Research output per year
Research output per year
Personal profile
Research interests
My practical and theoretical background enables me to take an integrative omics approach to identify driver genetic alterations, genes and biological pathways that are relevant for the pathophysiological behaviour and treatment response of tumors and rapidly translate these findings to clinical practice.
In addition to my training as a medical doctor, I completed one full year of Mathematics and Computer Science, after which I continued to obtain my MSc degree in Cognitive Science and Engineering.
In parallel to my medical studies, I worked for several years as a bio-informatician at the Department of Genetics, UMCG. In 2010, I obtained my PhD on high dimensional data analysis for new insights into ovarian cancer phenotypes, after which I continued as an affiliated post-doc at the Departments of Genetics and Medical Oncology (UMCG).
I followed the residency program in Internal Medicine / Medical Oncology and now work as a medical oncologist (staff member) at the department of Medical Oncology at the UMCG. In addition, I am a principal investigator at the Cancer Research Center Groningen in the research programmes: ‘Guided Treatment in Optimal Selected Cancer Patients (GUTS)’ and ‘Damage and Repair in Cancer Development and Cancer (DARE)’.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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128P - Whole blood transcriptomics identifies transcriptional patterns linked to outcomes in patients receiving immune checkpoint inhibitors
Hone Lopez, S., Loipfinger, S., Bhattacharya, A., Jalving, M., Oosting, S. F., Hiltermann, J., de Bruyn, M., de Vries, E. G. E., de Haan, J.-J. & Fehrmann, R., 14-Sept-2024, In: Annals of Oncology. 35, Supplement 2, p. S266 1 p.Research output: Contribution to journal › Meeting Abstract › Academic
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Exploring combinations of dimensionality reduction, transfer learning, and regularization methods for predicting binary phenotypes with transcriptomic data
Oshternian, S. R., Loipfinger, S., Bhattacharya, A. & Fehrmann, R. S. N., 26-Apr-2024, In: Bmc Bioinformatics. 25, 19 p., 167.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile2 Citations (Scopus)34 Downloads (Pure) -
Functional ex vivo DNA fibre assay to measure replication dynamics in breast cancer tissue
Chen, M., van den Tempel, N., Bhattacharya, A., Yu, S., Rutgers, B., Fehrmann, R. S. N., de Haas, S., van der Vegt, B. & van Vugt, M. A. T. M., Sept-2024, In: Journal of Pathology. 264, 1, p. 90-100 11 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile38 Downloads (Pure) -
Identification of new head and neck squamous cell carcinoma molecular imaging targets
van Schaik, J. E., van der Vegt, B., Slagter-Menkema, L., van der Laan, B. F. A. M., Witjes, M. J. H., Oosting, S. F., Fehrmann, R. S. N. & Plaat, B. E. C., Apr-2024, In: Oral Oncology. 151, 7 p., 106736.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile46 Downloads (Pure) -
Independent transcriptional patterns reveal biological processes associated with disease-free survival in early colorectal cancer
Knapen, D. G., Hone Lopez, S., de Groot, D. J. A., de Haan, J.-J., de Vries, E. G. E., Dienstmann, R., de Jong, S., Bhattacharya, A. & Fehrmann, R. S. N., 3-May-2024, In: Communications medicine. 4, 10 p., 79.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile41 Downloads (Pure)
Activities
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Novel AI-enabled strategies in biomarker-informed clinical trials
Fehrmann, R. (Invited speaker)
15-Sept-2024Activity: Talk and presentation › Professional or public presentation › Professional
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The significance of real-world data: OncoLifeS
Fehrmann, R. (Invited speaker)
22-Jan-2024Activity: Talk and presentation › Academic presentation › Academic
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Deciphering the Role of Leukocytes in Sepsis-Induced Acute Lung Injury: Pathogenesis, Biomarkers, and Therapeutic Implications.
Fehrmann, R. (Supervisor)
2024 → …Activity: Examination, teaching and supervision › Supervision and examination of PhD students of the UG › Academic
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Using machine learning to unravel the 'cancer-immune setpoint' in rare cancers (SETPOINT)
Fehrmann, R. (Invited speaker)
26-Nov-2024Activity: Talk and presentation › Professional or public presentation › Professional
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Mechanistic understanding and therapeutic targeting of immune evasion in triple-negative breast cancer
van Vugt, M. (Supervisor) & Fehrmann, R. (Supervisor)
2023 → 2027Activity: Examination, teaching and supervision › Supervision and examination of PhD students of the UG › Academic
Datasets
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Data to: Evidence Based Selection of Housekeeping Genes
de Jonge, H. (Creator), Fehrmann, R. (Creator), de Bont, E. (Creator), Hofstra, R. M. W. (Creator), Gerbens, F. (Creator), Kamps, W. (Creator), de Vries, E. G. E. (Creator), van der Zee, A. (Creator), te Meerman, G. (Creator) & ter Elst, A. (Creator), University of Groningen, 19-Sept-2007
https://figshare.com/articles/Evidence_Based_Selection_of_Housekeeping_Genes/151673
Dataset
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Additional file 2 of Total serum N-glycans associate with response to immune checkpoint inhibition therapy and survival in patients with advanced melanoma
Visconti, A. (Creator), Rossi, N. (Creator), Deriš, H. (Creator), Lee, K. A. (Creator), Hanić, M. (Creator), Trbojević-Akmačić, I. (Creator), Thomas, A. M. (Creator), Bolte, L. (Creator), Björk, J. (Creator), Hooiveld-Noeken, J. (Creator), Board, R. (Creator), Harland, M. (Creator), Newton-Bishop, J. (Creator), Harries, M. (Creator), Sacco, J. J. (Creator), Lorigan, P. (Creator), Shaw, H. M. (Creator), de Vries, L. (Creator), Fehrmann, R. S. N. (Creator), Weersma, R. K. (Creator), Spector, T. D. (Creator), Nathan, P. (Creator), Hospers, G. A. P. (Creator), Sasieni, P. (Creator), Bataille, V. (Creator), Lauc, G. (Creator) & Falchi, M. (Creator), figshare, 18-Feb-2023
DOI: 10.6084/m9.figshare.22613744.v1, https://springernature.figshare.com/articles/dataset/Additional_file_2_of_Total_serum_N-glycans_associate_with_response_to_immune_checkpoint_inhibition_therapy_and_survival_in_patients_with_advanced_melanoma/22613744/1
Dataset
Press/Media
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KWF-subsidie voor onderzoek naar werking immuuntherapie bij triple-negatieve borstkanker
22/07/2022 → 25/07/2022
3 items of Media coverage
Press/Media: Expert Comment › Popular
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UMCG krijgt miljoen euro voor onderzoek naar therapie bij agressieve borstkanker
22/07/2022
1 item of Media coverage
Press/Media: Expert Comment › Popular
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UMCG krijgt miljoen euro voor onderzoek naar therapie bij agressieve borstkanker
22/07/2022
1 Media contribution
Press/Media: Expert Comment › Popular
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Prangende vragen én antwoorden over artificial intelligence in de zorg
02/09/2021
1 item of Media coverage
Press/Media: Expert Comment › Professional
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Artificial Intelligence in Medical Oncology
02/09/2021
1 Media contribution
Press/Media: Expert Comment › Professional
Prizes
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Selected for the J.W.R. Nortier lecture
Fehrmann, R. (Recipient), 11-Apr-2013
Prize: National/international honour › Academic
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