Research output per year
Research output per year
Personal profile
Research interests
Steven Bergink received his master in molecular biology at the university of Groningen. He obtained his PhD at the ErasmusMC in Rotterdam in the group of Jan Hoeijmakers. He continued with a postdoc at the Max Planck Institute of Biochemistry (Munich, Germany) in the group of Stefan Jentsch. During both his PhD and postdoctoral period he focused on the regulation of DNA repair mechanisms by posttranslational modifications of the ubiquitin family.
Currently he is a group leader at the medical faculty in Groningen. His current research at the Department of Cell biology aims to investigate the intertwinement of DNA repair, protein quality control and neurodegeneration.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Glioblastoma and its treatment are associated with extensive accelerated brain aging
Ainslie, A. P., Klaver, M., Voshart, D. C., Gerrits, E., den Dunnen, W. F. A., Eggen, B. J. L., Bergink, S. & Barazzuol, L., Mar-2024, In: Aging Cell. 23, 3, 14 p., e14066.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile5 Citations (Scopus)50 Downloads (Pure) -
Cooling of Cells and Organs Confers Extensive DNA Strand Breaks Through Oxidative Stress and ATP Depletion
Tolouee Nodolaghi, M., Hendriks, K., Lie, F., Gartzke, L., Goris, M., Hoogstra-Berends, F., Bergink, S. & Henning, R. H., 8-Jul-2022, In: Cell Transplantation. 31, p. 1-12 12 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile11 Citations (Scopus)81 Downloads (Pure) -
Targeting DNA topoisomerases or checkpoint kinases results in an overload of chaperone systems, triggering aggregation of a metastable subproteome
Huiting, W., Dekker, S. L., van der Lienden, J. C. J., Mergener, R., Musskopf, M. K., Furtado, G. V., Gerrits, E., Coit, D., Oghbaie, M., Di Stefano, L. H., Schepers, H., van Waarde-Verhagen, M. A. W. H., Couzijn, S., Barazzuol, L., LaCava, J., Kampinga, H. H. & Bergink, S., 24-Feb-2022, In: eLife. 11, 29 p., e70726.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile11 Citations (Scopus)118 Downloads (Pure) -
The chaperone DNAJB6 surveils FG-nucleoporins and is required for interphase nuclear pore complex biogenesis
Kuiper, E. F. E., Gallardo, P., Bergsma, T., Mari, M., Kolbe Musskopf, M., Kuipers, J., Giepmans, B. N. G., Steen, A., Kampinga, H. H., Veenhoff, L. M. & Bergink, S., Nov-2022, In: Nature Cell Biology. 24, p. 1584-1594 11 p.Research output: Contribution to journal › Letter › Academic › peer-review
Open AccessFile27 Citations (Scopus)226 Downloads (Pure) -
DNAJB chaperones suppress destabilised protein aggregation via a region unique from that used to inhibit amyloidogenesis
McMahon, S., Bergink, S., Kampinga, H. H. & Ecroyd, H., Apr-2021, In: Journal of Cell Science. 134 , 7, 13 p., 255596.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile11 Citations (Scopus)167 Downloads (Pure)
Press/Media
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Interview about Ataxias at 'Benefietavond Charity4Brains'
31/03/2023
1 Media contribution
Press/Media: Public Engagement Activities › Popular
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Prizes
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Understanding the cause of ataxia in the DNA repair deficiency syndrome Ataxia Telangiectasia: a possible link between DNA damage and proteostasis
Bergink, S. (Recipient), 2013
Prize: Fellowship awarded competitively › Academic