Research output per year
Research output per year
Personal profile
Research interests
- Physiology and pathophysiology of the enterohepatic circulation in humans and experimental animals: hepatic and intestinal transport systems, mechanisms of bile formation and cholestasis, (patho)physiology of biliary lipid secretion, metabolic control by bile acids via newly identified signaling cascades
- Hepatic lipid metabolism in humans and experimental animals: lipoprotein assembly and secretion, causes and consequences of hepatic steatosis, interactions between carbohydrate and lipid metabolism, inborn errors of metabolism, inflammatory pathways, role of nuclear receptors (LXR, CHREBP)
- Regulation of cholesterol synthesis and trafficking: transcription factors and nuclear receptors (SREBP/PPAR/FXR/LXR) and transporter proteins, perinatal development, metabolic programming, application of stable isotope approaches
- Quantification of metabolic fluxes by stable isotope procedures
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
External positions
Boardmember, Stichting De Cock-Hadders
1-Jan-2025 → …
Supervisory Board , G-CURE B.V.
1-Jan-2023 → …
Scientific Advisory Board, Nederlandse Hartstichting
1-Jan-2023 → …
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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SMC Abca1 and Abcg1 Deficiency Enhances Urinary Bladder Distension but Not Atherosclerosis
Halmos, B., La Rose, A. M., Methorst, D., Groenen, A. G., Nakládal, D., Bazioti, V., Koster, M. H., Kloosterhuis, N. J., Buiten, A. V., Schouten, E. M., Huijkman, N. C. A., Langelaar-Makkinje, M., Bongiovanni, L., De Neck, S. M., de Bruin, A., Buikema, H., Deelman, L. E., van den Heuvel, M. C., Kuipers, F. & de Jong, I. J. & 4 others, , 28-Feb-2025, In: Circulation Research. 136, 5, p. 491-507 17 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile3 Downloads (Pure) -
The impact of a humanized bile acid composition on atherosclerosis development in hypercholesterolaemic Cyp2c70 knockout mice
Yntema, T., Eijgenraam, T. R., Kloosterhuis, N. J., Havinga, R., Koster, M. H., Hovingh, M. V., de Boer, J. F., Koonen, D. P. Y. & Kuipers, F., 15-Jan-2025, In: Scientific Reports. 15, 1, 11 p., 2100.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile9 Downloads (Pure) -
Changes in bile acid composition are correlated with reduced intestinal cholesterol uptake in intestine-specific WASH-deficient mice
Heida, A., van Dijk, T., Smit, M., Koehorst, M., Koster, M., Kloosterhuis, N., Havinga, R., Bloks, V. W., Wolters, J. C., de Bruin, A., Kuivenhoven, J. A., de Boer, J. F., Kuipers, F. & van de Sluis, B., Mar-2024, In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1869, 2, 11 p., 159445.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile90 Downloads (Pure) -
Characterization of milk oligosaccharide and sialic acid content and their influence on brain sialic acid in a lean mouse model for gestational diabetes
Liu, F., Tol, A. J. C., Kuipers, F., Oosterveer, M. H., van der Beek, E. M. & van Leeuwen, S. S., 15-Feb-2024, In: Heliyon. 10, 3, 13 p., e24539.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile3 Citations (Scopus)105 Downloads (Pure) -
Comparative Analysis of Digestion Methods for Bile Proteomics: The Key to Unlocking Biliary Biomarker Potential
Thorne, A. M., Hoekzema, M., Porte, R. J., Kuipers, F., de Meijer, V. E. & Wolters, J. C., 2024, In: Analytical Chemistry. 96, 36, p. 14393–14404 12 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile53 Downloads (Pure)
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Supervision of PhD student Sandra Nagy
Kuipers, F. (Supervisor), Hoek, A. (Supervisor) & Tietge, U. J. F. (Supervisor)
23-Sept-2020Activity: Examination, teaching and supervision › Supervision and examination of PhD students of the UG › Academic
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Nederlandse Vereniging voor Hepatologie (NVH) (External organisation)
Kuipers, F. (Member)
2019Activity: Membership › Professional
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Dutch Association for Diabetes Research (NVDO) (External organisation)
Kuipers, F. (Member)
2019Activity: Membership › Professional
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European Atherosclerosis Society (External organisation)
Kuipers, F. (Member)
2019Activity: Membership › Professional
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European Association for the Study of Diabetes (External organisation)
Kuipers, F. (Member)
2019Activity: Membership › Professional
Datasets
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Data for: Dynamic binning peak detection and assessment of various lipidomics liquid chromatography-mass spectrometry pre-processing platforms
Horvatovich, P. (Contributor), Kuipers, F. (Contributor), Zhang, W. (Contributor), Kema, I. (Contributor), Barcaru, A. (Contributor) & Feng, X. (Contributor), Mendeley Data, 25-May-2021
DOI: 10.17632/xnzwg3n5w5.1, https://data.mendeley.com/datasets/xnzwg3n5w5
Dataset
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Hepatic SREBP signaling requires SPRING to govern systemic lipid metabolism in mice and humans
Hendrix, S. (Creator), Valiloo, M. (Creator), Kingma, J. (Creator), Ottenhof, R. (Creator), Zijlstra, L. (Creator), Sachdev, V. (Creator), Svecla, M. (Creator), Jongejan, A. (Creator), Kuipers, F. (Creator), Brummelkamp, T. (Creator), Rimbert, A. (Creator), Norata, G. D. (Creator), Loregger, A. (Creator) & Zelcer, N. (Creator), figshare, 28-Jul-2023
DOI: 10.6084/m9.figshare.22699408, https://figshare.com/articles/dataset/SPRING-dependent_regulation_of_hepatic_SREBP_signaling_governs_systemic_lipid_metabolism_in_mice_and_humans_-_raw_proteomics_files/22699408
Dataset
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SPRING-dependent regulation of hepatic SREBP signaling governs systemic lipid metabolism in mice and humans - raw proteomics files
Hendrix, S. (Creator), Valiloo, M. (Creator), Kingma, J. (Creator), Ottenhof, R. (Creator), Zijlstra, L. (Creator), Sachdev, V. (Creator), Svecla, M. (Creator), Jongejan, A. (Creator), Kuipers, F. (Creator), Brummelkamp, T. (Creator), Rimbert, A. (Creator), Loregger, A. (Creator) & Zelcer, N. (Creator), figshare, 28-Jun-2023
DOI: 10.6084/m9.figshare.22699408.v1, https://figshare.com/articles/dataset/SPRING-dependent_regulation_of_hepatic_SREBP_signaling_governs_systemic_lipid_metabolism_in_mice_and_humans_-_raw_proteomics_files/22699408/1
Dataset
Press/Media
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Verouderingsproces tegenhouden
21/08/2024 → 23/08/2024
4 Media contributions
Press/Media: Expert Comment › Popular
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Verouderingsonderzoek Eriba bestaat 10 jaar: ‘Zoeken naar medicijnen om gezond te blijven’
14/12/2023
1 Media contribution
Press/Media: Expert Comment › Popular
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De rol van het microbioom bij het ontstaan van hart- en vaatziekten
01/05/2019
1 item of Media coverage
Press/Media: Research › Popular