Research output per year
Research output per year
- 26 results
Search results
-
2024
Targeting the reprogrammed metabolism in H3.3K27M pediatric high-grade gliomas
de Camargo Magalhães, E. S., de Bont, E. S. J. M., Bruggeman, S. W. M. & Lima, F. R. S., Aug-2024, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1870, 6, 5 p., 167248.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile1 Citation (Scopus)41 Downloads (Pure) -
2022
Chromosomal Instability Characterizes Pediatric Medulloblastoma but Is Not Tolerated in the Developing Cerebellum
Bockaj, I., Martini, T. E., Smit, M. J., Armandari, I., Bakker, B., Wardenaar, R., Meeuwsen-de Boer, T. G. J., Bakker, P. L., Spierings, D. C. J., Hoving, E. W., Guryev, V., Foijer, F. & Bruggeman, S. W. M., 30-Aug-2022, In: International Journal of Molecular Sciences. 23, 17, 15 p., 9852.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile2 Citations (Scopus)82 Downloads (Pure) -
The developmental stage of the medulloblastoma cell-of-origin restricts Hedgehog pathway usage and drug sensitivity
Smit, M. J., Martini, T. E. I., Armandari, I., Bočkaj, I., Zomerman, W. W., de Camargo Magalhães, E. S., Siragna, Z., Meeuwsen, T. G. J., Scherpen, F. J. G., Schoots, M. H., Ritsema, M., den Dunnen, W. F. A., Hoving, E. W., Paridaen, J. T. M. L., de Haan, G., Guryev, V. & Bruggeman, S. W. M., Jun-2022, In: Journal of Cell Science. 135, 11, 14 p., jeb258608.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile5 Citations (Scopus)156 Downloads (Pure) -
2021
CREB signaling activity correlates with differentiation and survival in medulloblastoma
Armandari, I., Zomerman, W. W., Plasschaert, S. L. A., Smit, M. J., Martini, T. E., Magalhaes, E. S. D. C., Hogeling, S. M., Rozema-Huizinga, G. C., Lourens, H. J., Meeuwsen-de Boer, T. G. J., Scherpen, F. J. G., de Bont, E. S. J. M. & Bruggeman, S. W. M., 9-Aug-2021, In: Scientific Reports. 11, 1, 12 p., 16077.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile5 Citations (Scopus)102 Downloads (Pure) -
Heat Shock Factor 1 (HSF1-pSer326) Predicts Response to Bortezomib-Containing Chemotherapy in Pediatric AML: A COG Study
Hoff, F. W., van Dijk, A. D., Qiu, Y. H., Ruvolo, P. P., Gerbing, R. B., Leonti, A. R., Jenkins, G. N., Gamis, A. S., Aplenc, R., Kolb, E. A., Alonzo, T., Meshinchi, S., De Bont, E., Bruggeman, S. W., Kornblau, S. M. & Horton, T. M., 25-Feb-2021, In: Blood. 137, 8, p. 1050-1060 11 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile11 Citations (Scopus)151 Downloads (Pure) -
The H3.3K27M oncohistone affects replication stress outcome and provokes genomic instability in pediatric glioma
Bočkaj, I., Martini, T. E. I., de Camargo Magalhães, E. S., Bakker, P. L., Meeuwsen-de Boer, T. G. J., Armandari, I., Meuleman, S. L., Mondria, M. T., Stok, C., Kok, Y. P., Bakker, B., Wardenaar, R., Seiler, J., Broekhuis, M. J. C., van den Bos, H., Spierings, D. C. J., Ringnalda, F. C. A., Clevers, H., Schüller, U. & van Vugt, M. A. T. M. & 2 others, , Nov-2021, In: PLoS genetics. 17, 11, 28 p., 1009868.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile27 Citations (Scopus)170 Downloads (Pure) -
2020
Loss of H3K27 Methylation Identifies Poor Outcome in Adult-Onset Acute Myeloid Leukemia
van Dijk, A. D., Hoff, F. W., Qiu, Y., de Bont, E. S., Bruggeman, S. W. M., Horton, T. M. & Kornblau, S. M., 5-Nov-2020, In: Blood. 136, 3 p.Research output: Contribution to journal › Meeting Abstract › Academic
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Loss of H3K27 Methylation Identifies Poor Outcomes in Adult-Onset Acute Lymphoblastic and Myeloid Leukemia
van Dijk, A., Hoff, F., Qiu, Y., Jabbour, E., de Bont, E., Bruggeman, S., Horton, T. & Kornblau, S., Sept-2020, In: Clinical lymphoma myeloma & leukemia. 20, p. S205-S206 2 p.Research output: Contribution to journal › Meeting Abstract › Academic
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2019
Prognostic Significance of FOXO3 in Pediatric Acute Myeloid Leukemia (AML) Patients Treated with Bortezomib Addition to Standard Therapy: Results from a Children's Oncology Group Phase 3 Clinical Trial
van Dijk, A. D., Ruvolo, P. P., Hoff, F. W., Qiu, Y., Gamis, A. S., Aplenc, R., Kolb, A. E., Alonzo, T. A., Gerbing, R. B., de Bont, E. S., Bruggeman, S. W. M., Horton, T. M. & Kornblau, S. M., 13-Nov-2019, In: Blood. 134, 4 p.Research output: Contribution to journal › Meeting Abstract › Academic
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The developmental stage of the medulloblastoma cell-of-origin is maintained in cancer and restricts hedgehog pathway usage and drug sensitivity
Smit, M., Armandari, I., Bockaj, I., Martini, T., Zomerman, W., Siragna, Z., Meeuwsen-de Boer, T., Scherpen, F., Schoots, M., Ritsema, M., den Dunnen, W., Hoving, E., Paridaen, J., de Haan, G., Guryev, V. & Bruggeman, S., Apr-2019, In: Neuro-Oncology. 21, p. 104 1 p.Research output: Contribution to journal › Meeting Abstract › Academic
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2018
Identification of Two Protein-Signaling States Delineating Transcriptionally Heterogeneous Human Medulloblastoma
Zomerman, W. W., Plasschaert, S. L. A., Conroy, S., Scherpen, F. J., Meeuwsen-de Boer, T. G. J., Lourens, H. J., Guerrero Llobet, S., Smit, M. J., Slagter-Menkema, L., Seitz, A., Gidding, C. E. M., Hulleman, E., Wesseling, P., Meijer, L., van Kempen, L. C., van den Berg, A., Warmerdam, D. O., Kruyt, F. A. E., Foijer, F. & van Vugt, M. A. T. M. & 5 others, , 20-Mar-2018, In: Cell reports. 22, 12, p. 3206-3216 11 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile17 Citations (Scopus)367 Downloads (Pure) -
IDENTIFICATION OF TWO PROTEIN-SIGNALING STATES DELINEATING TRANSCRIPTIONALLY HETEROGENEOUS HUMAN MEDULLOBLASTOMA
Zomerman, W., Plasschaert, S., Conroy, S., Scherpen, F., Meeuwsen-de Boer, T., Lourens, H.-J., Llobet, S. G., Smit, M., Slagter-Menkema, L., Seitz, A., Gidding, C., Hulleman, E., Wesseling, P., Meijer, L., van Kempen, L., van den Berg, A., Warmerdam, D., Kruyt, F., Foijer, F. & van Vugt, M. & 5 others, , Jun-2018, In: Neuro-Oncology. 20, p. 136-136 1 p.Research output: Contribution to journal › Meeting Abstract › Academic
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RPPA-Profiling Identifies Patients with Low Phosphorylation Levels of HSF1 at Serine 326 As Potential Candidate for Bortezomib Treatment in Addition to Standard Therapy in Pediatric Acute Myeloid Leukemia
Hoff, F. W., Hu, W., Qiu, Y., Gamis, A. S., Aplenc, R., Kolb, E. A., Alonzo, T. A., Qutub, A. A., de Bont, E. S., Bruggeman, S. W. M., Kornblau, S. M. & Horton, T. M., 29-Nov-2018, In: Blood. 132, Suppl.1, 3 p.Research output: Contribution to journal › Meeting Abstract › Academic
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2017
Revisiting the chromosome separation checkpoint
Bockaj, I., Bruggeman, S. W. M. & Foijer, F., Jul-2017, In: BioEssays. 39, 7, 1 p., 1700084.Research output: Contribution to journal › Editorial › Academic › peer-review
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2013
In Vivo RNAi Screen for BMI1 Targets Identifies TGF-beta/BMP-ER Stress Pathways as Key Regulators of Neural- and Malignant Glioma-Stem Cell Homeostasis
Gargiulo, G., Cesaroni, M., Serresi, M., de Vries, N., Hulsman, D., Bruggeman, S. W., Lancini, C. & van Lohuizen, M., 13-May-2013, In: Cancer cell. 23, 5, p. 660-676 17 p.Research output: Contribution to journal › Article › Academic › peer-review
155 Citations (Scopus) -
Polycomb Cbx family members mediate the balance between haematopoietic stem cell self-renewal and differentiation
Klauke, K., Radulovic, V., Broekhuis, M., Weersing, E., Zwart, E., Olthof, S., Ritsema, M., Bruggeman, S., Wu, X., Helin, K., Bystrykh, L. & de Haan, G., Apr-2013, In: Nature Cell Biology. 15, 4, p. 353-+ 22 p.Research output: Contribution to journal › Article › Academic › peer-review
198 Citations (Scopus) -
2010
Molecular Maps of the Reorganization of Genome-Nuclear Lamina Interactions during Differentiation
Peric-Hupkes, D., Meuleman, W., Pagie, L., Bruggeman, S. W. M., Solovei, I., Brugman, W., Graef, S., Flicek, P., Kerkhoven, R. M., van Lohuizen, M., Reinders, M., Wessels, L. & van Steensel, B., 28-May-2010, In: Molecular Cell. 38, 4, p. 603-613 11 p.Research output: Contribution to journal › Article › Academic › peer-review
811 Citations (Scopus) -
Rapid and Robust Transgenic High-Grade Glioma Mouse Models for Therapy Intervention Studies
de Vries, N. A., Bruggeman, S. W., Hulsman, D., de Vries, H. I., Zevenhoven, J., Buckle, T., Hamans, B. C., Leenders, W. P., Beijnen, J. H., van Lohuizen, M., Berns, A. J. M. & van Tellingen, O., 1-Jul-2010, In: Clinical Cancer Research. 16, 13, p. 3431-3441 11 p.Research output: Contribution to journal › Article › Academic › peer-review
42 Citations (Scopus) -
2009
Bmi1 deficient neural stem cells have increased Integrin dependent adhesion to self-secreted matrix
Bruggeman, S. W. M., Hulsman, D. & van Lohuizen, M., May-2009, In: Biochimica et Biophysica Acta-General Subjects. 1790, 5, p. 351-360 10 p.Research output: Contribution to journal › Article › Academic › peer-review
13 Citations (Scopus) -
2008
Tumor marker nucleoporin 88 kDa regulates nucleocytoplasmic transport of NF-kappa B
Takahashi, N., van Kilsdonk, J. W. J., Ostendorf, B., Smeets, R., Bruggeman, S. W. M., Alonso, A., van de Loo, F., Schneider, M., van den Berg, W. B. & Swart, G. W. M., 26-Sept-2008, In: Biochemical and Biophysical Research Communications. 374, 3, p. 424-430 7 p.Research output: Contribution to journal › Article › Academic › peer-review
38 Citations (Scopus) -
2007
Bmi1 controls tumor development in an ink4a/Arf-independent manner in a mouse model for glioma
Bruggeman, S. W. M., Hulsman, D., Tanger, E., Buckle, T., Blom, M., Zevenhoven, J., van Tellingen, O. & van Lohuizen, M., Oct-2007, In: Cancer cell. 12, 4, p. 328-341 14 p.Research output: Contribution to journal › Article › Academic › peer-review
255 Citations (Scopus) -
2006
Controling stem cell proliferation - CKIs at work
Bruggeman, S. & van Lohuizen, M., 15-Jun-2006, In: Cell Cycle. 5, 12, p. 1281-1285 5 p.Research output: Contribution to journal › Article › Academic › peer-review
6 Citations (Scopus) -
2005
Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice
Bruggeman, S. W. M., Valk-Lingbeek, M. E., van der Stoop, P. P. M., Jacobs, J. J. L., Kieboom, K., Tanger, E., Hulsman, D., Leung, C., Arsenijevic, Y., Marino, S. & van Lohuizen, M., 15-Jun-2005, In: Genes & Development. 19, 12, p. 1438-1443 6 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile293 Citations (Scopus)191 Downloads (Pure) -
2004
Emerging roles of Polycomb silencing in X-inactivation and stem cell maintenance
Muyrers-Chen, I., Hernandez-Munoz, I., Lund, A., Valk-Lingbeek, M., Van der Stoop, P., Boutsma, E., Tolhuis, B., Bruggeman, S. W. M., Taghavi, P., Verhoeven, E., Hulsman, D., Noback, S., Tanger, E., Theunissen, H. & van Lohuizen, M., 2004, In: Cold spring harbor symposia on quantitative biology. 69, p. 319-326 8 p.Research output: Contribution to journal › Article › Academic › peer-review
12 Citations (Scopus) -
Stem colls and cancer: The polycomb connection
Valk-Lingbeek, M., Bruggeman, S. & Van Lohuizen, M., 20-Aug-2004, In: Cell. 118, 4, p. 409-418 10 p.Research output: Contribution to journal › Review article › peer-review
650 Citations (Scopus) -
2002
Distribution of components of the glutathione detoxification system across the human placenta after uncomplicated vaginal deliveries
Raijmakers, M., Bruggeman, S., Steegers, E. & Peters, W., Jul-2002, In: Placenta. 23, 6, p. 490-496 7 p.Research output: Contribution to journal › Article › Academic › peer-review
22 Citations (Scopus)