Research output per year
Research output per year
Personal profile
Research interests
During his routine TDM training he developed great interest into infectious diseases in critically ill patients. His research is focussed on the pharmacokinetics and pharmacodynamics of antimicrobial agents, in particular antifungal agents and anti-TB drugs. The aim is to optimize antimicrobial therapy based on PK/PD principles. The overall aim is to find a balance between efficacy and toxicity. Helpful tools are therapeutic drug monitoring, pharmacokinetic modeling, optimal sampling strategies. Also his more analytical oriented reasearch is focused on optimization of treatment by using alternative sampling strategies like dried blood spot sampling and oral fluid as alternative for plasma and serum.
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Bedaquiline exposure in people with drug-resistant TB treated for diabetes: analysis of two phase 2 trials
Bolhuis, M. S., Akkerman, O. W., Sturkenboom, M. G. G., van Boven, J. F. M., Alffenaar, J-W. C. & Stevens, J., 1-Apr-2023, In: The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease. 27, 4, p. 335-337 3 p.Research output: Contribution to journal › Article › Academic › peer-review
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Dried Blood Spot Sampling to Assess Rifampicin Exposure and Treatment Outcomes among Native and Non-Native Tuberculosis Patients in Paraguay: An Exploratory Study
Ghimire, S., Molinas, G., Battaglia, A., Martinez, N., Gómez Paciello, L., Aguirre, S., Alffenaar, J. W. C., Sturkenboom, M. G. G. & Magis-Escurra, C., Apr-2023, In: Pharmaceutics. 15, 4, 1089.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile6 Downloads (Pure) -
Global estimates and determinants of antituberculosis drug pharmacokinetics in children and adolescents: a systematic review and individual patient data meta-analysis
Global Collaborative Group for Meta-Analysis of Paediatric Individual Patient Data in Pharmacokinetics of Anti-TB Drugs, Gafar, F., Wasmann, R. E., McIlleron, H. M., Aarnoutse, R. E., Schaaf, H. S., Marais, B. J., Agarwal, D., Antwi, S., Bang, N. D., Bekker, A., Bell, D. J., Chabala, C., Choo, L., Davies, G. R., Day, J. N., Dayal, R., Denti, P., Donald, P. R., Engidawork, E., & 31 others, 2023, In: European Respiratory Journal. 61, 23 p., 2201596.Research output: Contribution to journal › Review article › peer-review
Open AccessFile5 Citations (Scopus)18 Downloads (Pure) -
Is it time for new fixed-dose combinations and revised weight bands for children with drug-susceptible TB?
Gafar, F. & Alffenaar, J-W. C., 1-May-2023, In: The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease. 27, 5, p. 345-347 3 p.Research output: Contribution to journal › Article › Academic › peer-review
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Subtherapeutic Exposure of Ganciclovir in Children Despite Appropriate Dosing: A Short Communication
Marfil, S., Märtson, A-G., Toren-Wielema, M., Leer-Buter, C. V., Schölvinck, E. H., Alffenaar, J-W. C., Touw, D. J. & Sturkenboom, M. G. G., Apr-2023, In: Therapeutic Drug Monitoring. 45, 2, p. 269-272 4 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile1 Citation (Scopus)12 Downloads (Pure)