Personal profile

Research interests

Obesity continues to be a global health crisis, increased by an overabundance of food and the body’s natural sensitivity to energy deficits. Bariatric surgery, such as the Roux-en-Y gastric bypass, offers long-term weight loss, but its mechanisms remain unclear. Likewise, vagus nerve stimulation has been explored as a potential treatment for obesity, but it has shown varied results.

During my thesis I focused on three different interventions:
1. Roux-en-Y gastric bypass: Energy intake reduction and weight loss in rats was mainly explained by pre-surgery weight and cumulative energy intake. A high fat diet was associated with less disruption in daily activity and body temperature after surgery. However, we also found that the high fat with added sucrose diet had a major impact on ingestion rate and led to higher glucose levels after a meal.
2. Ileal Transposition: Weight loss was observed, partly due to increased energy expenditure during digestion and a temporary reduction in energy intake.
3. Vagus nerve stimulation: While not leading to weight loss or improvements in glucose regulation in type 2 diabetic rats. It did result in faster glucose processing in healthy rats offering promise for future type 2 diabetes prevention strategies.

🔗 Key Publications:
- Roux-en-Y gastric bypass surgery
- Ileal Transposition
- Vagus nerve stimulation

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

Neuro-endocrinology, PhD, Energy balance in Obesity: effects of bariatric surgery and vagus nerve stimulation

1-Feb-20181-Sept-2022

Award Date: 4-Dec-2024

Biomedical Scienses, MSc., University of Groningen

1-Sept-201530-Aug-2017

Honours Master, MSc., University of Groningen

1-Sept-201530-Aug-2016

Biology, BSc., University of Groningen

1-Sept-201030-Aug-2015

External positions

Jr. Scientist in vivo biology at uniQure

1-Sept-2022 → …

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