Research output per year
Research output per year
Obesity continues to be a global health crisis, increased by an overabundance of food and the body’s natural sensitivity to energy deficits. Bariatric surgery, such as the Roux-en-Y gastric bypass, offers long-term weight loss, but its mechanisms remain unclear. Likewise, vagus nerve stimulation has been explored as a potential treatment for obesity, but it has shown varied results.
During my thesis I focused on three different interventions:
1. Roux-en-Y gastric bypass: Energy intake reduction and weight loss in rats was mainly explained by pre-surgery weight and cumulative energy intake. A high fat diet was associated with less disruption in daily activity and body temperature after surgery. However, we also found that the high fat with added sucrose diet had a major impact on ingestion rate and led to higher glucose levels after a meal.
2. Ileal Transposition: Weight loss was observed, partly due to increased energy expenditure during digestion and a temporary reduction in energy intake.
3. Vagus nerve stimulation: While not leading to weight loss or improvements in glucose regulation in type 2 diabetic rats. It did result in faster glucose processing in healthy rats offering promise for future type 2 diabetes prevention strategies.
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Neuro-endocrinology, PhD, Energy balance in Obesity: effects of bariatric surgery and vagus nerve stimulation
1-Feb-2018 → 1-Sept-2022
Award Date: 4-Dec-2024
Biomedical Scienses, MSc., University of Groningen
1-Sept-2015 → 30-Aug-2017
Honours Master, MSc., University of Groningen
1-Sept-2015 → 30-Aug-2016
Biology, BSc., University of Groningen
1-Sept-2010 → 30-Aug-2015
Jr. Scientist in vivo biology at uniQure
1-Sept-2022 → …
Research output: Thesis › Thesis fully internal (DIV)
Research output: Contribution to journal › Article › Academic › peer-review
Research output: Contribution to journal › Article › Academic › peer-review
Research output: Contribution to journal › Article › Academic › peer-review
Research output: Contribution to journal › Article › Academic › peer-review
Olivier, J. (Contributor) & Hoornenborg, W. (Contributor)
Activity: Organising and attending an event › Organising and contributing to an event › Popular
Hoornenborg, W. (Contributor)
Activity: Organising and attending an event › Organising and contributing to an event › Popular
Hoornenborg, C. W. (Creator), Somogyi, E. (Creator), Bruggink, J. (Creator), Boyle, C. N. (Creator), Lutz, T. A. (Creator), Emous, M. (Creator), Van Beek, A. P. (Creator), Nyakas, C. (Creator) & Van Dijk, G. (Creator), DataverseNL, 2-Apr-2024
DOI: 10.34894/s0x3ty
Dataset
Olivier, J., Rauws, W., Hoornenborg, W., Peters, L., Weiland, S., Douwenga, W., Cabrera Arreola, A. & Scheurink, A.
12/08/2019 → 19/08/2019
4 items of Media coverage
Press/Media: Public Engagement Activities › Popular
Scheurink, A. & Hoornenborg, W.
01/12/2014 → 21/01/2016
2 items of Media coverage, 1 Media contribution
Press/Media: Public Engagement Activities › Professional