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  • 2024
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  • Donor genetic burden for cerebrovascular risk and kidney transplant outcome

    Collins, K. E., Gilbert, E., Mauduit, V., Benson, K. A., Elhassan, E. A. E., O'Seaghdha, C., Hill, C., McKnight, A. J., Maxwell, A. P., van der Most, P. J., de Borst, M. H., Guan, W., Jacobson, P. A., Israni, A. K., Keating, B. J., Lord, G. M., Markkinen, S., Helanterä, I., Hyvärinen, K. & Partanen, J. & 4 others, Madden, S. F., Limou, S., Cavalleri, G. L. & Conlon, P. J., 29-May-2024, (E-pub ahead of print) In: Journal of Nephrology. 10 p.

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  • Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits

    Million Veteran Program, Keaton, J. M., Kamali, Z., Xie, T., Vaez, A., Williams, A., Goleva, S. B., Ani, A., Evangelou, E., Hellwege, J. N., Yengo, L., Young, W. J., Traylor, M., Giri, A., Zheng, Z., Zeng, J., Chasman, D. I., Morris, A. P., Caulfield, M. J. & Hwang, S.-J. & 33 others, Kooner, J. S., Conen, D., Attia, J. R., Morrison, A. C., Loos, R. J. F., Kristiansson, K., Schmidt, R., Hicks, A. A., Pramstaller, P. P., Nelson, C. P., Samani, N. J., Risch, L., Gyllensten, U., Melander, O., Riese, H., Wilson, J. F., Campbell, H., Rich, S. S., Psaty, B. M., Lu, Y., Rotter, J. I., Guo, X., Rice, K. M., Vollenweider, P., van der Harst, P., van der Most, P. J., Oldehinkel, A. J., De Borst, M. H., Nolte, I. M., Visscher, P. M., Edwards, T. L., Snieder, H. & Warren, H. R., May-2024, In: Nature genetics. 56, 5, p. 778-791 14 p.

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  • Prioritization of Kidney Cell Types Highlights Myofibroblast Cells in Regulating Human Blood Pressure

    Ganji-Arjenaki, M., Kamali, Z., International Consortium Of Blood Pressure, Sardari, S., de Borst, M., Snieder, H. & Vaez, A., 2024, (Accepted/In press) In: Kidney International Reports.

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  • Open Access
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  • X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements

    Scholz, M., Horn, K., Pott, J., Wuttke, M., Kühnapfel, A., Nasr, M. K., Kirsten, H., Li, Y., Hoppmann, A., Gorski, M., Ghasemi, S., Li, M., Tin, A., Chai, J.-F., Cocca, M., Wang, J., Nutile, T., Akiyama, M., Åsvold, B. O. & Bansal, N. & 139 others, Biggs, M. L., Boutin, T., Brenner, H., Brumpton, B., Burkhardt, R., Cai, J., Campbell, A., Campbell, H., Chalmers, J., Chasman, D. I., Chee, M. L., Chee, M. L., Chen, X., Cheng, C.-Y., Cifkova, R., Daviglus, M., Delgado, G., Dittrich, K., Edwards, T. L., Endlich, K., Michael Gaziano, J., Giri, A., Giulianini, F., Gordon, S. D., Gudbjartsson, D. F., Hallan, S., Hamet, P., Hartman, C. A., Hayward, C., Heid, I. M., Hellwege, J. N., Holleczek, B., Holm, H., Hutri-Kähönen, N., Hveem, K., Isermann, B., Jonas, J. B., Joshi, P. K., Kamatani, Y., Kanai, M., Kastarinen, M., Khor, C. C., Kiess, W., Kleber, M. E., Körner, A., Kovacs, P., Krajcoviechova, A., Kramer, H., Krämer, B. K., Kuokkanen, M., Kähönen, M., Lange, L. A., Lash, J. P., Lehtimäki, T., Li, H., Lin, B. M., Liu, J., Loeffler, M., Lyytikäinen, L.-P., Magnusson, P. K. E., Martin, N. G., Matsuda, K., Milaneschi, Y., Mishra, P. P., Mononen, N., Montgomery, G. W., Mook-Kanamori, D. O., Mychaleckyj, J. C., März, W., Nauck, M., Nikus, K., Nolte, I. M., Noordam, R., Okada, Y., Olafsson, I., Oldehinkel, A. J., Penninx, B. W. J. H., Perola, M., Pirastu, N., Polasek, O., Porteous, D. J., Poulain, T., Psaty, B. M., Rabelink, T. J., Raffield, L. M., Raitakari, O. T., Rasheed, H., Reilly, D. F., Rice, K. M., Richmond, A., Ridker, P. M., Rotter, J. I., Rudan, I., Sabanayagam, C., Salomaa, V., Schneiderman, N., Schöttker, B., Sims, M., Snieder, H., Stark, K. J., Stefansson, K., Stocker, H., Stumvoll, M., Sulem, P., Sveinbjornsson, G., Svensson, P. O., Tai, E.-S., Taylor, K. D., Tayo, B. O., Teren, A., Tham, Y.-C., Thiery, J., Thio, C. H. L., Thomas, L. F., Tremblay, J., Tönjes, A., van der Most, P. J., Vitart, V., Völker, U., Wang, Y. X., Wang, C., Wei, W. B., Whitfield, J. B., Wild, S. H., Wilson, J. F., Winkler, T. W., Wong, T.-Y., Woodward, M., Sim, X., Chu, A. Y., Feitosa, M. F., Thorsteinsdottir, U., Hung, A. M., Teumer, A., Franceschini, N., Parsa, A., Köttgen, A., Schlosser, P. & Pattaro, C., 18-Jan-2024, (E-pub ahead of print) In: Nature Communications. 15, 1, 17 p., 586.

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  • 2023

    Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci

    de las Fuentes, L., Schwander, K. L., Brown, M. R., Bentley, A. R., Winkler, T. W., Sung, Y. J., Munroe, P. B., Miller, C. L., Aschard, H., Aslibekyan, S., Bartz, T. M., Bielak, L. F., Chai, J. F., Cheng, C. Y., Dorajoo, R., Feitosa, M. F., Guo, X., Hartwig, F. P., Horimoto, A. & Kolčić, I. & 178 others, Lim, E., Liu, Y., Manning, A. K., Marten, J., Musani, S. K., Noordam, R., Padmanabhan, S., Rankinen, T., Richard, M. A., Ridker, P. M., Smith, A. V., Vojinovic, D., Zonderman, A. B., Alver, M., Boissel, M., Christensen, K., Freedman, B. I., Gao, C., Giulianini, F., Harris, S. E., He, M., Hsu, F. C., Kühnel, B., Laguzzi, F., Li, X., Lyytikäinen, L. P., Nolte, I. M., Poveda, A., Rauramaa, R., Riaz, M., Robino, A., Sofer, T., Takeuchi, F., Tayo, B. O., van der Most, P. J., Verweij, N., Ware, E. B., Weiss, S., Wen, W., Yanek, L. R., Zhan, Y., Amin, N., Arking, D. E., Ballantyne, C., Boerwinkle, E., Brody, J. A., Broeckel, U., Campbell, A., Canouil, M., Chai, X., Chen, Y. D. I., Chen, X., Chitrala, K. N., Concas, M. P., de Faire, U., de Mutsert, R., de Silva, H. J., de Vries, P. S., Do, A., Faul, J. D., Fisher, V., Floyd, J. S., Forrester, T., Friedlander, Y., Girotto, G., Gu, C. C., Hallmans, G., Heikkinen, S., Heng, C. K., Homuth, G., Hunt, S., Ikram, M. A., Jacobs, D. R., Kavousi, M., Khor, C. C., Kilpeläinen, T. O., Koh, W. P., Komulainen, P., Langefeld, C. D., Liang, J., Liu, K., Liu, J., Lohman, K., Mägi, R., Manichaikul, A. W., McKenzie, C. A., Meitinger, T., Milaneschi, Y., Nauck, M., Nelson, C. P., O’Connell, J. R., Palmer, N. D., Pereira, A. C., Perls, T., Peters, A., Polašek, O., Raitakari, O. T., Rice, K., Rice, T. K., Rich, S. S., Sabanayagam, C., Schreiner, P. J., Shu, X. O., Sidney, S., Sims, M., Smith, J. A., Starr, J. M., Strauch, K., Tai, E. S., Taylor, K. D., Tsai, M. Y., Uitterlinden, A. G., van Heemst, D., Waldenberger, M., Wang, Y. X., Wei, W. B., Wilson, G., Xuan, D., Yao, J., Yu, C., Yuan, J. M., Zhao, W., Becker, D. M., Bonnefond, A., Bowden, D. W., Cooper, R. S., Deary, I. J., Divers, J., Esko, T., Franks, P. W., Froguel, P., Gieger, C., Jonas, J. B., Kato, N., Lakka, T. A., Leander, K., Lehtimäki, T., Magnusson, P. K. E., North, K. E., Ntalla, I., Penninx, B., Samani, N. J., Snieder, H., Spedicati, B., van der Harst, P., Völzke, H., Wagenknecht, L. E., Weir, D. R., Wojczynski, M. K., Wu, T., Zheng, W., Zhu, X., Bouchard, C., Chasman, D. I., Evans, M. K., Fox, E. R., Gudnason, V., Hayward, C., Horta, B. L., Kardia, S. L. R., Krieger, J. E., Mook-Kanamori, D. O., Peyser, P. A., Province, M. M., Psaty, B. M., Rudan, I., Sim, X., Smith, B. H., van Dam, R. M., van Duijn, C. M., Wong, T. Y., Arnett, D. K., Rao, D. C., Gauderman, J., Liu, C. T., Morrison, A. C., Rotter, J. I. & Fornage, M., 2-Nov-2023, In: Frontiers in Genetics. 14, 16 p., 1235337.

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  • Genetic insights into resting heart rate and its role in cardiovascular disease

    DCCT/EDIC Research Group, 2-Aug-2023, In: Nature Communications. 14, 21 p., 4646.

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  • Genetic Risk Score for Intracranial Aneurysms: Prediction of Subarachnoid Hemorrhage and Role in Clinical Heterogeneity

    HUNT All-In Stroke, CADISP group, International Consortium for Blood Pressure (ICBP), The International Headache Genetics Consortium (IHGC), International Stroke Genetics Consortium, ISGC Intracranial Aneurysm Working Group, Bakker, M. K., Kanning, J. P., Abraham, G., Martinsen, A. E., Winsvold, B. S., Zwart, J. A., Bourcier, R., Sawada, T., Koido, M., Kamatani, Y., Morel, S., Amouyel, P., Debette, S. & Bijlenga, P. & 8 others, Berrandou, T., Ganesh, S. K., Bouatia-Naji, N., Jones, G., Bown, M., Rinkel, G. J. E., Veldink, J. H. & Ruigrok, Y. M., Mar-2023, In: Stroke. 54, 3, p. 810-818 9 p.

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  • Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus

    eQTLgen Consortium, Mathieson, I., Day, F. R., Barban, N., Tropf, F. C., Brazel, D. M., Vaez, A., van Zuydam, N., Bitarello, B. D., Gardner, E. J., Akimova, E. T., Azad, A., Bergmann, S., Bielak, L. F., Boomsma, D. I., Bosak, K., Brumat, M., Buring, J. E., Cesarini, D. & Chasman, D. I. & 32 others, Chavarro, J. E., Cocca, M., Concas, M. P., Davey Smith, G., Davies, G., Deary, I. J., Esko, T., Faul, J. D., Franco, O., Ganna, A., Gaskins, A. J., Gelemanovic, A., de Geus, E. J. C., Gieger, C., Girotto, G., Gopinath, B., Grabe, H. J., Gunderson, E. P., Hayward, C., He, C., van Heemst, D., Hill, W. D., Kamali, Z., van der Most, P. J., Nolte, I. M., Penninx, B. W. J. H., Swertz, M. A., Zhao, J. H., Zhao, W., Snieder, H., Mills, M. C. & Perry, J. R. B., May-2023, In: Nature Human Behaviour. 7, p. 790–801 12 p.

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  • 2022

    A genome-wide association study of total child psychiatric problems scores

    Neumann, A., Nolte, I. M., Pappa, I., Ahluwalia, T. S., Pettersson, E., Rodriguez, A., Whitehouse, A., van Beijsterveldt, C. E. M., Benyamin, B., Hammerschlag, A. R., Helmer, Q., Karhunen, V., Krapohl, E., Lu, Y., van der Most, P. J., Palviainen, T., St Pourcain, B., Seppälä, I., Suarez, A. & Vilor-Tejedor, N. & 41 others, Tiesler, C. M. T., Wang, C., Wills, A., Zhou, A., Alemany, S., Bisgaard, H., Bønnelykke, K., Davies, G. E., Hakulinen, C., Henders, A. K., Hyppönen, E., Stokholm, J., Bartels, M., Hottenga, J.-J., Heinrich, J., Hewitt, J., Keltikangas-Järvinen, L., Korhonen, T., Kaprio, J., Lahti, J., Lahti-Pulkkinen, M., Lehtimäki, T., Middeldorp, C. M., Najman, J. M., Pennell, C., Power, C., Oldehinkel, A. J., Plomin, R., Räikkönen, K., Raitakari, O. T., Rimfeld, K., Sass, L., Snieder, H., Standl, M., Sunyer, J., Williams, G. M., Bakermans-Kranenburg, M. J., Boomsma, D. I., van IJzendoorn, M. H., Hartman, C. A. & Tiemeier, H., 22-Aug-2022, In: PLoS ONE. 17, 8, 23 p., e0273116.

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  • A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids

    Ramdas, S., Judd, J., Graham, S. E., Kanoni, S., Wang, Y., Surakka, I., Wenz, B., Million Veterans Program, Clarke, S. L., Chesi, A., Wells, A., Bhatti, K. F., Vedantam, S., Winkler, T. W., Locke, A. E., Marouli, E., Zajac, G. J. M., Wu, K.-H. H., Ntalla, I. & Hui, Q. & 31 others, Klarin, D., Hilliard, A. T., Wang, Z., Xue, C., Thorleifsson, G., Helgadottir, A., Gudbjartsson, D. F., Holm, H., Olafsson, I., Hwang, M. Y., Han, S., Akiyama, M., Zhao, W., Zhao, J.-H., Le, P., Verweij, N., Benjamins, J. W., Wang, Y. X., van der Most, P. J., van der Laan, S. W., Wang, J.-S., Asselbergs, F. W., Oldehinkel, A. J., Snieder, H., Penninx, B., Kumari, M., van der Harst, P., Huang, W., Kim, Y. J., de Vries, P. S. & Zhu, X., 4-Aug-2022, In: American Journal of Human Genetics. 109, 8, p. 1366-1387 22 p.

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  • A saturated map of common genetic variants associated with human height

    23andMe Res Team, VA Million Vet Program, DiscovEHR DiscovEHR MyCode Communi, eEMERGE Elect Med Records Genomics, Lifelines Cohort Study, PRACTICAl Consortium, Understanding Soc Sci Grp, Yengo, L., Vedantam, S., Marouli, E., Sidorenko, J., Bartell, E., Sakaue, S., Graff, M., Eliasen, A. U., Jiang, Y., Raghavan, S., Miao, J., Arias, J. D. & Graham, S. E. & 37 others, Mukamel, R. E., Spracklen, C. N., Yin, X., Chen, S.-H., Ferreira, T., Highland, H. H., Ji, Y., Karaderi, T., Lin, K., Lull, K., Malden, D. E., Medina-Gomez, C., Ani, A., Demirkan, A., Huang, J., Kim, Y. J., Le, P., Nolte, I. M., Raven, D., Smith, A., van der Laan, S. W., van der Most, P. J., Verweij, N., Xie, T., Zhao, J.-H., Zhao, W., Asselbergs, F. W., Hartman, C. A., Huang, W., Kumari, M., Oldehinkel, A. J., Penninx, B. W. J. H., Rienstra, M., Snieder, H., van der Harst, P., Wang, Y. X. & Visscher, P. M., Oct-2022, In: Nature. 610, p. 704–712 9 p.

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  • Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals

    Lifelines Cohort Study, VA Million Veteran Program, DiscovEHR/MyCode , Winkler, T. W., Rasheed, H., Teumer, A., Gorski, M., Rowan, B. X., Stanzick, K. J., Thomas, L. F., Tin, A., Hoppmann, A., Chu, A. Y., Tayo, B., Thio, C. H. L., Cusi, D., Chai, J.-F., Sieber, K. B., Horn, K. & Li, M. & 34 others, Scholz, M., Cocca, M., Wuttke, M., van der Most, P. J., Yang, Q., Ghasemi, S., Nutile, T., Li, Y., Pontali, G., Günther, F., Dehghan, A., Correa, A., Parsa, A., Feresin, A., de Vries, A. P. J., Zonderman, A. B., Smith, A. V., Oldehinkel, A. J., De Grandi, A., Rosenkranz, A. R., Franke, A., Teren, A., Penninx, B. W. J. H., Hartman, C. A., Snieder, H., Nolte, I. M., de Borst, M. H., Verweij, N., van der Harst, P., Gansevoort, R. T., Bakker, S. J. L., Huang, W., Wang, Y. X. & Heid, I. M., 13-Jun-2022, In: Communications biology. 5, 1, 20 p., 580.

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  • Genetic Determinants of Serum Calcification Propensity and Cardiovascular Outcomes in the General Population

    de Haan, A., Ahmadizar, F., van der Most, P. J., Thio, C. H. L., Kamali, Z., Ani, A., Ghanbari, M., Chaker, L., van Meurs, J., Ikram, M. K., van Goor, H., Bakker, S. J. L., van der Harst, P., Snieder, H., Kavousi, M., Pasch, A., Eijgelsheim, M. & de Borst, M. H., 14-Jan-2022, In: Frontiers in cardiovascular medicine. 8, 11 p., 809717.

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  • Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies

    Lifelines Cohort Study, Gorski, M., Rasheed, H., Teumer, A., Thomas, L. F., Graham, S. E., Sveinbjornsson, G., Winkler, T. W., Günther, F., Stark, K. J., Chai, J.-F., Tayo, B. O., Wuttke, M., Li, Y., Tin, A., Ahluwalia, T. S., Ärnlöv, J., Åsvold, B. O., Bakker, S. J. L. & Banas, B. & 31 others, Bansal, N., Biggs, M. L., Biino, G., Böhnke, M., Boerwinkle, E., Bottinger, E. P., Brenner, H., Brumpton, B., Carroll, R. J., Chaker, L., Chalmers, J., Chee, M.-L., Chee, M.-L., Cheng, C.-Y., Chu, A. Y., Ciullo, M., Cocca, M., Cook, J. P., Coresh, J., Cusi, D., de Borst, M. H., Degenhardt, F., Eckardt, K.-U., Gansevoort, R. T., Nolte, I. M., Penninx, B. W. J. H., Snieder, H., Thio, C. H. L., van der Harst, P., van der Most, P. J. & Verweij, N., Sept-2022, In: Kidney International. 102, 3, p. 624-639 16 p.

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  • Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention

    Lifelines Cohort Study, Wang, Z., Emmerich, A., Pillon, N. J., Moore, T., Hemerich, D., Cornelis, M. C., Mazzaferro, E., Broos, S., Ahluwalia, T. S., Bartz, T. M., Bentley, A. R., Bielak, L. F., Chong, M., Chu, A. Y., Berry, D., Dorajoo, R., Dueker, N. D., Kasbohm, E. & Feenstra, B. & 31 others, Feitosa, M. F., Gieger, C., Graff, M., Hall, L. M., Haller, T., Hartwig, F. P., Hillis, D. A., Huikari, V., Heard-Costa, N., Holzapfel, C., Jackson, A. U., Johansson, A., Jorgensen, A. M., Kaakinen, M. A., Karlsson, R., Kerr, K. F., Kim, B., Koolhaas, C. M., Kutalik, Z., Lagou, V., Van der Most, P. J., Van Vliet-Ostaptchouk, J. V., Zhao, J.-H., Zhao, W., Bruinenberg, M., Hartman, C. A., Nolte, I. M., Smith, A., Oldehinkel, A. J., Penninx, B. W. J. H. & Snieder, H., Sept-2022, In: Nature genetics. 54, 9, p. 1332–1344 13 p.

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  • Identification and single-base gene-editing functional validation of a cis-EPO variant as a genetic predictor for EPO-increasing therapies

    Harlow, C. E., Gandawijaya, J., Bamford, R. A., Martin, E. R., Wood, A. R., van der Most, P. J., Tanaka, T., Leonard, H. L., Etheridge, A. S., Innocenti, F., Beaumont, R. N., Tyrrell, J., Nalls, M. A., Simonsick, E. M., Garimella, P. S., Shiroma, E. J., Verweij, N., van der Meer, P., Gansevoort, R. T. & Snieder, H. & 13 others, Gallins, P. J., Jima, D. D., Wright, F., Zhou, Y.-H., Ferrucci, L., Bandinelli, S., Hernandez, D. G., van der Harst, P., Patel, V. V., Waterworth, D. M., Chu, A. Y., Oguro-Ando, A. & Frayling, T. M., 1-Sept-2022, In: American Journal of Human Genetics. 109, 9, p. 1638-1652 15 p.

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  • Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

    Kanoni, S., Graham, S. E., Wang, Y., Surakka, I., Ramdas, S., Zhu, X., Clarke, S. L., Bhatti, K. F., Vedantam, S., Winkler, T. W., Locke, A. E., Marouli, E., Zajac, G. J. M., Wu, K. H. H., Ntalla, I., Hui, Q., Klarin, D., Hilliard, A. T., Wang, Z. & Xue, C. & 519 others, Thorleifsson, G., Helgadottir, A., Gudbjartsson, D. F., Holm, H., Olafsson, I., Hwang, M. Y., Han, S., Akiyama, M., Sakaue, S., Terao, C., Kanai, M., Zhou, W., Brumpton, B. M., Rasheed, H., Havulinna, A. S., Veturi, Y., Pacheco, J. A., Rosenthal, E. A., Lingren, T., Feng, Q. P., Kullo, I. J., Narita, A., Takayama, J., Martin, H. C., Hunt, K. A., Trivedi, B., Haessler, J., Giulianini, F., Bradford, Y., Miller, J. E., Campbell, A., Lin, K., Millwood, I. Y., Rasheed, A., Hindy, G., Faul, J. D., Zhao, W., Weir, D. R., Turman, C., Huang, H., Graff, M., Choudhury, A., Sengupta, D., Mahajan, A., Brown, M. R., Zhang, W., Yu, K., Schmidt, E. M., Pandit, A., Gustafsson, S., Yin, X., Luan, J., Zhao, J. 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A., Lee, J. Y., Petersen, E. R. B., Nielsen, A. A., Choi, H. S., Nethander, M., Freitag-Wolf, S., Southam, L., Rayner, N. W., Wang, C. A., Lin, S. Y., Wang, J. S., Couture, C., Lyytikäinen, L. P., Nikus, K., Cuellar-Partida, G., Vestergaard, H., Hidalgo, B., Giannakopoulou, O., Cai, Q., Obura, M. O., van Setten, J., Li, X., Liang, J., Tang, H., Terzikhan, N., Shin, J. H., Jackson, R. D., Reiner, A. P., Martin, L. W., Chen, Z., Li, L., Kawaguchi, T., Thiery, J., Bis, J. C., Launer, L. J., Li, H., Nalls, M. A., Raitakari, O. T., Ichihara, S., Wild, S. H., Nelson, C. P., Campbell, H., Jäger, S., Nabika, T., Al-Mulla, F., Niinikoski, H., Braund, P. S., Kolcic, I., Kovacs, P., Giardoglou, T., Katsuya, T., de Kleijn, D., de Borst, G. J., Kim, E. K., Adams, H. H. H., Ikram, M. A., Zhu, X., Asselbergs, F. W., Kraaijeveld, A. O., Beulens, J. W. J., Shu, X. O., Rallidis, L. S., Pedersen, O., Hansen, T., Mitchell, P., Hewitt, A. W., Kähönen, M., Pérusse, L., Bouchard, C., Tönjes, A., Chen, Y. D. 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M., de Graaf, J., Loeffler, M., Kronenberg, F., Gu, D., Erdmann, J., Schunkert, H., Franks, P. W., Linneberg, A., Jukema, J. W., Khera, A. V., Männikkö, M., Jarvelin, M. R., Kutalik, Z., Francesco, C., Mook-Kanamori, D. O., van Dijk, K. W., Watkins, H., Strachan, D. P., Grarup, N., Sever, P., Poulter, N., Chuang, L. M., Rotter, J. I., Dantoft, T. M., Karpe, F., Neville, M. J., Timpson, N. J., Cheng, C. Y., Wong, T. Y., Khor, C. C., Li, H., Sabanayagam, C., Peters, A., Gieger, C., Hattersley, A. T., Pedersen, N. L., Magnusson, P. K. E., Boomsma, D. I., Willemsen, A. H. M., Cupples, L. A., van Meurs, J. B. J., Ghanbari, M., Gordon-Larsen, P., Huang, W., Kim, Y. J., Tabara, Y., Wareham, N. J., Langenberg, C., Zeggini, E., Kuusisto, J., Laakso, M., Ingelsson, E., Abecasis, G., Chambers, J. C., Kooner, J. S., de Vries, P. S., Morrison, A. C., Hazelhurst, S., Ramsay, M., North, K. E., Daviglus, M., Kraft, P., Martin, N. G., Whitfield, J. B., Abbas, S., Saleheen, D., Walters, R. G., Holmes, M. V., Black, C., Smith, B. H., Baras, A., Justice, A. E., Buring, J. E., Ridker, P. M., Chasman, D. I., Kooperberg, C., Tamiya, G., Yamamoto, M., van Heel, D. A., Trembath, R. C., Wei, W. Q., Jarvik, G. P., Namjou, B., Hayes, M. G., Ritchie, M. D., Jousilahti, P., Salomaa, V., Hveem, K., Åsvold, B. O., Kubo, M., Kamatani, Y., Okada, Y., Murakami, Y., Kim, B. J., Thorsteinsdottir, U., Stefansson, K., Zhang, J., Chen, Y. E., Ho, Y. L., Lynch, J. A., Rader, D. J., Tsao, P. S., Chang, K. M., Cho, K., O’Donnell, C. J., Gaziano, J. M., Wilson, P. W. F., Frayling, T. M., Hirschhorn, J. N., Kathiresan, S., Mohlke, K. L., Sun, Y. V., Morris, A. P., Boehnke, M., Brown, C. D., Natarajan, P., Deloukas, P., Willer, C. J., Assimes, T. L. & Peloso, G. M., Dec-2022, In: Genome Biology. 23, 42 p., 268.

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  • Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals

    23andMe Research Team, Social Science Genetic Association Consortium, Okbay, A., Wu, Y., Wang, N., Jayashankar, H., Bennett, M., Nehzati, S. M., Sidorenko, J., Kweon, H., Goldman, G., Gjorgjieva, T., Jiang, Y., Hicks, B., Tian, C., Hinds, D. A., Ahlskog, R., Magnusson, P. K. E., Oskarsson, S. & Hayward, C. & 5 others, Campbell, A., Porteous, D. J., Freese, J., Herd, P. & Young, A. I., Apr-2022, In: Nature genetics. 54, 4, p. 437-449 13 p.

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  • 2021

    A Bidirectional Mendelian Randomization Study to evaluate the causal role of reduced blood vitamin D levels with type 2 diabetes risk in South Asians and Europeans

    Bejar, C. A., Goyal, S., Afzal, S., Mangino, M., Zhou, A., van der Most, P. J., Bao, Y., Gupta, V., Smart, M. C., Walia, G. K., Verweij, N., Power, C., Prabhakaran, D., Singh, J. R., Mehra, N. K., Wander, G. S., Ralhan, S., Kinra, S., Kumari, M. & de Borst, M. H. & 5 others, Hypponen, E., Spector, T. D., Nordestgaard, B. G., Blackett, P. R. & Sanghera, D. K., 27-Jul-2021, In: Nutrition journal. 20, 1, 11 p., 71.

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  • Open Access
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  • Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes

    Lifelines Cohort Study, VA Million Veteran Program, Pazoki, R., Vujkovic, M., Elliott, J., Evangelou, E., Gill, D., Ghanbari, M., van der Most, P. J., Pinto, R. C., Wielscher, M., Farlik, M., Zuber, V., de Knegt, R. J., Snieder, H., Uitterlinden, A. G., Lynch, J. A., Jiang, X., Said, S. & Kaplan, D. E. & 17 others, Lee, K. M., Serper, M., Carr, R. M., Tsao, P. S., Atkinson, S. R., Dehghan, A., Tzoulaki, I., Ikram, M. A., Herzig, K. H., Järvelin, M. R., Alizadeh, B. Z., O'Donnell, C. J., Saleheen, D., Voight, B. F., Chang, K. M., Thursz, M. R. & Elliott, P., 10-May-2021, In: Nature Communications. 12, 1, 12 p., 2579.

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  • Genomic analysis of diet composition finds novel loci and associations with health and lifestyle

    23andMe Research Team, Meddens, S. F. W., de Vlaming, R., Bowers, P., Burik, C. A. P., Linnér, R. K., Lee, C., Okbay, A., Turley, P., Rietveld, C. A., Fontana, M. A., Ghanbari, M., Imamura, F., McMahon, G., van der Most, P. J., Voortman, T., Wade, K. H., Anderson, E. L., Braun, K. V. E. & Emmett, P. M. & 24 others, Esko, T., Gonzalez, J. R., Kiefte-de Jong, J. C., Langenberg, C., Luan, J., Muka, T., Ring, S., Rivadeneira, F., Snieder, H., van Rooij, F. J. A., Wolffenbuttel, B. H. R., Smith, G. D., Franco, O. H., Forouhi, N. G., Ikram, M. A., Uitterlinden, A. G., van Vliet-Ostaptchouk, J. V., Wareham, N. J., Cesarini, D., Harden, K. P., Lee, J. J., Benjamin, D. J., Chow, C. C. & Koellinger, P. D., Jun-2021, In: Molecular Psychiatry. 26, p. 2056–2069 14 p.

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  • GWASinspector: comprehensive quality control of genome-wide association study results

    Ani, A., Van Der Most, P. J., Snieder, H., Vaez, A. & Nolte, I. M., 1-Jan-2021, In: Bioinformatics (Oxford, England). 37, 1, p. 129-130 2 p.

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  • Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline

    Lifelines Cohort Study, Regeneron Genetics Ctr, Gorski, M., Jung, B., Li, Y., Matias-Garcia, P. R., Wuttke, M., Coassin, S., Thio, C. H. L., Kleber, M. E., Winkler, T. W., Wanner, V., Chai, J.-F., Chu, A. Y., Cocca, M., Feitosa, M. F., Ghasemi, S., Hoppmann, A., Horn, K. & Li, M. & 32 others, Nutile, T., Scholz, M., Sieber, K. B., Teumer, A., Tin, A., Wang, J., Tayo, B. O., Ahluwalia, T. S., Almgren, P., Bakker, S. J. L., Banas, B., Bansal, N., Biggs, M. L., Boerwinkle, E., Bottinger, E. P., Brenner, H., Carroll, R. J., Chalmers, J., Chee, M.-L., Chee, M.-L., Cheng, C.-Y., Coresh, J., de Borst, M. H., Degenhardt, F., Gansevoort, R. T., Nolte, I. M., Penninx, B. W. J. H., van der Harst, P., van der Most, P. J., Verweij, N., Zhang, Y. & Snieder, H., Apr-2021, In: Kidney International. 99, 4, p. 926-939 14 p.

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  • Multi-Ancestry Genome-wide Association Study Accounting for Gene-Psychosocial Factor Interactions Identifies Novel Loci for Blood Pressure Traits

    Lifelines Cohort Study, Sun, D., Richard, M., Musani, S. K., Sung, Y. J., Winkler, T. W., Schwander, K., Chai, J. F., Guo, X., Kilpeläinen, T. O., Vojinovic, D., Aschard, H., Bartz, T. M., Bielak, L. F., Brown, M. R., Chitrala, K., Hartwig, F. P., Horimoto, A. R. V. R., Liu, Y. & Manning, A. K. & 32 others, Noordam, R., Smith, A. V., Harris, S. E., Kühnel, B., Lyytikäinen, L.-P., Nolte, I. M., Rauramaa, R., van der Most, P. J., Wang, R., Ware, E. B., Weiss, S., Wen, W., Yanek, L. R., Arking, D. E., Arnett, D. K., Barac, A., Boerwinkle, E., Broeckel, U., Chakravarti, A., Chen, Y.-D. I., Cupples, L. A., Davigulus, M. L., de Las Fuentes, L., de Mutsert, R., de Vries, P. S., Hartman, C. C. A., Zhao, W., Oldehinkel, A. J., Penninx, B. W. J. H., Snieder, H., Wang, Y.-X. & Fornage, M., 14-Jan-2021, In: HGG advances. 2, 1

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  • Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

    Wang, H., Noordam, R., Cade, B. E., Schwander, K., Winkler, T. W., Lee, J., Sung, Y. J., Bentley, A. R., Manning, A. K., Aschard, H., Kilpeläinen, T. O., Ilkov, M., Brown, M. R., Horimoto, A. R., Richard, M., Bartz, T. M., Vojinovic, D., Lim, E., Nierenberg, J. L. & Liu, Y. & 105 others, Chitrala, K., Rankinen, T., Musani, S. K., Franceschini, N., Rauramaa, R., Alver, M., Zee, P. C., Harris, S. E., van der Most, P. J., Nolte, I. M., Munroe, P. B., Palmer, N. D., Kühnel, B., Weiss, S., Wen, W., Hall, K. A., Lyytikäinen, L.-P., O'Connell, J., Eiriksdottir, G., Launer, L. J., de Vries, P. S., Arking, D. E., Chen, H., Boerwinkle, E., Krieger, J. E., Schreiner, P. J., Sidney, S., Shikany, J. M., Rice, K., Chen, Y.-D. I., Gharib, S. A., Bis, J. C., Luik, A. I., Ikram, M. A., Uitterlinden, A. G., Amin, N., Xu, H., Levy, D., He, J., Lohman, K. K., Zonderman, A. B., Rice, T. K., Sims, M., Wilson, G., Sofer, T., Rich, S. S., Palmas, W., Yao, J., Guo, X., Rotter, J. I., Biermasz, N. R., Mook-Kanamori, D. O., Martin, L. W., Barac, A., Wallace, R. B., Gottlieb, D. J., Komulainen, P., Heikkinen, S., Mägi, R., Milani, L., Metspalu, A., Starr, J. M., Milaneschi, Y., Waken, R. J., Gao, C., Waldenberger, M., Peters, A., Strauch, K., Meitinger, T., Roenneberg, T., Völker, U., Dörr, M., Shu, X.-O., Mukherjee, S., Hillman, D. R., Kähönen, M., Wagenknecht, L. E., Gieger, C., Grabe, H. J., Zheng, W., Palmer, L. J., Lehtimäki, T., Gudnason, V., Morrison, A. C., Pereira, A. C., Fornage, M., Psaty, B. M., van Duijn, C. M., Liu, C.-T., Kelly, T. N., Evans, M. K., Bouchard, C., Fox, E. R., Kooperberg, C., Zhu, X., Lakka, T. A., Esko, T., North, K. E., Deary, I. J., Snieder, H., Penninx, B. W. J. H., Gauderman, W. J., Rao, D. C., Redline, S. & van Heemst, D., 15-Apr-2021, In: Molecular Psychiatry. 12 p.

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  • Search for a Functional Genetic Variant Mimicking the Effect of SGLT2 Inhibitor Treatment

    Wang, S., Said, M. A., Groot, H. E., Most, P. J. V. D., Thio, C. H. L., Vegte, Y. J. V. D., Verweij, N., Snieder, H. & Harst, P. V. D., Aug-2021, In: Genes. 12, 8, p. 1-13 13 p., 1174.

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  • The power of genetic diversity in genome-wide association studies of lipids

    VA Million Veteran Program, Graham, S. E., Clarke, S. L., Wu, K.-H. H., Kanoni, S., Zajac, G. J. M., Ramdas, S., Surakka, I., Ntalla, I., Vedantam, S., Winkler, T. W., Locke, A. E., Marouli, E., Hwang, M. Y., Han, S., Narita, A., Choudhury, A., Bentley, A. R., Ekoru, K. & Verma, A. & 31 others, Trivedi, B., Martin, H. C., Hunt, K. A., Hui, Q., Klarin, D., Zhu, X., Thorleifsson, G., Helgadottir, A., Gudbjartsson, D. F., Holm, H., Olafsson, I., Akiyama, M., Sakaue, S., Terao, C., Zhao, W., Zhao, J.-H., Verweij, N., Benjamins, J. W., Le, P., Wang, Y. X., van der Most, P. J., van der Laan, S. W., Asselbergs, F. W., Oldehinkel, A. J., Snieder, H., Penninx, B., Kumari, M., van der Harst, P., Huang, W., Kim, Y. J. & de Vries, P. S., 23-Dec-2021, In: Nature. 600, p. 675-679 25 p.

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  • The trans-ancestral genomic architecture of glycemic traits

    Lifelines Cohort Study, Metaanal Glucose Insulin Related, Chen, J., Spracklen, C. N., Marenne, G., Varshney, A., Corbin, L. J., Luan, J., Willems, S. M., Wu, Y., Zhang, X., Horikoshi, M., Boutin, T. S., Magi, R., Waage, J., Li-Gao, R., Chan, K. H. K., Yao, J., Anasanti, M. D. & Chu, A. Y. & 33 others, Claringbould, A., Heikkinen, J., Hong, J., Hottenga, J.-J., Huo, S., Kaakinen, M. A., Louie, T., Maerz, W., Moreno-Macias, H., Ndungu, A., Nelson, S. C., Nolte, I. M., North, K. E., Demirkan, A., Kim, Y. J., Sanna, S., Smith, A. V., van der Most, P. J., Verweij, N., Xie, T., Zhao, J.-H., Zhao, W., Bakker, S. J. L., Hartman, C. A., Raven, D., van Vliet-Ostaptchouk, J. V., Boomsma, D. I., Huang, W., Kumari, M., Snieder, H., van der Harst, P., Wang, Y. X. & Oldehinkel, A. J., Jun-2021, In: Nature Genetics. 53, p. 840-860 41 p.

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  • 2020

    Genetic Risk Scores for Complex Disease Traits in Youth

    Xie, T., Wang, B., Nolte, I. M., van der Most, P. J., Oldehinkel, A. J., Hartman, C. A. & Snieder, H., Aug-2020, In: Circulation. Genomic and precision medicine. 13, 4, p. 212-221 10 p., e002775.

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  • Identification, Heritability, and Relation With Gene Expression of Novel DNA Methylation Loci for Blood Pressure

    Huang, Y., Ollikainen, M., Muniandy, M., Zhang, T., van Dongen, J., Hao, G., van Der Most, P. J., Pan, Y., Pervjakova, N., Sun, Y., Hui, Q., Lahti, J., Fraszczyk, E., Lu, X., Sun, D., Richard, M. A., Willemsen, G., Heikkila, K., Leach, I. M. & Mononen, N. & 30 others, Kahonen, M., Hurme, M. A., Raitakari, O. T., Drake, A. J., Perola, M., Nuotio, M.-L., Huang, Y., Khulan, B., Raikkonen, K., Wolffenbuttel, B. H. R., Zhernakova, A., Fu, J., Zhu, H., Dong, Y., van Vliet-Ostaptchouk, J. V., Franke, L., Eriksson, J. G., Fornage, M., Milani, L., Lehtimaki, T., Vaccarino, V., Boomsma, D., van Der Harst, P., de Geus, E. J. C., Salomaa, V., Li, S., Chen, W., Su, S., Wilson, J. & Snieder, H., Jul-2020, In: Hypertension. 76, 1, p. 195-205 11 p.

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  • Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits

    Early Growth Genetics Consortium, Vogelezang, S., Bradfield, J. P., Ahluwalia, T. S., Curtin, J. A., Lakka, T. A., Grarup, N., Scholz, M., van der Most, P. J., Monnereau, C., Stergiakouli, E., Heiskala, A., Horikoshi, M., Fedko, I. O., Vilor-Tejedor, N., Cousminer, D. L., Standl, M., Wang, C. A., Viikari, J. & Geller, F. & 31 others, Íñiguez, C., Pitkänen, N., Chesi, A., Bacelis, J., Yengo, L., Torrent, M., Ntalla, I., Helgeland, Ø., Selzam, S., Vonk, J. M., Zafarmand, M. H., Heude, B., Farooqi, I. S., Alyass, A., Beaumont, R. N., Have, C. T., Rzehak, P., Bilbao, J. R., Schnurr, T. M., Barroso, I., Bønnelykke, K., Beilin, L. J., Carstensen, L., Charles, M.-A., Chawes, B., Clément, K., Closa-Monasterolo, R., Custovic, A., Reijneveld, S. A., Koppelman, G. H. & Snieder, H., 12-Oct-2020, In: PLoS genetics. 16, 10, 26 p., e1008718.

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  • Post-GWAS analysis of six substance use traits improves the identification and functional interpretation of genetic risk loci

    Int Cannabis Consortium, 1-Jan-2020, In: Drug and Alcohol Dependence. 206, 9 p., 107703.

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  • 2019

    A catalog of genetic loci associated with kidney function from analyses of a million individuals

    Lifelines Cohort Study, Wuttke, M., Li, Y., Li, M., Sieber, K. B., Feitosa, M. F., Gorski, M., Tin, A., Wang, L., Chu, A. Y., Hoppmann, A., Kirsten, H., Giri, A., Chai, J.-F., Sveinbjornsson, G., Tayo, B. O., Nutile, T., Fuchsberger, C., Marten, J. & Cocca, M. & 32 others, Ghasemi, S., Xu, Y., Horn, K., Noce, D., Van der Most, P. J., Sedaghat, S., Yu, Z., Akiyama, M., Afaq, S., Ahluwalia, T. S., Almgren, P., Amin, N., Arnlov, J., Bakker, S. J. L., Bansal, N., De Borst, M. H., De Vries, A. P. J., Demirkan, A., Gansevoort, R. T., Hartman, C. A., Huang, W., Nolte, I. M., Oldehinkel, A. J., Penninx, B. W. J. H., Prins, B. P., Smith, A. V., Van der Harst, P., Verweij, N., Wang, Y. X., Xu, L., Snieder, H. & Thio, C. H. L., Jun-2019, In: Nature Genetics. 51, 6, p. 957-+ 19 p.

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  • A Potential Role for the STXBP5-AS1 Gene in Adult ADHD Symptoms

    EAGLE-ADHD Consortium, May-2019, In: Behavior Genetics. 49, 3, p. 270-285 16 p.

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  • Associations of autozygosity with a broad range of human phenotypes

    Clark, D. W., Okada, Y., Moore, K. H. S., Mason, D., Pirastu, N., Gandin, I., Mattsson, H., Barnes, C. L. K., Lin, K., Zhao, J. H., Deelen, P., Rohde, R., Schurmann, C., Guo, X., Giulianini, F., Zhang, W., Medina-Gomez, C., Karlsson, R., Bao, Y. & Bartz, T. M. & 416 others, Baumbach, C., Biino, G., Bixley, M. J., Brumat, M., Chai, J.-F., Corre, T., Cousminer, D. L., Dekker, A. M., Eccles, D. A., van Eijk, K. R., Fuchsberger, C., Gao, H., Germain, M., Gordon, S. D., de Haan, H. G., Harris, S. E., Hofer, E., Huerta-Chagoya, A., Igartua, C., Jansen, I. E., Jia, Y., Kacprowski, T., Karlsson, T., Kleber, M. E., Li, S. A., Li-Gao, R., Mahajan, A., Matsuda, K., Meidtner, K., Meng, W., Montasser, M. E., van der Most, P. J., Munz, M., Nutile, T., Palviainen, T., Prasad, G., Prasad, R. B., Priyanka, T. D. S., Rizzi, F., Salvi, E., Sapkota, B. R., Shriner, D., Skotte, L., Smart, M. C., Smith, A. V., van der Spek, A., Spracklen, C. N., Strawbridge, R. J., Tajuddin, S. M., Trompet, S., Turman, C., Verweij, N., Viberti, C., Wang, L., Warren, H. R., Wootton, R. E., Yanek, L. R., Yao, J., Yousri, N. A., Zhao, W., Adeyemo, A. A., Afaq, S., Aguilar-Salinas, C. A., Akiyama, M., Albert, M. L., Allison, M. A., Alver, M., Aung, T., Azizi, F., Bentley, A. R., Boeing, H., Boerwinkle, E., Borja, J. B., de Borst, G. J., Bottinger, E. P., Broer, L., Campbell, H., Chanock, S., Chee, M.-L., Chen, G., Chen, Y.-D. I., Chen, Z., Chiu, Y.-F., Cocca, M., Collins, F. S., Concas, M. P., Corley, J., Cugliari, G., van Dam, R. M., Damulina, A., Daneshpour, M. S., Day, F. R., Delgado, G. E., Dhana, K., Doney, A. S. F., Dörr, M., Doumatey, A. P., Dzimiri, N., Ebenesersdóttir, S. S., Elliott, J., Elliott, P., Ewert, R., Felix, J. F., Fischer, K., Freedman, B. I., Girotto, G., Goel, A., Gögele, M., Goodarzi, M. O., Graff, M., Granot-Hershkovitz, E., Grodstein, F., Guarrera, S., Gudbjartsson, D. F., Guity, K., Gunnarsson, B., Guo, Y., Hagenaars, S. P., Haiman, C. A., Halevy, A., Harris, T. B., Hedayati, M., van Heel, D. A., Hirata, M., Höfer, I., Hsiung, C. A., Huang, J., Hung, Y.-J., Ikram, M. A., Jagadeesan, A., Jousilahti, P., Kamatani, Y., Kanai, M., Kerrison, N. D., Kessler, T., Khaw, K.-T., Khor, C. C., de Kleijn, D. P. V., Koh, W.-P., Kolcic, I., Kraft, P., Krämer, B. K., Kutalik, Z., Kuusisto, J., Langenberg, C., Launer, L. J., Lawlor, D. A., Lee, I.-T., Lee, W.-J., Lerch, M. M., Li, L., Liu, J., Loh, M., London, S. J., Loomis, S., Lu, Y., Luan, J., Mägi, R., Manichaikul, A. W., Manunta, P., Másson, G., Matoba, N., Mei, X. W., Meisinger, C., Meitinger, T., Mezzavilla, M., Milani, L., Millwood, I. Y., Momozawa, Y., Moore, A., Morange, P.-E., Moreno-Macías, H., Mori, T. A., Morrison, A. C., Muka, T., Murakami, Y., Murray, A. D., de Mutsert, R., Mychaleckyj, J. C., Nalls, M. A., Nauck, M., Neville, M. J., Nolte, I. M., Ong, K. K., Orozco, L., Padmanabhan, S., Pálsson, G., Pankow, J. S., Pattaro, C., Pattie, A., Polasek, O., Poulter, N., Pramstaller, P. P., Quintana-Murci, L., Räikkönen, K., Ralhan, S., Rao, D. C., van Rheenen, W., Rich, S. S., Ridker, P. M., Rietveld, C. A., Robino, A., van Rooij, F. J. A., Ruggiero, D., Saba, Y., Sabanayagam, C., Sabater-Lleal, M., Sala, C. F., Salomaa, V., Sandow, K., Schmidt, H., Scott, L. J., Scott, W. R., Sedaghati-Khayat, B., Sennblad, B., van Setten, J., Sever, P. J., Sheu, W. H.-H., Shi, Y., Shrestha, S., Shukla, S. R., Sigurdsson, J. K., Sikka, T. T., Singh, J. R., Smith, B. H., Stančáková, A., Stanton, A., Starr, J. M., Stefansdottir, L., Straker, L., Sulem, P., Sveinbjornsson, G., Swertz, M. A., Taylor, A. M., Taylor, K. D., Terzikhan, N., Tham, Y.-C., Thorleifsson, G., Thorsteinsdottir, U., Tillander, A., Tracy, R. P., Tusié-Luna, T., Tzoulaki, I., Vaccargiu, S., Vangipurapu, J., Veldink, J. H., Vitart, V., Völker, U., Vuoksimaa, E., Wakil, S. M., Waldenberger, M., Wander, G. S., Wang, Y. X., Wareham, N. J., Wild, S., Yajnik, C. S., Yuan, J.-M., Zeng, L., Zhang, L., Zhou, J., Amin, N., Asselbergs, F. W., Bakker, S. J. L., Becker, D. M., Lehne, B., Bennett, D. A., van den Berg, L. H., Berndt, S. I., Bharadwaj, D., Bielak, L. F., Bochud, M., Boehnke, M., Bouchard, C., Bradfield, J. P., Brody, J. A., Campbell, A., Carmi, S., Caulfield, M. J., Cesarini, D., Chambers, J. C., Chandak, G. R., Cheng, C.-Y., Ciullo, M., Cornelis, M., Cusi, D., Smith, G. D., Deary, I. J., Dorajoo, R., van Duijn, C. M., Ellinghaus, D., Erdmann, J., Eriksson, J. G., Evangelou, E., Evans, M. K., Faul, J. D., Feenstra, B., Feitosa, M., Foisy, S., Franke, A., Friedlander, Y., Gasparini, P., Gieger, C., Gonzalez, C., Goyette, P., Grant, S. F. A., Griffiths, L. R., Groop, L., Gudnason, V., Gyllensten, U., Hakonarson, H., Hamsten, A., van der Harst, P., Heng, C.-K., Hicks, A. A., Hochner, H., Huikuri, H., Hunt, S. C., Jaddoe, V. W. V., De Jager, P. L., Johannesson, M., Johansson, Å., Jonas, J. B., Jukema, J. W., Junttila, J., Kaprio, J., Kardia, S. L. R., Karpe, F., Kumari, M., Laakso, M., van der Laan, S. W., Lahti, J., Laudes, M., Lea, R. A., Lieb, W., Lumley, T., Martin, N. G., März, W., Matullo, G., McCarthy, M. I., Medland, S. E., Merriman, T. R., Metspalu, A., Meyer, B. F., Mohlke, K. L., Montgomery, G. W., Mook-Kanamori, D., Munroe, P. B., North, K. E., Nyholt, D. R., O'connell, J. R., Ober, C., Oldehinkel, A. J., Palmas, W., Palmer, C., Pasterkamp, G. G., Patin, E., Pennell, C. E., Perusse, L., Peyser, P. A., Pirastu, M., Polderman, T. J. C., Porteous, D. J., Posthuma, D., Psaty, B. M., Rioux, J. D., Rivadeneira, F., Rotimi, C., Rotter, J. I., Rudan, I., Den Ruijter, H. M., Sanghera, D. K., Sattar, N., Schmidt, R., Schulze, M. B., Schunkert, H., Scott, R. A., Shuldiner, A. R., Sim, X., Small, N., Smith, J. A., Sotoodehnia, N., Tai, E.-S., Teumer, A., Timpson, N. J., Toniolo, D., Tregouet, D.-A., Tuomi, T., Vollenweider, P., Wang, C. A., Weir, D. R., Whitfield, J. B., Wijmenga, C., Wong, T.-Y., Wright, J., Yang, J., Yu, L., Zemel, B. S., Zonderman, A. B., Perola, M., Magnusson, P. K. E., Uitterlinden, A. G., Kooner, J. S., Chasman, D. I., Loos, R. J. F., Franceschini, N., Franke, L., Haley, C. S., Hayward, C., Walters, R. G., Perry, J. R. B., Esko, T., Helgason, A., Stefansson, K., Joshi, P. K., Kubo, M. & Wilson, J. F., 31-Oct-2019, In: Nature Communications. 10, 1, 17 p., 4957.

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  • Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder

    ADHD Working Grp Psychiat Genomics, Early Lifecourse Genetic, 23andMe Res Team, Demontis, D., Walters, R. K., Martin, J., Mattheisen, M., Als, T. D., Agerbo, E., Baldursson, G., Belliveau, R., Bybjerg-Grauholm, J., Baekvad-Hansen, M., Cerrato, F., Chambert, K., Churchhouse, C., Dumont, A., Eriksson, N., Gandal, M. & Goldstein, J. I. & 33 others, Grasby, K. L., Grove, J., Gudmundsson, O. O., Hansen, C. S., Hauberg, M. E., Hollegaard, M. V., Howrigan, D. P., Huang, H., Maller, J. B., Martin, A. R., Martin, N. G., Moran, J., Pallesen, J., Palmer, D. S., Pedersen, C. B., Pedersen, M. G., Poterba, T., Poulsen, J. B., Ripke, S., Robinson, E. B., Satterstrom, F. K., Stefansson, H., Stevens, C., Turley, P., Walters, G. B., Won, H., Wright, M. J., Nguyen, T. T., Davies, G. E., Hartman, C. A., Nolte, I. M., Ormel, J. & van der Most, P. J., Jan-2019, In: Nature Genetics. 51, 1, p. 63–75 16 p.

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  • Effects of Calcium, Magnesium, and Potassium Concentrations on Ventricular Repolarization in Unselected Individuals

    Noordam, R., Young, W. J., Salman, R., Kanters, J. K., van den Berg, M. E., van Heemst, D., Lin, H. J., Barreto, S. M., Biggs, M. L., Biino, G., Catamo, E., Concas, M. P., Ding, J., Evans, D. S., Foco, L., Grarup, N., Lyytikäinen, L.-P., Mangino, M., Mei, H. & van der Most, P. J. & 83 others, Müller-Nurasyid, M., Nelson, C. P., Qian, Y., Repetto, L., Said, M. A., Shah, N., Schramm, K., Vidigal, P. G., Weiss, S., Yao, J., Zilhao, N. R., Brody, J. A., Braund, P. S., Brumat, M., Campana, E., Christofidou, P., Caulfield, M. J., De Grandi, A., Dominiczak, A. F., Doney, A. S. F., Eiriksdottir, G., Ellervik, C., Giatti, L., Gögele, M., Graff, C., Guo, X., van der Harst, P., Joshi, P. K., Kähönen, M., Kestenbaum, B., Lima-Costa, M. F., Linneberg, A., Maan, A. C., Meitinger, T., Padmanabhan, S., Pattaro, C., Peters, A., Petersmann, A., Sever, P., Sinner, M. F., Shen, X., Stanton, A., Strauch, K., Soliman, E. Z., Tarasov, K. V., Taylor, K. D., Thio, C. H. L., Uitterlinden, A. G., Vaccargiu, S., Waldenberger, M., Robino, A., Correa, A., Cucca, F., Cummings, S. R., Dörr, M., Girotto, G., Gudnason, V., Hansen, T., Heckbert, S. R., Juhl, C. R., Kääb, S., Lehtimäki, T., Liu, Y., Lotufo, P. A., Palmer, C. N. A., Pirastu, M., Pramstaller, P. P., Ribeiro, A. L. P., Rotter, J. I., Samani, N. J., Snieder, H., Spector, T. D., Stricker, B. H., Verweij, N., Wilson, J. F., Wilson, J. G., Jukema, J. W., Tinker, A., Newton-Cheh, C. H., Sotoodehnia, N., Mook-Kanamori, D. O., Munroe, P. B. & Warren, H. R., 25-Jun-2019, In: Journal of the American College of Cardiology. 73, 24, p. 3118-3131 14 p.

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  • Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria

    Teumer, A., Li, Y., Ghasemi, S., Prins, B. P., Wuttke, M., Hermle, T., Giri, A., Sieber, K. B., Qiu, C., Kirsten, H., Tin, A., Chu, A. Y., Bansal, N., Feitosa, M. F., Wang, L., Chai, J.-F., Cocca, M., Fuchsberger, C., Gorski, M. & Hoppmann, A. & 166 others, Horn, K., Li, M., Marten, J., Noce, D., Nutile, T., Sedaghat, S., Sveinbjornsson, G., Tayo, B. O., Van der Most, P. J., Xu, Y., Yu, Z., Gerstner, L., Arnlov, J., Bakker, S. J. L., Baptista, D., Biggs, M. L., Boerwinkle, E., Brenner, H., Burkhardt, R., Carroll, R. J., Chee, M.-L., Chee, M.-L., Chen, M., Cheng, C.-Y., Cook, J. P., Coresh, J., Corre, T., Danesh, J., de Borst, M. H., De Grandi, A., de Mutsert, R., de Vries, A. P. J., Degenhardt, F., Dittrich, K., Divers, J., Eckardt, K.-U., Ehret, G., Endlich, K., Felix, J. F., Franco, O. H., Franke, A., Freedman, B. I., Freitag-Wolf, S., Gansevoort, R. T., Giedraitis, V., Gogele, M., Grundner-Culemann, F., Gudbjartsson, D. F., Gudnason, V., Hamet, P., Harris, T. B., Hicks, A. A., Holm, H., Foo, V. H. X., Hwang, S.-J., Ikram, M. A., Ingelsson, E., Jaddoe, V. W. V., Jakobsdottir, J., Josyula, N. S., Jung, B., Kahonen, M., Khor, C.-C., Kiess, W., Koenig, W., Koerner, A., Kovacs, P., Kramer, H., Kraemer, B. K., Kronenberg, F., Lange, L. A., Langefeld, C. D., Lee, J. J.-M., Lehtimaki, T., Lieb, W., Lim, S.-C., Lind, L., Lindgren, C. M., Liu, J., Loeffler, M., Lyytikainen, L.-P., Mahajan, A., Maranville, J. C., Mascalzoni, D., McMullen, B., Meisinger, C., Meitinger, T., Miliku, K., Mook-Kanamori, D. O., Mueller-Nurasyid, M., Mychaleckyj, J. C., Nauck, M., Nikus, K., Ning, B., Noordam, R., Connell, J. O., Olafsson, I., Palmer, N. D., Peters, A., Podgornaia, A. I., Ponte, B., Poulain, T., Pramstaller, P. P., Rabelink, T. J., Raffield, L. M., Reilly, D. F., Rettig, R., Rheinberger, M., Rice, K. M., Rivadeneira, F., Runz, H., Ryan, K. A., Sabanayagam, C., Saum, K.-U., Schoettker, B., Shaffer, C. M., Shi, Y., Smith, A. V., Strauch, K., Stumvoll, M., Sun, B. B., Szymczak, S., Tai, E.-S., Tan, N. Y. Q., Taylor, K. D., Teren, A., Tham, Y.-C., Thiery, J., Thio, C. H. L., Thomsen, H., Thorsteinsdottir, U., Tonjes, A., Tremblay, J., Uitterlinden, A. G., Van der Harst, P., Verweij, N., Vogelezang, S., Voelker, U., Waldenberger, M., Wang, C., Wilson, O. D., Wong, C., Wong, T.-Y., Yang, Q., Yasuda, M., Akilesh, S., Bochud, M., Boeger, C. A., Devuyst, O., Edwards, T. L., Ho, K., Morris, A. P., Parsa, A., Pendergrass, S. A., Psaty, B. M., Rotter, J. I., Stefansson, K., Wilson, J. G., Susztak, K., Snieder, H., Heid, I. M., Scholz, M., Butterworth, A. S., Hung, A. M., Pattaro, C. & Koettgen, A., 11-Sept-2019, In: Nature Communications. 10, 1, p. 4130 19 p., 4130.

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  • Genome-Wide Association Scan of Serum Urea in European Populations Identifies Two Novel Loci

    Lifelines Cohort Study group, Thio, C. H. L., Reznichenko, A., van der Most, P. J., Kamali, Z., Vaez, A., Smit, J. H., Penninx, B. W. J. H., Haller, T., Mihailov, E., Metspalu, A., Damman, J., de Borst, M. H., van der Harst, P., Verweij, N., Navis, G. J., Gansevoort, R. T., Nolte, I. M. & Snieder, H., 2019, In: American Journal of Nephrology. 49, 3, p. 193-202 10 p.

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  • Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions

    InterAct Consortium & LifeLines Cohort Study Grp, Jun-2019, In: American Journal of Epidemiology. 188, 6, p. 1033-1054 22 p.

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  • Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

    Kilpelainen, T. O., Nolte, I. M., van der Most, P. J., Verweij, N., Snieder, H., van der Ende, M. Y., Oldehinkel, A. J., van der Harst, P., Van Vliet-Ostaptchouk, J. V., Lifelines Cohort Study & Wang, Y. X., 22-Jan-2019, In: Nature Communications. 10, 1, 11 p., 376.

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  • Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels

    German Chronic Kidney Disease Study, Tin, A., Marten, J., Halperin Kuhns, V. L., Li, Y., Wuttke, M., Kirsten, H., Sieber, K. B., Qiu, C., Gorski, M., Yu, Z., Giri, A., Sveinbjornsson, G., Li, M., Chu, A. Y., Hoppmann, A., O'Connor, L. J., Prins, B., Nutile, T. & Noce, D. & 31 others, Akiyama, M., Cocca, M., Ghasemi, S., van der Most, P. J., Horn, K., Xu, Y., Fuchsberger, C., Sedaghat, S., Afaq, S., Amin, N., Ärnlöv, J., Bakker, S. J. L., Bansal, N., Baptista, D., Bergmann, S., Biggs, M. L., Biino, G., Boerwinkle, E., Bottinger, E. P., Boutin, T. S., Brumat, M., de Borst, M. H., de Vries, A. P. J., Gansevoort, R. T., Huang, W., Nolte, I. M., Penninx, B. W. J. H., Smith, A. V., van der Harst, P., Verweij, N. & Snieder, H., Oct-2019, In: Nature Genetics. 51, 10, p. 1459-1474 22 p.

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  • The impact of donor and recipient common clinical and genetic variation on estimated glomerular filtration rate in a European renal transplant population

    UK Ireland Renal Transplant Consortium, Stapleton, C. P., Heinzel, A., Guan, W., van der Most, P. J., van Setten, J., Lord, G. M., Keating, B. J., Israni, A. K., de Borst, M. H., Bakker, S. J. L., Snieder, H., Weale, M. E., Delaney, F., Hernandez-Fuentes, M. P., Reindl-Schwaighofer, R., Oberbauer, R., Jacobson, P. A., Mark, P. B. & Chapman, F. A. & 16 others, Phelan, P. J., Kennedy, C., Sexton, D., Murray, S., Jardine, A., Traynor, J. P., McKnight, A. J., Maxwell, A. P., Smyth, L. J., Oetting, W. S., Matas, A. J., Mannon, R. B., Schladt, D. P., Iklé, D. N., Cavalleri, G. L. & Conlon, P. J., Aug-2019, In: American Journal of Transplantation. 19, 8, p. 2262-2273 12 p.

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