Patrick Deelen

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Research interests

I am primarily interested in improving the diagnostic yield of genome sequencing of patients who have a rare disease. I do this by integrating population genetics and transcriptomics.

Education/Academic qualification

PhD student, University of Groningen

27-Aug-2012 → 6-May-2019

Award Date: 6-May-2019

Master Bioinformatics, Vrije Universiteit Amsterdam, Amsterdam

2010 → 2012

Bachelor Bioinformatics, Hanze University of Applied Sciences

2006 → 2010

68 Article
7 Meeting Abstract
5 Letter
4 Erratum
More

Improving the diagnostic yield of exome-sequencing by predicting gene-phenotype associations using large-scale gene expression analysis
Deelen, P., van Dam, S., Herkert, J. C., Karjalainen, J. M., Brugge, H., Abbott, K. M., van Diemen, C. C., van der Zwaag, P. A., Gerkes, E. H., Zonneveld-Huijssoon, E., Boer-Bergsma, J. J., Folkertsma, P., Gillett, T., van der Velde, K. J., Kanninga, R., van den Akker, P. C., Jan, S. Z., Hoorntje, E. T., Te Rijdt, W. P., Vos, Y. J., & 7 othersJongbloed, J. D. H., van Ravenswaaij-Arts, C. M. A., Sinke, R., Sikkema-Raddatz, B., Kerstjens-Frederikse, W. S., Swertz, M. A. & Franke, L., 28-Jun-2019, In: Nature Communications. 10, 1, 13 p., 2837.
Research output: Contribution to journal › Article › Academic › peer-review

Open Access
File

71 Citations (Scopus)

286 Downloads (Pure)
Identification of context-dependent expression quantitative trait loci in whole blood
Pital-Zhernakova, D., Deelen, P., Vermaat, M., van Iterson, M., van Galen, M., Arindrarto, W., van 't Hof, P., Mei, H., van Dijk, F., Westra, H-J., Bonder, M. J., van Rooij, J., Verkerk, M., Jhamai, P. M., Moed, M., Kielbasa, S. M., Bot, J., Nooren, I., Pool, R., van Dongen, J., & 27 othersHottenga, J. J., Stehouwer, C. D. A., van der Kallen, C. J. H., Schalkwijk, C. G., Zhernakova, A., Li, Y., Tigchelaar, E. F., de Klein, N., Beekman, M., Deelen, J., van Heemst, D., van den Berg, L. H., Hofman, A., Uitterlinden, A. G., van Greevenbroek, M. M. J., Veldink, J. H., Boomsma, D. I., van Duijn, C. M., Wijmenga, C., Slagboom, P. E., Swertz, M. A., Isaacs, A., van Meurs, J. B. J., Jansen, R., Heijmans, B. T., 't Hoen, P. A. C. & Franke, L., Jan-2017, In: Nature Genetics. 49, 1, p. 139-145 7 p.
Research output: Contribution to journal › Letter › Academic › peer-review

243 Citations (Scopus)
Calling genotypes from public RNA-sequencing data enables identification of genetic variants that affect gene-expression levels
Deelen, P., Zhernakova, D. V., de Haan, M., van der Sijde, M., Bonder, M. J., Karjalainen, J., van der Velde, K. J., Abbott, K. M., Fu, J., Wijmenga, C., Sinke, R. J., Swertz, M. A. & Franke, L., 27-Mar-2015, In: Genome medicine. 7, 1, 13 p., 30.
Research output: Contribution to journal › Article › Academic › peer-review

Open Access
File

2 Citations (Scopus)

481 Downloads (Pure)
Brain expression quantitative trait locus and network analyses reveal downstream effects and putative drivers for brain-related diseases
de Klein, N., Tsai, E. A., Vochteloo, M., Baird, D., Huang, Y., Chen, C. Y., van Dam, S., Oelen, R., Deelen, P., Bakker, O. B., El Garwany, O., Ouyang, Z., Marshall, E. E., Zavodszky, M. I., van Rheenen, W., Bakker, M. K., Veldink, J., Gaunt, T. R., Runz, H., Franke, L., & 1 othersWestra, H. J., Mar-2023, In: Nature genetics. 55, 3, p. 377-388 12 p.
Research output: Contribution to journal › Article › Academic › peer-review

Open Access
File

9 Citations (Scopus)

22 Downloads (Pure)
Global Biobank analyses provide lessons for developing polygenic risk scores across diverse cohorts
BBJ, BioMe, BioVU, Canadian Partnership for Tomorrow's Health/OHS, China Kadoorie Biobank Collaborative Group, Colorado Center for Personalized Medicine, deCODE Genetics, ESTBB, FinnGen, Generation Scotland, Genes & Health, LifeLines, Mass General Brigham Biobank, Michigan Genomics Initiative, QIMR Berghofer Biobank, Taiwan Biobank, The HUNT Study, UCLA ATLAS Community Health Initiative, UKBB, Wang, Y., & 22 othersNamba, S., Lopera, E., Tsuo, K., Läll, K., Kanai, M., Zhou, W., Wu, K. H. H., Favé, M. J., Bhatta, L., Awadalla, P., Brumpton, B., Deelen, P., Hveem, K., Lo Faro, V., Mägi, R., Murakami, Y., Sanna, S., Smoller, J. W., Uzunovic, J., Wolford, B. N., Martin, A. R. & Hirbo, J. B., 11-Jan-2023, In: Cell Genomics. 3, 1, 18 p., 100241.
Research output: Contribution to journal › Article › Academic › peer-review

Open Access
File

10 Citations (Scopus)

17 Downloads (Pure)

Additional file 6 of Controlling bias and inflation in epigenome- and transcriptome-wide association studies using the empirical null distribution
't Hoen, P. A. C. (Contributor), Verbiest, M. (Contributor), Vermaat, M. (Contributor), Tigchelaar - Feenstra, E. (Contributor), Verkerk, M. (Contributor), Heijmans, B. T. (Contributor), van der Breggen, R. (Contributor), Nooren, I. (Contributor), Isaacs, A. (Contributor), 't Hoen, P. (Contributor), Lakenberg, N. (Contributor), Mei, H. (Contributor), van Dijk, F. (Contributor), Wijmenga, C. (Contributor), Zhernakova, D. (Contributor), van Heemst, D. (Contributor), Boomsma, D. I. (Contributor), Stehouwer, C. D. A. (Contributor), Deelen, J. (Contributor), Bonder, M. J. (Contributor), Hofman, B. A. (Contributor), Schalkwijk, C. G. (Contributor), Bot, J. (Contributor), Zhernakova, S. (Contributor), Kielbasa, S. M. (Contributor), van Duijn, C. M. (Contributor), Franke, L. (Contributor), Uitterlinden, A. G. (Contributor), Beekman, M. (Contributor), Jhamai, P. M. (Contributor), Moed, M. (Contributor), Luijk, R. (Contributor), van Meurs, J. (Contributor), Arindrarto, W. (Contributor), van Zwet, E. W. (Contributor), Jansen, R. (Contributor), Swertz, M. (Contributor), van 't Hof, P. (Contributor), van Rooij, J. (Contributor), van Dongen, J. (Contributor), van den Berg, L. H. (Contributor), Veldink, J. H. (Contributor), Eline Slagboom (Contributor), van Greevenbroek, M. M. J. (Contributor), Deelen, P. (Contributor), Suchiman, H. E. D. (Contributor), van Iterson, M. (Contributor), van der Kallen, C. J. H. (Contributor), Hottenga, J. J. (Contributor), Pool, R. (Contributor) & van Galen, M. (Contributor), University of Groningen, 28-Jan-2017
DOI: 10.6084/m9.figshare.c.3676579_d7.v1, https://doi.org/10.6084%2Fm9.figshare.c.3676579_d7.v1
Dataset
Additional file 7 of Controlling bias and inflation in epigenome- and transcriptome-wide association studies using the empirical null distribution
van Galen, M. (Contributor), Luijk, R. (Contributor), van der Kallen, C. J. H. (Contributor), 't Hoen, P. A. C. (Contributor), van der Breggen, R. (Contributor), van Dongen, J. (Contributor), van Heemst, D. (Contributor), van Iterson, M. (Contributor), van Rooij, J. (Contributor), Lakenberg, N. (Contributor), van 't Hof, P. (Contributor), Verkerk, M. (Contributor), Vermaat, M. (Contributor), Beekman, M. (Contributor), Verbiest, M. (Contributor), Boomsma, D. I. (Contributor), Jhamai, P. M. (Contributor), Bot, J. (Contributor), Suchiman, H. E. D. (Contributor), Franke, L. (Contributor), Heijmans, B. T. (Contributor), Hottenga, J. J. (Contributor), Moed, M. (Contributor), Deelen, J. (Contributor), Deelen, P. (Contributor), Nooren, I. (Contributor), Jansen, R. (Contributor), Swertz, M. (Contributor), 't Hoen, P. (Contributor), Zhernakova, S. (Contributor), van Dijk, F. (Contributor), Pool, R. (Contributor), Hofman, B. A. (Contributor), van den Berg, L. H. (Contributor), Uitterlinden, A. G. (Contributor), Bonder, M. J. (Contributor), Kielbasa, S. M. (Contributor), van Meurs, J. (Contributor), Eline Slagboom (Contributor), Stehouwer, C. D. A. (Contributor), Tigchelaar - Feenstra, E. (Contributor), Zhernakova, D. (Contributor), Schalkwijk, C. G. (Contributor), Mei, H. (Contributor), Arindrarto, W. (Contributor), Wijmenga, C. (Contributor), van Zwet, E. W. (Contributor), van Duijn, C. M. (Contributor), Veldink, J. H. (Contributor), Isaacs, A. (Contributor) & van Greevenbroek, M. M. J. (Contributor), University of Groningen, 28-Jan-2017
DOI: 10.6084/m9.figshare.c.3676579_d5.v1, https://doi.org/10.6084%2Fm9.figshare.c.3676579_d5.v1
Dataset
Additional file 4 of Controlling bias and inflation in epigenome- and transcriptome-wide association studies using the empirical null distribution
van der Breggen, R. (Contributor), Hofman, B. A. (Contributor), Pool, R. (Contributor), Nooren, I. (Contributor), Deelen, P. (Contributor), Vermaat, M. (Contributor), Zhernakova, S. (Contributor), van Zwet, E. W. (Contributor), Heijmans, B. T. (Contributor), Moed, M. (Contributor), van den Berg, L. H. (Contributor), Arindrarto, W. (Contributor), Suchiman, H. E. D. (Contributor), Zhernakova, D. (Contributor), van 't Hof, P. (Contributor), van Dongen, J. (Contributor), Bonder, M. J. (Contributor), Tigchelaar - Feenstra, E. (Contributor), Schalkwijk, C. G. (Contributor), Kielbasa, S. M. (Contributor), van Iterson, M. (Contributor), van der Kallen, C. J. H. (Contributor), van Duijn, C. M. (Contributor), Deelen, J. (Contributor), Veldink, J. H. (Contributor), van Heemst, D. (Contributor), 't Hoen, P. (Contributor), Mei, H. (Contributor), Jhamai, P. M. (Contributor), van Dijk, F. (Contributor), Jansen, R. (Contributor), Eline Slagboom (Contributor), Luijk, R. (Contributor), Wijmenga, C. (Contributor), van Rooij, J. (Contributor), Bot, J. (Contributor), Lakenberg, N. (Contributor), van Galen, M. (Contributor), Isaacs, A. (Contributor), Boomsma, D. I. (Contributor), 't Hoen, P. A. C. (Contributor), van Meurs, J. (Contributor), Verkerk, M. (Contributor), Stehouwer, C. D. A. (Contributor), Beekman, M. (Contributor), Swertz, M. (Contributor), Uitterlinden, A. G. (Contributor), Franke, L. (Contributor), Hottenga, J. J. (Contributor), Verbiest, M. (Contributor) & van Greevenbroek, M. M. J. (Contributor), University of Groningen, 28-Jan-2017
DOI: 10.6084/m9.figshare.c.3676579_d6.v1, https://doi.org/10.6084%2Fm9.figshare.c.3676579_d6.v1
Dataset
Additional file 3 of Controlling bias and inflation in epigenome- and transcriptome-wide association studies using the empirical null distribution
Hofman, B. A. (Contributor), Arindrarto, W. (Contributor), Mei, H. (Contributor), van der Kallen, C. J. H. (Contributor), Schalkwijk, C. G. (Contributor), van Dongen, J. (Contributor), Eline Slagboom (Contributor), van den Berg, L. H. (Contributor), Luijk, R. (Contributor), Jansen, R. (Contributor), 't Hoen, P. A. C. (Contributor), Lakenberg, N. (Contributor), van Galen, M. (Contributor), Heijmans, B. T. (Contributor), Verbiest, M. (Contributor), Wijmenga, C. (Contributor), Bonder, M. J. (Contributor), Beekman, M. (Contributor), Kielbasa, S. M. (Contributor), van 't Hof, P. (Contributor), van Rooij, J. (Contributor), van Heemst, D. (Contributor), Deelen, P. (Contributor), Uitterlinden, A. G. (Contributor), Pool, R. (Contributor), Vermaat, M. (Contributor), Verkerk, M. (Contributor), van Duijn, C. M. (Contributor), Isaacs, A. (Contributor), Moed, M. (Contributor), van Iterson, M. (Contributor), Stehouwer, C. D. A. (Contributor), Tigchelaar - Feenstra, E. (Contributor), Suchiman, H. E. D. (Contributor), Zhernakova, D. (Contributor), van Greevenbroek, M. M. J. (Contributor), van der Breggen, R. (Contributor), Swertz, M. (Contributor), Veldink, J. H. (Contributor), Boomsma, D. I. (Contributor), Bot, J. (Contributor), van Meurs, J. (Contributor), Jhamai, P. M. (Contributor), Deelen, J. (Contributor), 't Hoen, P. (Contributor), Zhernakova, S. (Contributor), Nooren, I. (Contributor), Hottenga, J. J. (Contributor), Franke, L. (Contributor), van Zwet, E. W. (Contributor) & van Dijk, F. (Contributor), University of Groningen, 28-Jan-2017
DOI: 10.6084/m9.figshare.c.3676579_d4.v1, https://doi.org/10.6084%2Fm9.figshare.c.3676579_d4.v1
Dataset
Additional file 5 of Controlling bias and inflation in epigenome- and transcriptome-wide association studies using the empirical null distribution
Wijmenga, C. (Contributor), Verbiest, M. (Contributor), Hofman, B. A. (Contributor), Vermaat, M. (Contributor), Nooren, I. (Contributor), Mei, H. (Contributor), Eline Slagboom (Contributor), van Iterson, M. (Contributor), Veldink, J. H. (Contributor), van Galen, M. (Contributor), van 't Hof, P. (Contributor), van Meurs, J. (Contributor), 't Hoen, P. (Contributor), van Heemst, D. (Contributor), Franke, L. (Contributor), Zhernakova, S. (Contributor), Moed, M. (Contributor), Verkerk, M. (Contributor), Pool, R. (Contributor), Beekman, M. (Contributor), van Dijk, F. (Contributor), van den Berg, L. H. (Contributor), Zhernakova, D. (Contributor), Bot, J. (Contributor), Hottenga, J. J. (Contributor), Lakenberg, N. (Contributor), van der Breggen, R. (Contributor), van der Kallen, C. J. H. (Contributor), Bonder, M. J. (Contributor), Deelen, P. (Contributor), Jansen, R. (Contributor), Schalkwijk, C. G. (Contributor), Jhamai, P. M. (Contributor), Swertz, M. (Contributor), Tigchelaar - Feenstra, E. (Contributor), Isaacs, A. (Contributor), Kielbasa, S. M. (Contributor), Luijk, R. (Contributor), Uitterlinden, A. G. (Contributor), van Dongen, J. (Contributor), van Greevenbroek, M. M. J. (Contributor), Arindrarto, W. (Contributor), van Rooij, J. (Contributor), Heijmans, B. T. (Contributor), Stehouwer, C. D. A. (Contributor), van Zwet, E. W. (Contributor), 't Hoen, P. A. C. (Contributor), Suchiman, H. E. D. (Contributor), Deelen, J. (Contributor), van Duijn, C. M. (Contributor) & Boomsma, D. I. (Contributor), University of Groningen, 28-Jan-2017
DOI: 10.6084/m9.figshare.c.3676579_d1.v1, https://doi.org/10.6084%2Fm9.figshare.c.3676579_d1.v1
Dataset

Did you follow COVID lockdown rules? Whether or not you did is partially driven by your DNA
Patrick Deelen
22/08/2022
1 Media contribution
Press/Media: Expert Comment › Popular
COVID-19: Whether you followed lockdown rules may have been influenced by your genetics
Patrick Deelen
23/05/2022
1 Media contribution
Press/Media: Expert Comment › Popular
Whether you followed lockdown rules may have been influenced by your genetics – new research
Patrick Deelen
22/05/2022
1 Media contribution
Press/Media: Expert Comment › Popular
Followed lockdown rules? It may have been your genetics, says new research
Patrick Deelen
22/05/2022
1 Media contribution
Press/Media: Expert Comment › Popular
Genetic regulation of blood cells: Proximity of a gene to a genetic change plays an important role
Marc Jan Bonder, Annique Claringbould & Patrick Deelen
22/09/2021
1 item of Media coverage
Press/Media: Research › Popular

Patrick Deelen

Personal profile

Research interests

Education/Academic qualification

Collaborations and top research areas from the last five years

Dive into details

Improving the diagnostic yield of exome-sequencing by predicting gene-phenotype associations using large-scale gene expression analysis

Identification of context-dependent expression quantitative trait loci in whole blood

Calling genotypes from public RNA-sequencing data enables identification of genetic variants that affect gene-expression levels

Brain expression quantitative trait locus and network analyses reveal downstream effects and putative drivers for brain-related diseases

Global Biobank analyses provide lessons for developing polygenic risk scores across diverse cohorts

Additional file 6 of Controlling bias and inflation in epigenome- and transcriptome-wide association studies using the empirical null distribution

Additional file 7 of Controlling bias and inflation in epigenome- and transcriptome-wide association studies using the empirical null distribution

Additional file 4 of Controlling bias and inflation in epigenome- and transcriptome-wide association studies using the empirical null distribution

Additional file 3 of Controlling bias and inflation in epigenome- and transcriptome-wide association studies using the empirical null distribution

Additional file 5 of Controlling bias and inflation in epigenome- and transcriptome-wide association studies using the empirical null distribution

Did you follow COVID lockdown rules? Whether or not you did is partially driven by your DNA

COVID-19: Whether you followed lockdown rules may have been influenced by your genetics

Whether you followed lockdown rules may have been influenced by your genetics – new research

Followed lockdown rules? It may have been your genetics, says new research

Genetic regulation of blood cells: Proximity of a gene to a genetic change plays an important role

Patrick Deelen

Personal profile

Research interests

Education/Academic qualification

Collaborations and top research areas from the last five years

Research output

Datasets

Press/Media