Personal profile
Research interests
Curriculum Vitae
Sophia Bruggeman (The Netherlands, 1979) studied Biology at the University of Nijmegen. As PhD student, she worked at the Netherlands Cancer Institute on the role of Polycomb group genes in brain development and cancer (2008, cum laude). She next moved to King's College London to work on the development of the chick and zebrafish forebrain on a KWF postdoctoral fellowship. This fellowship was completed at the European Research Institute for the Biology of Ageing (ERIBA/University Medical Center Groningen).
After awardance of a Rosalind Franklin fellowship (tenure track position) and a KWF Cancer Research career award, Sophia started her own research group at the department of Pediatric Oncology and Hematology/Pediatrics, UMCG (2014). In 2019, Sophia's research group moved to ERIBA, UMCG. Her research aims at understaning how normal neurodevelopmental processes influence pediatric brain cancer initiation and progression.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
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Targeting the reprogrammed metabolism in H3.3K27M pediatric high-grade gliomas
de Camargo Magalhães, E. S., de Bont, E. S. J. M., Bruggeman, S. W. M. & Lima, F. R. S., Aug-2024, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1870, 6, 5 p., 167248.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile2 Citations (Scopus)62 Downloads (Pure) -
Chromosomal Instability Characterizes Pediatric Medulloblastoma but Is Not Tolerated in the Developing Cerebellum
Bockaj, I., Martini, T. E., Smit, M. J., Armandari, I., Bakker, B., Wardenaar, R., Meeuwsen-de Boer, T. G. J., Bakker, P. L., Spierings, D. C. J., Hoving, E. W., Guryev, V., Foijer, F. & Bruggeman, S. W. M., 30-Aug-2022, In: International Journal of Molecular Sciences. 23, 17, 15 p., 9852.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile2 Citations (Scopus)108 Downloads (Pure) -
The developmental stage of the medulloblastoma cell-of-origin restricts Hedgehog pathway usage and drug sensitivity
Smit, M. J., Martini, T. E. I., Armandari, I., Bočkaj, I., Zomerman, W. W., de Camargo Magalhães, E. S., Siragna, Z., Meeuwsen, T. G. J., Scherpen, F. J. G., Schoots, M. H., Ritsema, M., den Dunnen, W. F. A., Hoving, E. W., Paridaen, J. T. M. L., de Haan, G., Guryev, V. & Bruggeman, S. W. M., Jun-2022, In: Journal of Cell Science. 135, 11, 14 p., jeb258608.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile8 Citations (Scopus)198 Downloads (Pure) -
CREB signaling activity correlates with differentiation and survival in medulloblastoma
Armandari, I., Zomerman, W. W., Plasschaert, S. L. A., Smit, M. J., Martini, T. E., Magalhaes, E. S. D. C., Hogeling, S. M., Rozema-Huizinga, G. C., Lourens, H. J., Meeuwsen-de Boer, T. G. J., Scherpen, F. J. G., de Bont, E. S. J. M. & Bruggeman, S. W. M., 9-Aug-2021, In: Scientific Reports. 11, 1, 12 p., 16077.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile7 Citations (Scopus)118 Downloads (Pure) -
Heat Shock Factor 1 (HSF1-pSer326) Predicts Response to Bortezomib-Containing Chemotherapy in Pediatric AML: A COG Study
Hoff, F. W., van Dijk, A. D., Qiu, Y. H., Ruvolo, P. P., Gerbing, R. B., Leonti, A. R., Jenkins, G. N., Gamis, A. S., Aplenc, R., Kolb, E. A., Alonzo, T., Meshinchi, S., De Bont, E., Bruggeman, S. W., Kornblau, S. M. & Horton, T. M., 25-Feb-2021, In: Blood. 137, 8, p. 1050-1060 11 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile12 Citations (Scopus)186 Downloads (Pure)
Activities
- 1 Visiting an external institution
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Princess Maxima Ctr Paediat Oncol
Bruggeman, S. (Visiting researcher)
19-Dec-2017Activity: Visiting an external institution › Academic
Datasets
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"The H3.3K27M oncohistone affects replication stress outcome and provokes genomic instability in pediatric glioma" by Bockaj, Martini, de Camargo Magalhães et al, PLoS Genetics 2021
Bruggeman, S. (Contributor), Mendeley Data, 3-Nov-2021
DOI: 10.17632/3dwkjjc85m.1, https://data.mendeley.com/datasets/3dwkjjc85m
Dataset
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"CREB signaling activity correlates with differentiation and survival in medulloblastoma" by Armandari et al.
Bruggeman, S. (Contributor), University of Groningen, 21-Jul-2021
DOI: 10.17632/s7j3gkd58p.1, https://data.mendeley.com/datasets/s7j3gkd58p
Dataset
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Smit_Martini_et_al_manuscript_J_Cell_Science_2022_raw_data
Bruggeman, S. (Contributor), Mendeley Data, 19-May-2022
DOI: 10.17632/kvx2wxfnyj.1, https://data.mendeley.com/datasets/kvx2wxfnyj
Dataset
Prizes
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Differential drug sensitivity in pediatric brain cancer precursor cells: towards tailored treatments for infant and childhood medulloblastoma.
Bruggeman, S. (Recipient), 19-Jul-2018
Prize: Fellowship awarded competitively › Academic