Research output per year
Research output per year
- 14 results
Search results
-
2024
Hepatic glucokinase regulatory protein and carbohydrate response element binding protein attenuation reduce de novo lipogenesis but do not mitigate intrahepatic triglyceride accumulation in Aldob deficiency
Buziau, A. M., Oosterveer, M. H., Wouters, K., Bos, T., Tolan, D. R., Agius, L., Ford, B. E., Cassiman, D., Stehouwer, C. D. A., Schalkwijk, C. G. & Brouwers, M. C. G. J., Sept-2024, In: Molecular metabolism. 87, 7 p., 101984.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile17 Downloads (Pure) -
Precision-cut liver slices as an ex vivo model to assess impaired hepatic glucose production
Kiyuna, L. A., Krishnamurthy, K. A., Homan, E. B., Langelaar-Makkinje, M., Gerding, A., Bos, T., Oosterhuis, D., Overduin, R. J., Schreuder, A. B., de Meijer, V. E., Olinga, P., Derks, T. G. J., van Eunen, K., Bakker, B. M. & Oosterveer, M. H., 9-Nov-2024, In: Communications biology. 7, 13 p., 1479.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile2 Downloads (Pure) -
2023
Normalization of hepatic ChREBP activity does not protect against liver disease progression in a mouse model for Glycogen Storage Disease type Ia
Rutten, M. G. S., Lei, Y., Hoogerland, J. H., Bloks, V. W., Yang, H., Bos, T., Krishnamurthy, K. A., Bleeker, A., Koster, M. H., Thomas, R. E., Wolters, J. C., van den Bos, H., Mithieux, G., Rajas, F., Mardinoglu, A., Spierings, D. C. J., de Bruin, A., van de Sluis, B. & Oosterveer, M. H., 21-Apr-2023, In: Cancer & Metabolism. 11, 11 p., 5.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile64 Downloads (Pure) -
2021
Disrupted glucose-6-phosphate-ChREBP signalling aggravates hepatomegaly and accelerates liver disease progression in a mouse model for Glycogen Storage Disease type 1a
Rutten, M., Lei, Y., Hoogerland, J., Bos, T., Bleeker, A., Thomas, R., Mithieux, G., Rajas, F., de Bruin, A., van de Sluis, B. & Oosterveer, M., Jul-2021, In: Journal of Hepatology. 75, p. S531-S532 2 p.Research output: Contribution to journal › Meeting Abstract › Academic
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Impaired Very-Low-Density Lipoprotein catabolism links hypoglycemia to hypertriglyceridemia in Glycogen Storage Disease type Ia
Hoogerland, J. A., Peeks, F., Hijmans, B. S., Wolters, J. C., Kooijman, S., Bos, T., Bleeker, A., van Dijk, T. H., Wolters, H., Gerding, A., van Eunen, K., Havinga, R., Pronk, A. C. M., Rensen, P. C. N., Mithieux, G., Rajas, F., Kuipers, F., Reijngoud, D.-J., Derks, T. G. J. & Oosterveer, M. H., Jul-2021, In: Journal of Inherited Metabolic Disease. 44, 4, p. 879–892 14 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile11 Citations (Scopus)78 Downloads (Pure) -
Modeling Phenotypic Heterogeneity of Glycogen Storage Disease Type 1a Liver Disease in Mice by Somatic CRISPR/CRISPR-associated protein 9-Mediated Gene Editing
Rutten, M. G. S., Derks, T. G. J., Huijkman, N. C. A., Bos, T., Kloosterhuis, N. J., van de Kolk, K. C. W. A., Wolters, J. C., Koster, M. H., Bongiovanni, L., Thomas, R. E., de Bruin, A., van de Sluis, B. & Oosterveer, M. H., Nov-2021, In: Hepatology. 74, 5, p. 2491-2507 17 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile8 Citations (Scopus)140 Downloads (Pure) -
2019
Glucose-6-phosphate regulates hepatic bile acid synthesis in mice
Hoogerland, J. A., Lei, Y., Wolters, J. C., de Boer, J. F., Bos, T., Bleeker, A., Mulder, N. L., van Dijk, T. H., Kuivenhoven, J. A., Rajas, F., Mithieux, G., Haeusler, R. A., Verkade, H. J., Bloks, V. W., Kuipers, F. & Oosterveer, M. H., Dec-2019, In: Hepatology. 70, 6, p. 2171-2184 14 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile23 Citations (Scopus)194 Downloads (Pure) -
2017
Intestinal Farnesoid X Receptor Controls Transintestinal Cholesterol Excretion in Mice
Boer, de, J. F., Schonewille, M., Boesjes, M., Wolters, H., Bloks, V. W., Bos, T., van Dijk, T. H., Jurdzinski, A., Boverhof, R., Wolters, J. C., Kuivenhoven, J. A., van Deursen, J. M., Oude Elferink, R. P. J., Moschetta, A., Kremoser, C., Verkade, H. J., Kuipers, F. & Groen, A. K., Apr-2017, In: Gastroenterology. 152, 5, p. 1126-1138 13 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile118 Citations (Scopus)720 Downloads (Pure) -
2015
Gut microbiota inhibit Asbt-dependent intestinal bile acid reabsorption via Gata4
Out, C., Patankar, J. V., Doktorova, M., Boesjes, M., Bos, T., de Boer, S., Havinga, R., Wolters, H., Boverhof, R., van Dijk, T. H., Smoczek, A., Bleich, A., Sachdev, V., Kratky, D., Kuipers, F., Verkade, H. J. & Groen, A. K., Sept-2015, In: Journal of Hepatology. 63, 3, p. 697-704 8 p.Research output: Contribution to journal › Article › Academic › peer-review
100 Citations (Scopus) -
2014
Hepatic Farnesoid X-Receptor Isoforms α2 and α4 Differentially Modulate Bile Salt and Lipoprotein Metabolism in Mice
Boesjes, M., Bloks, V. W., Hageman, J., Bos, T., van Dijk, T. H., Havinga, R., Wolters, H., Jonker, J. W., Kuipers, F. & Groen, A. K., 15-Dec-2014, In: PLoS ONE. 9, 12, 19 p., e115028.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile31 Citations (Scopus)308 Downloads (Pure) -
2011
Liver Receptor Homolog-1 Is Critical for Adequate Up-regulation of Cyp7a1 Gene Transcription and Bile Salt Synthesis During Bile Salt Sequestration
Out, C., Hageman, J., Bloks, V. W., Gerrits, H., Gelpke, M. D. S., Bos, T., Havinga, R., Smit, M. J., Kuipers, F. & Groen, A. K., Jun-2011, In: Hepatology. 53, 6, p. 2075-2085 11 p.Research output: Contribution to journal › Article › Academic › peer-review
46 Citations (Scopus) -
Resistance to diet-induced adiposity in cannabinoid receptor-1 deficient mice is not due to impaired adipocyte function
Oosterveer, M. H., Koolman, A. H., de Boer, P. T., Bos, T., Bleeker, A., Bloks, V. W., Kuipers, F., Sauer, P. J. J. & van Dijk, G., 27-Dec-2011, In: Nutrition & Metabolism. 8, 1, p. 93-1-93-12 12 p., 93.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile5 Citations (Scopus)427 Downloads (Pure) -
2008
Neonatal screening for medium-chain acyl-CoA dehydrogenase (MCAD) deficiency in The Netherlands: The importance of enzyme analysis to ascertain true MCAD deficiency
Derks, T., Boer, T. S., van Assen, A., Bos, T., Ruiter, J. H., Waterham, H. R., Niezen-Koning, K. E., Wanders, R. J. A., Rondeel, J. M. M., Loeber, J. G., ten Kate, L. P., Smit, G. P. A. & Reijngoud, D.-J., Feb-2008, In: Journal of Inherited Metabolic Disease. 31, 1, p. 88-96 9 p.Research output: Contribution to journal › Article › Academic › peer-review
48 Citations (Scopus) -
2005
Essential fatty acid deficiency in mice is associated with hepatic steatosis and secretion of large VLDL particles
Werner, A., Havinga, R., Bos, T., Bloks, V., Kuipers, F. & Verkade, H., Jun-2005, In: American Journal of Physiology-Gastrointestinal and Liver Physiology. 288, 6, p. G1150-G1158 9 p.Research output: Contribution to journal › Article › Academic › peer-review
38 Citations (Scopus)