Harm Brugge

2025

Low-cost generation of clinical-grade, layperson-friendly pharmacogenetic passports using oligonucleotide arrays

Lifelines NEXT cohort study, Lanting, P., Warmerdam, R., Slager, J., Brugge, H., Ochi, T., Benjamins, M., Lopera-Maya, E., Jankipersadsing, S., Gelderloos-Arends, J., Teuben, D., Hendriksen, D., Charbon, B., Johansson, L., Munnink, T. O., de Boer-Veger, N., Wilffert, B., Swertz, M., Touw, D. & Deelen, P. & 3 others, Knoers, N., Dekens, J. & Franke, L., 1-May-2025, In: American Journal of Human Genetics. 112, 5, p. 1015-1028 14 p.

Research output: Contribution to journal › Article › Academic › peer-review

2022

Single-cell RNA-sequencing of peripheral blood mononuclear cells reveals widespread, context-specific gene expression regulation upon pathogenic exposure

Single-Cell EQTLGen Consortium, Bios Consortium , Oelen, R., de Vries, D. H., Brugge, H., Gordon, M. G., Vochteloo, M., Ye, C. J., Westra, H.-J., Franke, L. & van der Wijst, M. G. P., 7-Jun-2022, In: Nature Communications. 13, 1, 15 p., 3267.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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52 Citations (Scopus)

281 Downloads (Pure)

2021

Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression

BIOS Consortium, i2QTL Consortium, Võsa, U., Claringbould, A., Westra, H.-J., Bonder, M. J., Deelen, P., Zeng, B., Kirsten, H., Saha, A., Kreuzhuber, R., Yazar, S., Brugge, H., Oelen, R., de Vries, D. H., van der Wijst, M. G. P., Kasela, S., Pervjakova, N., Alves, I. & Fave, M.-J. & 32 others, Agbessi, M., Christiansen, M. W., Jansen, R., Seppala, I., Tong, L., Teumer, A., Schramm, K., Hemani, G., Verlouw, J., Yaghootkar, H., Flitman, R. S., Brown, A., Kukushkina, V., Kalnapenkis, A., Rueger, S., Porcu, E., Kronberg, J., Kettunen, J., Lee, B., Zhang, F., Qi, T., Hernandez, J. A., Arindrarto, W., Beutner, F., Dmitrieva, J., Li, S., Penninx, B. W. J. H., Veldink, J. H., Warmerdam, R., Wijmenga, C., Swertz, M. & Franke, L., Sept-2021, In: Nature Genetics. 53, 9, p. 1300-1310 11 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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1000 Citations (Scopus)

1456 Downloads (Pure)

2020

Deconvolution of bulk blood eQTL effects into immune cell subpopulations

BIOS Consortium, Aguirre-Gamboa, R., de Klein, N., di Tommaso, J., Claringbould, A., van der Wijst, M. G. P., de Vries, D., Brugge, H., Oelen, R., Vosa, U., Zorro, M. M., Chu, X., Bakker, O. B., Borek, Z., Ricano-Ponce, I., Deelen, P., Xu, C.-J., Swertz, M., Jonkers, I. & Withoff, S. & 9 others, Joosten, I., Sanna, S., Kumar, V., Koenen, H. J. P. M., Joosten, L. A. B., Netea, M. G., Wijmenga, C., Franke, L. & Li, Y., 12-Jun-2020, In: Bmc Bioinformatics. 21, 1, 23 p., 243.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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