Personal profile
Research interests
My practical and theoretical background enables me to take an integrative omics approach to identify driver genetic alterations, genes and biological pathways that are relevant for the pathophysiological behaviour and treatment response of tumors and rapidly translate these findings to clinical practice.
In addition to my training as a medical doctor, I completed one full year of Mathematics and Computer Science, after which I continued to obtain my MSc degree in Cognitive Science and Engineering.
In parallel to my medical studies, I worked for several years as a bio-informatician at the Department of Genetics, UMCG. In 2010, I obtained my PhD on high dimensional data analysis for new insights into ovarian cancer phenotypes, after which I continued as an affiliated post-doc at the Departments of Genetics and Medical Oncology (UMCG).
I followed the residency program in Internal Medicine / Medical Oncology and now work as a medical oncologist (staff member) at the department of Medical Oncology at the UMCG. In addition, I am a principal investigator at the Cancer Research Center Groningen in the research programmes: ‘Guided Treatment in Optimal Selected Cancer Patients (GUTS)’ and ‘Damage and Repair in Cancer Development and Cancer (DARE)’.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being -
SDG 4 Quality Education
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Collaborations and top research areas from the last five years
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Cyclin E1 overexpression triggers interferon signaling and is associated with antitumor immunity in breast cancer
Yu, S., Stappenbelt, C., Chen, M., Dekker, M., Bhattacharya, A., van der Sluis, T., Zwager, M. C., Schröder, C. P., Fehrmann, R. S. N., van Vugt, M. A. T. M. & van der Vegt, B., 17-Mar-2025, In: Journal for immunotherapy of cancer. 13, 3, 12 p., e009239.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile55 Downloads (Pure) -
MYC controls STING levels to downregulate inflammatory signaling in breast cancer cells upon DNA damage
Linstra, R., Stappenbelt, C., Bakker, F. J., Everts, M., Bhattacharya, A., Yu, S., van Bergen, S. D., van der Vegt, B., Wisman, G. B. A., Fehrmann, R. S. N., de Bruyn, M. & van Vugt, M. A. T. M., Jun-2025, In: The Journal of Biological Chemistry. 301, 6, 16 p., 108560.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile2 Citations (Scopus)33 Downloads (Pure) -
Transcriptional pattern enriched for synaptic signaling is associated with shorter survival of patients with high-grade serous ovarian cancer
Bhattacharya, A., Stutvoet, T. S., Perla, M., Loipfinger, S., Jalving, M., Reyners, A. K. L., Vermeer, P. D., Drapkin, R., de Bruyn, M., de Vries, E. G. E., de Jong, S. & Fehrmann, R. S. N., 13-May-2025, In: eLife. 13, 27 p., RP101369.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile36 Downloads (Pure) -
Upfront whole blood transcriptional patterns in patients receiving immune checkpoint inhibitors associate with clinical outcome
Hone Lopez, S., Loipfinger, S., Bhattacharya, A., Jalving, M., Oosting, S. F., Hiltermann, T. J. N., de Bruyn, M., de Vries, E. G. E., de Haan, J. J. & Fehrmann, R. S. N., 11-Sept-2025, In: Cancer Immunology Immunotherapy. 74, 10, 13 p., 301.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile20 Downloads (Pure) -
128P - Whole blood transcriptomics identifies transcriptional patterns linked to outcomes in patients receiving immune checkpoint inhibitors
Hone Lopez, S., Loipfinger, S., Bhattacharya, A., Jalving, M., Oosting, S. F., Hiltermann, J., de Bruyn, M., de Vries, E. G. E., de Haan, J.-J. & Fehrmann, R., 14-Sept-2024, In: Annals of Oncology. 35, Supplement 2, p. S266 1 p.Research output: Contribution to journal › Meeting Abstract › Academic
Activities
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ESMO Precision Oncology Working Group (External organisation)
Fehrmann, R. (Member)
13-Dec-2024 → …Activity: Membership › Professional
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36th EORTC-NCI-AACR Symposium
Fehrmann, R. (Session chair)
23-Oct-2024 → 25-Oct-2024Activity: Organising and attending an event › Organising and contributing to an event › Professional
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Dutch Cancer Society (KWF Kankerbestrijding) (External organisation)
Fehrmann, R. (Member)
2024 → …Activity: Membership › Professional
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The significance of real-world data: OncoLifeS
Fehrmann, R. (Invited speaker)
22-Jan-2024Activity: Talk and presentation › Academic presentation › Academic
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Novel AI-enabled strategies in biomarker-informed clinical trials
Fehrmann, R. (Invited speaker)
15-Sept-2024Activity: Talk and presentation › Professional or public presentation › Professional
Datasets
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Additional file 2 of Total serum N-glycans associate with response to immune checkpoint inhibition therapy and survival in patients with advanced melanoma
Visconti, A. (Creator), Rossi, N. (Creator), Deriš, H. (Creator), Lee, K. A. (Creator), Hanić, M. (Creator), Trbojević-Akmačić, I. (Creator), Thomas, A. M. (Creator), Bolte, L. (Creator), Björk, J. (Creator), Hooiveld-Noeken, J. (Creator), Board, R. (Creator), Harland, M. (Creator), Newton-Bishop, J. (Creator), Harries, M. (Creator), Sacco, J. J. (Creator), Lorigan, P. (Creator), Shaw, H. M. (Creator), de Vries, L. (Creator), Fehrmann, R. S. N. (Creator), Weersma, R. K. (Creator), Spector, T. D. (Creator), Nathan, P. (Creator), Hospers, G. A. P. (Creator), Sasieni, P. (Creator), Bataille, V. (Creator), Lauc, G. (Creator) & Falchi, M. (Creator), figshare, 13-Apr-2023
DOI: 10.6084/m9.figshare.22613744.v1, https://springernature.figshare.com/articles/dataset/Additional_file_2_of_Total_serum_N-glycans_associate_with_response_to_immune_checkpoint_inhibition_therapy_and_survival_in_patients_with_advanced_melanoma/22613744/1
Dataset
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Data to: Evidence Based Selection of Housekeeping Genes
de Jonge, H. (Creator), Fehrmann, R. (Creator), de Bont, E. (Creator), Hofstra, R. M. W. (Creator), Gerbens, F. (Creator), Kamps, W. (Creator), de Vries, E. G. E. (Creator), van der Zee, A. (Creator), te Meerman, G. (Creator) & ter Elst, A. (Creator), University of Groningen, 19-Sept-2007
https://figshare.com/articles/Evidence_Based_Selection_of_Housekeeping_Genes/151673
Dataset
Press/Media
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AI may be key to streamline patient allocation to clinical trials
13/11/2025
1 item of Media coverage, 1 Media contribution
Press/Media: Expert Comment › Popular
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KWF-subsidie voor onderzoek naar werking immuuntherapie bij triple-negatieve borstkanker
22/07/2022 → 25/07/2022
3 items of Media coverage
Press/Media: Expert Comment › Popular
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UMCG krijgt miljoen euro voor onderzoek naar therapie bij agressieve borstkanker
22/07/2022
1 Media contribution
Press/Media: Expert Comment › Popular
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UMCG krijgt miljoen euro voor onderzoek naar therapie bij agressieve borstkanker
22/07/2022
1 item of Media coverage
Press/Media: Expert Comment › Popular
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Prangende vragen én antwoorden over artificial intelligence in de zorg
02/09/2021
1 item of Media coverage
Press/Media: Expert Comment › Professional
Prizes
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Selected for the J.W.R. Nortier lecture
Fehrmann, R. (Recipient), 11-Apr-2013
Prize: National/international honour › Academic
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