebvre, P., Lestavel, S., Tailleux, A., Dombrowicz, D., Caron, S. & Staels, B., Mar-2023, In: Molecular metabolism. 69, 13 p., 101686.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile4 Citations (Scopus)18 Downloads (Pure) -
Bile Acid Sequestration via Colesevelam Reduces Bile Acid Hydrophobicity and Improves Liver Pathology in Cyp2c70-/- Mice with a Human-like Bile Acid Composition
Palmiotti, A., de Vries, H. D., Hovingh, M. V., Koehorst, M., Mulder, N. L., Verkade, E., Veentjer, M. K., van Dijk, T. H., Bloks, V. W., Havinga, R., Verkade, H. J., de Boer, J. F. & Kuipers, F., 8-Sept-2023, In: Biomedicines. 11, 9, 15 p., 2495.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile2 Downloads (Pure) -
Bile proteome reveals biliary regeneration during normothermic preservation of human donor livers
Thorne, A. M., Wolters, J. C., Lascaris, B., Bodewes, S. B., Lantinga, V. A., van Leeuwen, O. B., de Jong, I. E. M., Ustyantsev, K., Berezikov, E., Lisman, T., Kuipers, F., Porte, R. J. & de Meijer, V. E., 30-Nov-2023, (E-pub ahead of print) In: Nature Communications. 14, 1, 13 p., 7880.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile
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Supervision of PhD student Sandra Nagy
Folkert Kuipers (Supervisor), Annemieke Hoek (Supervisor) & U.J.F. Tietge (Supervisor)
23-Sept-2020Activity: Examination, teaching and supervision › Supervision and examination of PhD students of the UG › Academic
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Dutch Association for Diabetes Research (NVDO) (External organisation)
Folkert Kuipers (Member)
2019Activity: Membership › Professional
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European Atherosclerosis Society (External organisation)
Folkert Kuipers (Member)
2019Activity: Membership › Professional
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Nederlandse Vereniging voor Gastro-Enterologie(NVGE) (External organisation)
Folkert Kuipers (Member)
2019Activity: Membership › Professional
Datasets
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Data for: Dynamic binning peak detection and assessment of various lipidomics liquid chromatography-mass spectrometry pre-processing platforms
Horvatovich, P. (Contributor), Kuipers, F. (Contributor), Zhang, W. (Contributor), Kema, I. (Contributor), Barcaru, A. (Contributor) & Feng, X. (Contributor), Mendeley Data, 25-May-2021
DOI: 10.17632/xnzwg3n5w5.1, https://data.mendeley.com/datasets/xnzwg3n5w5
Dataset
Press/Media
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De rol van het microbioom bij het ontstaan van hart- en vaatziekten
Debby Koonen & Folkert Kuipers
01/05/2019
1 item of Media coverage
Press/Media: Research › Popular