Research output per year
Research output per year
Research output
Search results
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2020
A common variant in CCDC93 protects against myocardial infarction and cardiovascular mortality by regulating endosomal trafficking of low-density lipoprotein receptor
Biobank Based Int, 1-Mar-2020, In : European Heart Journal. 41, 9, p. 1040-1053 14 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile -
A human-like bile acid pool induced by deletion of hepatic Cyp2c70 modulates effects of FXR activation in mice[S]
de Boer, J. F., Verkade, E., Mulder, N. L., de Vries, H. D., Huijkman, N. C., Koehorst, M., Boer, T., Wolters, J. C., Bloks, V. W., van de Sluis, B. & Kuipers, F., Mar-2020, In : Journal of Lipid Research. 61, 3, p. 291-305 15 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile -
Taking One Step Back in Familial Hypercholesterolemia: STAP1 Does Not Alter Plasma LDL (Low-Density Lipoprotein) Cholesterol in Mice and Humans
Loaiza, N., Hartgers, M. L., Reeskamp, L. F., Balder, J-W., Rimbert, A., Bazioti, V., Wolters, J. C., Winkelmeijer, M., Jansen, H. P. G., Dallinga-Thie, G. M., Volta, A., Huijkman, N., Smit, M., Kloosterhuis, N., Koster, M., Flohr Svendsen, A., van de Sluis, B., Hovingh, G. K., Grefhorst, A. & Kuivenhoven, J. A., Apr-2020, In : Arteriosclerosis thrombosis and vascular biology. 40, 4, p. 973-985 13 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile -
2019
A humanized bile acid pool induced by somatic CRISPR/Cas9-mediated deletion of Cyp2c70 modulates effects of pharmacological FXR activation in mice
de Boer, J. F., Verkade, E., Mulder, N. L., de Vries, H. D., Huijkman, N., Koehorst, M., Boer, T., Wolters, J. C., Bloks, V. W., van de Sluis, B. & Kuipers, F., Apr-2019, In : Journal of Hepatology. 70, p. E25-E26 2 p.Research output: Contribution to journal › Meeting Abstract › Academic
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FXR overexpression alters adipose tissue architecture in mice and limits its storage capacity leading to metabolic derangements[S]
van Zutphen, T., Stroeve, J. H. M., Yang, J., Bloks, V. W., Jurdzinski, A., Roelofsen, H., Huijkman, N. C. A., van Dijk, T. H., Vonk, R. J., van Deursen, J., Staels, B., Groen, A. K. & Kuipers, F., Sep-2019, In : Journal of Lipid Research. 60, 9, p. 1547-1561 15 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile -
Partial Deletion of Tie2 Affects Microvascular Endothelial Responses to Critical Illness in A Vascular Bed and Organ-Specific Way
Jongman, R. M., Zwiers, P. J., van de Sluis, B., van der Laan, M., Moser, J., Zijlstra, J. G., Dekker, D., Huijkman, N., Moorlag, H. E., Popa, E. R., Molema, G. & van Meurs, M., Jun-2019, In : Shock. 51, 6, p. 757-769 13 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile -
The hepatic WASH complex is required for efficient plasma LDL and HDL cholesterol clearance
Wijers, M., Zanoni, P., Liv, N., Vos, D. Y., Jackstein, M. Y., Smit, M., Wilbrink, S., Wolters, J. C., van der Veen, Y. T., Huijkman, N., Dekker, D., Kloosterhuis, N., van Dijk, T. H., Billadeau, D. D., Kuipers, F., Klumperman, J., von Eckardstein, A., Kuivenhoven, J. A. & van de Sluis, B., 6-Jun-2019, In : JCI Insight. 4, 11, 16 p., 126462.Research output: Contribution to journal › Article › Academic › peer-review
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2018
The COMMD Family Regulates Plasma LDL Levels and Attenuates Atherosclerosis Through Stabilizing the CCC Complex in Endosomal LDLR Trafficking
Fedoseienko, A., Wijers, M., Wolters, J. C., Dekker, D., Smit, M., Huijkman, N., Kloosterhuis, N., Klug, H., Schepers, A., Willems van Dijk, K., Levels, J. H. M., Billadeau, D. D., Hofker, M. H., van Deursen, J., Westerterp, M., Burstein, E., Kuivenhoven, J. A. & van de Sluis, B., 8-Jun-2018, In : Circulation research. 122, 12, p. 1648-1660 13 p.Research output: Contribution to journal › Article › Academic › peer-review
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2017
NF-kappa B p65 serine 467 phosphorylation sensitizes mice to weight gain and TNF alpha-or diet-induced inflammation
Riedlinger, T., Dommerholt, M. B., Wijshake, T., Kruit, J. K., Huijkman, N., Dekker, D., Koster, M., Kloosterhuis, N., Koonen, D. P. Y., de Bruin, A., Baker, D., Hofker, M. H., van Deursen, J., Jonker, J. W., Schmitz, M. L. & van de Sluis, B., Oct-2017, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1864, 10, p. 1785-1798 14 p.Research output: Contribution to journal › Article › Academic › peer-review
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2016
CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL
Bartuzi, P., Billadeau, D. D., Favier, R., Rong, S., Dekker, D., Fedoseienko, A., Fieten, H., Wijers, M., Levels, J. H., Huijkman, N., Kloosterhuis, N., van der Molen, H., Brufau, G., Groen, A. K., Elliott, A. M., Kuivenhoven, J. A., Plecko, B., Grangl, G., McGaughran, J., Horton, J. D. & 3 others, , Mar-2016, In : Nature Communications. 7, 11 p., 10961.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile -
2013
IL-1 beta and TGF beta 2 synergistically induce endothelial to mesenchymal transition in an NF kappa B-dependent manner
Maleszewska, M., Moonen, J-R. A. J., Huijkman, N., van de Sluis, B., Krenning, G. & Harmsen, M. C., Apr-2013, In : Immunobiology. 218, 4, p. 443-454 12 p.Research output: Contribution to journal › Article › Academic › peer-review
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2012
Sex-Dependent Programming of Glucose and Fatty Acid Metabolism in Mouse Offspring by Maternal Protein Restriction
van Straten, E. M. E., Bloks, V. W., van Dijk, T. H., Baller, J. F. W., Huijkman, N. C. A., Kuipers, I., Verkade, H. J. & Plosch, T., Jun-2012, In : Gender medicine. 9, 3, p. 166-179 14 p.Research output: Contribution to journal › Article › Academic › peer-review
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2010
The Liver X Receptor (LXR) and its Target Gene ABCA1 are Regulated Upon Low Oxygen in Human Trophoblast Cells: A Reason for Alterations in Preeclampsia?
Plosch, T., Gellhaus, A., van Straten, E. M. E., Wolf, N., Huijkman, N. C. A., Schmidt, M., Dunk, C. E., Kuipers, F. & Winterhager, E., Oct-2010, In : Placenta. 31, 10, p. 910-918 9 p.Research output: Contribution to journal › Article › Academic › peer-review
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The liver X-receptor gene promoter is hypermethylated in a mouse model of prenatal protein restriction
van Straten, E. M. E., Bloks, V. W., Huijkman, N. C. A., Baller, J. F. W., van Meer, H., Lutjohann, D., Kuipers, F. & Plosch, T., Feb-2010, In : American journal of physiology-Regulatory integrative and comparative physiology. 298, 2, p. R275-R282 8 p.Research output: Contribution to journal › Article › Academic › peer-review
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2009
Fetal liver X receptor activation acutely induces lipogenesis but does not affect plasma lipid response to a high-fat diet in adult mice
van Straten, E. M. E., van Meer, H., Huijkman, N. C. A., van Dijk, T. H., Baller, J. F. W., Verkade, H. J., Kuipers, F. & Plosch, T., Nov-2009, In : American Journal of Physiology - Endocrinology and Metabolism. 297, 5, p. E1171-E1178 8 p.Research output: Contribution to journal › Article › Academic › peer-review
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2008
Pharmacological activation of LXR in utero directly influences ABC transporter expression and function in mice but does not affect adult cholesterol metabolism
van Straten, E. M. E., Huijkman, N. C. A., Baller, J. F. W., Kuipers, F. & Plosch, T., Dec-2008, In : American Journal of Physiology - Endocrinology and Metabolism. 295, 6, p. E1341-E1348 8 p.Research output: Contribution to journal › Article › Academic › peer-review
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2006
Abcg5/Abcg8-independent pathways contribute to hepatobiliary cholesterol secretion in mice
Plosch, T., van der Veen, J. N., Havinga, R., Huijkman, N. C. A., Bloks, V. W. & Kuipers, F., Sep-2006, In : American Journal of Physiology-Gastrointestinal and Liver Physiology. 291, 3, p. G414-G423 10 p.Research output: Contribution to journal › Article › Academic › peer-review
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Reduction of cholesterol absorption by dietary plant sterols and stanols in mice is independent of the Abcg5/8 transporter
Plosch, T., Kruit, J. K., Bloks, V. W., Huijkman, N. C. A., Havinga, R., Duchateau, G. S. M. J. E., Lin, Y. & Kuipers, F., Aug-2006, In : Journal of Nutrition. 136, 8, p. 2135-2140 6 p.Research output: Contribution to journal › Article › Academic › peer-review
79 Citations (Scopus) -
2003
Cloning and expression of the liver and muscle isoforms of ovine carnitine palmitoyltransferase 1: residues within the N-terminus of the muscle isoform influence the kinetic properties of the enzyme
Price, NT., Jackson, VN., van der Leij, FR., Cameron, JM., Travers, MT., Bartelds, B., Huijkman, NC. & Zammit, VA., 15-Jun-2003, In : Biochemical Journal. 372, p. 871-879 9 p.Research output: Contribution to journal › Article › Academic › peer-review
22 Citations (Scopus) -
2002
Structural and functional genomics of the CPT1B gene for muscle-type carnitine palmitoyltransferase I in mammals
van der Leij, FR., Cox, KB., Jackson, VN., Huijkman, NCA., Bartelds, B., Kuipers, JRG., Dijkhuizen, T., Terpstra, P., Wood, PA., Zammit, VA. & Price, NT., 26-Jul-2002, In : The Journal of Biological Chemistry. 277, 30, p. 26994-27005 12 p.Research output: Contribution to journal › Article › Academic › peer-review
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2000
Genomics of the human carnitine acyltransferase genes
van der Leij, FR., Huijkman, NCA., Boomsma, C., Kuipers, JRG. & Bartelds, B., 2000, In : Molecular Genetics and Metabolism. 71, 1-2, p. 139-153 15 p.Research output: Contribution to journal › Review article › Academic › peer-review
75 Citations (Scopus)