Nicolette Huijkman

2025

SMC Abca1 and Abcg1 Deficiency Enhances Urinary Bladder Distension but Not Atherosclerosis

Halmos, B., La Rose, A. M., Methorst, D., Groenen, A. G., Nakládal, D., Bazioti, V., Koster, M. H., Kloosterhuis, N. J., Buiten, A. V., Schouten, E. M., Huijkman, N. C. A., Langelaar-Makkinje, M., Bongiovanni, L., De Neck, S. M., de Bruin, A., Buikema, H., Deelman, L. E., van den Heuvel, M. C., Kuipers, F. & de Jong, I. J. & 4 others, Sluimer, J. C., Jørgensen, H. F., Henning, R. H. & Westerterp, M., 28-Feb-2025, In: Circulation Research. 136, 5, p. 491-507 17 p.

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33 Downloads (Pure)

2024

ERICH4 is not involved in the assembly and secretion of intestinal lipoproteins

Visser, A., van Zwol, W., Kloosterhuis, N., Huijkman, N., Smit, M., Koster, M., Bloks, V., Hussain, M. M., van de Sluis, B. & Kuivenhoven, J. A., Dec-2024, In: Atherosclerosis. 399, 10 p., 118635.

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85 Downloads (Pure)

2023

Cargo-Specific Role for Retriever Subunit VPS26C in Hepatocyte Lipoprotein Receptor Recycling to Control Postprandial Triglyceride-Rich Lipoproteins

Vos, D. Y., Wijers, M., Smit, M., Huijkman, N., Kloosterhuis, N. J., Wolters, J. C., Tissink, J. J., Pronk, A. C. M., Kooijman, S., Rensen, P. C. N., Kuivenhoven, J. A. & van de Sluis, B., 1-Jan-2023, In: Arteriosclerosis, thrombosis, and vascular biology. 43, 1, p. e29-e45

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9 Citations (Scopus)

139 Downloads (Pure)

Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion

van Zwol, W., Rimbert, A., Wolters, J. C., Smit, M., Bloks, V. W., Kloosterhuis, N. J., Huijkman, N., Koster, M. H., Tharehalli, U., de Neck, S. M., Bournez, C., Fuh, M. M., Kuipers, J., Rajan, S., de Bruin, A., Ginsberg, H. N., van Westen, G. J. P., Hussain, M. M., Scheja, L. & Heeren, J. & 3 others, Zimmerman, P., van de Sluis, B. & Kuivenhoven, J. A., Nov-2023, In: Hepatology. 78, 5, p. 1418-1432 15 p.

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13 Citations (Scopus)

109 Downloads (Pure)

Personalised modelling of clinical heterogeneity between medium-chain acyl-CoA dehydrogenase patients

Odendaal, C., Jager, E. A., Martines, A.-C. M. F., Vieira-Lara, M. A., Huijkman, N. C. A., Kiyuna, L. A., Gerding, A., Wolters, J. C., Heiner-Fokkema, R., van Eunen, K., Derks, T. G. J. & Bakker, B. M., 4-Sept-2023, In: BMC Biology. 21, 22 p., 184.

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5 Citations (Scopus)

91 Downloads (Pure)

Selective Hepatic Cbs Knockout Aggravates Liver Damage, Endothelial Dysfunction and ROS Stress in Mice Fed a Western Diet

Lambooy, S., Heida, A., Joschko, C., Nakladal, D., van Buiten, A., Kloosterhuis, N., Huijkman, N., Gerding, A., van de Sluis, B., Henning, R. & Deelman, L., 10-Apr-2023, In: International Journal of Molecular Sciences. 24, 8, 19 p., 7019.

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7 Citations (Scopus)

115 Downloads (Pure)

2022

Butyrate oxidation attenuates the butyrate-induced improvement of insulin sensitivity in myotubes

Rios-Morales, M., Vieira-Lara, M. A., Homan, E., Langelaar-Makkinje, M., Gerding, A., Li, Z., Huijkman, N., Rensen, P. C. N., Wolters, J. C., Reijngoud, D.-J. & Bakker, B. M., 1-Nov-2022, In: Biochimica et biophysica acta-Molecular basis of disease. 1868, 11, 13 p., 166476.

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13 Citations (Scopus)

180 Downloads (Pure)

Homozygous whole body Cbs knockout in adult mice features minimal pathology during ageing despite severe homocysteinemia

Nakladal, D., Lambooy, S. P. H., Mišúth, S., Čepcová, D., Joschko, C. P., van Buiten, A., Goris, M., Hoogstra-Berends, F., Kloosterhuis, N. J., Huijkman, N., van de Sluis, B., Diercks, G. F., Buikema, J. H., Henning, R. H. & Deelman, L. E., Apr-2022, In: The FASEB Journal. 36, 4, 16 p., 22260.

Research output: Contribution to journal › Article › Academic › peer-review

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11 Citations (Scopus)

227 Downloads (Pure)

Mice with a deficiency in Peroxisomal Membrane Protein 4 (PXMP4) display mild changes in hepatic lipid metabolism

Blankestijn, M., Bloks, V. W., Struik, D., Huijkman, N., Kloosterhuis, N., Wolters, J. C., Wanders, R. J. A., Vaz, F. M., Islinger, M., Kuipers, F., van de Sluis, B., Groen, A. K., Verkade, H. J. & Jonker, J. W., 15-Feb-2022, In: Scientific Reports. 12, 1, 13 p., 2512.

Research output: Contribution to journal › Article › Academic › peer-review

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10 Citations (Scopus)

103 Downloads (Pure)

Posttranscriptional Regulation of the Human LDL Receptor by the U2-Spliceosome

Zanoni, P., Panteloglou, G., Othman, A., Haas, J. T., Meier, R., Rimbert, A., Futema, M., Abou-Khalil, Y., Nørrelykke, S. F., Rzepiela, A., Stoma, S., Stebler, M., Dijk, F. V., Wijers, M., Wolters, J. C., Dalila, N., Huijkman, N., Smit, M., Gallo, A. & Carreau, V. & 26 others, Philippi, A., Rabès, J.-P., Boileau, C., Visentin, M., Vonghia, L., Weyler, J., Francque, S., Verrijken, A., Verhaegen, A., Van Gaal, L. F., van der Graaf, A., van Rosmalen, B. V., Robert, J., Velagapudi, S., Yalcinkaya, M., Keel, M., Radosavljevic, S., Geier, A., Tybjærg-Hansen, A., Varret, M., Rohrer, L., Humphries, S. E., Staels, B., van de Sluis, B., Kuivenhoven, J. A. & Von Eckardstein, A., 7-Jan-2022, In: Circulation Research. 130, 1, p. 80-95

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14 Citations (Scopus)

137 Downloads (Pure)

2021

Corrigendum to "NF-κB p65 serine 467 phosphorylation sensitizes mice to weight gain and TNFα-or diet-induced inflammation" [Biochim. Biophys. Acta Mol. Cell Res., 1864 (2017): 1785-1798]

Riedlinger, T., Dommerholt, M. B., Wijshake, T., Kruit, J. K., Huijkman, N., Dekker, D., Koster, M., Kloosterhuis, N., Koonen, D. P. Y., de Bruin, A., Baker, D., Hofker, M. H., van Deursen, J., Jonker, J. W., Lienhard Schmitz, M. & van de Sluis, B., May-2021, In: Biochimica et Biophysica Acta - Molecular Cell Research. 1868, 6, 2 p., 119008.

Research output: Contribution to journal › Erratum

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Modeling Phenotypic Heterogeneity of Glycogen Storage Disease Type 1a Liver Disease in Mice by Somatic CRISPR/CRISPR-associated protein 9-Mediated Gene Editing

Rutten, M. G. S., Derks, T. G. J., Huijkman, N. C. A., Bos, T., Kloosterhuis, N. J., van de Kolk, K. C. W. A., Wolters, J. C., Koster, M. H., Bongiovanni, L., Thomas, R. E., de Bruin, A., van de Sluis, B. & Oosterveer, M. H., Nov-2021, In: Hepatology. 74, 5, p. 2491-2507 17 p.

Research output: Contribution to journal › Article › Academic › peer-review

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9 Citations (Scopus)

159 Downloads (Pure)

2020

A common variant in CCDC93 protects against myocardial infarction and cardiovascular mortality by regulating endosomal trafficking of low-density lipoprotein receptor

Biobank Based Int, 1-Mar-2020, In: European Heart Journal. 41, 9, p. 1040-1053 14 p.

Research output: Contribution to journal › Article › Academic › peer-review

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19 Citations (Scopus)

172 Downloads (Pure)

A human-like bile acid pool induced by deletion of hepatic Cyp2c70 modulates effects of FXR activation in mice[S]

de Boer, J. F., Verkade, E., Mulder, N. L., de Vries, H. D., Huijkman, N. C., Koehorst, M., Boer, T., Wolters, J. C., Bloks, V. W., van de Sluis, B. & Kuipers, F., Mar-2020, In: Journal of Lipid Research. 61, 3, p. 291-305 15 p.

Research output: Contribution to journal › Article › Academic › peer-review

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106 Citations (Scopus)

289 Downloads (Pure)

Taking One Step Back in Familial Hypercholesterolemia: STAP1 Does Not Alter Plasma LDL (Low-Density Lipoprotein) Cholesterol in Mice and Humans

Loaiza, N., Hartgers,, M. L., Reeskamp, L. F., Balder, J.-W., Rimbert, A., Bazioti, V., Wolters, J. C., Winkelmeijer, M., Jansen, H. P. G., Dallinga-Thie, G. M., Volta, A., Huijkman, N., Smit, M., Kloosterhuis, N., Koster, M., Flohr Svendsen, A., van de Sluis, B., Hovingh, G. K., Grefhorst, A. & Kuivenhoven, J. A., Apr-2020, In: Arteriosclerosis thrombosis and vascular biology. 40, 4, p. 973-985 13 p.

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37 Citations (Scopus)

234 Downloads (Pure)

2019

A humanized bile acid pool induced by somatic CRISPR/Cas9-mediated deletion of Cyp2c70 modulates effects of pharmacological FXR activation in mice

de Boer, J. F., Verkade, E., Mulder, N. L., de Vries, H. D., Huijkman, N., Koehorst, M., Boer, T., Wolters, J. C., Bloks, V. W., van de Sluis, B. & Kuipers, F., Apr-2019, In: Journal of Hepatology. 70, p. E25-E26 2 p.

Research output: Contribution to journal › Meeting Abstract › Academic

FXR overexpression alters adipose tissue architecture in mice and limits its storage capacity leading to metabolic derangements[S]

van Zutphen, T., Stroeve, J. H. M., Yang, J., Bloks, V. W., Jurdzinski, A., Roelofsen, H., Huijkman, N. C. A., van Dijk, T. H., Vonk, R. J., van Deursen, J., Staels, B., Groen, A. K. & Kuipers, F., Sept-2019, In: Journal of Lipid Research. 60, 9, p. 1547-1561 15 p.

Research output: Contribution to journal › Article › Academic › peer-review

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25 Citations (Scopus)

494 Downloads (Pure)

Partial Deletion of Tie2 Affects Microvascular Endothelial Responses to Critical Illness in A Vascular Bed and Organ-Specific Way

Jongman, R. M., Zwiers, P. J., van de Sluis, B., van der Laan, M., Moser, J., Zijlstra, J. G., Dekker, D., Huijkman, N., Moorlag, H. E., Popa, E. R., Molema, G. & van Meurs, M., Jun-2019, In: Shock. 51, 6, p. 757-769 13 p.

Research output: Contribution to journal › Article › Academic › peer-review

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18 Citations (Scopus)

379 Downloads (Pure)

The hepatic WASH complex is required for efficient plasma LDL and HDL cholesterol clearance

Wijers, M., Zanoni, P., Liv, N., Vos, D. Y., Jackstein, M. Y., Smit, M., Wilbrink, S., Wolters, J. C., van der Veen, Y. T., Huijkman, N., Dekker, D., Kloosterhuis, N., van Dijk, T. H., Billadeau, D. D., Kuipers, F., Klumperman, J., von Eckardstein, A., Kuivenhoven, J. A. & van de Sluis, B., 6-Jun-2019, In: JCI Insight. 4, 11, 16 p., 126462.

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30 Citations (Scopus)

67 Downloads (Pure)

2018

The COMMD Family Regulates Plasma LDL Levels and Attenuates Atherosclerosis Through Stabilizing the CCC Complex in Endosomal LDLR Trafficking

Fedoseienko, A., Wijers, M., Wolters, J. C., Dekker, D., Smit, M., Huijkman, N., Kloosterhuis, N., Klug, H., Schepers, A., Willems van Dijk, K., Levels, J. H. M., Billadeau, D. D., Hofker, M. H., van Deursen, J., Westerterp, M., Burstein, E., Kuivenhoven, J. A. & van de Sluis, B., 8-Jun-2018, In: Circulation Research. 122, 12, p. 1648-1660 13 p.

Research output: Contribution to journal › Article › Academic › peer-review

98 Citations (Scopus)

2017

NF-kappa B p65 serine 467 phosphorylation sensitizes mice to weight gain and TNF alpha-or diet-induced inflammation

Riedlinger, T., Dommerholt, M. B., Wijshake, T., Kruit, J. K., Huijkman, N., Dekker, D., Koster, M., Kloosterhuis, N., Koonen, D. P. Y., de Bruin, A., Baker, D., Hofker, M. H., van Deursen, J., Jonker, J. W., Schmitz, M. L. & van de Sluis, B., Oct-2017, In: Biochimica et Biophysica Acta - Molecular Cell Research. 1864, 10, p. 1785-1798 14 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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11 Citations (Scopus)

93 Downloads (Pure)

Revealing the role of the endosmal sorting machinery in cholesterol homeostasis

Wijers, M., Fedoseienko, A., Wolters, K., Dekkers, D., Huijkman, N., Wilbrink, S., Kloosterhuis, N., Burstein, E., Billadeau, D., Kuivenhoven, J.-A. & Van De Sluis, B., 1-Aug-2017, In: Atherosclerosis. 263, p. e13 1 p.

Research output: Contribution to journal › Meeting Abstract › Academic

2016

CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL

Bartuzi, P., Billadeau, D. D., Favier, R., Rong, S., Dekker, D., Fedoseienko, A., Fieten, H., Wijers, M., Levels, J. H., Huijkman, N., Kloosterhuis, N., van der Molen, H., Brufau, G., Groen, A. K., Elliott, A. M., Kuivenhoven, J. A., Plecko, B., Grangl, G., McGaughran, J. & Horton, J. D. & 4 others, Burstein, E., Hofker, M. H., van de Sluis , B. & Wilbrink, S., Mar-2016, In: Nature Communications. 7, 11 p., 10961.

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154 Citations (Scopus)

420 Downloads (Pure)

2013

IL-1 beta and TGF beta 2 synergistically induce endothelial to mesenchymal transition in an NF kappa B-dependent manner

Maleszewska, M., Moonen, J.-R. A. J., Huijkman, N., van de Sluis, B., Krenning, G. & Harmsen, M. C., Apr-2013, In: Immunobiology. 218, 4, p. 443-454 12 p.

Research output: Contribution to journal › Article › Academic › peer-review

179 Citations (Scopus)

2012

Sex-Dependent Programming of Glucose and Fatty Acid Metabolism in Mouse Offspring by Maternal Protein Restriction

van Straten, E. M. E., Bloks, V. W., van Dijk, T. H., Baller, J. F. W., Huijkman, N. C. A., Kuipers, I., Verkade, H. J. & Plosch, T., Jun-2012, In: Gender medicine. 9, 3, p. 166-179 14 p.

Research output: Contribution to journal › Article › Academic › peer-review

16 Citations (Scopus)

2010

The Liver X Receptor (LXR) and its Target Gene ABCA1 are Regulated Upon Low Oxygen in Human Trophoblast Cells: A Reason for Alterations in Preeclampsia?

Plosch, T., Gellhaus, A., van Straten, E. M. E., Wolf, N., Huijkman, N. C. A., Schmidt, M., Dunk, C. E., Kuipers, F. & Winterhager, E., Oct-2010, In: Placenta. 31, 10, p. 910-918 9 p.

Research output: Contribution to journal › Article › Academic › peer-review

48 Citations (Scopus)

The liver X-receptor gene promoter is hypermethylated in a mouse model of prenatal protein restriction

van Straten, E. M. E., Bloks, V. W., Huijkman, N. C. A., Baller, J. F. W., van Meer, H., Lutjohann, D., Kuipers, F. & Plosch, T., Feb-2010, In: American journal of physiology-Regulatory integrative and comparative physiology. 298, 2, p. R275-R282 8 p.

Research output: Contribution to journal › Article › Academic › peer-review

127 Citations (Scopus)

2009

Fetal liver X receptor activation acutely induces lipogenesis but does not affect plasma lipid response to a high-fat diet in adult mice

van Straten, E. M. E., van Meer, H., Huijkman, N. C. A., van Dijk, T. H., Baller, J. F. W., Verkade, H. J., Kuipers, F. & Plosch, T., Nov-2009, In: American Journal of Physiology - Endocrinology and Metabolism. 297, 5, p. E1171-E1178 8 p.

Research output: Contribution to journal › Article › Academic › peer-review

11 Citations (Scopus)

2008

Pharmacological activation of LXR in utero directly influences ABC transporter expression and function in mice but does not affect adult cholesterol metabolism

van Straten, E. M. E., Huijkman, N. C. A., Baller, J. F. W., Kuipers, F. & Plosch, T., Dec-2008, In: American Journal of Physiology - Endocrinology and Metabolism. 295, 6, p. E1341-E1348 8 p.

Research output: Contribution to journal › Article › Academic › peer-review

15 Citations (Scopus)

2006

Abcg5/Abcg8-independent pathways contribute to hepatobiliary cholesterol secretion in mice

Plosch, T., van der Veen, J. N., Havinga, R., Huijkman, N. C. A., Bloks, V. W. & Kuipers, F., Sept-2006, In: American Journal of Physiology-Gastrointestinal and Liver Physiology. 291, 3, p. G414-G423 10 p.

Research output: Contribution to journal › Article › Academic › peer-review

52 Citations (Scopus)

Reduction of cholesterol absorption by dietary plant sterols and stanols in mice is independent of the Abcg5/8 transporter

Plosch, T., Kruit, J. K., Bloks, V. W., Huijkman, N. C. A., Havinga, R., Duchateau, G. S. M. J. E., Lin, Y. & Kuipers, F., Aug-2006, In: The Journal of Nutrition. 136, 8, p. 2135-2140 6 p.

Research output: Contribution to journal › Article › Academic › peer-review

89 Citations (Scopus)

2003

Cloning and expression of the liver and muscle isoforms of ovine carnitine palmitoyltransferase 1: residues within the N-terminus of the muscle isoform influence the kinetic properties of the enzyme

Price, N., Jackson, V., van der Leij, F., Cameron, J., Travers, M., Bartelds, B., Huijkman, N. & Zammit, V., 15-Jun-2003, In: Biochemical Journal. 372, p. 871-879 9 p.

Research output: Contribution to journal › Article › Academic › peer-review

27 Citations (Scopus)

2002

Structural and functional genomics of the CPT1B gene for muscle-type carnitine palmitoyltransferase I in mammals

van der Leij, F., Cox, K., Jackson, V., Huijkman, N., Bartelds, B., Kuipers, J., Dijkhuizen, T., Terpstra, P., Wood, P., Zammit, V. & Price, N., 26-Jul-2002, In: The Journal of Biological Chemistry. 277, 30, p. 26994-27005 12 p.

Research output: Contribution to journal › Article › Academic › peer-review

41 Citations (Scopus)

2000

Genomics of the human carnitine acyltransferase genes

van der Leij, F., Huijkman, N., Boomsma, C., Kuipers, J. & Bartelds, B., 2000, In: Molecular Genetics and Metabolism. 71, 1-2, p. 139-153 15 p.

Research output: Contribution to journal › Review article › peer-review

91 Citations (Scopus)

Nicolette Huijkman

Research output

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