Research output per year
Research output per year
- 1 - 50 out of 259 results
Search results
-
2024
Asymmetric Sulfoxidations Catalyzed by Bacterial Flavin-Containing Monooxygenases
de Gonzalo, G., Coto-Cid, J. M., Lončar, N. & Fraaije, M. W., Aug-2024, In: Molecules. 29, 15, 10 p., 3474.Research output: Contribution to journal › Article › Academic › peer-review
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Biocatalytic Oxidative Amination of para-Substituted Phenols
Guo, Y., Ashley, B., Marić, I., Saifuddin, M., Dunleavy, T., Onet, A. & Fraaije, M. W., 21-Apr-2024, (E-pub ahead of print) In: ChemCatChem. 7 p., e202400277.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile1 Citation (Scopus)20 Downloads (Pure) -
Biochemical, kinetic, and structural characterization of a Bacillus tequilensis nitroreductase
Russo, S., Rozeboom, H. J., Wijma, H. J., Poelarends, G. J. & Fraaije, M. W., 1-Jul-2024, (E-pub ahead of print) In: The FEBS Journal. 15 p., 17210.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile17 Downloads (Pure) -
Discovery and biochemical characterization of thermostable glycerol oxidases
Santema, L. L., Rotilio, L., Xiang, R., Tjallinks, G., Guallar, V., Mattevi, A. & Fraaije, M. W., 6-Jan-2024, In: Applied Microbiology and Biotechnology. 108, 1, p. 1-14 14 p., 61.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile1 Citation (Scopus)51 Downloads (Pure) -
Discovery and structural characterization of a thermostable bacterial monoamine oxidase
Santema, L. L., Basile, L., Binda, C. & Fraaije, M. W., Mar-2024, In: The FEBS Journal. 291, 5, p. 849-864 16 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile1 Citation (Scopus)54 Downloads (Pure) -
Discovery of a new class of bacterial heme-containing CC cleaving oxygenases
Purwani, N. N., Rozeboom, H. J., Willers, V. P., Wijma, H. J. & Fraaije, M. W., 25-Nov-2024, In: New Biotechnology. 83, p. 82-90 9 p.Research output: Contribution to journal › Article › Academic › peer-review
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Equipping Saccharomyces cerevisiae with an Additional Redox Cofactor Allows F 420-Dependent Bioconversions in Yeast.
Lee, M. & Fraaije, M. W., 15-Mar-2024, In: ACS Synthetic Biology. 13, 3, p. 921–929 9 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile1 Citation (Scopus)45 Downloads (Pure) -
Evolution, Structure, and Drug-Metabolising Activity of Mammalian Prenylcysteine Oxidases
Barone, M., Pizzorni, L., Fraaije, M. W., Mascotti, M. L. & Mattevi, A., 23-Sept-2024, (E-pub ahead of print) In: The Journal of Biological Chemistry. 27 p., 107810.Research output: Contribution to journal › Article › Academic › peer-review
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Evolution of the catalytic mechanism at the dawn of the Baeyer-Villiger monooxygenases
Yang, G., Pećanac, O., Wijma, H. J., Rozeboom, H. J., de Gonzalo, G., Fraaije, M. W. & Mascotti, M. L., 28-May-2024, In: Cell reports. 43, 5, 15 p., 114130.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile24 Downloads (Pure) -
Prenylation of aromatic amino acids and plant phenolics by an aromatic prenyltransferase from Rasamsonia emersonii
Chunkrua, P., Leschonski, K. P., Gran-Scheuch, A. A., Vreeke, G. J. C., Vincken, J.-P., Fraaije, M. W., van Berkel, W. J. H., de Bruijn, W. J. C. & Kabel, M. A., 18-Jul-2024, In: Applied Microbiology and Biotechnology. 108, 1, 14 p., 421.Research output: Contribution to journal › Article › Academic › peer-review
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Structure, mechanism, and evolution of the last step in vitamin C biosynthesis
Boverio, A., Jamil, N., Mannucci, B., Mascotti, M. L., Fraaije, M. W. & Mattevi, A., 16-May-2024, In: Nature Communications. 15, 1, 10 p., 4158.Research output: Contribution to journal › Article › Academic › peer-review
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Sulphoxidation reactions catalysed by the Baeyer-Villiger monooxygenase OTEMO from Pseudomonas putida ATCC 17453
de Gonzalo, G., Loncar, N. & Fraaije, M., 2024, In: Biocatalysis and Biotransformation. 42, 1, p. 77-84 8 p., 2113519.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile1 Citation (Scopus)70 Downloads (Pure) -
Synthesis of Pharmaceutically Relevant Arylamines Enabled by a Nitroreductase from Bacillus tequilensis
Russo, S., Prats Luján, A., Fraaije, M. & Poelarends, G. J., 17-May-2024, In: ChemBioChem. 25, 10, 10 p., e202300846.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile3 Citations (Scopus)29 Downloads (Pure) -
2023
A biosynthetic aspartate N-hydroxylase performs successive oxidations by holding intermediates at a site away from the catalytic center
Rotilio, L., Boverio, A., Nguyen, Q.-T., Mannucci, B., Fraaije, M. & Mattevi, A., Jul-2023, In: The Journal of Biological Chemistry. 299, 7, 14 p., 104904.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile2 Citations (Scopus)36 Downloads (Pure) -
A CRISPR/Cas9-based multicopy integration system for protein production in Aspergillus niger
Arentshorst, M., Kooloth Valappil, P., Mózsik, L., Regensburg-Tuïnk, T. J. G., Seekles, S., Tjallinks, G., Fraaije, M., Visser, J. & Ram, A. F. J., Nov-2023, In: The FEBS Journal. p. 5127-5140 14 p., 16891.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile7 Citations (Scopus)116 Downloads (Pure) -
A One-Pot, Whole-Cell Biocatalysis Approach for Vanillin Production using Lignin Oil
Marić, I., Guo, Y., Fürst, M. J. L. J., Van Aelst, K., Van den Bosch, S., De Simone, M., Martins, L. O., Sels, B. F. & Fraaije, M. W., 21-Nov-2023, In: Advanced Synthesis and Catalysis. 365, 22, p. 3987-3995 9 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile4 Citations (Scopus)49 Downloads (Pure) -
Biochemical and Structural Characterization of a Uronic Acid Oxidase from Citrus sinensis
Boverio, A., van Beek, H. L., Savino, S., Ranoux, A., Huijgen, W. J. J., Raaijmakers, H. W. C., Fraaije, M. W. & Lončar, N., Nov-2023, In: ChemCatChem. 15, 21, 10 p., e202300847.Research output: Contribution to journal › Article › Academic › peer-review
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Characterization of two bacterial multi-flavinylated proteins harboring multiple covalent flavin cofactors
Tong, Y., Rozeboom, H. J., Loonstra, M. R., Wijma, H. J. & Fraaije, M. W., Jan-2023, In: BBA Advances. 4, 8 p., 100097.Research output: Contribution to journal › Article › Academic › peer-review
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Efficient Oxidation of 5-Hydroxymethylfurfural Using a Flavoprotein Oxidase from the Honeybee Apis mellifera
Tjallinks, G., Boverio, A., Jager, A. W., Kaya, S. G., Mattevi, A. & Fraaije, M. W., 14-Dec-2023, In: ChemBioChem. 24, 24, 7 p., e202300588.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile1 Citation (Scopus)40 Downloads (Pure) -
Evolution of enzyme functionality in the flavin-containing monooxygenases
Bailleul, G., Yang, G., Nicoll, C. R., Mattevi, A., Fraaije, M. W. & Mascotti, M. L., 24-Feb-2023, In: Nature Communications. 14, 1, 10 p., 1042.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile13 Citations (Scopus)101 Downloads (Pure) -
Fixing Flavins: Hijacking a Flavin Transferase for Equipping Flavoproteins with a Covalent Flavin Cofactor
Tong, Y., Kaya, S. G., Russo, S., Rozeboom, H. J., Wijma, H. J. & Fraaije, M. W., 13-Dec-2023, In: Journal of the American Chemical Society. 145, 49, p. 27140–27148 9 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile1 Citation (Scopus)62 Downloads (Pure) -
Identification and characterization of archaeal and bacterial F420-dependent thioredoxin reductases
Yang, G., Wijma, H. J., Rozeboom, H. J., Mascotti, M. L. & Fraaije, M. W., Oct-2023, In: The FEBS Journal. 290, 19, p. 4777-4791 15 p.Research output: Contribution to journal › Article › Academic › peer-review
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One-pot biocatalytic synthesis of rac-syringaresinol from a lignin-derived phenol
Guo, Y., Alvigini, L., Saifuddin, M., Ashley, B., Trajkovic, M., Alonso-Cotchico, L., Mattevi, A. & Fraaije, M. W., 17-Nov-2023, In: ACS Catalysis. 13, 22, p. 14639-14649 11 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile3 Citations (Scopus)41 Downloads (Pure) -
Structural Elucidation and Engineering of a Bacterial Carbohydrate Oxidase
Boverio, A., Widodo, W. S., Santema, L. L., Rozeboom, H. J., Xiang, R., Guallar, V., Mattevi, A. & Fraaije, M. W., 17-Jan-2023, In: Biochemistry. 62, 2, p. 429-436 8 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile1 Citation (Scopus)88 Downloads (Pure) -
Structure elucidation and characterization of patulin synthase, insights into the formation of a fungal mycotoxin
Tjallinks, G., Boverio, A., Maric, I., Rozeboom, H., Arentshorst, M., Visser, J., Ram, A. F. J., Mattevi, A. & Fraaije, M. W., Nov-2023, In: The FEBS Journal. 290, 21, p. 5114-5126 13 p., 16804.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile4 Citations (Scopus)38 Downloads (Pure) -
Systematic Assessment of Uncoupling in Flavoprotein Oxidases and Monooxygenases
Gran-Scheuch, A., Parra, L. & Fraaije, M. W., 3-Apr-2023, In: ACS Sustainable Chemistry and Engineering. p. 4948–4959 12 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile9 Citations (Scopus)58 Downloads (Pure) -
Vanillyl alcohol oxidase from Diplodia corticola: Residues Ala420 and Glu466 allow for efficient catalysis of syringyl derivatives
Eggerichs, D., Weindorf, N., Mascotti, M. L., Welzel, N., Fraaije, M. W. & Tischler, D., Jul-2023, In: The Journal of Biological Chemistry. 299, 7, 13 p., 104898.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile3 Citations (Scopus)49 Downloads (Pure) -
2022
A conserved sequence motif in the E. coli soluble FAD-containing pyridine nucleotide transhydrogenase is important for reaction efficiency
Partipilo, M., Yang, G., Mascotti, L., Slotboom, D. & Fraaije, M., Sept-2022, In: The Journal of Biological Chemistry. 298, 9, 13 p., 102304.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile1 Citation (Scopus)63 Downloads (Pure) -
Broadening the scope of the Flavin-tag method by improving flavin incorporation and incorporating flavin analogs
Tong, Y., Loonstra, M. R. & Fraaije, M., 3-Jun-2022, In: ChemBioChem. 23, 11, 8 p., e202200144.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile3 Citations (Scopus)118 Downloads (Pure) -
Chemoenzymatic Synthesis of the Most Pleasant Stereoisomer of Jessemal
Venturi, S., Trajkovic, M., Colombo, D., Brenna, E., Fraaije, M. W., Gatti, F. G., Macchi, P. & Zamboni, E., 6-May-2022, In: The Journal of Organic Chemistry. 87, 9, p. 6499-6503 5 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile3 Citations (Scopus)107 Downloads (Pure) -
Discovery of two novel oxidases using a high-throughput activity screen
Rembeza, E., Boverio, A., Fraaije, M. W. & Engqvist, M., 19-Jan-2022, In: ChemBioChem. 23, 2, 9 p., e202100510.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile3 Citations (Scopus)115 Downloads (Pure) -
Introducing an Artificial Deazaflavin Cofactor in Escherichia coli and Saccharomyces cerevisiae
Lee, M., Drenth, J., Trajkovic, M., de Jong, R. M. & Fraaije, M. W., 18-Feb-2022, In: ACS Synthetic Biology. 11, 2, p. 938-952 15 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile4 Citations (Scopus)93 Downloads (Pure) -
Kinetic resolution of racemic benzofused alcohols catalysed by HMFO variants in presence of natural deep eutectic solvents
de Gonzalo, G., Lončar, N. & Fraaije, M., 2022, In: Biocatalysis and Biotransformation. 41, 2, p. 145-152 8 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile3 Citations (Scopus)67 Downloads (Pure) -
Structure- and computational-aided engineering of an oxidase to produce isoeugenol from a lignin-derived compound
Guo, Y., Alvigini, L., Trajkovic, M., Alonso-Cotchico, L., Monza, E., Savino, S., Marić, I., Mattevi, A. & Fraaije, M. W., 23-Nov-2022, In: Nature Communications. 13, 1, 12 p., 7195.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile13 Citations (Scopus)143 Downloads (Pure) -
2021
Ancestral reconstruction of mammalian FMO1 enables structural determination, revealing unique features that explain its catalytic properties
Bailleul, G., Nicoll, C. R., Mascotti, M. L., Mattevi, A. & Fraaije, M. W., Jan-2021, In: The Journal of Biological Chemistry. 296, 13 p., 100221.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile12 Citations (Scopus)107 Downloads (Pure) -
A Tailor-Made Deazaflavin-Mediated Recycling System for Artificial Nicotinamide Cofactor Biomimetics
Drenth, J., Yang, G., Paul, C. E. & Fraaije, M. W., 17-Sept-2021, In: ACS Catalysis. 11, p. 11561-11569 9 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile11 Citations (Scopus)85 Downloads (Pure) -
Discovery, Biocatalytic Exploration and Structural Analysis of a 4-Ethylphenol Oxidase from Gulosibacter chungangensis
Laura, A., Gran-Scheuch, A., Guo, Y., Trajkovic, M., Saifuddin, M., Fraaije, M. W. & Mattevi, A., 16-Nov-2021, In: ChemBioChem. 22, 22, p. 3225-3233 9 p., cbic.202100457.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile9 Citations (Scopus)39 Downloads (Pure) -
Enantioselective oxidation of secondary alcohols by the flavoprotein alcohol oxidase from Phanerochaete chrysosporium
Tjallinks, G., Martin, C. & Fraaije, M. W., 15-Jun-2021, In: Archives of Biochemistry and Biophysics. 704, 4 p., 108888.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile10 Citations (Scopus)100 Downloads (Pure) -
Facile Stereoselective Reduction of Prochiral Ketones by using an F 420-dependent alcohol dehydrogenase
Martin, C., Tjallinks, G., Trajkovic, M. & Fraaije, M., 5-Jan-2021, In: ChemBioChem. 22, 1, p. 156-159 4 p., cbic.202000651.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile6 Citations (Scopus)141 Downloads (Pure) -
Flavin-Tag: A Facile Method for Site-Specific Labeling of Proteins with a Flavin Fluorophore
Tong, Y., Lee, M., Drenth, J. & Fraaije, M. W., 18-Aug-2021, In: BIOCONJUGATE CHEMISTRY. 32, 8, p. 1559-1563 5 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile4 Citations (Scopus)126 Downloads (Pure) -
Kinetic and structural properties of a robust bacterial L-amino acid oxidase
Savino, S., Daniël‐Moráh Meijer, J., Rozeboom, H. J., van Beek, H. L. & Fraaije, M. W., Nov-2021, In: Catalysts. 11, 11, 9 p., 1309.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile3 Citations (Scopus)94 Downloads (Pure) -
Modular assembly of phosphite dehydrogenase and phenylacetone monooxygenase for tuning cofactor regeneration
Purwani, N. N., Martin, C., Savino, S. & Fraaije, M. W., 17-Jun-2021, In: Biomolecules. 11, 6, 10 p., 905.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile6 Citations (Scopus)83 Downloads (Pure) -
Mutational and structural analysis of an ancestral fungal dye decolorizing peroxidase
Zitare, U. A., Habib, M. H., Rozeboom, H., Mascotti, M. L., Todorovic, S. & Fraaije, M. W., Jun-2021, In: The FEBS Journal. 288, 11, p. 3602-3618 17 p., febs.15687.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile13 Citations (Scopus)105 Downloads (Pure) -
On the diversity of F420 -dependent oxidoreductases: A sequence- and structure-based classification
Mascotti, M. L., Juri Ayub, M. & Fraaije, M. W., Nov-2021, In: Proteins. 89, 11, p. 1497-1507 11 p., 26170.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile6 Citations (Scopus)65 Downloads (Pure) -
Serr spectroelectrochemistry as a guide for rational design of dyp-based bioelectronics devices
Zuccarello, L., Barbosa, C., Galdino, E., Lončar, N., Silveira, C. M., Fraaije, M. W. & Todorovic, S., 1-Aug-2021, In: International Journal of Molecular Sciences. 22, 15, 15 p., 7998.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile2 Citations (Scopus)74 Downloads (Pure) -
Whole-cell screening of oxidative enzymes using genetically encoded sensors
Kardashliev, T., Weingartner, A., Romero, E., Schwaneberg, U., Fraaije, M., Panke, S. & Held, M., Nov-2021, In: Chemical Science. 12, 44, p. 14766-14772 7 p., d1sc02578c.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile5 Citations (Scopus)40 Downloads (Pure) -
2020
Analysis of the structure and substrate scope of chitooligosaccharide oxidase reveals high affinity for C2-modified glucosamines
Savino, S., Jensen, S., Terwisscha van Scheltinga, A. & Fraaije, M. W., 1-Sept-2020, In: FEBS Letters. 594, 17, p. 2819-2828 10 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile9 Citations (Scopus)120 Downloads (Pure) -
Approaching boiling point stability of an alcohol dehydrogenase through computationally-guided enzyme engineering
Aalbers, F. S., Fürst, M. J., Rovida, S., Trajkovic, M., Gómez Castellanos, J. R., Bartsch, S., Vogel, A., Mattevi, A. & Fraaije, M. W., 31-Mar-2020, In: eLife. 9, 18 p., e54639.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile37 Citations (Scopus)168 Downloads (Pure) -
Creating Flavin Reductase Variants with Thermostable and Solvent‐Tolerant Properties by Rational‐Design Engineering
Maenpuen, S., Pongsupasa, V., Pensook, W., Anuwan, P., Kraivisitkul, N., Pinthong, C., Phonbuppha, J., Luanloet, T., Wijma, H. J., Fraaije, M. W., Lawan, N., Chaiyen, P., Wongnate, T. & Kraivisitkul, N., 15-May-2020, In: ChemBioChem. 21, 10, p. 1481-1491 11 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile17 Citations (Scopus)168 Downloads (Pure) -
Genome mining of oxidation modules in trans-acyltransferase polyketide synthases reveals a culturable source for lobatamides
Ueoka, R., Meoded, R., Gran-Scheuch, A., Bhushan, A., Fraaije, M. & Piel, J., 11-May-2020, In: Angewandte Chemie (International ed. in English). 59, 20, p. 7761-7765 5 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile20 Citations (Scopus)91 Downloads (Pure)