Inge de Graaf

Search results

• 2022

  Disruption of vitamin A homeostasis by the biocide tetrakis(hydroxymethyl) phosphonium sulphate in pregnant rabbits

  Estrada-Ortiz, N., Starokozhko, V., van Steenwijk, H., van der Heide, C., Permentier, H., van Heemskerk, L., Prins, G. H., Heegsma, J., Faber, K. N., Bressers, S., Steiblen, G., de Groot, A., Groome, S., van Miert, E., Groothuis, G. & de Graaf, I. A. M., Dec-2022, In: Journal of Applied Toxicology. 42, 12, p. 1921-1936 16 p.

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• Exploring Porcine Precision-Cut Kidney Slices as a Model for Transplant-Related Ischemia-Reperfusion Injury

  van Furth, L. A., Leuvenink, H. G. D., Seras, L., Graaf, I. A. M. D., Olinga, P. & Leeuwen, L. L. V., 26-Apr-2022, In: Transplantology. 3, 2, p. 139–151 13 p.

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  1 Citation (Scopus)

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• Extending the viability of human precision-cut intestinal slice model for drug metabolism studies

  Biel, C., Martinec, O., Sibering, B., van Summeren, K., Wessels, A. M. A., Touw, D. J., de Jong, K. P., de Meijer, V. E., Faber, K. N., Klooster, J. P. T., de Graaf, I. A. M. & Olinga, P., 2022, In: Archives of toxicology.

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  1 Citation (Scopus)

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• 2021

  Postnatal Smoke Exposure Further Increases the Hepatic Nicotine Metabolism in Prenatally Smoke Exposed Male Offspring and Is Linked with Aberrant Cyp2a5 Methylation

  Lkhagvadorj, K., Zeng, Z., Meyer, K. F., Verweij, L. P., Kooistra, W., Reinders-Luinge, M., Dijkhuizen, H. W., de Graaf, I. A. M., Plösch, T. & Hylkema, M. N., Jan-2021, In: International Journal of Molecular Sciences. 22, 1, 14 p., 164.

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  4 Citations (Scopus)

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• Rifampicin Induces Gene, Protein, and Activity of P-Glycoprotein (ABCB1) in Human Precision-Cut Intestinal Slices

  Martinec, O., Biel, C., de Graaf, I. A. M., Huliciak, M., de Jong, K. P., Staud, F., Cecka, F., Olinga, P., Vokral, I. & Cerveny, L., 9-Jun-2021, In: Frontiers in Pharmacology. 12, 12 p., 684156.

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  6 Citations (Scopus)

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• 2020

  Carbosilane Dendrimers Loaded with siRNA Targeting Nrf2 as a Tool to Overcome Cisplatin Chemoresistance in Bladder Cancer Cells

  Ambrosio, L., Argenziano, M., Cucci, M. A., Grattarola, M., de Graaf, I. A. M., Dianzani, C., Barrera, G., Sánchez Nieves, J., Gomez, R., Cavalli, R. & Pizzimenti, S., 2020, In: Antioxidants (Basel, Switzerland). 9, 10, 16 p., 9100993.

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  19 Citations (Scopus)

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• Glutathione-responsive cyclodextrin-nanosponges as drug delivery systems for doxorubicin: Evaluation of toxicity and transport mechanisms in the liver

  Daga, M., de Graaf, I. A. M., Argenziano, M., Martinez Barranco, A. S., Loeck, M., Al-Adwi, Y., Cucci, M. A., Caldera, F., Trotta, F., Barrera, G., Casini, A., Cavalli, R. & Pizzimenti, S., Jun-2020, In: Toxicology in Vitro. 65, 10 p., 104800.

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  30 Citations (Scopus)

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• Prenatal smoke exposure induces persistent Cyp2a5 methylation and increases nicotine metabolism in the liver of neonatal and adult male offspring

  Lkhagvadorj, K., Meyer, K. F., Verweij, L. P., Kooistra, W., Reinders-Luinge, M., Dijkhuizen, H. W., de Graaf, I. A. M., Plösch, T. & Hylkema, M. N., 2020, In: Epigenetics. 15, 12, p. 1370-1385 16 p.

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  7 Citations (Scopus)

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• 2019

  Development of a Novel Ex-vivo 3D Model to Screen Amoebicidal Activity on Infected Tissue

  Elena Guzman-Delgado, N., Edith Carranza-Torres, I., Garcia-Davis, S., Rivera, G., Moran-Martinez, J., Denys Betancourt-Martinez, N., Groothuis, G. M. M., de Graaf, I. A. M. & Carranza-Rosales, P., 10-Jun-2019, In: Scientific Reports. 9, 12 p., 8396.

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  3 Citations (Scopus)

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• Ex vivo toxicological evaluation of experimental anticancer gold(i) complexes with lansoprazole-type ligands

  Estrada-Ortiz, N., Lopez-Gonzales, E., Woods, B., Sturup, S., de Graaf, I. A. M., Groothuis, G. M. M. & Casini, A., 1-Nov-2019, In: Toxicology research. 8, 6, p. 885-895 11 p.

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  10 Citations (Scopus)

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• Growth factors of stem cell niche extend the life-span of precision-cut intestinal slices in culture: A proof-of-concept study

  Bigaeva, E., Bomers, J. J. M., Biel, C., Mutsaers, H. A. M., de Graaf, I. A. M., Boersema, M. & Olinga, P., Sept-2019, In: Toxicology in Vitro. 59, p. 312-321 10 p.

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  7 Citations (Scopus)

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• 2018

  Human and rat precision-cut intestinal slices as ex vivo models to study bile acid uptake by the apical sodium-dependent bile acid transporter

  Li, M., Vokral, I., Evers, B., de Graaf, I. A. M., de Jager, M. H. & Groothuis, G. M. M., 30-Aug-2018, In: European Journal of Pharmaceutical Sciences. 121, p. 65-73 9 p.

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  6 Citations (Scopus)

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• Schot in behandelperspectief intoxicatie groene knolamaniet: Ex vivo-onderzoek met humane nier- en lever-slices

  Translated title of the contribution: Report on treatment perspective for green Amanita phalloides poisoning: Ex vivo study with human kidney and liver slicesDekkers, B., Broek, A., Ahmed, M., Notenboom, S., de Graaf, I. & Touw, D., 7-Sept-2018, In: Pharmaceutisch Weekblad. p. 14-15 2 p.

  Research output: Contribution to journal › Article › Popular
• 2017

  Anticancer Gold N-Heterocyclic Carbene Complexes: A Comparative in vitro and ex vivo Study

  Estrada-Ortiz, N., Guarra, F., de Graaf, I. A. M., Marchetti, L., de Jager, M. H., Groothuis, G. M. M., Gabbiani, C. & Casini, A., 7-Sept-2017, In: ChemMedChem. 12, 17, p. 1429-1435 7 p.

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  36 Citations (Scopus)

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• On the toxicity and transport mechanisms of cisplatin in kidney tissues in comparison to a gold-based cytotoxic agent

  Spreckelmeyer, S., Estrada Ortiz, N., Prins, G., van der Zee, M., Gammelgaard, B., Sturup, S., de Graaf, I., Groothuis, G. M. M. & Casini, A., 2017, In: Metallomics. 9, p. 1786-1795 10 p.

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  20 Citations (Scopus)

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• P-gp activity and inhibition in the different regions of human intestine ex vivo

  Li, M., de Graaf, I. A. M., de Jager, M. H. & Groothuis, G. M. M., Mar-2017, In: Biopharmaceutics & drug disposition. 38, 2, p. 127-138 12 p.

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  15 Citations (Scopus)

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• Rat precision-cut liver slices predict drug-induced cholestatic injury

  Starokozhko, V., Greupink, R., van de Broek, P., Nashwa, S., Ghimire, S., de Graaf, I. & Groothuis, G., Oct-2017, In: Archives of toxicology. 91, 10, p. 3403-3413 11 p.

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  12 Citations (Scopus)

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• The consequence of regional gradients of P-gp and CYP3A4 for drug-drug interactions by P-gp inhibitors and the P-gp/CYP3A4 interplay in the human intestine ex vivo

  Li, M., de Graaf, I. A. M., van de Steeg, E., de Jager, M. H. & Groothuis, G. M. M., Apr-2017, In: Toxicology in Vitro. 40, p. 26-33 8 p.

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  21 Citations (Scopus)

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• 2016

  Intracellular RIG-I Signaling Regulates TLR4-Independent Endothelial Inflammatory Responses to Endotoxin

  Moser, J., Heeringa, P., Jongman, R. M., Zwiers, P. J., Niemarkt, A. E., Yan, R., de Graaf, I. A., Li, R., Regan, E. R., Kuempers, P., Aird, W. C., Amerongen, G. P. V. N., Zijlstra, J. G., Molema, G. & van Meurs, M., 1-Jun-2016, In: Journal of Immunology. 196, 11, p. 4681-4691 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  30 Citations (Scopus)

• Precision-cut intestinal slices: alternative model for drug transport, metabolism, and toxicology research

  Li, M., de Graaf, I. A. M. & Groothuis, G. M. M., 9-Jan-2016, In: Expert Opinion on Drug Metabolism & Toxicology. p. 1-16 16 p.

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  45 Citations (Scopus)

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• The Consequence of Drug–Drug Interactions Influencing the Interplay between P-Glycoprotein and Cytochrome P450 3a: An Ex Vivo Study with Rat Precision-Cut Intestinal Slices

  Li, M., de Graaf, I., Siissalo, S., de Jager, M., van Dam, A. & Groothuis, G., 1-May-2016, In: Drug Metabolism and Disposition. 44, 5, p. 683-691 9 p.

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  15 Citations (Scopus)

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• 2015

  Adjusting the DNA Interaction and Anticancer Activity of Pt(II) N-Heterocyclic Carbene Complexes by Steric Shielding of the Trans Leaving Group

  Muenzner, J. K., Rehm, T., Biersack, B., Casini, A., de Graaf, I. A. M., Worawutputtapong, P., Noor, A., Kempe, R., Brabec, V., Kasparkova, J. & Schobert, R., 13-Aug-2015, In: Journal of Medicinal Chemistry. 58, 15, p. 6283-6292 10 p.

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  68 Citations (Scopus)

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• Consequences of Mrp2 deficiency for diclofenac toxicity in the rat intestine ex vivo

  Niu, X., de Graaf, I. A. M., van de Vegte, D., Langelaar-Makkinje, M., Sekine, S. & Groothuis, G. M. M., Feb-2015, In: Toxicology in Vitro. 29, 1, p. 168-175 8 p.

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  10 Citations (Scopus)

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• Diclofenac toxicity in human intestine ex vivo is not related to the formation of intestinal metabolites

  Niu, X., de Graaf, I. A. M., Langelaar-Makkinje, M., Horvatovich, P. & Groothuis, G. M. M., Jan-2015, In: Archives of toxicology. 89, 1, p. 107-119 13 p.

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  18 Citations (Scopus)

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• Improved Synthesis of N-Benzylaminoferrocene-Based Prodrugs and Evaluation of Their Toxicity and Antileukemic Activity

  Daum, S., Chekhun, V. F., Todor, I. N., Lukianova, N. Y., Shvets, Y. V., Sellner, L., Putzker, K., Lewis, J., Zenz, T., de Graaf, I. A. M., Groothuis, G. M. M., Casini, A., Zozulia, O., Hampel, F. & Mokhir, A., 9-Feb-2015, In: Journal of Medicinal Chemistry. 58, 4, p. 2015-2024 10 p.

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  63 Citations (Scopus)

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• Precision-cut rat, mouse, and human intestinal slices as novel models for the early-onset of intestinal fibrosis

  Pham, B. T., van Haaften, W. T., Oosterhuis, D., Nieken, J., de Graaf, I. A. M. & Olinga, P., Apr-2015, In: Physiological Reports. 3, 4, 13 p., e12323.

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  21 Citations (Scopus)

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• Rat precision-cut intestinal slices to study P-gp activity and the potency of its inhibitors ex vivo

  Li, M., de Graaf, I. A. M., de Jager, M. H. & Groothuis, G. M. M., Aug-2015, In: Toxicology in Vitro. 29, 5, p. 1070-1078 9 p.

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  15 Citations (Scopus)

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• 2014

  Precision cut intestinal slices are an appropriate ex vivo model to study NSAID-induced intestinal toxicity in rats

  Niu, X., de Graaf, I. A. M., van der Bij, H. A. & Groothuis, G. M. M., Oct-2014, In: Toxicology in Vitro. 28, 7, p. 1296-1305 10 p.

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  30 Citations (Scopus)
• 2013

  Analysis of gene expression changes to elucidate the mechanism of chilling injury in precision-cut liver slices

  Guan, N., Fahy, G. M., Groothuis, G. M. M., de Graaf, I. A. M. & Blomsma, S., Mar-2013, In: Toxicology in Vitro. 27, 2, p. 890-899 10 p.

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  14 Citations (Scopus)

• Nanoparticle formulation of a poorly soluble cannabinoid receptor 1 antagonist improves absorption by rat and human intestine

  Siissalo, S., De Waard, H., De Jager, M. H., Hayeshi, R., Frijlink, H. W., Hinrichs, W. L. J., Dinter-Heidorn, H., Van Dam, A., Proost, J. H., Groothuis, G. M. M. & De Graaf, I. A. M., Aug-2013, In: Drug Metabolism and Disposition. 41, 8, p. 1557-1565 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  8 Citations (Scopus)
• 2012

  Bilitranslocase is involved in the uptake of bromosulfophthalein in rat and human liver

  Terdoslavich, M., de Graaf, I. A. M., Proost, J. H., Cocolo, A., Passamonti, S. & Groothuis, G. M. M., 1-Sept-2012, In: Drug Metabolism Letters. 6, 3, p. 165-173 9 p.

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  10 Citations (Scopus)

• Effects of cryoprotectant addition and washout methods on the viability of precision-cut liver slices

  Guan, N., van Midwoud, P. M., Blomsma, S., Fahy, G. M., Groothuis, G. M. M. & de Graaf, I. A. M., Dec-2012, In: Cryobiology. 65, 3, p. 179-187 9 p.

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  14 Citations (Scopus)

• Transport of the Coumarin Metabolite 7-Hydroxycoumarin Glucuronide Is Mediated via Multidrug Resistance-Associated Proteins 3 and 4

  Wittgen, H. G. M., van den Heuvel, J. J. M. W., van den Broek, P. H. H., Siissalo, S., Groothuis, G. M. M., de Graaf, I. A. M., Koenderink, J. B. & Russel, F. G. M., Jun-2012, In: Drug Metabolism and Disposition. 40, 6, p. 1076-1079 4 p.

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  12 Citations (Scopus)
• 2011

  On-line HPLC Analysis System for Metabolism and Inhibition Studies in Precision-Cut Liver Slices

  van Midwoud, P. M., Janssen, J., Merema, M. T., de Graaf, I. A. M., Groothuis, G. M. M. & Verpoorte, E., 1-Jan-2011, In: Analytical Chemistry. 83, 1, p. 84-91 8 p.

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  37 Citations (Scopus)
• 2010

  Preparation and incubation of precision-cut liver and intestinal slices for application in drug metabolism and toxicity studies

  de Graaf, I. A. M., Olinga, P., de Jager, M. H., Merema, M. T., de Kanter, R., van de Kerkhof, E. G. & Groothuis, G. M. M., Sept-2010, In: Nature protocols. 5, 9, p. 1540-1551 12 p.

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  269 Citations (Scopus)

• Reduced Ischemia-Reoxygenation Injury in Rat Intestine After Luminal Preservation With a Tailored Solution

  Roskott, A. M., Nieuwenhuijs, V. B., Leuvenink, H. G. D., Dijkstra, G., Ottens, P., de Jager, M. H., Pereira, P. G. D., Fidler, V., Groothuis, G. M. M., Ploeg, R. J. & de Graaf, I. A. M., 27-Sept-2010, In: Transplantation. 90, 6, p. 622-629 8 p.

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  19 Citations (Scopus)

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• Targeted transfection increases siRNA uptake and gene silencing of primary endothelial cells in vitro - A quantitative study

  Asgeirsdottir, S. A., Talman, E. G., de Graaf, I. A., Kamps, J. A. A. M., Satchell, S. C., Mathieson, P. W., Ruiters, M. H. J. & Molema, G., 25-Jan-2010, In: Journal of Controlled Release. 141, 2, p. 241-251 11 p.

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  33 Citations (Scopus)
• 2009

  Shock-induced stress induces loss of microvascular endothelial Tie2 in the kidney which is not associated with reduced glomerular barrier function

  van Meurs, M., Kurniati, N. F., Wulfert, F. M., Asgeirsdottir, S. A., de Graaf, I. A., Satchell, S. C., Mathieson, P. W., Jongman, R. M., Kuempers, P., Zijlstra, J. G., Heeringa, P. & Molema, G., Aug-2009, In: American journal of physiology-Renal physiology. 297, 2, p. F272-F281 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  47 Citations (Scopus)
• 2008

  Induction of metabolism and transport in human intestine: Validation of precision-cut slices as a tool to study induction of drug metabolism in human intestine in vitro

  van de Kerkhof, E., De Graaf, I. A. M., Ungell, A-L. B. & Groothuis, G. M. M., Mar-2008, In: Drug Metabolism and Disposition. 36, 3, p. 604-613 10 p.

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  68 Citations (Scopus)
• 2007

  Cryopreservation of rat precision-cut liver and kidney slices by rapid freezing and vitrification

  de Graaf, I. A. M., Draaisma, A. L., Schoeman, O., Fahy, G. M., Groothuis, G. M. M. & Koster, H. J., Feb-2007, In: Cryobiology. 54, 1, p. 1-12 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  52 Citations (Scopus)

• Induction of phase I and II drug metabolism in rat small intestine and colon in vitro

  van de Kerkhof, E. G., de Graaf, I. A. M., de Jager, M. H. & Groothuis, G. M. M., Jun-2007, In: Drug Metabolism and Disposition. 35, 6, p. 898-907 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  31 Citations (Scopus)
• 2006

  Empirical validation of a rat in vitro organ slice model as a tool for in vivo clearance prediction

  de Graaf, IAM., de Kanter, R., de Jager, MH., Camacho, R., Langenkamp, E., van de Kerkhof, EG. & Groothuis, GMM., Apr-2006, In: Drug Metabolism and Disposition. 34, 4, p. 591-599 9 p.

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  42 Citations (Scopus)

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• Innovative methods to study human intestinal drug metabolism in vitro: Precision-cut slices compared with Ussing chamber preparations

  van de Kerkhof, E. G., Ungell, A-L. B., Sjoberg, A. K., de Jager, M. H., Hilgendorf, C., de Graaf, I. A. M. & Groothuis, G. M. M., Nov-2006, In: Drug Metabolism and Disposition. 34, 11, p. 1893-1902 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  83 Citations (Scopus)
• 2005

  A new technique for preparing precision-cut slices from small intestine and colon for drug biotransformation studies

  de Kanter, R., Tuin, A., van de Kerkhof, E. G., Martignoni, M., Draaisma, A. L., de Jager, M. H., de Graaf, I. A. M., Meijer, D. K. F. & Groothuis, G., 2005, In: Journal of Pharmacological and Toxicological Methods. 51, 1, p. 65 - 72 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  45 Citations (Scopus)

• Characterization of rat small intestinal and colon precision-cut slices as an in vitro system for drug metabolism and induction studies

  van de Kerkhof, EG., de Graaf, IAM., de Jager, MH., Meijer, DKF. & Groothuis, GMM., Nov-2005, In: Drug Metabolism and Disposition. 33, 11, p. 1613-1620 8 p.

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• 2004

  Prediction of whole-body metabolic clearance of drugs through the combined use of slices from rat liver, lung, kidney, small intestine and colon

  de Kanter, R., Monshouwer, M., Draaisma, A. L., de Jager, M. H., de Graaf, I. A. M., Proost, J. H., Meijer, D. K. F. & Groothuis, G., 2004, In: Xenobiotica. 34, 3, p. 229-241 13 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  51 Citations (Scopus)
• 2003

  Cryopreservation of precision-cut tissue slices for application in drug metabolism research

  de Graaf, I. A. M. & Koster, H., Feb-2003, In: Toxicol.In Vitro. 17, 1, p. 1-17 17 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  29 Citations (Scopus)
• 2002

  Comparison of in vitro preparations for semi-quantitative prediction of in vivo drug metabolism

  De Graaf, I. A. M., Van Meijeren, C. E., Pektaş, F. & Koster, H. J., Oct-2002, In: Drug Metabolism and Disposition. 30, 10, p. 1129-36 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  44 Citations (Scopus)

• Incubation at 37 degrees C prior to cryopreservation decreases viability of liver slices after cryopreservation by rapid freezing

  de Graaf, I. A. M., Geerlinks, A. & Koster, H. J., Aug-2002, In: Cryobiology. 45, 1, p. 1-9 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  5 Citations (Scopus)
• 2001

  Water crystallization within rat precision-cut liver slices in relation to their viability

  de Graaf, I. A. & Koster, H. J., Nov-2001, In: Cryobiology. 43, 3, p. 224-37 14 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  15 Citations (Scopus)