Research output per year
Research output per year
Personal profile
Research interests
Applied Research Activities
Structure-based drug design in human diseases
Basic Research Activities
Structural, biochemical and molecular biology investigation of malarial pathways:
Carbon metabolism in P falciparum
Vitamin biosynthesis in P. falciparum
Method Developments
Crystal identification for structural biology
Biological imaging on free-electron lasers
Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Actionability of on-target ALK Resistance Mutations in Patients With Non-Small Cell Lung Cancer: Local Experience and Review of the Literature
Koopman, B., Groen, H. J. M., Schuuring, E., Hiltermann, J., Timens, W., den Dunnen, W. F. A., van den Berg, A., ter Elst, A., van Kruchten, M., Kluiver, J., Hiddinga, B., Hijmering-Kappelle, L., Groves, M., Vilachá Madeira R Santos, J., van Kempen, L. & van der Wekken, A. J., Mar-2022, In: Clinical lung cancer. 23, 2, p. e104-e115 12 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile16 Downloads (Pure) -
Design, synthesis and biological evaluation of 1,5-disubstituted α-amino tetrazole derivatives as non-covalent inflammasome-caspase-1 complex inhibitors with potential application against immune and inflammatory disorders
Ulgheri, F., Spanu, P., Deligia, F., Loriga, G., Fuggetta, M. P., de Haan, I., Chandgudge, A., Groves, M. & Domling, A., 5-Feb-2022, In: European Journal of Medicinal Chemistry. 229, 114002.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile -
Feasibility of Follow-Up Studies and Reclassification in Spinocerebellar Ataxia Gene Variants of Unknown Significance
Ghorbani, F., Alimohamed, M. Z., Vilacha, J. F., Van Dijk, K. K., De Boer-Bergsma, J., Fokkens, M. R., Lemmink, H., Sijmons, R. H., Sikkema-Raddatz, B., Groves, M. R., Verschuuren-Bemelmans, C. C., Verbeek, D. S., Van Diemen, C. C. & Westers, H., 25-Mar-2022, In: Frontiers in Genetics. 13, 13 p., 782685.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile2 Downloads (Pure) -
First crystal structures of 1-deoxy-D-xylulose 5-phosphate synthase (DXPS) from Mycobacterium tuberculosis indicate a distinct mechanism of intermediate stabilization
Gierse, R. M., Oerlemans, R., Reddem, E. R., Gawriljuk, V. O., Alhayek, A., Baitinger, D., Jakobi, H., Laber, B., Lange, G., Hirsch, A. K. H. & Groves, M. R., 25-Mar-2022, In: Scientific Reports. 12, 1, 13 p., 7221.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile -
Novel Highlight in Malarial Drug Discovery: Aspartate Transcarbamoylase
Wang, C., Krüger, A., Du, X., Wrenger, C. & Groves, M. R., 4-Mar-2022, In: Frontiers in Cellular and Infection Microbiology. 12, 9 p., 841833.Research output: Contribution to journal › Review article › Academic › peer-review
Open AccessFile1 Downloads (Pure)
Activities
- 1 Organising and contributing to an event
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Pharmacy Day 2018
Anna Salvati (Organiser), Amalia Dolga (Organiser), Matthew Groves (Organiser), Klaus Mathwig (Organiser), Peter Horvatovich (Organiser), Wim J. Quax (Organiser), Anne Lexmond (Organiser) & Gillian Dempsey (Organiser)
12-Jun-2018Activity: Organising and attending an event › Organising and contributing to an event › Academic