Marjan Reinders-Luinge

Search results

• 2023

  Targeted epigenetic silencing of UCHL1 expression suppresses collagen-1 production in human lung epithelial cells

  Wu, D. D., Lau, A. T. Y., Xu, Y. M., Reinders-Luinge, M., Koncz, M., Kiss, A., Timens, W., Rots, M. G. & Hylkema, M. N., 22-Feb-2023, In: Epigenetics. 18, 1, 21 p., 2175522.

  Research output: Contribution to journal › Article › Academic › peer-review

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• 2022

  A lung tissue gene expression profile of severe early onset COPD

  Bekker, N., Van Nijnatten, J., Horvatovich, P., Wolters, J., Guryev, V., Kooistra, W., Reinders-Luinge, M., Woldhuis, R., Timens, W., Van Den berge, M. & Brandsma, C., 4-Sept-2022, In: European Respiratory Journal. 60, p. 3035

  Research output: Contribution to journal › Meeting Abstract › Academic
• 2021

  Postnatal Smoke Exposure Further Increases the Hepatic Nicotine Metabolism in Prenatally Smoke Exposed Male Offspring and Is Linked with Aberrant Cyp2a5 Methylation

  Lkhagvadorj, K., Zeng, Z., Meyer, K. F., Verweij, L. P., Kooistra, W., Reinders-Luinge, M., Dijkhuizen, H. W., de Graaf, I. A. M., Plösch, T. & Hylkema, M. N., Jan-2021, In: International Journal of Molecular Sciences. 22, 1, 14 p., 164.

  Research output: Contribution to journal › Article › Academic › peer-review

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  4 Citations (Scopus)

  75 Downloads (Pure)
• 2020

  Prenatal smoke effect on mouse offspring Igf1 promoter methylation from fetal stage to adulthood is organ- and sex-specific

  Zeng, Z., Meyer, K. F., Lkhagvadorj, K., Kooistra, W., Reinders-Luinge, M., Xu, X., Huo, X., Song, J., Plösch, T. & Hylkema, M. N., Mar-2020, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 318, 3, p. L549-L561 13 p.

  Research output: Contribution to journal › Article › Academic › peer-review

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  7 Citations (Scopus)

  35 Downloads (Pure)

• Prenatal smoke exposure dysregulates lung epithelial cell differentiation in mouse offspring - Role for AREG-induced EGFR signaling

  Lkhagvadorj, K., Zeng, Z., Song, J., Reinders-Luinge, M., Kooistra, W., Song, S., Krauss-Etschmann, S., Melgert, B. N., Cao, J. & Hylkema, M. N., 1-Oct-2020, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 319, 4, p. L742-L751 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review

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  6 Citations (Scopus)

  193 Downloads (Pure)

• Prenatal smoke exposure induces persistent Cyp2a5 methylation and increases nicotine metabolism in the liver of neonatal and adult male offspring

  Lkhagvadorj, K., Meyer, K. F., Verweij, L. P., Kooistra, W., Reinders-Luinge, M., Dijkhuizen, H. W., de Graaf, I. A. M., Plösch, T. & Hylkema, M. N., 2020, In: Epigenetics. 15, 12, p. 1370-1385 16 p.

  Research output: Contribution to journal › Article › Academic › peer-review

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  7 Citations (Scopus)

  111 Downloads (Pure)
• 2019

  A cellular census of healthy lung and asthmatic airway wall identifies novel cell states in health and disease

  Braga, F. V., Kar, G., Berg, M., Carpaij, O., polanski, K., Simon, L., Brouwer, S., Gomes, T., Hesse, L., Jiang, J., Fasouli, E. S., Efremova, M., Vento-Tormo, R., Affleck, K., Palit, S., strzelecka, P., Firth, H. V., Mahbubani, K. T. A., Cvejic, A., Meyer, K., & 13 othersSaeb-Parsy, K., Luinge, M., Brandsma, C., Timens, W., Angelidis, I., Strunz, M., Koppelman, G., van Oosterhout, A., Schiller, H. B., Theis, F., van den Berge, M., Nawijn, M. & Teichmann, S. A., 23-Jan-2019, BioRxiv, (bioRxiv).

  Research output: Working paper › Preprint › Academic

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• A cellular census of human lungs identifies novel cell states in health and in asthma

  Braga, F. A. V., Kar, G., Berg, M., Carpaij, O. A., Polanski, K., Simon, L. M., Brouwer, S., Gomes, T., Hesse, L., Jiang, J., Fasouli, E. S., Efremova, M., Vento-Tormo, R., Talavera-Lopez, C., Jonker, M. R., Affleck, K., Palit, S., Strzelecka, P. M., Firth, H. V., Mahbubani, K. T., & 15 othersCvejic, A., Meyer, K. B., Saeb-Parsy, K., Luinge, M., Brandsma, C-A., Timens, W., Angelidis, I., Strunz, M., Koppelman, G. H., van Oosterhout, A. J., Schiller, H. B., Theis, F. J., van den Berge, M., Nawijn, M. C. & Teichmann, S. A., Jul-2019, In: Nature Medicine. 25, 7, p. 1153-1163 24 p.

  Research output: Contribution to journal › Article › Academic › peer-review

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  440 Citations (Scopus)

  415 Downloads (Pure)

• Characterizing smoking-induced transcriptional heterogeneity in the human bronchial epithelium at single-cell resolution

  Duclos, G. E., Teixeira, V. H., Autissier, P., Gesthalter, Y. B., Reinders-Luinge, M. A., Terrano, R., Dumas, Y. M., Liu, G., Mazzilli, S. A., Brandsma, C-A., van den Berge, M., Janes, S. M., Timens, W., Lenburg, M. E., Spira, A., Campbell, J. D. & Beane, J., Dec-2019, In: Science Advances. 5, 12, 11 p., 3413.

  Research output: Contribution to journal › Article › Academic › peer-review

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  42 Citations (Scopus)

  117 Downloads (Pure)
• 2017

  Aberrant DNA methylation and expression of SPDEF and FOXA2 in airway epithelium of patients with COPD

  Song, J., Heijink, I. H., Kistemaker, L. E. M., Reinders-Luinge, M., Kooistra, W., Noordhoek, J. A., Gosens, R., Brandsma, C. A., Timens, W., Hiemstra, P. S., Rots, M. G. & Hylkema, M. N., 24-Apr-2017, In: Clinical Epigenetics. 9, 10 p., 42.

  Research output: Contribution to journal › Article › Academic › peer-review

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  30 Citations (Scopus)

  322 Downloads (Pure)

• Prenatal exposure to tobacco smoke sex dependently influences methylation and mRNA levels of the Igf axis in lungs of mouse offspring

  Meyer, K. F., Krauss-Etschmann, S., Kooistra, W., Reinders-Luinge, M., Timens, W., Kobzik, L., Plösch, T. & Hylkema, M. N., 5-Apr-2017, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 312, 4, p. L542-L555 14 p.

  Research output: Contribution to journal › Article › Academic › peer-review

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  26 Citations (Scopus)

  302 Downloads (Pure)
• 2016

  Atopy and Inhaled Corticosteroid Use Associate with Fewer IL-17(+) Cells in Asthmatic Airways

  Fattahi, F., Brandsma, C-A., Lodewijk, M., Reinders-Luinge, M., Postma, D. S., Timens, W., Hylkema, M. N. & Hacken, ten, N., 23-Aug-2016, In: PLoS ONE. 11, 8, 12 p., e0161433.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

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  8 Citations (Scopus)

  260 Downloads (Pure)
• 2015

  Correction: Susceptibility to Chronic Mucus Hypersecretion, a Genome Wide Association Study

  Dijkstra, A. E., Smolonska, J., van den Berge, M., Wijmenga, C., Zanen, P., Luinge, M. A., Platteel, M., Lammers, J-W., Dahlback, M., Tosh, K., Hiemstra, P. S., Sterk, P. J., Spira, A., Vestbo, J., Nordestgaard, B. G., Benn, M., Nielsen, S. F., Dahl, M., Verschuren, W. M., Picavet, H. S. J., & 31 othersSmit, H. A., Owsijewitsch, M., Kauczor, H. U., de Koning, H. J., Nizankowska-Mogilnicka, E., Mejza, F., Nastalek, P., van Diemen, C. C., Cho, M. H., Silverman, E. K., Crapo, J. D., Beaty, T. H., Lomas, D. A., Bakke, P., Gulsvik, A., Bossé, Y., Obeidat, M., Loth, D. W., Lahousse, L., Rivadeneira, F., Uitterlinden, A. G., Hofman, A., Brouwer, U., Koppelman, G. H., Vonk, J. M., Nawijn, M. C., Groen, H. J. M., Timens, W., Boezen, H. M., Postma, D. S. & Lifelines Cohort Study, 30-May-2015, In: PLoS ONE. 10, 5, 1 p., e0129524.

  Research output: Contribution to journal › Erratum

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  385 Downloads (Pure)

• Distinct macrophage phenotypes in allergic and nonallergic lung inflammation

  Robbe, P., Draijer, C., Rebelo Borg, T., Luinge, M., Timens, W., Wouters, I. M., Melgert, B. N. & Hylkema, M. N., Feb-2015, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 308, 4, p. L358-L367 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review

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  86 Citations (Scopus)

  5 Downloads (Pure)

• Farm dust directs phenotype-specific macrophage activation which may contribute to protection against Th2-related disorders

  Gonçalves Dias Pereira, P., Draijer, C., Borg, T. R., Luinge, M., Timens, W., Wouters, I. M., Melgert, B. & Hylkema, M., 2015, Farming exposure and asthma phenotypes in mice and men. Groningen: Rijksuniversiteit Groningen, p. 139-147 9 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic

  Open Access

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• Fluticasone propionate suppresses farm dust-induced airway hyperresponsiveness in mice but has no effect on lung neutrophils

  Gonçalves Dias Pereira, P., Draijer, C., Brandsma, C-A., Hesse, L., Luinge, M., Melgert, B., Timens, W., Wouters, I. M. & Hylkema, M., 2015, Farming exposure and asthma phenotypes in mice and men. Groningen: Rijksuniversiteit Groningen, p. 77-97 21 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic

  Open Access

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  2 Downloads (Pure)
• 2014

  Farm Dust Exposure Induces Corticosteroid Resistant Airway Neutrophilia In Mice

  Robbe, P., Draijer, C., Spierenburg, E., Brandsma, C., Hesse, L., Luinge, M., Melgert, B. N., Timens, W., Wouters, I. M. & Hylkema, M. N., 2014, In: American Journal of Respiratory and Critical Care Medicine. 189, 1 p.

  Research output: Contribution to journal › Meeting Abstract › Academic

• Mouse Protocadherin-1 Gene Expression Is Regulated by Cigarette Smoke Exposure In Vivo

  Koning, H., van Oosterhout, A. J. M., Brouwer, U., den Boef, L. E., Gras, R., Reinders-Luinge, M., Brandsma, C-A., van der Toorn, M., Hylkema, M. N., Willemse, B. W. M., Sayers, I., Koppelman, G. H. & Nawijn, M. C., 3-Jul-2014, In: PLoS ONE. 9, 7, 10 p., e98197.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

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  8 Citations (Scopus)

  282 Downloads (Pure)

• Pim1 kinase protects airway epithelial cells from cigarette smoke-induced damage and airway inflammation

  de Vries, M., Heijink, H., Gras, R., den Boef, L. E., Reinders-Luinge, M., Pouwels, S. D., Hylkema, M., van der Toorn, M., Brouwer, U., van Oosterhout, A. J. M. & Nawijn, M. C., 1-Aug-2014, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 307, 3, p. L240-L251 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  22 Citations (Scopus)

• Susceptibility to chronic mucus hypersecretion, a genome wide association study

  Dijkstra, A. E., Smolonska, J., van den Berge, M., Wijmenga, C., Zanen, P., Luinge, M. A., Platteel, M., Lammers, J-W., Dahlback, M., Tosh, K., Hiemstra, P. S., Sterk, P. J., Spira, A., Vestbo, J., Nordestgaard, B. G., Benn, M., Nielsen, S. F., Dahl, M., Verschuren, W. M., Picavet, H. S. J., & 31 othersSmit, H. A., Owsijewitsch, M., Kauczor, H. U., de Koning, H. J., Nizankowska-Mogilnicka, E., Mejza, F., Nastalek, P., van Diemen, C. C., Cho, M. H., Silverman, E. K., Crapo, J. D., Beaty, T. H., Lomas, D. A., Bakke, P., Gulsvik, A., Bosse, Y., Obeidat, M. A., Loth, D. W., Lahousse, L., Rivadeneira, F., Uitterlinden, A. G., Hofman, A., Brouwer, U., Koppelman, G. H., Vonk, J. M., Nawijn, M. C., Groen, H. J. M., Timens, W., Boezen, H., Postma, D. S. & Lifelines Cohort Study, 8-Apr-2014, In: PLoS ONE. 9, 4, 13 p., e91621.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

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  22 Citations (Scopus)

  224 Downloads (Pure)
• 2013

  Skewed Th17/th1 Immune Balance In Peripheral Blood Of Occupationally Exposed Agricultural Workers

  Robbe, P., Spierenburg, E., Draijer, C., Brandsma, C., Telenga, E. D., Oosterhout, A., Van den Berge, M., Luinge, M., Melgert, B. N., Heederik, D., Timens, W., Wouters, I. M. & Hylkema, M. N., 2013, In: American Journal of Respiratory and Critical Care Medicine. 187, 1 p.

  Research output: Contribution to journal › Meeting Abstract › Academic
• 2008

  Association of mast cells with lung function in chronic obstructive pulmonary disease

  Gosman, M. ME., Postma, D. S., Vonk, J. M., Rutgers, B., Lodewijk, M., Smith, M., Luinge, M. A., ten Hacken, N. H. T. & Timens, W., 10-Sept-2008, In: Respiratory Research. 9, 9 p., 64.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

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  33 Citations (Scopus)

  251 Downloads (Pure)

• Heme oxygenase-1 prevents smoke induced B-cell infiltrates: a role for regulatory T cells?

  Brandsma, C-A., Hylkema, M. N., van der Strate, B. W. A., Slebos, D-J., Luinge, M. A., Geerlings, M., Timens, W., Postma, D. S. & Kerstjens, H. A. M., 6-Feb-2008, In: Respiratory Research. 9, 12 p., 17.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

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  26 Citations (Scopus)

  219 Downloads (Pure)

• Proteomics analysis of Hodgkin lymphoma: identification of new players involved in the cross-talk between HRS cells and infiltrating lymphocytes

  Ma, Y., Visser, L., Roelofsen, J., de Vries, M., Diepstra, A., van Imhoff, G., van der Wal, T., Luinge, M., Alvarez Llamas, G., Vos, H., Poppema, S., Vonk, R. & van den Berg, A., 15-Feb-2008, In: Blood. 111, 4, p. 2339-2346 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  104 Citations (Scopus)
• 2007

  Het identificeren van mijlpalen in de taalontwikkeling van kinderen van 1 tot 6 jaar

  Luinge, M. R., Post, W. J. & Goorhuis-Brouwer, S. M., 2007, In: Stem-, spraak- en taalpathologie. 15, 1, p. 33-52 20 p.

  Research output: Contribution to journal › Article › Academic

  Open Access

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  649 Downloads (Pure)

• Spreeknormen voor jonge kinderen: van GMS naar SNEL

  Goorhuis-Brouwer, S. M., Luinge, M. R. & Post, W. J., 2007, In: Tijdschrift voor Jeugdgezondheidszorg. 39, p. 9-14 6 p.

  Research output: Contribution to journal › Article › Academic

• The language screening instrument SNEL

  Luinge, M. R., Post, W. J. & Goorhuis-Brouwer, S. M., 2007, In: Educational & Child Psychology. 24, p. 18-28 11 p.

  Research output: Contribution to journal › Article › Academic

  4 Citations (Scopus)