Research output per year
Research output per year
Personal profile
Research interests
During his routine TDM training he developed great interest into infectious diseases in critically ill patients. His research is focussed on the pharmacokinetics and pharmacodynamics of antimicrobial agents, in particular antifungal agents and anti-TB drugs. The aim is to optimize antimicrobial therapy based on PK/PD principles. The overall aim is to find a balance between efficacy and toxicity. Helpful tools are therapeutic drug monitoring, pharmacokinetic modeling, optimal sampling strategies. Also his more analytical oriented reasearch is focused on optimization of treatment by using alternative sampling strategies like dried blood spot sampling and oral fluid as alternative for plasma and serum.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Analysis of Health-Related Quality of Life and Incurred Costs Among Human Immunodeficiency Virus, Tuberculosis, and Tuberculosis/HIV Coinfected Outpatients in Indonesia
Idrus, L. R., Fitria, N., Purba, F. D., Alffenaar, J. W. C. & Postma, M. J., May-2024, In: Value in Health Regional Issues. 41, p. 32-40 9 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile34 Downloads (Pure) -
Ten-year results of an international external quality control programme for measurement of anti-tuberculosis drug concentrations
Stemkens, R., Mouhdad, C., Franssen, E. J. F., Touw, D., Alffenaar, J.-W., Te Brake, L. H. M., Sturkenboom, M. G. G. & Aarnoutse, R. E., Jun-2024, In: The Journal of antimicrobial chemotherapy. 79, 6, p. 1346–1352 7 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile14 Downloads (Pure) -
Tuberculosis impacts multiple aspects in quality of life in a Romanian cohort of drug-susceptible and drug resistant patients: A patient-reported outcome measures study
Margineanu, I., Butnaru, T., Lam, M., Baiceanu, D., Dragomir, R., Arbore, A. S., Mahler, B., Munteanu, I., Mihaltan, F., Akkerman, O., Alffenaar, J.-W. & Stienstra, Y., Jul-2024, In: Tropical Medicine & International Health. 29, 7, p. 584-593 10 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile12 Downloads (Pure) -
Bedaquiline exposure in people with drug-resistant TB treated for diabetes: analysis of two phase 2 trials
Bolhuis, M. S., Akkerman, O. W., Sturkenboom, M. G. G., van Boven, J. F. M., Alffenaar, J.-W. C. & Stevens, J., 1-Apr-2023, In: The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease. 27, 4, p. 335-337 3 p.Research output: Contribution to journal › Article › Academic › peer-review
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Clinical standards for the management of adverse effects during treatment for TB
Singh, K. P., Carvalho, A. C. C., Centis, R., D'Ambrosio, L., Migliori, G. B., Mpagama, S. G., Nguyen, B. C., Aarnoutse, R. E., Aleksa, A., van Altena, R., Bhavani, P. K., Bolhuis, M. S., Borisov, S., van 't Boveneind-Vrubleuskaya, N., Bruchfeld, J., Caminero, J. A., Carvalho, I., Cho, J. G., Davies Forsman, L. & Dedicoat, M. & 45 others, , 1-Jul-2023, In: The International Journal of Tuberculosis and Lung Disease. 27, 7, p. 506-519 14 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile7 Citations (Scopus)33 Downloads (Pure)