Research output per year
Research output per year
- 1 - 50 out of 130 results
Search results
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2024
Artificial, biomimetic and hybrid enzymes: general discussion
Acevedo-Rocha, C., Bakshi, A., Bornscheuer, U. T., Campopiano, D. J., Čivić, J., Drienovská, I., Ehinger, F. J., Gomm, A., Góra, A., Green, A. P., Hanzevacki, M., Harvey, J. N., Hilvert, D., Huang, M., Jarvis, A. G., Kamerlin, S. C. L., Lichtenstein, B. R., Luk, L. Y. P., Lutz, S. & Marsh, E. N. G. & 17 others, , 23-Aug-2024, (E-pub ahead of print) In: Faraday Discussions. 33 p., d4fd90024c.Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review
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Boron catalysis in a designer enzyme
Longwitz, L., Leveson-Gower, R. B., Rozeboom, H. J., Thunnissen, A.-M. W. H. & Roelfes, G., 23-May-2024, In: Nature. 629, p. 824–829 17 p.Research output: Contribution to journal › Article › Academic › peer-review
4 Citations (Scopus) -
Computation-guided engineering of distal mutations in an artificial enzyme
Casilli, F., Canyelles-Niño, M., Roelfes, G. & Alonso-Cotchico, L., 22-Apr-2024, (E-pub ahead of print) In: Faraday Discussions. 17 p., d4fd00069b.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile1 Citation (Scopus)7 Downloads (Pure) -
Enzyme evolution, engineering and design: mechanism and dynamics: general discussion
Acevedo-Rocha, C., Berlicki, L., Bornscheuer, U. T., Campopiano, D. J., Chaiyen, P., Čivić, J., Cong, Z., Ehinger, F. J., Flitsch, S., Góra, A., Hanzevacki, M., Harvey, J. N., Hilvert, D., Hollfelder, F., Jarvis, A. G., Lichtenstein, B. R., Lutz, S., Malcomson, T., Marsh, E. N. G. & McFarlane, N. R. & 13 others, , 23-Aug-2024, (E-pub ahead of print) In: Faraday Discussions. 30 p., d4fd90022g.Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review
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Microbial cell factories for cycloalkene synthesis
Jiang, R. & Roelfes, G., 27-Jun-2024, (E-pub ahead of print) In: Nature synthesis.Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review
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Selective Aza-Michael Addition to Dehydrated Amino Acids in Natural Antimicrobial Peptides
Vargiu, M., Xu, Y., Kuipers, O. & Roelfes, G., 2-Apr-2024, In: ChemBioChem. 25, 7, 5 p., e202400043.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile65 Downloads (Pure) -
2023
In Vivo Biocatalytic Cascades Featuring an Artificial-Enzyme-Catalysed New-to-Nature Reaction**
Ofori Atta, L., Zhou, Z. & Roelfes, G., 2-Jan-2023, In: Angewandte Chemie - International Edition. 62, 1, 6 p., e202214191.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile6 Citations (Scopus)66 Downloads (Pure) -
2022
Biocatalytic Friedel-Crafts Reactions
Leveson-Gower, R. B. & Roelfes, G., 20-Sept-2022, In: ChemCatChem. 14, 18, 19 p., e202200636.Research output: Contribution to journal › Review article › peer-review
Open AccessFile17 Citations (Scopus)87 Downloads (Pure) -
Supramolecular Assembly of DNA- and Protein-Based Artificial Metalloenzymes
Roelfes, G., 14-Mar-2022, Supramolecular Catalysis: New Directions and Developments. Wiley, p. 561-572 12 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review
1 Citation (Scopus) -
Tandem Friedel-Crafts-Alkylation-Enantioselective-Protonation by Artificial Enzyme Iminium Catalysis
Leveson-Gower, R. B., de Boer, R. M. & Roelfes, G., 22-Apr-2022, In: ChemCatChem. 14, 8, e202101875.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile13 Citations (Scopus)109 Downloads (Pure) -
2021
A Water-Soluble Iridium Photocatalyst for Chemical Modification of Dehydroalanines in Peptides and Proteins
van Lier, R. C. W., de Bruijn, A. D. & Roelfes, G., 18-Jan-2021, In: Chemistry. 27, 4, p. 1430-1437 8 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile27 Citations (Scopus)179 Downloads (Pure) -
Chemogenetic Tags with Probe Exchange for Live-Cell Fluorescence Microscopy
Iyer, A., Baranov, M., Foster, A. J., Chordia, S., Roelfes, G., Vlijm, R., van den Bogaart, G. & Poolman, B., 21-May-2021, In: ACS chemical biology. 16, 5, p. 891-904 14 p., acschembio.1c00100.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile5 Citations (Scopus)141 Downloads (Pure) -
In vivo Assembly of Artificial Metalloenzymes and Application in Whole-Cell Biocatalysis
Chordia, S., Narasimhan, S., Lucini Paioni, A., Baldus, M. & Roelfes, G., 8-Mar-2021, In: Angewandte Chemie (International ed. in English). 60, 11, p. 5913-5920 8 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile58 Citations (Scopus)97 Downloads (Pure) -
Merging Whole-cell Biosynthesis of Styrene and Transition-metal Catalyzed Derivatization Reactions
Maaskant, R. V., Chordia, S. & Roelfes, G., 19-Mar-2021, In: ChemCatChem. 13, 6, p. 1607-1613 7 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile15 Citations (Scopus)74 Downloads (Pure) -
Rapid and selective chemical editing of Ribosomally synthesized and Post-translationally modified Peptides (RiPPs) via Cu(II)-catalyzed β-borylation of dehydroamino acids
de Vries, R. H., Viel, J. H., Kuipers, O. P. & Roelfes, G., 19-Feb-2021, In: Angewandte Chemie (International ed. in English). 60, 8, p. 3946-3950 5 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile23 Citations (Scopus)124 Downloads (Pure) -
Repurposed and artificial heme enzymes for cyclopropanation reactions
Roelfes, G., Sept-2021, In: Journal of Inorganic Biochemistry. 222, 111523.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile10 Citations (Scopus)101 Downloads (Pure) -
Synergistic Catalysis of Tandem Michael Addition/Enantioselective Protonation Reactions by an Artificial Enzyme
Zhou, Z. & Roelfes, G., 6-Aug-2021, In: ACS Catalysis. 11, 15, p. 9366-9369 4 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile16 Citations (Scopus)185 Downloads (Pure) -
Unlocking Iminium Catalysis in Artificial Enzymes to Create a Friedel-Crafts Alkylase
Leveson-Gower, R. B., Zhou, Z., Drienovská, I. & Roelfes, G., 18-Jun-2021, In: ACS Catalysis. 11, 12, p. 6763-6770 8 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile26 Citations (Scopus)242 Downloads (Pure) -
2020
A Hydroxyquinoline-Based Unnatural Amino Acid for the Design of Novel Artificial Metalloenzymes
Drienovská, I., Scheele, R. A., de Souza, C. G. & Roelfes, G., 2-Nov-2020, In: ChemBioChem. 21, 21, p. 3077-3081 6 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile23 Citations (Scopus)79 Downloads (Pure) -
Artificial Metalloenzymes based on TetR Proteins and Cu(II) for Enantioselective Friedel-Crafts Alkylation Reactions
de Souza, C. G., Roelfes, G. & Bersellini, M., 18-Jun-2020, In: ChemCatChem. 12, 12, p. 3190-3194 5 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile9 Citations (Scopus)90 Downloads (Pure) -
A trifunctional linker for palmitoylation and peptide and protein localization in biological membranes
Syga, L., De Vries, R. H., van Oosterhout, H., Bartelds, R., Boersma, A. J., Roelfes, G. & Poolman, B., 4-May-2020, In: ChemBioChem. 21, 9, p. 1320-1328 9 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile224 Downloads (Pure) -
Cationic iron porphyrins with sodium dodecyl sulphate for micellar catalysis of cyclopropanation reactions
Maaskant, R. V., Polanco, E. A., van Lier, R. C. W. & Roelfes, G., 28-Jan-2020, In: Organic & Biomolecular Chemistry. 18, 4, p. 638-641 4 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile16 Citations (Scopus)111 Downloads (Pure) -
Characterization of two relacidines belonging to a novel class of circular lipopeptides that act against Gram-negative bacterial pathogens
Li, Z., Chakraborty, P., de Vries, R. H., Song, C., Zhao, X., Roelfes, G., Scheffers, D.-J. & Kuipers, O. P., Dec-2020, In: Environmental Microbiology. 22, 12, p. 5125-5136 12 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile19 Citations (Scopus)158 Downloads (Pure) -
Cofactor Binding Dynamics Influence the Catalytic Activity and Selectivity of an Artificial Metalloenzyme
Villarino, L., Chordia, S., Alonso-Cotchico, L., Reddem, E., Zhou, Z., Thunnissen, A. M. W. H., Maréchal, J.-D. & Roelfes, G., 18-Sept-2020, In: ACS Catalysis. 10, 20, p. 11783-11790 8 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile30 Citations (Scopus)138 Downloads (Pure) -
Cu(ii)-Catalysed β-silylation of dehydroalanine residues in peptides and proteins
de Vries, R. H. & Roelfes, G., 25-Sept-2020, In: Chemical communications (Cambridge, England). 56, 75, p. 11058-11061 4 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile12 Citations (Scopus)82 Downloads (Pure) -
Expanding the enzyme universe with genetically encoded unnatural amino acids
Drienovska, I. & Roelfes, G., 6-Jan-2020, In: Nature Catalysis. 3, 3, p. 193-202 10 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile143 Citations (Scopus)644 Downloads (Pure) -
Impact of binding to the multidrug resistance regulator protein LmrR on the photo-physics and -chemistry of photosensitizers
Mejias, S. H., Roelfes, G. & Browne, W. R., 7-Jun-2020, In: PPCP : Physical Chemistry Chemical Physics. 22, 21, p. 12228-12238 11 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile6 Citations (Scopus)133 Downloads (Pure) -
Novel modifications of nonribosomal peptides from Brevibacillus laterosporus MG64 and investigation of their mode of action
Li, Z., de Vries, R. H., Chakraborty, P., Song, C., Zhao, X., Scheffers, D.-J., Roelfes, G. & Kuipers, O. P., Dec-2020, In: Applied and environmental microbiology. 86, 24, p. 1-14 14 p., e01981-20.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile6 Citations (Scopus)167 Downloads (Pure) -
Synergistic catalysis in an artificial enzyme by simultaneous action of two abiological catalytic sites
Zhou, Z. & Roelfes, G., Mar-2020, In: Nature Catalysis. 3, 3, p. 289–294 8 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile106 Citations (Scopus)499 Downloads (Pure) -
2019
A "Broad Spectrum" Carbene Transferase for Synthesis of Chiral α-Trifluoromethylated Organoborons
Alonso-Cotchico, L. & Roelfes, G., 27-Feb-2019, In: ACS central science. 5, 2, p. 206-208 3 p.Research output: Contribution to journal › Article › Academic
Open AccessFile2 Citations (Scopus)244 Downloads (Pure) -
Bio-orthogonal metalloporphyrin catalyzed selective methionine alkylation in the lanthipeptide Nisin
Maaskant, R. V. & Roelfes, G., 2-Jan-2019, In: ChemBioChem. 20, p. 57-61Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile4 Citations (Scopus)212 Downloads (Pure) -
Directed Evolution of a Designer Enzyme Featuring an Unnatural Catalytic Amino Acid
Mayer, C., Dulson, C., Reddem, E., Thunnissen, A.-M. W. H. & Roelfes, G., 11-Feb-2019, In: Angewandte Chemie-International Edition. 58, 7, p. 2083-2087 5 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile65 Citations (Scopus)489 Downloads (Pure) -
Folic acid conjugates of a bleomycin mimic for selective targeting of folate receptor positive cancer cells
Geersing, A., de Vries, R. H., Jansen, G., Rots, M. G. & Roelfes, G., 1-Aug-2019, In: Bioorganic & Medicinal Chemistry Letters. 29, 15, p. 1922-1927 6 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile26 Citations (Scopus)200 Downloads (Pure) -
Integrated Computational Study of the Cu-Catalyzed Hydration of Alkenes in Water Solvent and into the Context of an Artificial Metallohydratase
Alonso-Cotchico, L., Sciortino, G., Vidossich, P., Rodriguez-Guerra Pedregal, J., Drienovska, I., Roelfes, G., Lledos, A. & Marechal, J.-D., May-2019, In: ACS Catalysis. 9, 5, p. 4616-4626 21 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile11 Citations (Scopus)112 Downloads (Pure) -
LmrR: A Privileged Scaffold for Artificial Metalloenzymes
Roelfes, G., 19-Mar-2019, In: Accounts of Chemical Research. 52, 3, p. 545−556 12 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile116 Citations (Scopus)402 Downloads (Pure) -
Selective Modification of RiPPs via Diels-Alder Cycloadditions on Dehydroalanine Residues
de Vries, R., Viel, J., Oudshoorn, R., Kuipers, O. & Roelfes, G., 1-Oct-2019, In: Chemistry. 25, 55, p. 12698–12702 5 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile24 Citations (Scopus)138 Downloads (Pure) -
The importance of catalytic promiscuity for enzyme design and evolution
Leveson-Gower, R. B., Mayer, C. & Roelfes, G., Dec-2019, In: Nature reviews chemistry. 3, 12, p. 687-705 19 p.Research output: Contribution to journal › Review article › peer-review
183 Citations (Scopus) -
2018
A designer enzyme for hydrazone and oxime formation featuring an unnatural catalytic aniline residue
Drienovská, I., Mayer, C., Dulson, C. & Roelfes, G., Sept-2018, In: Nature Chemistry. 10, 9, p. 946-952 7 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile104 Citations (Scopus)657 Downloads (Pure) -
An Artificial Heme Enzyme for Cyclopropanation Reactions
Villarino, L., Splan, K. E., Reddem, E., Alonso-Cotchico, L., Gutiérrez de Souza, C., Lledós, A., Maréchal, J.-D., Thunnissen, A.-M. W. H. & Roelfes, G., 25-Jun-2018, In: Angewandte Chemie - International Edition. 57, 26, p. 7785-7789 5 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile96 Citations (Scopus)421 Downloads (Pure) -
Catalytic Modification of Dehydroalanine in Peptides and Proteins by Palladium-Mediated Cross-Coupling
de Bruijn, A. D. & Roelfes, G., Aug-2018, In: Chemistry. 24, 48, p. 12728-12733 6 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile29 Citations (Scopus)494 Downloads (Pure) -
Chemical modification of dehydrated amino acids in natural antimicrobial peptides by photoredox catalysis
de Bruijn, A. D. & Roelfes, G., 6-Aug-2018, In: Chemistry. 24, 44, p. 11314-11318 5 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile48 Citations (Scopus)309 Downloads (Pure) -
Correction: Author Correction: A simple and versatile design concept for fluorophore derivatives with intramolecular photostabilization
van der Velde, J. H. M., Oelerich, J., Huang, J., Smit, J. H., Jazi, A. A., Galiani, S., Kolmakov, K., Gouridis, G., Eggeling, C., Herrmann, A., Roelfes, G. & Cordes, T., 23-Nov-2018, In: Nature Communications. 9, 1, 1 p., 16232.Research output: Contribution to journal › Erratum
Open AccessFile14 Downloads (Pure) -
Importance of Metal-Ion Exchange for the Biological Activity of Coordination Complexes of the Biomimetic Ligand N4Py
Geersing, A., Ségaud, N., van der Wijst, M. G. P., Rots, M. G. & Roelfes, G., 2-Jul-2018, In: Inorganic Chemistry. 57, 13, p. 7748-7756 9 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile26 Citations (Scopus)339 Downloads (Pure) -
Responsive DNA G-quadruplex micelles
Cozzoli, L., Gjonaj, L., Stuart, M. C. A., Poolman, B. & Roelfes, G., 11-Jan-2018, In: Chemical communications (Cambridge, England). 54, p. 260-263 4 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile27 Citations (Scopus)400 Downloads (Pure) -
2017
A metal ion regulated artificial metalloenzyme
Bersellini, M. & Roelfes, G., 2017, In: Dalton Transactions. 46, 13, p. 4325-4330 6 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile16 Citations (Scopus)105 Downloads (Pure) -
Artificial Metalloproteins for Binding and Stabilization of a Semiquinone Radical
Ségaud, N., Drienovská, I., Chen, J., Browne, W. R. & Roelfes, G., 6-Nov-2017, In: Inorganic Chemistry. 56, 21, p. 13293-13299 7 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile17 Citations (Scopus)395 Downloads (Pure) -
Bio-orthogonal metalloporphyrin catalyzed modification of lantibiotics
Maaskant, R. & Roelfes, G., 20-Aug-2017, In: Abstracts of Papers of the American Chemical Society. 254, 1 p.Research output: Contribution to journal › Meeting Abstract › Academic
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Corrigendum: A simple and versatile design concept for fluorophore derivatives with intramolecular photostabilization
van der Velde, J. H. M., Oelerich, J., Huang, J., Smit, J. H., Jazi, A. A., Galiani, S., Kolmakov, K., Gouridis, G., Eggeling, C., Herrmann, A., Roelfes, G. & Cordes, T., 16-Nov-2017, In: Nature Communications. 8, 1 p., 16173.Research output: Contribution to journal › Erratum
Open AccessFile1 Citation (Scopus)12 Downloads (Pure) -
Design of an enantioselective artificial metallo-hydratase enzyme containing an unnatural metal-binding amino acid
Drienovská, I., Alonso-Cotchico, L., Vidossich, P., Lledós, A., Maréchal, J.-D. & Roelfes, G., Oct-2017, In: Chemical Science. 8, 10, p. 7228-7235 8 p., C7SC03477F.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile65 Citations (Scopus)323 Downloads (Pure) -
Multidrug resistance regulators (MDRs) as scaffolds for the design of artificial metalloenzymes
Bersellini, M. & Roelfes, G., 14-Apr-2017, In: Organic & Biomolecular Chemistry. 15, 14, p. 3069-3073 5 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile30 Citations (Scopus)88 Downloads (Pure)