Personal profile
Research interests
For the latest information please consult the resources below.
Personal Website - http://www.macromolecule.fun
Twitter - https://twitter.com/macro_momo
ORCID - https://orcid.org/0000-0002-6307-7713
External positions
Research Associate Professor, Laboratory of Cellular and Structural Biology, The Rockefeller University
Jun-2019 → …
Founder, Managing Director, B13LOGY LLC
2016 → …
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
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Repeats mimic pathogen-associated patterns across a vast evolutionary landscape
Šulc, P., Di Gioacchino, A., Solovyov, A., Sun, S., Martis, S., Marhon, S. A., Lindholm, H. T., Chen, R., Hosseini, A., Jiang, H., Ly, B. H., Taylor, M. S., Mehdipour, P., Abdel-Wahab, O., Rusk, N., Vabret, N., LaCava, J., De Carvalho, D. D., Monasson, R. & Cocco, S. & 1 others, , 10-Dec-2025, In: Cell Genomics. 5, 12, 23 p., 101011.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile3 Citations (Scopus)2 Downloads (Pure) -
Targeted detection of endogenous LINE-1 proteins and ORF2p interactions
Nielsen, M. I., Wolters, J. C., Bringas, O. G. R., Jiang, H., Di Stefano, L. H., Oghbaie, M., Hozeifi, S., Nitert, M. J., van Pijkeren, A., Smit, M., ter Morsche, L., Mourtzinos, A., Deshpande, V., Taylor, M. S., Chait, B. T. & LaCava, J., 6-Feb-2025, In: Mobile dna. 16, 1, 19 p., 3.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile4 Citations (Scopus)19 Downloads (Pure) -
Cancer cells restrict immunogenicity of retrotransposon expression via distinct mechanisms
Sun, S., You, E., Hong, J., Hoyos, D., Del Priore, I., Tsanov, K. M., Mattagajasingh, O., Di Gioacchino, A., Marhon, S. A., Chacon-Barahona, J., Li, H., Jiang, H., Hozeifi, S., Rosas-Bringas, O., Xu, K. H., Song, Y., Lang, E. R., Rojas, A. S., Nieman, L. T. & Patel, B. K. & 12 others, , 10-Dec-2024, In: Immunity. 57, 12, p. 2879-2894.e11 27 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile21 Citations (Scopus)173 Downloads (Pure) -
CCDC88B interacts with RASAL3 and ARHGEF2 and regulates dendritic cell function in neuroinflammation and colitis
Olivier, J. F., Langlais, D., Jeyakumar, T., Polyak, M. J., Galarneau, L., Cayrol, R., Jiang, H., Molloy, K. R., Xu, G., Suzuki, H., LaCava, J., Gros, P. & Fodil, N., 10-Jan-2024, In: Communications biology. 7, 19 p., 77.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile5 Citations (Scopus)148 Downloads (Pure) -
Multiparameter screen optimizes immunoprecipitation
Xie, S., Saba, L., Jiang, H., Bringas, O. R., Oghbaie, M., Stefano, L. D., Sherman, V. & LaCava, J., Apr-2024, In: Biotechniques. 76, 4, p. 145-152 8 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile56 Downloads (Pure)
Activities
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Mobile DNA: mechanisms and impact on human health. FASEB SRC
LaCava, J. (Organiser)
Jun-2025Activity: Organising and attending an event › Organising and contributing to an event › Academic
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LINE-1 retrotransposons: interactomes, structures, and implications in human diseases
LaCava, J. (Invited speaker)
17-Jan-2024Activity: Talk and presentation › Academic presentation › Academic
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Driving biomedical discovery through adventures in affinity proteomics
LaCava, J. (Invited speaker)
24-Mar-2023Activity: Talk and presentation › Academic presentation › Academic
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Where is endogenous ORF2p?
LaCava, J. (Invited speaker)
13-Dec-2023Activity: Talk and presentation › Academic presentation › Academic
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Mobile dna (Journal)
LaCava, J. (Editorial board member)
Apr-2023 → …Activity: Peer-review and editorial work › Editorial work › Academic
Datasets
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Aggregation under genotoxic conditions in HEK293T and U2OS cells
LaCava, J. (Creator) & di Stefano, L. (Creator), University of Groningen, 7-Apr-2022
https://www.ebi.ac.uk/pride/archive/projects/PXD030166
Dataset
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Multi-condition affinity capture/MS analysis of LAP-tagged human NCBP1, NCBP2, and NCBP3
LaCava, J. (Creator), University of Groningen, 2020
https://www.ebi.ac.uk/pride/archive/projects/PXD016038
Dataset
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Colorectal cancer anti-ORF1p LFQ IP-MS
LaCava, J. (Creator), University of Groningen, 23-Aug-2019
https://www.ebi.ac.uk/pride/archive/projects/PXD013743
Dataset
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LFQMS of RING2 (RING1B, RNF2) immunoprecipitation from MDA-MB-231 and T47D breast cancer cells
LaCava, J. (Creator), University of Groningen, 19-Oct-2018
https://www.ebi.ac.uk/pride/archive/projects/PXD009570
Dataset
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MOESM2 of LINE-1 ORF2p expression is nearly imperceptible in human cancers
Ardeljan, D. (Contributor), Wang, X. (Contributor), Oghbaie, M. (Contributor), Taylor, M. S. (Contributor), Husband, D. (Contributor), Deshpande, V. (Contributor), Steranka, J. P. (Contributor), Gorbounov, M. (Contributor), Yang, W. R. (Contributor), Sie, B. (Contributor), Benjamin Larman (Contributor), Jiang, H. (Contributor), Molloy, K. R. (Contributor), Altukhov, I. (Contributor), Li, Z. (Contributor), McKerrow, W. (Contributor), Fenyö, D. (Contributor), Burns, K. H. (Contributor) & Lacava, J. (Contributor), University of Groningen, 1-Jan-2020
DOI: 10.6084/m9.figshare.11491026.v1, https://doi.org/10.6084%2Fm9.figshare.11491026.v1
Dataset
Press/Media
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Shiv Nadar Institution of Eminence and the Indraprastha Institute of Information Technology, Delhi Host India | EMBO Lecture Course on Ageing
19/06/2024
1 item of Media coverage
Press/Media: Expert Comment › Popular
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Revealing how ancient genetic invader inhabits our DNA
21/12/2023
1 Media contribution
Press/Media: Expert Comment › Popular
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New blood test could offer earlier detection of common deadly cancers
31/10/2023
1 Media contribution
Press/Media: Expert Comment › Academic
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MsPHep: An online application for low molecular weight heparin rapid characterization based on liquid chromatography-tandem mass spectrometry
30/08/2023
1 Media contribution
Press/Media: Research › Professional
Prizes
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Massachusetts Bay Community College Distinguished Alumni Award
La Cava, J. (Recipient), May-2008
Prize: Honorary degree › Academic
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EMBO Long Term Fellowship
La Cava, J. (Recipient), Dec-2005
Prize: Fellowship awarded competitively › Academic