Research output per year
Research output per year
I investigate how someone's genetic background (DNA) and non-coding RNA molecules (micro-RNAs (miRNAs) and long non-coding RNAs (lncRNAs)) contribute to the chance of developing a complex genetic, immune-mediated disease such as Celiac disease, Inflammatory Bowel Disease (IBD), Non-alcoholic Steatohepatitis (NASH) and Multiple Sclerosis (MS).
I predominantly use patientmaterial and celllines as disease models, which I manipulate and investigate using the latest 'genomics technologies' like for example CRISPR/Cas9, SNP (single nucleotide polymorphism) arrays, single-cell RNA sequencing, single-cell ATACseq, and oLINK targeted proteomics.
Recently I focus on the development of organ-on-chip platforms. I reprogram patient-derived cells into induced pluriptent stem cells (iPSCs) which in turn I differentiate into intestinal barrier cells, immune cells, bloodvessel cells, or liver cells. The microfluidic intestine-on-chip or liver-on-chip systems that I develop are currently the most promising modelsystems for personalized medicine and pharmacogenetics applications and research questions because the cells were originally obtained from patients meaning that the genetic background underlying the disease is present.
Research output: Contribution to journal › Review article › peer-review
Research output: Contribution to journal › Review article › peer-review
Research output: Contribution to journal › Article › Academic › peer-review
Research output: Contribution to journal › Article › Academic › peer-review
Research output: Contribution to journal › Article › Academic › peer-review
Sebo Withoff (Speaker)
Activity: Talk and presentation › Academic presentation › Academic
Jon Daniel Laman (Member of PhD Examining Committee), Sebo Withoff (Supervisor), Iris Jonkers (Co-supervisor) & Yang Li (Co-supervisor)
Activity: Examination, teaching and supervision › Supervision and examination of PhD students of the UG › Academic
Franke, L. (Contributor), Sharma, S. (Contributor), Watrous, J. D. (Contributor), Netea, M. G. (Contributor), Li, Y. (Contributor), Koenen, H. J. P. M. (Contributor), Xu, C. (Contributor), Xavier, R. J. (Contributor), Bakker, O. (Contributor), Mourits, V. P. (Contributor), Moorlag, S. (Contributor), Jonkers, I. (Contributor), Beumer, J. (Contributor), Smeekens, S. P. (Contributor), Chu, X. (Contributor), Jain, M. (Contributor), Joosten, L. A. B. (Contributor), Withoff, S. (Contributor), Koeken, V. A. C. M. (Contributor), Netea-Maier, R. T. (Contributor), Joosten, I. (Contributor), Sanna, S. (Contributor), Clevers, H. (Contributor), Jansen, T. (Contributor), Aguirre-Gamboa, R. (Contributor), Jaeger, M. (Contributor), Wijmenga, C. (Contributor), Oosting, M. (Contributor), Mathews, I. T. (Contributor), Magadi Gopalaiah, V. K. (Contributor), Dao, K. (Contributor), Najhawan, M. (Contributor) & de Bree, C. (Contributor), figshare Academic Research System, 7-Jul-2021
DOI: 10.6084/m9.figshare.14921236.v1, https://doi.org/10.6084%2Fm9.figshare.14921236.v1
Dataset
Mourits, V. P. (Contributor), Koenen, H. J. P. M. (Contributor), Netea, M. G. (Contributor), Magadi Gopalaiah, V. K. (Contributor), Xu, C. (Contributor), Mathews, I. T. (Contributor), Jansen, T. (Contributor), Smeekens, S. P. (Contributor), Jaeger, M. (Contributor), Jain, M. (Contributor), Xavier, R. J. (Contributor), Withoff, S. (Contributor), Clevers, H. (Contributor), Netea-Maier, R. T. (Contributor), Chu, X. (Contributor), Joosten, L. A. B. (Contributor), Joosten, I. (Contributor), Li, Y. (Contributor), Sanna, S. (Contributor), Bakker, O. (Contributor), Watrous, J. D. (Contributor), Najhawan, M. (Contributor), Koeken, V. A. C. M. (Contributor), Dao, K. (Contributor), Aguirre-Gamboa, R. (Contributor), Sharma, S. (Contributor), Franke, L. (Contributor), Jonkers, I. (Contributor), Moorlag, S. (Contributor), de Bree, C. (Contributor), Beumer, J. (Contributor), Wijmenga, C. (Contributor) & Oosting, M. (Contributor), figshare Academic Research System, 7-Jul-2021
DOI: 10.6084/m9.figshare.14920800.v1, https://doi.org/10.6084%2Fm9.figshare.14920800.v1
Dataset
Moorlag, S. (Contributor), Magadi Gopalaiah, V. K. (Contributor), Clevers, H. (Contributor), Koenen, H. J. P. M. (Contributor), Aguirre-Gamboa, R. (Contributor), Sanna, S. (Contributor), Mourits, V. P. (Contributor), Withoff, S. (Contributor), Joosten, I. (Contributor), Netea, M. G. (Contributor), Bakker, O. (Contributor), Smeekens, S. P. (Contributor), Wijmenga, C. (Contributor), Oosting, M. (Contributor), Mathews, I. T. (Contributor), Jain, M. (Contributor), Chu, X. (Contributor), Jonkers, I. (Contributor), de Bree, C. (Contributor), Najhawan, M. (Contributor), Jansen, T. (Contributor), Beumer, J. (Contributor), Sharma, S. (Contributor), Jaeger, M. (Contributor), Koeken, V. A. C. M. (Contributor), Joosten, L. A. B. (Contributor), Netea-Maier, R. T. (Contributor), Xu, C. (Contributor), Watrous, J. D. (Contributor), Xavier, R. J. (Contributor), Li, Y. (Contributor), Franke, L. (Contributor) & Dao, K. (Contributor), figshare Academic Research System, 7-Jul-2021
DOI: 10.6084/m9.figshare.14921251.v1, https://doi.org/10.6084%2Fm9.figshare.14921251.v1
Dataset
Oosting, M. (Contributor), Watrous, J. D. (Contributor), Mathews, I. T. (Contributor), Jain, M. (Contributor), Joosten, I. (Contributor), Withoff, S. (Contributor), Beumer, J. (Contributor), Dao, K. (Contributor), Aguirre-Gamboa, R. (Contributor), de Bree, C. (Contributor), Sharma, S. (Contributor), Jansen, T. (Contributor), Franke, L. (Contributor), Li, Y. (Contributor), Netea, M. G. (Contributor), Wijmenga, C. (Contributor), Koeken, V. A. C. M. (Contributor), Xavier, R. J. (Contributor), Koenen, H. J. P. M. (Contributor), Chu, X. (Contributor), Xu, C. (Contributor), Moorlag, S. (Contributor), Smeekens, S. P. (Contributor), Bakker, O. (Contributor), Joosten, L. A. B. (Contributor), Netea-Maier, R. T. (Contributor), Sanna, S. (Contributor), Clevers, H. (Contributor), Jaeger, M. (Contributor), Mourits, V. P. (Contributor), Najhawan, M. (Contributor), Magadi Gopalaiah, V. K. (Contributor) & Jonkers, I. (Contributor), figshare Academic Research System, 7-Jul-2021
DOI: 10.6084/m9.figshare.14921215.v1, https://doi.org/10.6084%2Fm9.figshare.14921215.v1
Dataset
Sanna, S. (Contributor), Sharma, S. (Contributor), Koenen, H. J. P. M. (Contributor), Smeekens, S. P. (Contributor), Oosting, M. (Contributor), Netea, M. G. (Contributor), Dao, K. (Contributor), Joosten, L. A. B. (Contributor), Beumer, J. (Contributor), Wijmenga, C. (Contributor), Jain, M. (Contributor), Franke, L. (Contributor), Watrous, J. D. (Contributor), Li, Y. (Contributor), Joosten, I. (Contributor), Xavier, R. J. (Contributor), Jaeger, M. (Contributor), Bakker, O. (Contributor), Najhawan, M. (Contributor), Clevers, H. (Contributor), Magadi Gopalaiah, V. K. (Contributor), Chu, X. (Contributor), Mathews, I. T. (Contributor), Netea-Maier, R. T. (Contributor), Koeken, V. A. C. M. (Contributor), Aguirre-Gamboa, R. (Contributor), Withoff, S. (Contributor), Jansen, T. (Contributor), Jonkers, I. (Contributor), Xu, C. (Contributor), Mourits, V. P. (Contributor), de Bree, C. (Contributor) & Moorlag, S. (Contributor), figshare Academic Research System, 7-Jul-2021
DOI: 10.6084/m9.figshare.14921230.v1, https://doi.org/10.6084%2Fm9.figshare.14921230.v1
Dataset
26/01/2023
2 Media contributions
Press/Media: Research › Academic
19/09/2019
1 Media contribution
Press/Media: Public Engagement Activities › Popular
30/05/2018
1 Media contribution
Press/Media: Public Engagement Activities › Popular
Withoff, Sebo (Recipient), 2005
Prize: Fellowship awarded competitively › Professional