Nieske Brouwer

2024

Radiotherapy induces persistent innate immune reprogramming of microglia into a primed state

Voshart, D. C., Oshima, T., Jiang, Y., van der Linden, G. P., Ainslie, A. P., Reali Nazario, L., van Buuren-Broek, F., Scholma, A. C., van Weering, H. R. J., Brouwer, N., Sewdihal, J., Brouwer, U., Coppes, R. P., Holtman, I. R., Eggen, B. J. L., Kooistra, S. M. & Barazzuol, L., 27-Feb-2024, 2 ed. 17 p. (Cell reports)

Research output: Book/Report › Report › Academic › peer-review

Open Access

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5 Citations (Scopus)

188 Downloads (Pure)

Sex-dependent APOE4 neutrophil–microglia interactions drive cognitive impairment in Alzheimer’s disease

Rosenzweig, N., Kleemann, K. L., Rust, T., Carpenter, M., Grucci, M., Aronchik, M., Brouwer, N., Valenbreder, I., Cooper-Hohn, J., Iyer, M., Krishnan, R. K., Sivanathan, K. N., Brandão, W., Yahya, T., Durao, A., Yin, Z., Chadarevian, J. P., Properzi, M. J., Nowarski, R. & Davtyan, H. & 6 others, Weiner, H. L., Blurton-Jones, M., Yang, H. S., Eggen, B. J. L., Sperling, R. A. & Butovsky, O., Oct-2024, In: Nature Medicine. 30, p. 2990–3003 37 p.

Research output: Contribution to journal › Article › Academic › peer-review

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16 Citations (Scopus)

354 Downloads (Pure)

2023

APOE4 impairs the microglial response in Alzheimer’s disease by inducing TGFβ-mediated checkpoints

Yin, Z., Rosenzweig, N., Kleemann, K. L., Zhang, X., Brandão, W., Margeta, M. A., Schroeder, C., Sivanathan, K. N., Silveira, S., Gauthier, C., Mallah, D., Pitts, K. M., Durao, A., Herron, S., Shorey, H., Cheng, Y., Barry, J. L., Krishnan, R. K., Wakelin, S. & Rhee, J. & 23 others, Yung, A., Aronchik, M., Wang, C., Jain, N., Bao, X., Gerrits, E., Brouwer, N., Deik, A., Tenen, D. G., Ikezu, T., Santander, N. G., McKinsey, G. L., Baufeld, C., Sheppard, D., Krasemann, S., Nowarski, R., Eggen, B. J. L., Clish, C., Tanzi, R. E., Madore, C., Arnold, T. D., Holtzman, D. M. & Butovsky, O., Nov-2023, In: Nature Immunology. 24, 11, p. 1839-1853 15 p.

Research output: Contribution to journal › Article › Academic › peer-review

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73 Citations (Scopus)

954 Downloads (Pure)

Characterizing microglial gene expression in a model of secondary progressive multiple sclerosis

Vainchtein, I. D., Alsema, A. M., Dubbelaar, M. L., Grit, C., Vinet, J., van Weering, H. R. J., Al-Izki, S., Biagini, G., Brouwer, N., Amor, S., Baker, D., Eggen, B. J. L., Boddeke, E. W. G. M. & Kooistra, S. M., Mar-2023, In: Glia. 71, 03, 588 p.

Research output: Contribution to journal › Article › Academic › peer-review

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5 Citations (Scopus)

114 Downloads (Pure)

2022

Brain macrophages acquire distinct transcriptomes in multiple sclerosis lesions and normal appearing white matter

Miedema, A., Gerrits, E., Brouwer, N., Jiang, Q., Kracht, L., Meijer, M., Nutma, E., Peferoen-Baert, R., Pijnacker, A. T. E., Wesseling, E. M., Wijering, M. H. C., Gabius, H.-J., Amor, S., Eggen, B. J. L. & Kooistra, S. M., 28-Jan-2022, In: Acta Neuropathologica Communications. 10, 1, 18 p., 8.

Research output: Contribution to journal › Article › Academic › peer-review

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37 Citations (Scopus)

184 Downloads (Pure)

Distinct gene expression in demyelinated white and grey matter areas of patients with multiple sclerosis

van Wageningen, T. A., Gerrits, E., Brouwer, N., Breve, J. J. P., Geurts, J. J. G., Eggen, B. J. L., Boddeke, H. W. G. M. & van Dam, A.-M., 1-Mar-2022, In: Brain Communications. 4, 2, 16 p., 005.

Research output: Contribution to journal › Article › Academic › peer-review

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13 Citations (Scopus)

147 Downloads (Pure)

Early-life stress lastingly impacts microglial transcriptome and function under basal and immune-challenged conditions

Reemst, K., Kracht, L., Kotah, J. M., Rahimian, R., van Irsen, A. A. S., Congrains Sotomayor, G., Verboon, L. N., Brouwer, N., Simard, S., Turecki, G., Mechawar, N., Kooistra, S. M., Eggen, B. J. L. & Korosi, A., 8-Dec-2022, In: Translational Psychiatry. 12, 1, 13 p., 507.

Research output: Contribution to journal › Article › Academic › peer-review

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34 Citations (Scopus)

219 Downloads (Pure)

Epigenetic regulation of innate immune memory in microglia

Zhang, X., Kracht, L., Lerario, A. M., Dubbelaar, M. L., Brouwer, N., Wesseling, E. M., Boddeke, E. W. G. M., Eggen, B. J. L. & Kooistra, S. M., 14-May-2022, In: Journal of neuroinflammation. 19, 1, 19 p., 111.

Research output: Contribution to journal › Article › Academic › peer-review

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40 Citations (Scopus)

146 Downloads (Pure)

Neurovascular dysfunction in GRN-associated frontotemporal dementia identified by single-nucleus RNA sequencing of human cerebral cortex

Brainbank Neuro-CEB Neuropathology, Gerrits, E., Giannini, L. A. A., Brouwer, N., Melhem, S., Seilhean, D., Le Ber, I., Kamermans, A., Kooij, G., de Vries, H. E., Boddeke, E. W. G. M., Seelaar, H., van Swieten, J. C. & Eggen, B. J. L., Aug-2022, In: Nature neuroscience. 25, 8, p. 1034-1048 34 p.

Research output: Contribution to journal › Article › Academic › peer-review

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37 Citations (Scopus)

1221 Downloads (Pure)

2021

Distinct amyloid-beta and tau-associated microglia profiles in Alzheimer's disease

Gerrits, E., Brouwer, N., Kooistra, S. M., Woodbury, M. E., Vermeiren, Y., Lambourne, M., Mulder, J., Kummer, M., Moller, T., Biber, K., den Dunnen, W. F. A., De Deyn, P. P., Eggen, B. J. L. & Boddeke, E. W. G. M., 20-Feb-2021, In: Acta Neuropathologica. 16 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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202 Citations (Scopus)

275 Downloads (Pure)

Human fetal microglia acquire homeostatic immune-sensing properties early in development

Kracht, L., Borggrewe, M., Eskandar, S., Brouwer, N., Lopes, S. C. D. S., Laman, J., Scherjon, S., Prins, J., Kooistra, S. & Eggen, B., Jul-2021, In: Glia. 69, p. E248-E249 2 p.

Research output: Contribution to journal › Meeting Abstract › Academic

Intrinsic DNA damage repair deficiency results in progressive microglia loss and replacement

Zhang, X., Heng, Y., Kooistra, S. M., van Weering, H. R. J., Brummer, M. L., Gerrits, E., Wesseling, E. M., Brouwer, N., Nijboer, T. W., Dubbelaar, M. L., Boddeke, E. W. G. M. & Eggen, B. J. L., Mar-2021, In: Glia. 3, p. 1-17 17 p., 23925.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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13 Citations (Scopus)

128 Downloads (Pure)

Regionally diverse astrocyte subtypes and their heterogeneous response to EAE

Borggrewe, M., Grit, C., Vainchtein, I. D., Brouwer, N., Wesseling, E. M., Laman, J. D., Eggen, B. J. L., Kooistra, S. M. & Boddeke, E. W. G. M., May-2021, In: Glia. 69, 5, p. 1140-1154 15 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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30 Citations (Scopus)

203 Downloads (Pure)

Transcriptional profiling of macaque microglia reveals an evolutionary preserved gene expression program

Dubbelaar, M. L., Misrielal, C., Bajramovic, J. J., Burm, S. M., Zuiderwijk-Sick, E. A., Brouwer, N., Grit, C., Kooistra, S. M., Shinjo, S. M. O., Marie, S. K. N., Boddeke, H. W. G. M. & Eggen, B. J. L., Aug-2021, In: Brain, behavior, & immunity - health. 15, 8 p., 100265.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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4 Citations (Scopus)

89 Downloads (Pure)

2020

Human fetal microglia acquire homeostatic immune-sensing properties early indevelopment

Kracht, L., Borggrewe, M., Eskandar, S., Brouwer, N., Chuva de Sousa Lopes, S. M., Laman, J. D., Scherjon, S. A., Prins, J. R., Kooistra, S. M. & Eggen, B. J. L., 31-Jul-2020, In: Science. 369, 6503, p. 530-537 8 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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120 Citations (Scopus)

351 Downloads (Pure)

Human Microglia Acquire a More Mature, Homeostatic Phenotype During the Transition of the First and Second Trimester of Gestation.

Eskandar, S., Borggrewe, M., Alsema, A. M., Brouwer, N., Meijer, M., Lopes, S. M. C. D. S., Nieveen, M. C., Kooistra, S. M., Scherjon, S. A., Prins, J. R. & Eggen, B. J. L., Mar-2020, In: Reproductive Sciences. 27, SUPPL 1, p. 109A-109A 1 p.

Research output: Contribution to journal › Meeting Abstract › Academic

Profiling Microglia From Alzheimer's Disease Donors and Non-demented Elderly in Acute Human Postmortem Cortical Tissue

Alsema, A. M., Jiang, Q., Kracht, L., Gerrits, E., Dubbelaar, M. L., Miedema, A., Brouwer, N., Hol, E. M., Middeldorp, J., van Dijk, R., Woodbury, M., Wachter, A., Xi, S., Möller, T., Biber, K. P., Kooistra, S. M., Boddeke, E. W. G. M. & Eggen, B. J. L., 28-Oct-2020, In: Frontiers in Molecular Neuroscience. 13, 14 p., 134.

Research output: Contribution to journal › Article › Academic › peer-review

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49 Citations (Scopus)

278 Downloads (Pure)

2019

Isolation and Characterization of Fetal Microglia and Placental Macrophages during First Trimester Human Pregnancy.

Eskandar, S., Kracht, L., Borggrewe, M., Brouwer, N., Scherjon, S. A., Prins, J. R. & Eggen, B. J., Mar-2019, In: Reproductive Sciences. 26, p. 157A 2 p.

Research output: Contribution to journal › Meeting Abstract › Academic

2018

Low-fat diet with caloric restriction reduces white matter microglia activation during aging

Yin, Z., Raj, D. D., Schaafsma, W., van der Heijden, R. A., Kooistra, S. M., Reijne, A. C., Zhang, X., Moser, J., Brouwer, N., Heeringa, P., Yi, C.-X., van Dijk, G., Laman, J. D., Boddeke, E. W. G. M. & Eggen, B. J. L., 12-Mar-2018, In: Frontiers in Molecular Neuroscience. 11, p. 65 13 p., 65.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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39 Citations (Scopus)

406 Downloads (Pure)

2017

Frequency of Nuclear Mutant Huntingtin Inclusion Formation in Neurons and Glia is Cell-Type-Specific

Jansen, A. H. P., van Hal, M., op den Kelder, I. C., Meier, R. T., de Ruiter, A.-A., Schut, M. H., Smith, D. L., Grit, C., Brouwer, N., Kamphuis, W., Boddeke, H. W. G. M., den Dunnen, W. F. A., van Roon, W. M. C., Bates, G. P., Hol, E. M. & Reits, E. A., Jan-2017, In: Glia. 65, 1, p. 50-61 12 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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87 Citations (Scopus)

422 Downloads (Pure)

Immune hyperreactivity of Aβ plaque-associated microglia in Alzheimer's disease

Yin, Z., Raj, D., Saiepour, N., Van Dam, D., Brouwer, N., Holtman, I. R., Eggen, B. J. L., Möller, T., Tamm, J. A., Abdourahman, A., Hol, E. M., Kamphuis, W., Bayer, T. A., De Deyn, P. P. & Boddeke, E., Jul-2017, In: Neurobiology of Aging. 55, p. 115-122 8 p.

Research output: Contribution to journal › Article › Academic › peer-review

196 Citations (Scopus)

Isolation of Microglia and Immune Infiltrates from Mouse and Primate Central Nervous System

Galatro, T. F., Vainchtein, I. D., Brouwer, N., Boddeke, E. W. G. M. & Eggen, B. J. L., 1-Jan-2017, Inflammation. Methods and Protocols. Clausen, B. E. & Laman, J. D. (eds.). Humana Press, p. 333-342 10 p. (Methods in Molecular Biology; vol. 1559).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

33 Citations (Scopus)

Maternal inflammation induces immune activation of fetal microglia and leads to disrupted microglia immune responses, behavior, and learning performance in adulthood

Schaafsma, W., Basterra, L. B., Jacobs, S., Brouwer, N., Meerlo, P., Schaafsma, A., Boddeke, E. W. G. M. & Eggen, B. J. L., Oct-2017, In: Neurobiology of Disease. 106, p. 291-300 10 p.

Research output: Contribution to journal › Article › Academic › peer-review

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90 Citations (Scopus)

239 Downloads (Pure)

Transcriptomic analysis of purified human cortical microglia reveals age-associated changes

Galatro, T. F., Holtman, I. R., Lerario, A. M., Vainchtein, I. D., Brouwer, N., Sola, P. R., Veras, M. M., Pereira, T. F., Leite, R. E. P., Möller, T., Wes, P. D., Sogayar, M. C., Laman, J. D., den Dunnen, W., Pasqualucci, C. A., Oba-Shinjo, S. M., Boddeke, E. W. G. M., Marie, S. K. N. & Eggen, B. J. L., Aug-2017, In: Nature neuroscience. 20, 8, p. 1162-1171 10 p.

Research output: Contribution to journal › Article › Academic › peer-review

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511 Citations (Scopus)

627 Downloads (Pure)

2016

Telomere shortening leads to an acceleration of synucleinopathy and impaired microglia response in a genetic mouse model

Scheffold, A., Holtman, I. R., Dieni, S., Brouwer, N., Katz, S.-F., Jebaraj, B. M. C., Kahle, P. J., Hengerer, B., Lechel, A., Stilgenbauer, S., Boddeke, E. W. G. M., Eggen, B. J. L., Rudolph, K.-L. & Biber, K., 22-Aug-2016, In: Acta Neuropathologica Communications. 4, 87, 17 p., 87.

Research output: Contribution to journal › Article › Academic › peer-review

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38 Citations (Scopus)

384 Downloads (Pure)

2015

Enhanced microglial pro-inflammatory response to lipopolysaccharide correlates with brain infiltration and blood-brain barrier dysregulation in a mouse model of telomere shortening

Raj, D. D. A., Moser, J., van der Pol, S. M. A., van Os, R. P., Holtman, I. R., Brouwer, N., Oeseburg, H., Schaafsma, W., Wesseling, E. M., Dunnen, den, W., Biber, K. P. H., de Vries, H. E., Eggen, B. J. L. & Boddeke, H. W. G. M., Dec-2015, In: Aging Cell. 14, 6, p. 1003-1013 11 p.

Research output: Contribution to journal › Article › Academic › peer-review

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49 Citations (Scopus)

523 Downloads (Pure)

Glia Open Access Database (GOAD): A comprehensive gene expression encyclopedia of glia cells in health and disease

Holtman, I. R., Noback, M., Bijlsma, M., Duong, K. N., van der Geest, M. A., Ketelaars, P. T., Brouwer, N., Vainchtein, I. D., Eggen, B. J. L. & Boddeke, H. W. G. M., Sept-2015, In: Glia. 63, 9, p. 1495-1506 12 p.

Research output: Contribution to journal › Article › Academic › peer-review

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52 Citations (Scopus)

136 Downloads (Pure)

Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis

Holtman, I. R., Raj, D., Miller, J. A., Schaafsma, W., Yin, Z., Brouwer, N., Wes, P. D., Möller, T., Orre, M., Kamphuis, W., Hol, E. M., Boddeke, E. W. G. M. & Eggen, B. J. L., 2015, In: Acta Neuropathologica Communications. 3, 18 p., 31.

Research output: Contribution to journal › Article › Academic › peer-review

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449 Citations (Scopus)

776 Downloads (Pure)

Long-lasting pro-inflammatory suppression of microglia by LPS-preconditioning is mediated by RelB-dependent epigenetic silencing

Schaafsma, W., Zhang, X., van Zomeren, K. C., Jacobs, S., Georgieva, P. B., Wolf, S. A., Kettenmann, H., Janova, H., Saiepour, N., Hanisch, U.-K., Meerlo, P., van den Elsen, P. J., Brouwer, N., Boddeke, H. W. G. M. & Eggen, B. J. L., Aug-2015, In: Brain, Behavior, and Immunity. 48, p. 205-221 17 p.

Research output: Contribution to journal › Article › Academic › peer-review

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129 Citations (Scopus)

272 Downloads (Pure)

Multipotent stem cell factor UGS148 is a marker for tanycytes in the adult hypothalamus

Ma, M.-S., Brouwer, N., Wesseling, E., Raj , D., van der Want, J., Boddeke, E., Balasubramaniyan, V. & Copray, S., Mar-2015, In: Molecular and Cellular Neuroscience. 65, p. 21-30 10 p.

Research output: Contribution to journal › Article › Academic › peer-review

10 Citations (Scopus)

2014

In Acute Experimental Autoimmune Encephalomyelitis, Infiltrating Macrophages Are Immune Activated, Whereas Microglia Remain Immune Suppressed

Vainchtein, I. D., Vinet, J., Brouwer, N., Brendecke, S., Biagini, G., Biber, K., Boddeke, H. W. G. M. & Eggen, B. J. L., Oct-2014, In: Glia. 62, 10, p. 1724-1735 12 p.

Research output: Contribution to journal › Article › Academic › peer-review

77 Citations (Scopus)

Priming of microglia in a DNA-repair deficient model of accelerated aging

Raj, D. D. A., Jaarsma, D., Holtman, I. R., Olah, M., Ferreira, F. M., Schaafsma, W., Brouwer, N., Meijer, M. M., de Waard, M. C., van der Pluijm, I., Brandt, R., Kreft, K. L., Laman, J. D., de Haan, G., Biber, K. P. H., Hoeijmakers, J. H. J., Eggen, B. J. L. & Boddeke, H. W. G. M., Sept-2014, In: Neurobiology of Aging. 35, 9, p. 2147-2160 14 p.

Research output: Contribution to journal › Article › Academic › peer-review

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106 Citations (Scopus)

201 Downloads (Pure)

2013

Histone deacetylase inhibitors suppress immune activation in primary mouse microglia

Kannan, V., Brouwer, N., Hanisch, U.-K., Regen, T., Eggen, B. J. L. & Boddeke, H. W. G. M., Sept-2013, In: Journal of Neuroscience Research. 91, 9, p. 1133-1142 10 p.

Research output: Contribution to journal › Article › Academic › peer-review

88 Citations (Scopus)

Inhibition of CXCR3-mediated chemotaxis by the human chemokine receptor-like protein CCX-CKR

Vinet, J., van Zwam, M., Dijkstra, I. M., Brouwer, N., van Weering, H. R. J., Watts, A., Meijer, M., Fokkens, M. R., Kannan, V., Verzijl, D., Vischer, H. F., Smit, M. J., Leurs, R., Biber, K. & Boddeke, H. W. G. M., Mar-2013, In: British Journal of Pharmacology. 168, 6, p. 1375-1387 13 p.

Research output: Contribution to journal › Article › Academic › peer-review

18 Citations (Scopus)

2012

An optimized protocol for the acute isolation of human microglia from autopsy brain samples

Olah, M., Raj, D., Brouwer, N., de Haas, A. H., Eggen, B. J. L., Den Dunnen, W. F. A., Biber, K. P. H. & Boddeke, H. W. G. M., Jan-2012, In: Glia. 60, 1, p. 96-111 16 p.

Research output: Contribution to journal › Article › Academic › peer-review

56 Citations (Scopus)

Identification of a microglia phenotype supportive of remyelination

Olah, M., Amor, S., Brouwer, N., Vinet, J., Eggen, B., Biber, K. & Boddeke, H. W. G. M., Feb-2012, In: Glia. 60, 2, p. 306-321 16 p.

Research output: Contribution to journal › Article › Academic › peer-review

299 Citations (Scopus)

Neuroprotective function for ramified microglia in hippocampal excitotoxicity

Vinet, J., van Weering, H. R. J., Heinrich, A., Kaelin, R. E., Wegner, A., Brouwer, N., Heppner, F. L., van Rooijen, N., Boddeke, H. W. G. M. & Biber, K., 31-Jan-2012, In: Journal of neuroinflammation. 9, 15 p., 27.

Research output: Contribution to journal › Article › Academic › peer-review

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230 Citations (Scopus)

366 Downloads (Pure)

2011

CXCL10/CXCR3 Signaling in Glia Cells Differentially Affects NMDA-Induced Cell Death in CA and DG Neurons of the Mouse Hippocampus

van Weering, H. R. J., Boddeke, H. W. G. M., Vinet, J., Brouwer, N., de Haas, A. H., van Rooijen, N., Thomsen, A. R. & Biber, K. P. H., 2011, In: Hippocampus. 21, 2, p. 220-232 13 p.

Research output: Contribution to journal › Article › Academic › peer-review

49 Citations (Scopus)

2010

Expression of CXCL10 in cultured cortical neurons

Vinet, J., de Jong, E. K., Boddeke, H. W. G. M., Stanulovic, V., Brouwer, N., Granic, I., Eisel, U. L. M., Liem, R. S. B. & Biber, K., Feb-2010, In: Journal of Neurochemistry. 112, 3, p. 703-714 12 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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17 Citations (Scopus)

451 Downloads (Pure)

2009

Enhanced hippocampal neurogenesis in the absence of microglia T cell interaction and microglia activation in the murine running wheel model

Olah, M., Ping, G., de Haas, A. H., Brouwer, N., Meerlo, P., van der Zee, E. A., Biber, K. & Boddeke, H. W. G. M., 2009, In: Glia. 57, p. 1046-1061

Research output: Contribution to journal › Article › Academic › peer-review

56 Citations (Scopus)

2008

Differentiation of Neural Stem Cells into Oligodendrocytes: Involvement of the Polycomb Group Protein Ezh2

Sher, F., Rossler, R., Brouwer, N., Balasubramaniyan, V., Boddeke, E. & Copray, S., 2008, In: STEM CELLS. 26, 11, p. 2875-2883 9 p.

Research output: Contribution to journal › Article › Academic › peer-review

155 Citations (Scopus)

Expression of CXCL4 in microglia in vitro and in vivo and its possible signaling through CXCR3

de Jong, E. K., de Haas, A. H., Brouwer, N., van Weering, H. R. J., Hensens, M., Bechmann, I., Pratley, P., Wesseling, E., Boddeke, H. W. G. M. & Biber, K., Jun-2008, In: Journal of Neurochemistry. 105, 5, p. 1726-1736 11 p.

Research output: Contribution to journal › Article › Academic › peer-review

72 Citations (Scopus)

2007

Optimized isolation enables Ex vivo analysis of microglia from various central nervous system regions

De Haas, A. H., Boddeke, H. W. G. M., Brouwer, N. & Biber, K., Oct-2007, In: Glia. 55, 13, p. 1374-1384 11 p.

Research output: Contribution to journal › Article › Academic › peer-review

69 Citations (Scopus)

2006

Challenge with innate and protein antigens induces CCR7 expression by microglia in vitro and in vivo

Dijkstra, I. M., de Haas, A. H., Brouwer, N., Boddeke, H. W. G. M. & Biber, K., Dec-2006, In: Glia. 54, 8, p. 861-872 12 p.

Research output: Contribution to journal › Article › Academic › peer-review

39 Citations (Scopus)

2005

Benchmarking en prestatieverbetering in de publieke sector: Ervaringen met de bedrijfsvergelijking zuiveringsbeheer

van Helden, J. & Brouwer, N., 2005, In: Maandblad voor Accountancy en Bedrijfseconomie. 79, 11, p. 573-581 9 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Vesicle-mediated transport and release of CCL21 in endangered neurons: A possible explanation for microglia activation remote from a primary lesion

de Jong, E., Dijkstra, I., Hensens, M., Brouwer, N., van Amerongen, M., Liem, R., Boddeke, H. & Biber, K., 17-Aug-2005, In: The Journal of Neuroscience. 25, 33, p. 7548-7557 10 p.

Research output: Contribution to journal › Article › Academic › peer-review

128 Citations (Scopus)

2004

Induction of glial L-CCR mRNA expression in spinal cord and brain in experimental autoimmune encephalomyelitis

Brouwer, N., Zuurman, M., Wei, T., Ransohoff, R., Boddeke, H. & Biber, K., 1-Apr-2004, In: Glia. 46, 1, p. 84-94 11 p.

Research output: Contribution to journal › Article › Academic › peer-review

35 Citations (Scopus)

Quantitative on-line monitoring of cellular glucose and lactate metabolism in vitro with slow perfusion

Leegsma-Vogt, G., Venema, K., Brouwer, N., Gramsbergen, J., Copray, S. & Korf, J., 15-Sept-2004, In: Analytical Chemistry. 76, 18, p. 5431-5435 5 p.

Research output: Contribution to journal › Article › Academic › peer-review

9 Citations (Scopus)

The postnatal developmental expression pattern of urocortin in the rat olivocerebellar system

Swinny, J., Kalicharan, D., Brouwer, N., Biber, K., Shi, F., Gramsbergen, A. & Van Der Want, J., 19-Apr-2004, In: Journal of comparative neurology. 472, 1, p. 40-51 12 p.

Research output: Contribution to journal › Article › Academic › peer-review

7 Citations (Scopus)

2003

Expression of the low affinity neurotrophin receptor p75 in spinal motoneurons in a transgenic mouse model for amyotrophic lateral sclerosis

Copray, J. C. V. M., Jaarsma, D., Kust, B. M., Bruggeman, R. W. G., Mantingh, I., Brouwer, N. & Boddeke, H. W. G. M., 2003, In: Neuroscience. 116, 3, p. 685-694 10 p.

Research output: Contribution to journal › Article › Academic › peer-review

50 Citations (Scopus)

Nieske Brouwer

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