Research output per year
Research output per year
Personal profile
Research interests
For the latest information please consult the resources below.
Personal Website - http://www.macromolecule.fun
Twitter - https://twitter.com/macro_momo
ORCID - https://orcid.org/0000-0002-6307-7713
Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Affinity-Based Interactome Analysis of Endogenous LINE-1 Macromolecules
Di Stefano, L. H., Saba, L. J., Oghbaie, M., Jiang, H., McKerrow, W., Benitez-Guijarro, M., Taylor, M. S. & LaCava, J., 2023, Methods in Molecular Biology. Humana Press, p. 215-256 42 p. (Methods in Molecular Biology; vol. 2607).Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review
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Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker
Taylor, M. S., Wu, C., Fridy, P. C., Senussi, Y., Cheng, W-C., Heaps, J., Mori, K., Cohen, L., Molloy, K. R., Chait, B. T., Goggins, M., Bhan, I., Franses, J. W., Yang, X., Taplin, M-E., Wang, X., Christiani, D. C., Johnson, B. E., Meyerson, M., Uppaluri, R., & 28 others, 25-Jan-2023, BioRxiv, (bioRxiv).Research output: Working paper › Preprint › Academic
Open Access -
LINE-1 expression in cancer correlates with p53 mutation, copy number alteration, and S phase checkpoint
McKerrow, W., Wang, X., Mendez-Dorantes, C., Mita, P., Cao, S., Grivainis, M., Ding, L., LaCava, J., Burns, K. H., Boeke, J. D. & Fenyo, D., 15-Feb-2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 8, 11 p., e2115999119.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile11 Citations (Scopus)29 Downloads (Pure) -
Targeting DNA topoisomerases or checkpoint kinases results in an overload of chaperone systems, triggering aggregation of a metastable subproteome
Huiting, W., Dekker, S. L., van der Lienden, J. C. J., Mergener, R., Musskopf, M. K., Furtado, G. V., Gerrits, E., Coit, D., Oghbaie, M., Di Stefano, L. H., Schepers, H., van Waarde-Verhagen, M. A. W. H., Couzijn, S., Barazzuol, L., LaCava, J., Kampinga, H. H. & Bergink, S., 24-Feb-2022, In: eLife. 11, 29 p., e70726.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile1 Citation (Scopus)33 Downloads (Pure) -
IgG and IgA autoantibodies against L1 ORF1p expressed in granulocytes correlate with granulocyte consumption and disease activity in pediatric systemic lupus erythematosus
Ukadike, K. C., Ni, K., Wang, X., Taylor, M. S., LaCava, J., Pachman, L. M., Eckert, M., Stevens, A., Lood, C. & Mustelin, T., 29-May-2021, In: ARTHRITIS RESEARCH & THERAPY. 23, 1, 13 p., 153.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile3 Citations (Scopus)30 Downloads (Pure)
Activities
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Multi-omic analyses of endogenous LINE-1-associated ribonucleoprotein indicates active translation and unique composition compared to other ribonucleoprotein granules
John LaCava (Invited speaker)
17-Mar-2022Activity: Talk and presentation › Professional or public presentation › Professional
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BioHack Academy: John LaCava - CRISPR research in Artistic Context
John LaCava (Speaker)
4-Apr-2022Activity: Talk and presentation › Professional or public presentation › Professional
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Endogenous LINE-1-associated RNA granules have unique composition and may be translationally active
John LaCava (Invited speaker)
12-May-2022Activity: Talk and presentation › Professional or public presentation › Professional
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NWO Vidi evaluation committee (External organisation)
John LaCava (Member)
2022 → …Activity: Membership › Academic
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Endogenous LINE-1-associated RNA granules have unique composition and may be translationally active
John LaCava (Invited speaker)
13-May-2022Activity: Talk and presentation › Professional or public presentation › Professional
Datasets
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Aggregation under genotoxic conditions in HEK293T and U2OS cells
LaCava, J. (Creator) & di Stefano, L. (Creator), University of Groningen, 7-Apr-2022
https://www.ebi.ac.uk/pride/archive/projects/PXD030166
Dataset
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Multi-condition affinity capture/MS analysis of LAP-tagged human NCBP1, NCBP2, and NCBP3
LaCava, J. (Creator), University of Groningen, 2020
https://www.ebi.ac.uk/pride/archive/projects/PXD016038
Dataset
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Colorectal cancer anti-ORF1p LFQ IP-MS
LaCava, J. (Creator), University of Groningen, 23-Aug-2019
https://www.ebi.ac.uk/pride/archive/projects/PXD013743
Dataset
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LFQMS of RING2 (RING1B, RNF2) immunoprecipitation from MDA-MB-231 and T47D breast cancer cells
LaCava, J. (Creator), University of Groningen, 19-Oct-2018
https://www.ebi.ac.uk/pride/archive/projects/PXD009570
Dataset
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MOESM2 of LINE-1 ORF2p expression is nearly imperceptible in human cancers
Ardeljan, D. (Contributor), Wang, X. (Contributor), Oghbaie, M. (Contributor), Taylor, M. S. (Contributor), Husband, D. (Contributor), Deshpande, V. (Contributor), Steranka, J. P. (Contributor), Gorbounov, M. (Contributor), Yang, W. R. (Contributor), Sie, B. (Contributor), Benjamin Larman (Contributor), Jiang, H. (Contributor), Molloy, K. R. (Contributor), Altukhov, I. (Contributor), Li, Z. (Contributor), McKerrow, W. (Contributor), Fenyö, D. (Contributor), Burns, K. H. (Contributor) & LaCava, J. (Contributor), University of Groningen, 1-Jan-2020
DOI: 10.6084/m9.figshare.11491026.v1, https://doi.org/10.6084%2Fm9.figshare.11491026.v1
Dataset
Press/Media
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Iris.ai Research Spotlight: John LaCava
20/04/2018
1 Media contribution
Press/Media: Expert Comment › Professional
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Prizes
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NCDIR fellowship
LaCava, John (Recipient), May-2012
Prize: Fellowship awarded competitively › Academic
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Massachusetts Bay Community College Distinguished Alumni Award
LaCava, John (Recipient), May-2008
Prize: Honorary degree › Academic
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EMBO Long Term Fellowship
LaCava, John (Recipient), Dec-2005
Prize: Fellowship awarded competitively › Academic