Research output per year
Research output per year
- 26 results
Search results
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2025
Elevated plasma bile acids coincide with cardiac stress and inflammation in young Cyp2c70−/− mice
de Vries, H. D., Eijgenraam, T. R., Bloks, V. W., Mulder, N. L., van Zutphen, T., Silljé, H. H. W., Kuipers, F. & de Boer, J. F., 2025, In: Pediatric Research. 97, p. 2145–2152 8 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile1 Citation (Scopus)5 Downloads (Pure) -
2024
Cannabidiolic acid mitigates postpartum development of metabolic dysfunction- associated steatotic liver disease in a lean mouse model of gestational diabetes
Kruit, J. K., Hribar, K., Giralt, A., van Oosten, A., Mulder, N., Koster, M. H., Smit, M., Bongiovanni, L., Sanders, M., de Bruin, A., Kraus, M. C. H. & van der Beek, E. M., 13-Sept-2024, In: Diabetologia. 67, Supplement 1, p. S235-S236Research output: Contribution to journal › Meeting Abstract › Academic
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2023
Bile Acid Sequestration via Colesevelam Reduces Bile Acid Hydrophobicity and Improves Liver Pathology in Cyp2c70-/- Mice with a Human-like Bile Acid Composition
Palmiotti, A., de Vries, H. D., Hovingh, M. V., Koehorst, M., Mulder, N. L., Verkade, E., Veentjer, M. K., van Dijk, T. H., Bloks, V. W., Havinga, R., Verkade, H. J., de Boer, J. F. & Kuipers, F., 8-Sept-2023, In: Biomedicines. 11, 9, 15 p., 2495.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile4 Citations (Scopus)116 Downloads (Pure) -
Characterization of a novel bile salt export pump deficiency mouse model with the p.E297g mutation
Felzen, A., Hovingh, M., Havinga, R., Mulder, N., Koehorst, M., van de Sluis, B., de Boer, J. F., Kuipers, F. & Verkade, H., Jun-2023, ESPGHAN 55th Annual Meeting Abstracts. Wolters Kluwer, Vol. 76. p. 671-672 2 p.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review
Open AccessFile3 Citations (Scopus)899 Downloads (Pure) -
Gut microbiota depletion aggravates bile acid-induced liver pathology in mice with a human-like bile acid composition
Verkade, E., Shen, W., Hovingh, M. V., Mulder, N. L., de Bruyn, K., Koehorst, M., de Vries, H. D., Bloks, V. W., Kuipers, F. & de Boer, J. F., Nov-2023, In: Clinical Science. 137, 21, p. 1637–1650 14 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile7 Citations (Scopus)78 Downloads (Pure) -
Perinatal exposure to UDCA prevents neonatal cholestasis in Cyp2c70-/- mice with human-like bile acids
de Vries, H. D., Palmiotti, A., Li, R., Hovingh, M. V., Mulder, N. L., Koehorst, M., Bloks, V. W., van Zutphen, T., Kuipers, F. & de Boer, J. F., 2023, In: Pediatric Research. 93, 6, p. 1582–1590 9 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile6 Citations (Scopus)125 Downloads (Pure) -
2021
Cholangiopathy and biliary fibrosis in Cyp2c70-deficient mice are fully reversed by ursodeoxycholic acid
de Boer, J. F., de Vries, H. D., Palmiotti, A., Li, R., Doestzada, M., Hoogerland, J. A., Fu, J., La Rose, A. M., Westerterp, M., Mulder, N. L., Hovingh, M. V., Koehorst, M., Kloosterhuis, N. J., Wolters, J. C., Bloks, V. W., Haas, J. T., Dombrowicz, D., Staels, B., van de Sluis, B. & Kuipers, F., 2021, In: Cellular and molecular gastroenterology and hepatology. 11, 4, p. 1045-1069 25 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile43 Citations (Scopus)167 Downloads (Pure) -
Increased insulin sensitivity and diminished pancreatic beta-cell function in DNA repair deficient Ercc1(d/-) mice
Huerta Guevara, A. P., McGowan, S. J., Kazantzis, M., Stallons, T. R., Sano, T., Mulder, N. L., Jurdzinski, A., van Dijk, T. H., Eggen, B. J. L., Jonker, J. W., Niedernhofer, L. J. & Kruit, J. K., Apr-2021, In: Metabolism: Clinical and Experimental. 117, p. 1-9 9 p., 154711.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile9 Citations (Scopus)106 Downloads (Pure) -
Low production of 12 alpha-hydroxylated bile acids prevents hepatic steatosis in Cyp2c70(-/-) mice by reducing fat absorption
Li, R., Palmiotti, A., de Vries, H. D., Hovingh, M. V., Koehorst, M., Mulder, N. L., Zhang, Y., Kats, K., Bloks, V. W., Fu, J., Verkade, H. J., de Boer, J. F. & Kuipers, F., 2021, In: Journal of Lipid Research. 62, 20 p., 100134.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile19 Citations (Scopus)536 Downloads (Pure) -
Low production of 12 alpha-hydroxylated bile acids prevents hepatic steatosis in mice with a human-like bile acid pool by reducing fat absorption
Li, R., Palmiotti, A., de Vries, H. D., Hovingh, M. V., Koehorst, M., Mulder, N. L., Zhang, Y., Kats, K., Bloks, V. W., Fu, J., Verkade, H. J., de Boer, J. F. & Kuipers, F., Oct-2021, In: Hepatology. 74, S1, p. 1077A-1078A 2 p.Research output: Contribution to journal › Meeting Abstract › Academic
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Silencing of FoXO1 gene in the livers of ApoE*3L.CETP mice with mets affects the expression of genes related to glucose metabolism and improves glucose tolerance
Nasias, D., De Boer, J. F., Mulder, N. L., Theodorou, V., Kuivenhoven, J. A. & Kardassis, D., Aug-2021, In: Atherosclerosis. 331, p. e44 1 p.Research output: Contribution to journal › Meeting Abstract › Academic
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URSODEOXYCHOLIC ACID TREATMENT OF MOTHERS DURING PREGNANCY AND SUCKLING PREVENTS NEONATAL CHOLESTASIS IN NEWBORN Cyp2c70-/- MICE WITH A HUMAN-LIKE BILE ACID POOL
de Vries, H., Palmiotti, A., Li, R., Hovingh, M., Mulder, N., Koehorst, M., Van Zutphen, T., Kuipers, F. & De Boer, J. F., Oct-2021, In: Hepatology. 74, p. 278A-279A 2 p.Research output: Contribution to journal › Meeting Abstract › Academic
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2020
A human-like bile acid pool induced by deletion of hepatic Cyp2c70 modulates effects of FXR activation in mice[S]
de Boer, J. F., Verkade, E., Mulder, N. L., de Vries, H. D., Huijkman, N. C., Koehorst, M., Boer, T., Wolters, J. C., Bloks, V. W., van de Sluis, B. & Kuipers, F., Mar-2020, In: Journal of Lipid Research. 61, 3, p. 291-305 15 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile106 Citations (Scopus)294 Downloads (Pure) -
Spontaneous liver disease in wild-type C57BL/6JOlaHsd mice fed semisynthetic diet
Ronda, O. A. H. O., van de Heijning, B. J. M., de Bruin, A., Thomas, R. E., Martini, I., Koehorst, M., Gerding, A., Koster, M. H., Bloks, V. W., Jurdzinski, A., Mulder, N. L., Havinga, R., van der Beek, E. M., Reijngoud, D.-J., Kuipers, F. & Verkade, H. J., 21-Sept-2020, In: PLoS ONE. 15, 9, p. e0232069 25 p., 0232069.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile7 Citations (Scopus)167 Downloads (Pure) -
2019
AAV8-mediated gene transfer of microRNA-132 improves beta cell function in mice fed a high-fat diet
Mulder, N. L., Havinga, R., Kluiver, J., Groen, A. K. & Kruit, J. K., Feb-2019, In: Journal of endocrinology. 240, 2, p. 123-132 10 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile15 Citations (Scopus)154 Downloads (Pure) -
A humanized bile acid pool induced by somatic CRISPR/Cas9-mediated deletion of Cyp2c70 modulates effects of pharmacological FXR activation in mice
de Boer, J. F., Verkade, E., Mulder, N. L., de Vries, H. D., Huijkman, N., Koehorst, M., Boer, T., Wolters, J. C., Bloks, V. W., van de Sluis, B. & Kuipers, F., Apr-2019, In: Journal of Hepatology. 70, p. E25-E26 2 p.Research output: Contribution to journal › Meeting Abstract › Academic
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Glucose-6-phosphate regulates hepatic bile acid synthesis in mice
Hoogerland, J. A., Lei, Y., Wolters, J. C., de Boer, J. F., Bos, T., Bleeker, A., Mulder, N. L., van Dijk, T. H., Kuivenhoven, J. A., Rajas, F., Mithieux, G., Haeusler, R. A., Verkade, H. J., Bloks, V. W., Kuipers, F. & Oosterveer, M. H., Dec-2019, In: Hepatology. 70, 6, p. 2171-2184 14 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile24 Citations (Scopus)196 Downloads (Pure) -
Lymphocyte-Derived Exosomal MicroRNAs Promote Pancreatic beta Cell Death and May Contribute to Type 1 Diabetes Development
Guay, C., Kruit, J. K., Rome, S., Menoud, V., Mulder, N. L., Jurdzinski, A., Mancarella, F., Sebastiani, G., Donda, A., Gonzalez, B. J., Jandus, C., Bouzakri, K., Pinget, M., Boitard, C., Romero, P., Dotta, F. & Regazzi, R., 5-Feb-2019, In: Cell Metabolism. 29, 2, p. 348-+ 20 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile228 Citations (Scopus)146 Downloads (Pure) -
2018
FXR activation normalizes dyslipidemia and alleviates obesity in western-type diet–fed APOE*3-Leiden.CETP transgenic mice
Paalvast, Y., Zhou, E., Mulder, N. L., Koehorst, M., Boverhof, R., van Dijk, K. W., Rensen, P. C. N., Kuivenhoven, J. A., Kremoser, C., Wang, Y., Kuipers, F., Groen, A. K. & de Boer, J. F., Aug-2018, In: Atherosclerosis. 275, p. E10 1 p.Research output: Contribution to journal › Meeting Abstract › Academic
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2016
DNA damage in pancreatic beta cells is connected with loss of cell mass and function in an ERCC1-deficient mouse model
Guevara, A. P. H., McGowan, S. J., Mulder, N. L., Sano, T., Jurdzinski, A., Eggen, B. J., Bodekke, E., Hoeijmakers, J. H., Groen, A. K., Jonker, J. W., Niedemhofer, L. J. & Kruit, J. K., Aug-2016, In: Diabetologia. 59, p. S215-S215 1 p.Research output: Contribution to journal › Meeting Abstract › Academic
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2013
Cloning, Expression, and Functional Characterization of Secondary Amino Acid Transporters of Lactococcus lactis
Trip, H., Mulder, N. L. & Lolkema, J. S., Jan-2013, In: Journal of Bacteriology. 195, 2, p. 340-350 11 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile28 Citations (Scopus)518 Downloads (Pure) -
2012
Evidence of Two Functionally Distinct Ornithine Decarboxylation Systems in Lactic Acid Bacteria (vol 78, pg 1953, 2012)
Romano, A., Trip, H., Mulder, N. L., Lonvaud-Funel, A., Lolkema, J. S. & Lucas, P. M., May-2012, In: Applied and environmental microbiology. 78, 9, p. 3513-3513 1 p.Research output: Contribution to journal › Article › Academic › peer-review
1 Citation (Scopus)65 Downloads (Pure) -
Improved Acid Stress Survival of Lactococcus lactis Expressing the Histidine Decarboxylation Pathway of Streptococcus thermophilus CHCC1524
Trip, H., Mulder, N. L. & Lolkema, J. S., 30-Mar-2012, In: The Journal of Biological Chemistry. 287, 14, p. 11195-11204 10 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile38 Citations (Scopus)301 Downloads (Pure) -
2011
Characterization of the tyramine-producing pathway in Sporolactobacillus sp P3J
Coton, M., Fernandez, M., Trip, H., Ladero, V., Mulder, N. L., Lolkema, J. S., Alvarez, M. A. & Coton, E., Jun-2011, In: Microbiology-Sgm. 157, 6, p. 1841-1849 9 p.Research output: Contribution to journal › Article › Academic › peer-review
22 Citations (Scopus)181 Downloads (Pure) -
HdcB, a novel enzyme catalysing maturation of pyruvoyl-dependent histidine decarboxylase
Trip, H., Mulder, N. L., Rattray, F. P. & Lolkema, J. S., Feb-2011, In: Molecular Microbiology. 79, 4, p. 861-871 11 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile41 Citations (Scopus)546 Downloads (Pure) -
2010
Origin of the Putrescine-Producing Ability of the Coagulase-Negative Bacterium Staphylococcus epidermidis 2015B
Coton, E., Mulder, N., Coton, M., Pochet, S., Trip, H. & Lolkema, J. S., Aug-2010, In: Applied and environmental microbiology. 76, 16, p. 5570-5576 7 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile44 Citations (Scopus)312 Downloads (Pure)