Research output per year
Research output per year
- 23 results
Search results
-
2022
Coenzyme A precursors flow from mother to zygote and from microbiome to host
Yu, Y., van der Zwaag, M., Wedman, J. J., Permentier, H., Plomp, N., Jia, X., Kanon, B., Eggens-Meijer, E., Buist, G., Harmsen, H., Kok, J., Salles, J. F., Wertheim, B., Hayflick, S. J., Strauss, E., Grzeschik, N. A., Schepers, H. & Sibon, O. C. M., 21-Jul-2022, In: Molecular Cell. 82, 14, p. 2650-2665.e12 29 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile11 Citations (Scopus)175 Downloads (Pure) -
2021
Coenzyme A levels influence protein acetylation, CoAlation and 4'-phosphopantetheinylation: Expanding the impact of a metabolic nexus molecule
Yu, Y., Moretti, I. F., Grzeschik, N. A., Sibon, O. C. M. & Schepers, H., Apr-2021, In: Biochimica et Biophysica Acta - Molecular Cell Research. 1868, 4, 6 p., 118965.Research output: Contribution to journal › Review article › peer-review
Open AccessFile11 Citations (Scopus)91 Downloads (Pure) -
2020
Vps13 is required for timely removal of nurse cell corpses
Faber, A. I. E., van der Zwaag, M., Schepers, H., Eggens-Meijer, E., Kanon, B., IJsebaart, C., Kuipers, J., Giepmans, B. N. G., Freire, R., Grzeschik, N. A., Rabouille, C. & Sibon, O. C. M., 29-Oct-2020, In: DEVELOPMENT. 147, 20, 15 p., 191759.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile9 Citations (Scopus)149 Downloads (Pure) -
2019
CoA-dependent activation of mitochondrial acyl carrier protein links four neurodegenerative diseases
Lambrechts, R. A., Schepers, H., Yu, Y., van der Zwaag, M., Autio, K. J., Vieira-Lara, M. A., Bakker, B. M., Tijssen, M. A., Hayflick, S. J., Grzeschik, N. A. & Sibon, O. C., 7-Nov-2019, In: EMBO Molecular Medicine. 21 p., 10488.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile47 Citations (Scopus)266 Downloads (Pure) -
Human VPS13A is associated with multiple organelles and influences mitochondrial morphology and lipid droplet motility
Yeshaw, W. M., van der Zwaag, M., Pinto, F., Lahaye, L. L., Faber, A. I., Gómez-Sánchez, R., Dolga, A. M., Poland, C., Monaco, A. P., van IJzendoorn, S., Grzeschik, N. A., Velayos-Baeza, A. & Sibon, O. C., 11-Feb-2019, In: eLife. 8, 37 p., 43561.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile112 Citations (Scopus)1811 Downloads (Pure) -
North Sea Progressive Myoclonus Epilepsy is Exacerbated by Heat, A Phenotype Primarily Associated with Affected Glia
Lambrechts, R. A., Polet, S. S., Hernandez-Pichardo, A., van Ninhuys, L., Gorter, J. A., Grzeschik, N. A., de Koning-Tijssen, M. A. J., de Koning, T. J. & Sibon, O. C. M., 15-Dec-2019, In: Neuroscience. 423, p. 1-11 11 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile10 Citations (Scopus)308 Downloads (Pure) -
2018
Mutations in PPCS, Encoding Phosphopantothenoylcysteine Synthetase, Cause Autosomal-Recessive Dilated Cardiomyopathy
Iuso, A., Wiersma, M., Schüller, H.-J., Pode-Shakked, B., Marek-Yagel, D., Grigat, M., Schwarzmayr, T., Berutti, R., Alhaddad, B., Kanon, B., Grzeschik, N. A., Okun, J. G., Perles, Z., Salem, Y., Barel, O., Vardi, A., Rubinshtein, M., Tirosh, T., Dubnov-Raz, G. & Messias, A. C. & 18 others, , 7-Jun-2018, In: American Journal of Human Genetics. 102, 6, p. 1018-1030 13 p.Research output: Contribution to journal › Article › Academic › peer-review
47 Citations (Scopus) -
2017
Acetyl-4'-phosphopantetheine is stable in serum and prevents phenotypes induced by pantothenate kinase deficiency
Di Meo, I., Colombelli, C., Srinivasan, B., de Villiers, M., Hamada, J., Jeong, S. Y., Fox, R., Woltjer, R. L., Tepper, P. G., Lahaye, L. L., Rizzetto, E., Harrs, C. H., de Boer, T., van der Zwaag, M., Jenko, B., Čusak, A., Pahor, J., Kosec, G., Grzeschik, N. A. & Hayflick, S. J. & 2 others, , 12-Sept-2017, In: Scientific Reports. 7, 1, 12 p., 11260.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile28 Citations (Scopus)446 Downloads (Pure) -
A Kinome RNAi Screen in Drosophila Identifies Novel Genes Interacting with Lgl, aPKC, and Crb Cell Polarity Genes in Epithelial Tissues
Parsons, L. M., Grzeschik, N. A., Amaratunga, K., Burke, P., Quinn, L. M. & Richardson, H. E., 1-Aug-2017, In: G3 : Genes, Genomes, Genetics. 7, 8, p. 2497-2509 13 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile10 Citations (Scopus)247 Downloads (Pure) -
Drosophila Vps13 Is Required for Protein Homeostasis in the Brain
Vonk, J. J., Yeshaw, W. M., Pinto, F., Faber, A. I. E., Lahaye, L. L., Kanon, B., van der Zwaag, M., Velayos-Baeza, A., Freire, R., van IJzendoorn, S. C., Grzeschik, N. A. & Sibon, O. C. M., 20-Jan-2017, In: PLoS ONE. 12, 1, 21 p., e0170106.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile30 Citations (Scopus)389 Downloads (Pure) -
Note of concern: Guanine quadruplex structures localize to heterochromatin
Hoffmann, R. F., Moshkin, Y. M., Mouton, S., Grzeschik, N. A., Kalicharan, R. D., Kuipers, J., Wolters, A. H. G., Nishida, K., Romashchenko, A. V., Postberg, J., Lipps, H., Berezikov, E., Sibon, O. C. M., Giepmans, B. N. G. & Lansdorp, P. M., 2-Jun-2017, In: Nucleic Acids Research. 45, 10, p. 6253-6253 1 p.Research output: Contribution to journal › Editorial › Academic › peer-review
Open AccessFile3 Citations (Scopus)250 Downloads (Pure) -
2016
Guanine quadruplex structures localize to heterochromatin
Hoffmann, R. F., Moshkin, Y. M., Mouton, S., Grzeschik, N. A., Kalicharan, R. D., Kuipers, J., Wolters, A. H. G., Nishida, K., Romashchenko, A. V., Postberg, J., Lipps, H., Berezikov, E., Sibon, O. C. M., Giepmans, B. N. G. & Lansdorp, P. M., 8-Jan-2016, In: Nucleic Acids Research. 44, 1, p. 152-163 12 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile55 Citations (Scopus)338 Downloads (Pure) -
2015
Extracellular 4 '-phosphopantetheine is a source for intracellular coenzyme A synthesis
Srinivasan, B., Baratashvili, M., van der Zwaag, M., Kanon, B., Colombelli, C., Lambrechts, R. A., Schaap, O., Nollen, E. A., Podgorsek, A., Kosec, G., Petkovic, H., Hayflick, S., Tiranti, V., Reijngoud, D.-J., Grzeschik, N. A. & Sibon, O. C. M., Oct-2015, In: Nature Chemical Biology. 11, 10, p. 784-792.e3 12 p.Research output: Contribution to journal › Article › Academic › peer-review
96 Citations (Scopus) -
Overexpression of Cystathionine gamma-Lyase Suppresses Detrimental Effects of Spinocerebellar Ataxia Type 3
Snijder, P. M., Baratashvili, M., Grzeschik, N. A., Leuvenink, H. G. D., Kuijpers, L., Huitema, S., Schaap, O., Giepmans, B. N. G., Kuipers, J., Miljkovic, J. L., Mitrovic, A., Bos, E. M., Szabo, C., Kampinga, H. H., Dijkers, P. F., den Dunnen, W. F. A., Filipovic, M. R., van Goor, H. & Sibon, O. C. M., 2015, In: Molecular medicine. 21, p. 758-768 11 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile37 Citations (Scopus)322 Downloads (Pure) -
Regulation of Notch signaling and endocytosis by the Lgl neoplastic tumor suppressor
Portela, M., Parsons, L. M., Grzeschik, N. A. & Richardson, H. E., 19-May-2015, In: Cell Cycle. 14, 10, p. 1496-1506 11 p.Research output: Contribution to journal › Article › Academic › peer-review
17 Citations (Scopus) -
2014
Lgl Regulates Notch Signaling via Endocytosis, Independently of the Apical aPKC-Par6-Baz Polarity Complex
Parsons, L. M., Portela, M., Grzeschik, N. A. & Richardson, H. E., 22-Sept-2014, In: Current Biology. 24, 18, p. 2073-2084 12 p.Research output: Contribution to journal › Article › Academic › peer-review
33 Citations (Scopus) -
Lgl regulates the hippo pathway independently of Fat/Dachs, Kibra/Expanded/Merlin and dRASSF/dSTRIPAK
Parsons, L. M., Grzeschik, N. A. & Richardson, H. E., 1-Jun-2014, In: Cancers. 6, 2, p. 879-896 18 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile13 Citations (Scopus)289 Downloads (Pure) -
2012
Cofilin/Twinstar Phosphorylation Levels Increase in Response to Impaired Coenzyme A Metabolism
Siudeja, K., Grzeschik, N. A., Rana, A., de Jong, J. & Sibon, O. C. M., 17-Aug-2012, In: PLoS ONE. 7, 8, 9 p., e43145.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile14 Citations (Scopus)254 Downloads (Pure) -
2010
Lgl, aPKC, and Crumbs Regulate the Salvador/Warts/Hippo Pathway through Two Distinct Mechanisms
Grzeschik, N. A., Parsons, L. M., Allott, M. L., Harvey, K. F. & Richardson, H. E., 13-Apr-2010, In: Current Biology. 20, 7, p. 573-581 9 p.Research output: Contribution to journal › Article › Academic › peer-review
295 Citations (Scopus) -
Lgl, the SWH pathway and tumorigenesis It's a matter of context & competition!
Grzeschik, N. A., Parsons, L. M. & Richardson, H. E., 15-Aug-2010, In: Cell Cycle. 9, 16, p. 3202-3212 11 p.Research output: Contribution to journal › Article › Academic › peer-review
35 Citations (Scopus) -
Lgl/aPKC and Crb regulate the Salvador/Warts/Hippo pathway
Parsons, L. M., Grzeschik, N. A., Allott, M. L. & Richardson, H. E., 2010, In: Fly. 4, 4, p. 288-293 6 p.Research output: Contribution to journal › Article › Academic › peer-review
34 Citations (Scopus) -
2009
Lgl acts antagonistically to Crumbs and aPKC to regulate the Salvador/Warts/Hippo pathway
Grzeschik, N. A., Parsons, L. M., Allott, M. L., Harvey, K. F. & Richardson, H. E., Aug-2009, In: Mechanisms of development. 126, p. S61-S61 1 p.Research output: Contribution to journal › Meeting Abstract › Academic
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Modelling cancer in Drosophila: The junctional neoplastic tumour suppressors, Lgl, Dlg and Scrib, in cell proliferation control and tumourigenesis
Richardson, H., Grzeschik, N., Parsons, L., Allott, M., Turkel, N., Goulding, K., Boulden, J., Harvey, K., Martin-Blanco, E. & Brumby, A., Aug-2009, In: Mechanisms of development. 126, p. S26-S26 1 p.Research output: Contribution to journal › Meeting Abstract › Academic