Keyphrases
Proteolysis Targeting chimera (PROTAC)
100%
Histone Deacetylase 3 (HDAC3)
50%
M1-like
50%
Macrophages
50%
Anti-inflammatory Potential
50%
Hydrazide
50%
HDAC8
50%
Solid Tumors
50%
Hematological Malignancies
50%
Macrophage Polarization
21%
Independent Functions
14%
Deacetylase
14%
Primary Macrophages
14%
Non-enzymatic Function
14%
HDAC Inhibition
14%
Small Molecules
7%
Genetic Depletion
7%
Inflammatory Cytokines
7%
Inflammatory Process
7%
Small Molecule Therapeutics
7%
Anti-inflammatory Cytokines
7%
Inflammatory Gene Expression
7%
THP-1 Cells
7%
Micromolar Concentration
7%
Molecular Mechanism
7%
THP1
7%
Anti-inflammatory Activity
7%
Cytokine Secretion
7%
Histone Acetylation
7%
Antiproliferative Activity
7%
Cancer Types
7%
Cancer Cell Lines
7%
Enzymatic Function
7%
Hyperacetylation
7%
Biological Function
7%
Structural Maintenance of Chromosomes Proteins
7%
High Concentration
7%
Biochemistry, Genetics and Molecular Biology
DNA Repair
50%
Ferroptosis
50%
Small Molecule
50%
Homologous Recombination
28%
BRCA1 Protein
14%
DNA Damage
7%
RAD51
7%
P53
7%
Mitochondrion
7%
Anticancer
7%
Cell Death
7%
Lipid Peroxidation
7%
Genetics
7%
Immunology and Microbiology
Macrophage
50%
Protein Degradation
15%
Secretion (Process)
5%
Gene Expression
5%
Proinflammatory Cytokine
5%
Inflammatory Cytokine
5%
Cytokine Release
5%
Antiinflammatory Activity
5%