Research output per year
Research output per year
- 1 - 50 out of 55 results
Search results
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2024
Unraveling Hematotoxicity of α-Amanitin in Cultured Hematopoietic Cells
Hof, W. F. J., Visser, M., de Jong, J. J., Rajasekar, M. N., Schuringa, J. J., de Graaf, I. A. M., Touw, D. J. & Dekkers, B. G. J., 2024, In: Toxins. 16, 1, 12 p., 61.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile51 Downloads (Pure) -
2022
Disruption of vitamin A homeostasis by the biocide tetrakis(hydroxymethyl) phosphonium sulphate in pregnant rabbits
Estrada-Ortiz, N., Starokozhko, V., van Steenwijk, H., van der Heide, C., Permentier, H., van Heemskerk, L., Prins, G. H., Heegsma, J., Faber, K. N., Bressers, S., Steiblen, G., de Groot, A., Groome, S., van Miert, E., Groothuis, G. & de Graaf, I. A. M., Dec-2022, In: Journal of Applied Toxicology. 42, 12, p. 1921-1936 16 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile2 Citations (Scopus)144 Downloads (Pure) -
Exploring Porcine Precision-Cut Kidney Slices as a Model for Transplant-Related Ischemia-Reperfusion Injury
van Furth, L. A., Leuvenink, H. G. D., Seras, L., Graaf, I. A. M. D., Olinga, P. & Leeuwen, L. L. V., 26-Apr-2022, In: Transplantology. 3, 2, p. 139–151 13 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile6 Citations (Scopus)111 Downloads (Pure) -
Extending the viability of human precision-cut intestinal slice model for drug metabolism studies
Biel, C., Martinec, O., Sibering, B., van Summeren, K., Wessels, A. M. A., Touw, D. J., de Jong, K. P., de Meijer, V. E., Faber, K. N., Klooster, J. P. T., de Graaf, I. A. M. & Olinga, P., 2022, In: Archives of toxicology.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile7 Citations (Scopus)85 Downloads (Pure) -
2021
Postnatal Smoke Exposure Further Increases the Hepatic Nicotine Metabolism in Prenatally Smoke Exposed Male Offspring and Is Linked with Aberrant Cyp2a5 Methylation
Lkhagvadorj, K., Zeng, Z., Meyer, K. F., Verweij, L. P., Kooistra, W., Reinders-Luinge, M., Dijkhuizen, H. W., de Graaf, I. A. M., Plösch, T. & Hylkema, M. N., Jan-2021, In: International Journal of Molecular Sciences. 22, 1, 14 p., 164.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile5 Citations (Scopus)118 Downloads (Pure) -
Rifampicin Induces Gene, Protein, and Activity of P-Glycoprotein (ABCB1) in Human Precision-Cut Intestinal Slices
Martinec, O., Biel, C., de Graaf, I. A. M., Huliciak, M., de Jong, K. P., Staud, F., Cecka, F., Olinga, P., Vokral, I. & Cerveny, L., 9-Jun-2021, In: Frontiers in Pharmacology. 12, 12 p., 684156.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile10 Citations (Scopus)89 Downloads (Pure) -
2020
Carbosilane Dendrimers Loaded with siRNA Targeting Nrf2 as a Tool to Overcome Cisplatin Chemoresistance in Bladder Cancer Cells
Ambrosio, L., Argenziano, M., Cucci, M. A., Grattarola, M., de Graaf, I. A. M., Dianzani, C., Barrera, G., Sánchez Nieves, J., Gomez, R., Cavalli, R. & Pizzimenti, S., 2020, In: Antioxidants (Basel, Switzerland). 9, 10, 16 p., 9100993.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile25 Citations (Scopus)100 Downloads (Pure) -
Glutathione-responsive cyclodextrin-nanosponges as drug delivery systems for doxorubicin: Evaluation of toxicity and transport mechanisms in the liver
Daga, M., de Graaf, I. A. M., Argenziano, M., Barranco, A. S. M., Loeck, M., Al-Adwi, Y., Cucci, M. A., Caldera, F., Trotta, F., Barrera, G., Casini, A., Cavalli, R. & Pizzimenti, S., Jun-2020, In: Toxicology in Vitro. 65, 10 p., 104800.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile40 Citations (Scopus)247 Downloads (Pure) -
Prenatal smoke exposure induces persistent Cyp2a5 methylation and increases nicotine metabolism in the liver of neonatal and adult male offspring
Lkhagvadorj, K., Meyer, K. F., Verweij, L. P., Kooistra, W., Reinders-Luinge, M., Dijkhuizen, H. W., de Graaf, I. A. M., Plösch, T. & Hylkema, M. N., 2020, In: Epigenetics. 15, 12, p. 1370-1385 16 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile10 Citations (Scopus)165 Downloads (Pure) -
2019
Development of a Novel Ex-vivo 3D Model to Screen Amoebicidal Activity on Infected Tissue
Elena Guzman-Delgado, N., Edith Carranza-Torres, I., Garcia-Davis, S., Rivera, G., Moran-Martinez, J., Denys Betancourt-Martinez, N., Groothuis, G. M. M., de Graaf, I. A. M. & Carranza-Rosales, P., 10-Jun-2019, In: Scientific Reports. 9, 12 p., 8396.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile4 Citations (Scopus)119 Downloads (Pure) -
Ex vivo toxicological evaluation of experimental anticancer gold(i) complexes with lansoprazole-type ligands
Estrada-Ortiz, N., Lopez-Gonzales, E., Woods, B., Sturup, S., de Graaf, I. A. M., Groothuis, G. M. M. & Casini, A., 1-Nov-2019, In: Toxicology research. 8, 6, p. 885-895 11 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile11 Citations (Scopus)72 Downloads (Pure) -
Growth factors of stem cell niche extend the life-span of precision-cut intestinal slices in culture: A proof-of-concept study
Bigaeva, E., Bomers, J. J. M., Biel, C., Mutsaers, H. A. M., de Graaf, I. A. M., Boersema, M. & Olinga, P., Sept-2019, In: Toxicology in Vitro. 59, p. 312-321 10 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile10 Citations (Scopus)355 Downloads (Pure) -
2018
Human and rat precision-cut intestinal slices as ex vivo models to study bile acid uptake by the apical sodium-dependent bile acid transporter
Li, M., Vokral, I., Evers, B., de Graaf, I. A. M., de Jager, M. H. & Groothuis, G. M. M., 30-Aug-2018, In: European Journal of Pharmaceutical Sciences. 121, p. 65-73 9 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile9 Citations (Scopus)123 Downloads (Pure) -
Schot in behandelperspectief intoxicatie groene knolamaniet: Ex vivo-onderzoek met humane nier- en lever-slices
Translated title of the contribution :Report on treatment perspective for green Amanita phalloides poisoning: Ex vivo study with human kidney and liver slices Research output: Contribution to journal › Article › Popular
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2017
Anticancer Gold N-Heterocyclic Carbene Complexes: A Comparative in vitro and ex vivo Study
Estrada-Ortiz, N., Guarra, F., de Graaf, I. A. M., Marchetti, L., de Jager, M. H., Groothuis, G. M. M., Gabbiani, C. & Casini, A., 7-Sept-2017, In: ChemMedChem. 12, 17, p. 1429-1435 7 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile49 Citations (Scopus)88 Downloads (Pure) -
On the toxicity and transport mechanisms of cisplatin in kidney tissues in comparison to a gold-based cytotoxic agent
Spreckelmeyer, S., Estrada Ortiz, N., Prins, G., van der Zee, M., Gammelgaard, B., Sturup, S., de Graaf, I., Groothuis, G. M. M. & Casini, A., 2017, In: Metallomics. 9, p. 1786-1795 10 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile21 Citations (Scopus)84 Downloads (Pure) -
P-gp activity and inhibition in the different regions of human intestine ex vivo
Li, M., de Graaf, I. A. M., de Jager, M. H. & Groothuis, G. M. M., Mar-2017, In: Biopharmaceutics & drug disposition. 38, 2, p. 127-138 12 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile20 Citations (Scopus)144 Downloads (Pure) -
Rat precision-cut liver slices predict drug-induced cholestatic injury
Starokozhko, V., Greupink, R., van de Broek, P., Nashwa, S., Ghimire, S., de Graaf, I. & Groothuis, G., Oct-2017, In: Archives of toxicology. 91, 10, p. 3403-3413 11 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile16 Citations (Scopus)274 Downloads (Pure) -
The consequence of regional gradients of P-gp and CYP3A4 for drug-drug interactions by P-gp inhibitors and the P-gp/CYP3A4 interplay in the human intestine ex vivo
Li, M., de Graaf, I. A. M., van de Steeg, E., de Jager, M. H. & Groothuis, G. M. M., Apr-2017, In: Toxicology in Vitro. 40, p. 26-33 8 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile23 Citations (Scopus)126 Downloads (Pure) -
2016
Intracellular RIG-I Signaling Regulates TLR4-Independent Endothelial Inflammatory Responses to Endotoxin
Moser, J., Heeringa, P., Jongman, R. M., Zwiers, P. J., Niemarkt, A. E., Yan, R., de Graaf, I. A., Li, R., Regan, E. R., Kuempers, P., Aird, W. C., Amerongen, G. P. V. N., Zijlstra, J. G., Molema, G. & van Meurs, M., 1-Jun-2016, In: Journal of Immunology. 196, 11, p. 4681-4691 11 p.Research output: Contribution to journal › Article › Academic › peer-review
36 Citations (Scopus) -
Precision-cut intestinal slices: alternative model for drug transport, metabolism, and toxicology research
Li, M., de Graaf, I. A. M. & Groothuis, G. M. M., 9-Jan-2016, In: Expert Opinion on Drug Metabolism & Toxicology. p. 1-16 16 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile57 Citations (Scopus)337 Downloads (Pure) -
The Consequence of Drug–Drug Interactions Influencing the Interplay between P-Glycoprotein and Cytochrome P450 3a: An Ex Vivo Study with Rat Precision-Cut Intestinal Slices
Li, M., de Graaf, I., Siissalo, S., de Jager, M., van Dam, A. & Groothuis, G., 1-May-2016, In: Drug Metabolism and Disposition. 44, 5, p. 683-691 9 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile17 Citations (Scopus)83 Downloads (Pure) -
2015
Adjusting the DNA Interaction and Anticancer Activity of Pt(II) N-Heterocyclic Carbene Complexes by Steric Shielding of the Trans Leaving Group
Muenzner, J. K., Rehm, T., Biersack, B., Casini, A., de Graaf, I. A. M., Worawutputtapong, P., Noor, A., Kempe, R., Brabec, V., Kasparkova, J. & Schobert, R., 13-Aug-2015, In: Journal of Medicinal Chemistry. 58, 15, p. 6283-6292 10 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile74 Citations (Scopus)145 Downloads (Pure) -
Consequences of Mrp2 deficiency for diclofenac toxicity in the rat intestine ex vivo
Niu, X., de Graaf, I. A. M., van de Vegte, D., Langelaar-Makkinje, M., Sekine, S. & Groothuis, G. M. M., Feb-2015, In: Toxicology in Vitro. 29, 1, p. 168-175 8 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile11 Citations (Scopus)69 Downloads (Pure) -
Diclofenac toxicity in human intestine ex vivo is not related to the formation of intestinal metabolites
Niu, X., de Graaf, I. A. M., Langelaar-Makkinje, M., Horvatovich, P. & Groothuis, G. M. M., Jan-2015, In: Archives of toxicology. 89, 1, p. 107-119 13 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile20 Citations (Scopus)156 Downloads (Pure) -
Improved Synthesis of N-Benzylaminoferrocene-Based Prodrugs and Evaluation of Their Toxicity and Antileukemic Activity
Daum, S., Chekhun, V. F., Todor, I. N., Lukianova, N. Y., Shvets, Y. V., Sellner, L., Putzker, K., Lewis, J., Zenz, T., de Graaf, I. A. M., Groothuis, G. M. M., Casini, A., Zozulia, O., Hampel, F. & Mokhir, A., 9-Feb-2015, In: Journal of Medicinal Chemistry. 58, 4, p. 2015-2024 10 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile73 Citations (Scopus)117 Downloads (Pure) -
Precision-cut rat, mouse, and human intestinal slices as novel models for the early-onset of intestinal fibrosis
Pham, B. T., van Haaften, W. T., Oosterhuis, D., Nieken, J., de Graaf, I. A. M. & Olinga, P., Apr-2015, In: Physiological Reports. 3, 4, 13 p., e12323.Research output: Contribution to journal › Article › Professional
Open AccessFile25 Citations (Scopus)263 Downloads (Pure) -
Rat precision-cut intestinal slices to study P-gp activity and the potency of its inhibitors ex vivo
Li, M., de Graaf, I. A. M., de Jager, M. H. & Groothuis, G. M. M., Aug-2015, In: Toxicology in Vitro. 29, 5, p. 1070-1078 9 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile16 Citations (Scopus)79 Downloads (Pure) -
2014
Precision cut intestinal slices are an appropriate ex vivo model to study NSAID-induced intestinal toxicity in rats
Niu, X., de Graaf, I. A. M., van der Bij, H. A. & Groothuis, G. M. M., Oct-2014, In: Toxicology in Vitro. 28, 7, p. 1296-1305 10 p.Research output: Contribution to journal › Article › Academic › peer-review
35 Citations (Scopus) -
2013
Analysis of gene expression changes to elucidate the mechanism of chilling injury in precision-cut liver slices
Guan, N., Fahy, G. M., Groothuis, G. M. M., de Graaf, I. A. M. & Blomsma, S., Mar-2013, In: Toxicology in Vitro. 27, 2, p. 890-899 10 p.Research output: Contribution to journal › Article › Academic › peer-review
18 Citations (Scopus) -
Nanoparticle formulation of a poorly soluble cannabinoid receptor 1 antagonist improves absorption by rat and human intestine
Siissalo, S., De Waard, H., De Jager, M. H., Hayeshi, R., Frijlink, H. W., Hinrichs, W. L. J., Dinter-Heidorn, H., Van Dam, A., Proost, J. H., Groothuis, G. M. M. & De Graaf, I. A. M., Aug-2013, In: Drug Metabolism and Disposition. 41, 8, p. 1557-1565 9 p.Research output: Contribution to journal › Article › Academic › peer-review
9 Citations (Scopus) -
2012
Bilitranslocase is involved in the uptake of bromosulfophthalein in rat and human liver
Terdoslavich, M., de Graaf, I. A. M., Proost, J. H., Cocolo, A., Passamonti, S. & Groothuis, G. M. M., 1-Sept-2012, In: Drug Metabolism Letters. 6, 3, p. 165-173 9 p.Research output: Contribution to journal › Article › Academic › peer-review
10 Citations (Scopus) -
Effects of cryoprotectant addition and washout methods on the viability of precision-cut liver slices
Guan, N., van Midwoud, P. M., Blomsma, S., Fahy, G. M., Groothuis, G. M. M. & de Graaf, I. A. M., Dec-2012, In: Cryobiology. 65, 3, p. 179-187 9 p.Research output: Contribution to journal › Article › Academic › peer-review
16 Citations (Scopus) -
Transport of the Coumarin Metabolite 7-Hydroxycoumarin Glucuronide Is Mediated via Multidrug Resistance-Associated Proteins 3 and 4
Wittgen, H. G. M., van den Heuvel, J. J. M. W., van den Broek, P. H. H., Siissalo, S., Groothuis, G. M. M., de Graaf, I. A. M., Koenderink, J. B. & Russel, F. G. M., Jun-2012, In: Drug Metabolism and Disposition. 40, 6, p. 1076-1079 4 p.Research output: Contribution to journal › Article › Academic › peer-review
16 Citations (Scopus) -
2011
On-line HPLC Analysis System for Metabolism and Inhibition Studies in Precision-Cut Liver Slices
van Midwoud, P. M., Janssen, J., Merema, M. T., de Graaf, I. A. M., Groothuis, G. M. M. & Verpoorte, E., 1-Jan-2011, In: Analytical Chemistry. 83, 1, p. 84-91 8 p.Research output: Contribution to journal › Article › Academic › peer-review
38 Citations (Scopus) -
2010
Preparation and incubation of precision-cut liver and intestinal slices for application in drug metabolism and toxicity studies
de Graaf, I. A. M., Olinga, P., de Jager, M. H., Merema, M. T., de Kanter, R., van de Kerkhof, E. G. & Groothuis, G. M. M., Sept-2010, In: Nature protocols. 5, 9, p. 1540-1551 12 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile322 Citations (Scopus)398 Downloads (Pure) -
Reduced Ischemia-Reoxygenation Injury in Rat Intestine After Luminal Preservation With a Tailored Solution
Roskott, A. M., Nieuwenhuijs, V. B., Leuvenink, H. G. D., Dijkstra, G., Ottens, P., de Jager, M. H., Pereira, P. G. D., Fidler, V., Groothuis, G. M. M., Ploeg, R. J. & de Graaf, I. A. M., 27-Sept-2010, In: Transplantation. 90, 6, p. 622-629 8 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile20 Citations (Scopus)649 Downloads (Pure) -
Targeted transfection increases siRNA uptake and gene silencing of primary endothelial cells in vitro - A quantitative study
Asgeirsdottir, S. A., Talman, E. G., de Graaf, I. A., Kamps, J. A. A. M., Satchell, S. C., Mathieson, P. W., Ruiters, M. H. J. & Molema, G., 25-Jan-2010, In: Journal of Controlled Release. 141, 2, p. 241-251 11 p.Research output: Contribution to journal › Article › Academic › peer-review
33 Citations (Scopus) -
2009
Shock-induced stress induces loss of microvascular endothelial Tie2 in the kidney which is not associated with reduced glomerular barrier function
van Meurs, M., Kurniati, N. F., Wulfert, F. M., Asgeirsdottir, S. A., de Graaf, I. A., Satchell, S. C., Mathieson, P. W., Jongman, R. M., Kuempers, P., Zijlstra, J. G., Heeringa, P. & Molema, G., Aug-2009, In: American journal of physiology-Renal physiology. 297, 2, p. F272-F281 10 p.Research output: Contribution to journal › Article › Academic › peer-review
54 Citations (Scopus) -
2008
Induction of metabolism and transport in human intestine: Validation of precision-cut slices as a tool to study induction of drug metabolism in human intestine in vitro
van de Kerkhof, E., De Graaf, I. A. M., Ungell, A.-L. B. & Groothuis, G. M. M., Mar-2008, In: Drug Metabolism and Disposition. 36, 3, p. 604-613 10 p.Research output: Contribution to journal › Article › Academic › peer-review
75 Citations (Scopus) -
2007
Cryopreservation of rat precision-cut liver and kidney slices by rapid freezing and vitrification
de Graaf, I. A. M., Draaisma, A. L., Schoeman, O., Fahy, G. M., Groothuis, G. M. M. & Koster, H. J., Feb-2007, In: Cryobiology. 54, 1, p. 1-12 12 p.Research output: Contribution to journal › Article › Academic › peer-review
56 Citations (Scopus) -
Induction of phase I and II drug metabolism in rat small intestine and colon in vitro
van de Kerkhof, E. G., de Graaf, I. A. M., de Jager, M. H. & Groothuis, G. M. M., Jun-2007, In: Drug Metabolism and Disposition. 35, 6, p. 898-907 10 p.Research output: Contribution to journal › Article › Academic › peer-review
34 Citations (Scopus) -
2006
Empirical validation of a rat in vitro organ slice model as a tool for in vivo clearance prediction
de Graaf, I., de Kanter, R., de Jager, M., Camacho, R., Langenkamp, E., van de Kerkhof, E. & Groothuis, G., Apr-2006, In: Drug Metabolism and Disposition. 34, 4, p. 591-599 9 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile42 Citations (Scopus)119 Downloads (Pure) -
Innovative methods to study human intestinal drug metabolism in vitro: Precision-cut slices compared with Ussing chamber preparations
van de Kerkhof, E. G., Ungell, A.-L. B., Sjoberg, A. K., de Jager, M. H., Hilgendorf, C., de Graaf, I. A. M. & Groothuis, G. M. M., Nov-2006, In: Drug Metabolism and Disposition. 34, 11, p. 1893-1902 10 p.Research output: Contribution to journal › Article › Academic › peer-review
90 Citations (Scopus) -
2005
A new technique for preparing precision-cut slices from small intestine and colon for drug biotransformation studies
de Kanter, R., Tuin, A., van de Kerkhof, E. G., Martignoni, M., Draaisma, A. L., de Jager, M. H., de Graaf, I. A. M., Meijer, D. K. F. & Groothuis, G., 2005, In: Journal of Pharmacological and Toxicological Methods. 51, 1, p. 65 - 72 8 p.Research output: Contribution to journal › Article › Academic › peer-review
49 Citations (Scopus) -
Characterization of rat small intestinal and colon precision-cut slices as an in vitro system for drug metabolism and induction studies
van de Kerkhof, E., de Graaf, I., de Jager, M., Meijer, D. & Groothuis, G., Nov-2005, In: Drug Metabolism and Disposition. 33, 11, p. 1613-1620 8 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile52 Citations (Scopus)140 Downloads (Pure) -
2004
Prediction of whole-body metabolic clearance of drugs through the combined use of slices from rat liver, lung, kidney, small intestine and colon
de Kanter, R., Monshouwer, M., Draaisma, A. L., de Jager, M. H., de Graaf, I. A. M., Proost, J. H., Meijer, D. K. F. & Groothuis, G., 2004, In: Xenobiotica. 34, 3, p. 229-241 13 p.Research output: Contribution to journal › Article › Academic › peer-review
53 Citations (Scopus) -
2003
Cryopreservation of precision-cut tissue slices for application in drug metabolism research
de Graaf, I. A. M. & Koster, H., Feb-2003, In: Toxicol.In Vitro. 17, 1, p. 1-17 17 p.Research output: Contribution to journal › Article › Academic › peer-review
32 Citations (Scopus) -
2002
Comparison of in vitro preparations for semi-quantitative prediction of in vivo drug metabolism
De Graaf, I. A. M., Van Meijeren, C. E., Pektaş, F. & Koster, H. J., Oct-2002, In: Drug Metabolism and Disposition. 30, 10, p. 1129-36 8 p.Research output: Contribution to journal › Article › Academic › peer-review
44 Citations (Scopus) -
Incubation at 37 degrees C prior to cryopreservation decreases viability of liver slices after cryopreservation by rapid freezing
de Graaf, I. A. M., Geerlinks, A. & Koster, H. J., Aug-2002, In: Cryobiology. 45, 1, p. 1-9 9 p.Research output: Contribution to journal › Article › Academic › peer-review
5 Citations (Scopus)