Roel Bovenberg

2021

CRISPR-based transcriptional activation tool for silent genes in filamentous fungi

Mózsik, L., Hoekzema, M., de Kok, N. A. W., Bovenberg, R. A. L., Nygård, Y. & Driessen, A. J. M., 13-Jan-2021, In: Scientific Reports. 11, 1, 13 p., 1118.

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33 Citations (Scopus)

240 Downloads (Pure)

Identification of a conserved N-terminal domain in the first module of ACV synthetases

Iacovelli, R., Mózsik, L., Bovenberg, R. A. L. & Driessen, A. J. M., Feb-2021, In: MicrobiologyOpen. 10, 1, 16 p., e1145.

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5 Citations (Scopus)

85 Downloads (Pure)

Modular Synthetic Biology Toolkit for Filamentous Fungi

Mózsik, L., Pohl, C., Meyer, V., Bovenberg, R. A. L., Nygård, Y. & Driessen, A. J. M., 19-Nov-2021, In: ACS Synthetic Biology. 10, 11, p. 2850–2861 12 p.

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44 Citations (Scopus)

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Nonribosomal peptide synthetases and their biotechnological potential in Penicillium rubens

Iacovelli, R., Bovenberg, R. A. L. & Driessen, A. J. M., Oct-2021, In: Journal of Industrial Microbiology & Biotechnology. 48, 7-8, 30 p., kuab045.

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25 Citations (Scopus)

148 Downloads (Pure)

2020

A Penicillium rubens platform strain for secondary metabolite production

Pohl, C., Polli, F., Schütze, T., Viggiano, A., Mózsik, L., Jung, S., de Vries, M., Bovenberg, R. A. L., Meyer, V. & Driessen, A. J. M., 1-Dec-2020, In: Scientific Reports. 10, 1, 16 p., 7630.

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37 Citations (Scopus)

320 Downloads (Pure)

Biochemical characterization of the Nocardia lactamdurans ACV synthetase

Iacovelli, R., Zwahlen, R. D., Bovenberg, R. A. L. & Driessen, A. J. M., Apr-2020, In: PLoS ONE. 15, 4, 16 p., e0231290.

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5 Citations (Scopus)

131 Downloads (Pure)

Impact of classical strain improvement of penicillium rubens on amino acid metabolism during β-Lactam production

Wu, M., Crismaru, C. G., Salo, O., Bovenberg, R. A. L. & Driessen, A. J. M., 1-Feb-2020, In: Applied and environmental microbiology. 86, 3, 14 p., e01561.

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14 Citations (Scopus)

103 Downloads (Pure)

2019

Bacterial MbtH-like proteins stimulate nonribosomal peptide synthetase-derived secondary metabolism in the filamentous fungi

Zwahlen, R., Pohl, C., Bovenberg, R. A. L. & Driessen, A. J. M., Sept-2019, In: ACS Synthetic Biology. 8, 8, p. 1776-1787 12 p.

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12 Citations (Scopus)

201 Downloads (Pure)

Synthetic control devices for gene regulation in Penicillium chrysogenum

Mózsik, L., Büttel, Z., Bovenberg, R. A. L., Driessen, A. J. M. & Nygård, Y., 18-Nov-2019, In: Microbial Cell Factories. 18, 1, 13 p., 203.

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16 Citations (Scopus)

199 Downloads (Pure)

2018

Deregulation of secondary metabolism in a histone deacetylase mutant of Penicillium chrysogenum

Guzman-Chavez, F., Salo, O., Samol, M., Ries, M., Kuipers, J., Bovenberg, R. A. L., Vreeken, R. J. & Driessen, A. J. M., Oct-2018, In: MicrobiologyOpen. 7, 5, 15 p., e00598.

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28 Citations (Scopus)

346 Downloads (Pure)

Pathway for the Biosynthesis of the Pigment Chrysogine by Penicillium chrysogenum

Viggiano, A., Salo, O., Ali, H., Szymanski, W., Lankhorst, P. P., Nygård, Y., Bovenberg, R. A. L. & Driessen, A. J. M., Feb-2018, In: Applied and environmental microbiology. 84, 4, 11 p., e02246-17.

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34 Citations (Scopus)

603 Downloads (Pure)

2017

Mechanism and regulation of sorbicillin biosynthesis by Penicillium chrysogenum

Guzmán-Chávez, F., Salo, O., Nygård, Y., Lankhorst, P. P., Bovenberg, R. A. L. & Driessen, A. J. M., Jul-2017, In: Microbial Biotechnology. 10, 4, p. 958-968 11 p.

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46 Citations (Scopus)

419 Downloads (Pure)

2016

A Minimal Model of Ribosome Allocation Dynamics Captures Trade-offs in Expression between Endogenous and Synthetic Genes

Gorochowski, T. E., Avcilar-Kucukgoze, I., Bovenberg, R. A. L., Roubos, J. A. & Ignatova, Z., 25-Apr-2016, In: ACS Synthetic Biology. 5, 7, p. 710-720 11 p., 6b00040.

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92 Citations (Scopus)

80 Downloads (Pure)

CRISPR/Cas9 based genome editing of Penicillium chrysogenum

Pohl, C., Kiel, J. A. K. W., Driessen, A. J. M., Bovenberg, R. A. L. & Nygård, Y., 12-Apr-2016, In: ACS Synthetic Biology. 5, 7, p. 754-764 11 p., 6b00082.

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285 Citations (Scopus)

467 Downloads (Pure)

Identification of a polyketide synthase involved in sorbicillin biosynthesis by Penicillium chrysogenum

Salo, O., Guzmán-Chávez, F., Ries, M. I., Lankhorst, P. P., Bovenberg, R. A. L., Vreeken, R. J. & Driessen, A. J. M., 22-Apr-2016, In: Applied and environmental microbiology. 82, 13, p. 3971-3978 8 p., 00350-00316.

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62 Citations (Scopus)

334 Downloads (Pure)

Metabolic Engineering toward Sustainable Production of Nylon-6

Turk, S. C. H. J., Kloosterman, W. P., Ninaber, D. K., Kolen, K. P. A. M., Knutova, J., Suir, E., Schurmann, M., Raemakers-Franken, P. C., Muller, M., de Wildeman, S. M. A., Raamsdonk, L. M., van der Pol, R., Wu, L., Temudo, M. F., van der Hoeven, R. A. M., Akeroyd, M., van der Stoel, R. E., Noorman, H. J., Bovenberg, R. A. L. & Trefzer, A. C., Jan-2016, In: ACS Synthetic Biology. 5, 1, p. 65-73 9 p.

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98 Citations (Scopus)

327 Downloads (Pure)

New promoters for strain engineering of Penicillium chrysogenum

Polli, F., Meijrink, B., Bovenberg, R. A. L. & Driessen, A. J. M., 1-Apr-2016, In: Fungal Genetics and Biology. 89, p. 62-71 10 p.

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37 Citations (Scopus)

150 Downloads (Pure)

2015

Algorithmic co-optimization of genetic constructs and growth conditions: application to 6-ACA, a potential nylon-6 precursor

Zhou, H., Vonk, B., Roubos, J. A., Bovenberg, R. A. L. & Voigt, C. A., 2015, In: Nucleic Acids Research.

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57 Citations (Scopus)

329 Downloads (Pure)

A Mutasynthesis Approach with a Penicillium chrysogenum ΔroqA Strain Yields New Roquefortine D Analogues

Ouchaou, K., Maire, F., Salo, O., Ali, H., Hankemeier, T., van der Marel, G. A., Filippov, D. V., Bovenberg, R. A. L., Vreeken, R. J., Driessen, A. J. M. & Overkleeft, H. S., 12-Mar-2015, In: ChemBioChem. 16, p. 915-923 9 p.

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9 Citations (Scopus)

79 Downloads (Pure)

Functional exchangeability of oxidase and dehydrogenase reactions in the biosynthesis of hydroxyphenylglycine, a non-ribosomal peptide building block

Diez, V., Loznik, M., Taylor, S., Winn, M., Rattray, N. J. W., Podmore, H., Micklefield, J., Goodacre, R., Medema, M. H., Müller, U., Bovenberg, R. A. L., Janssen, D. B. & Takano, E., 25-Feb-2015, In: ACS Synthetic Biology. 4, 7, p. 796-807 12 p.

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7 Citations (Scopus)

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Genomic mutational analysis of the impact of the classical strain improvement program on β-lactam producing Penicillium chrysogenum

Salo, O. V., Ries, M., Medema, M. H., Lankhorst, P. P., Vreeken, R. J., Bovenberg, R. A. L. & Driessen, A. J. M., 18-Nov-2015, In: BMC Genomics. 16, 1, 15 p., 937.

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51 Citations (Scopus)

313 Downloads (Pure)

2014

A Non-Canonical NRPS Is Involved in the Synthesis of Fungisporin and Related Hydrophobic Cyclic Tetrapeptides in Penicillium chrysogenum

Ali, H., Ries, M. I., Lankhorst, P. P., van der Hoeven, R. A. M., Schouten, O. L., Noga, M., Hankemeier, T., van Peij, N. N. M. E., Bovenberg, R. A. L., Vreeken, R. J. & Driessen, A. J. M., 2-Jun-2014, In: PLoS ONE. 9, 6, 10 p., e98212.

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38 Citations (Scopus)

282 Downloads (Pure)

Using Synthetic Biological Parts and Microbioreactors to Explore the Protein Expression Characteristics of Escherichia coli

Gorochowski, T. E., van den Berg, E., Kerkman, R., Roubos, J. A. & Bovenberg, R. A. L., Mar-2014, In: ACS Synthetic Biology. 3, 3, p. 129-139 11 p.

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32 Citations (Scopus)

87 Downloads (Pure)

2013

A Branched Biosynthetic Pathway Is Involved in Production of Roquefortine and Related Compounds in Penicillium chrysogenum

Ali, H., Ries, M. I., Nijland, J. G., Lankhorst, P. P., Hankemeier, T., Bovenberg, R. A. L., Vreeken, R. J. & Driessen, A. J. M., 12-Jun-2013, In: PLoS ONE. 8, 6, 12 p., e65328.

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81 Citations (Scopus)

696 Downloads (Pure)

Novel Key Metabolites Reveal Further Branching of the Roquefortine/Meleagrin Biosynthetic Pathway

Ries, M. I., Ali, H., Lankhorst, P. P., Hankemeier, T., Bovenberg, R. A. L., Driessen, A. J. M. & Vreeken, R. J., 2013, In: J. Biol. Chem.. 288, 52, p. 37289-37295 7 p.

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46 Citations (Scopus)

309 Downloads (Pure)

2012

A turning point for natural product discovery - ESF-EMBO research conference: synthetic biology of antibiotic production

Takano, E., Bovenberg, R. A. L. & Breitling, R., Mar-2012, In: Molecular Microbiology. 83, 5, p. 884-893 10 p.

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4 Citations (Scopus)

369 Downloads (Pure)

Genetic Circuit Performance under Conditions Relevant for Industrial Bioreactors

Moser, F., Broers, N. J., Hartmans, S., Tamsir, A., Kerkman, R., Roubos, J. A., Bovenberg, R. & Voigt, C. A., Nov-2012, In: ACS Synthetic Biology. 1, 11, p. 555-564 10 p.

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83 Citations (Scopus)

Impact of Velvet Complex on Transcriptome and Penicillin G Production in Glucose-Limited Chemostat Cultures of a beta-Lactam High-Producing Penicillium chrysogenum Strain

Veiga, T., Nijland, J. G., Driessen, A. J. M., Bovenberg, R. A. L., Touw, H., van den Berg, M. A., Pronk, J. T., Daran, J.-M. & Veiga, T., Jun-2012, In: OMICS: A Journal of Integrative Biology. 16, 6, p. 320-333 14 p.

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22 Citations (Scopus)

65 Downloads (Pure)

Increased Penicillin Production in Penicillium chrysogenum Production Strains via Balanced Overexpression of Isopenicillin N Acyltransferase

Weber, S. S., Polli, F., Boer, R., Bovenberg, R. A. L. & Driessen, A. J. M., Oct-2012, In: Applied and environmental microbiology. 78, 19, p. 7107-7113 7 p.

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44 Citations (Scopus)

657 Downloads (Pure)

Metabolic engineering of beta-oxidation in Penicillium chrysogenum for improved semi-synthetic cephalosporin biosynthesis

Veiga, T., Gombert, A. K., Landes, N., Verhoeven, M. D., Kiel, J. A. K. W., Krikken, A. M., Nijland, J. G., Touw, H., Luttik, M. A. H., van der Toorn, J. C., Driessen, A. J. M., Bovenberg, R. A. L., van den Berg, M. A., van der Klei, I. J., Pronk, J. T. & Daran, J.-M., Jul-2012, In: Metabolic Engineering. 14, 4, p. 437-448 12 p.

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23 Citations (Scopus)

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The ABC transporter ABC40 encodes a phenylacetic acid export system in Penicillium chrysogenum

Weber, S. S., Kovalchuk, A., Bovenberg, R. A. L. & Driessen, A. J. M., Nov-2012, In: Fungal Genetics and Biology. 49, 11, p. 915-921 7 p.

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17 Citations (Scopus)

107 Downloads (Pure)

2011

Aminoacyl-coenzyme A synthesis catalyzed by a CoA ligase from Penicillium chrysogenum

Koetsier, M. J., Jekel, P. A., Wijma, H. J., Bovenberg, R. A. L. & Janssen, D. B., 23-Mar-2011, In: FEBS Letters. 585, 6, p. 893-898 6 p.

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9 Citations (Scopus)

39 Downloads (Pure)

Autophagy Deficiency Promotes β-Lactam Production in Penicillium chrysogenum

Bartosweska, M., Kiel, J. A. K. W., Bovenberg, R. A. L., Veenhuis, M. & van der Klei, I. J., Feb-2011, In: Applied and environmental microbiology. 77, 4, p. 1413-1422 10 p.

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45 Citations (Scopus)

19 Downloads (Pure)

Degeneration of penicillin production in ethanol-limited chemostat cultivations of Penicillium chrysogenum: A systems biology approach

Douma, R. D., Batista, J. M., Touw, K. M., Kiel, J. A. K. W., Zhao, Z., Veiga, T., Klaassen, P., Bovenberg, R. A. L., Daran, J.-M., van Gulik, W. M., Heijnen, J. J. & Krikken, A., 19-Aug-2011, In: BMC Systems Biology. 5, 16 p., 132.

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31 Citations (Scopus)

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Exploiting plug-and-play synthetic biology for drug discovery and production in microorganisms

Medema, M. H., Breitling, R., Bovenberg, R. & Takano, E., Feb-2011, In: Nature Reviews Microbiology. 9, 2, p. 131-137 7 p.

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146 Citations (Scopus)

Genome-wide gene expression changes in an industrial clavulanic acid overproduction strain of Streptomyces clavuligerus

Medema, M. H., Alam, M. T., Heijne, W. H. M., Berg, M. A. V. D., Müller, U., Trefzer, A., Bovenberg, R. A. L., Breitling, R. & Takano, E., Mar-2011, In: Microbial Biotechnology. 4, 2, p. 300-305 6 p.

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44 Citations (Scopus)

268 Downloads (Pure)

2010

Biosynthesis of active pharmaceuticals: β-lactam biosynthesis in filamentous fungi

van den Berg, M. A., Gidijala, L., Kiel, J. A. K. W., Bovenberg, R. A. L. & van der Klei, I. J., 2010, In: Biotechnol Genet Eng Rev. 27, 1, p. 1-31 31 p.

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16 Citations (Scopus)

Nonlinear Biosynthetic Gene Cluster Dose Effect on Penicillin Production by Penicillium chrysogenum

Nijland, J. G., Ebbendorf, B., Woszczynska, M., Boer, R., Bovenberg, R. A. L. & Driessen, A. J. M., Nov-2010, In: Applied and environmental microbiology. 76, 21, p. 7109-7115 7 p.

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39 Citations (Scopus)

342 Downloads (Pure)

Peroxisomes are required for efficient penicillin biosynthesis in Penicillium chrysogenum

Meijer, W. H., Gidijala, L., Fekken, S., Kiel, J. A. K. W., van den Berg, M. A., Lascaris, R., Bovenberg, R. A. L. & van der Klei, I. J., Sept-2010, In: Applied and environmental microbiology. 76, 17, p. 5702-5709 8 p.

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85 Citations (Scopus)

603 Downloads (Pure)

The Penicillium chrysogenum aclA gene encodes a broad-substrate-specificity acyl-coenzyme A ligase involved in activation of adipic acid, a side-chain precursor for cephem antibiotics

Koetsier, M. J., Gombert, A. K., Fekken, S., Bovenberg, R. A. L., Van den Berg, M. A., Kiel, J. A. K. W., Jekel, P. A., Janssen, D. B., Pronk, J. T., Van der Klei, I. J. & Daran, J.-M., Jan-2010, In: Fungal Genetics and Biology. 47, 1, p. 33-42 10 p.

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29 Citations (Scopus)

92 Downloads (Pure)

The Sequence of a 1.8-Mb Bacterial Linear Plasmid Reveals a Rich Evolutionary Reservoir of Secondary Metabolic Pathways

Medema, M. H., Trefzer, A., Kovalchuk, A., van den Berg, M., Muller, U., Heijne, W., Wu, L., Alam, M. T., Ronning, C. M., Nierman, W. C., Bovenberg, R. A. L., Breitling, R. & Takano, E., 2010, In: Genome Biology and Evolution. 2, p. 212-224 13 p.

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168 Citations (Scopus)

681 Downloads (Pure)

2009

An Engineered Yeast Efficiently Secreting Penicillin

Gidijala, L., Kiel, J. A. K. W., Douma, R. D., Seifar, R. M., van Gulik, W. M., Bovenberg, R. A. L., Veenhuis, M. & van der Klei, I. J., 15-Dec-2009, In: PLoS ONE. 4, 12, 9 p., 8317.

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71 Citations (Scopus)

428 Downloads (Pure)

Characterization of a phenylacetate-CoA ligase from Penicillium chrysogenum

Koetsier, M. J., Jekel, P. A., van den Berg, M. A., Bovenberg, R. A. L. & Janssen, D. B., 15-Jan-2009, In: Biochemical Journal. 417, p. 467-476 10 p.

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45 Citations (Scopus)

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Matching the proteome to the genome: the microbody of penicillin-producing Penicillium chrysogenum cells

Kiel, J. A. K. W., van den Berg, M. A., Fusetti, F., Poolman, B., Bovenberg, R. A. L., Veenhuis, M. & van der Klei, I. J., May-2009, In: FUNCTIONAL & INTEGRATIVE GENOMICS. 9, 2, p. 167-184 18 p.

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85 Citations (Scopus)

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2008

Expression of the transporter encoded by the cefT gene of Acremonium chrysogenum increases cephalosporin production in Penicillium chrysogenum

Nijland, J. G., Kovalchuk, A., van den Berg, M. A., Bovenberg, R. A. L. & Driessen, A. J. M., Oct-2008, In: Fungal Genetics and Biology. 45, 10, p. 1415-1421 7 p.

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39 Citations (Scopus)

107 Downloads (Pure)

Genome sequencing and analysis of the filamentous fungus Penicillium chrysogenum

van den Berg, M. A., Albang, R., Albermann, K., Badger, J. H., Daran, J.-M., Driessen, A. J. M., Garcia-Estrada, C., Fedorova, N. D., Harris, D. M., Heijne, W. H. M., Joardar, V., Kiel, J. A. K. W., Kovalchuk, A., Martin, J. F., Nierman, W. C., Nijland, J. G., Pronk, J. T., Roubos, J. A., van der Klei, I. J. & van Peij, N. N. M. E. & 5 others, Veenhuis, M., von Doehren, H., Wagner, C., Wortman, J. & Bovenberg, R. A. L., Oct-2008, In: Nature Biotechnology. 26, 10, p. 1161-1168 8 p.

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