Research output per year
Research output per year
Personal profile
Research interests
Obesity continues to be a global health crisis, increased by an overabundance of food and the body’s natural sensitivity to energy deficits. Bariatric surgery, such as the Roux-en-Y gastric bypass, offers long-term weight loss, but its mechanisms remain unclear. Likewise, vagus nerve stimulation has been explored as a potential treatment for obesity, but it has shown varied results.
During my thesis I focused on three different interventions:
1. Roux-en-Y gastric bypass: Energy intake reduction and weight loss in rats was mainly explained by pre-surgery weight and cumulative energy intake. A high fat diet was associated with less disruption in daily activity and body temperature after surgery. However, we also found that the high fat with added sucrose diet had a major impact on ingestion rate and led to higher glucose levels after a meal.
2. Ileal Transposition: Weight loss was observed, partly due to increased energy expenditure during digestion and a temporary reduction in energy intake.
3. Vagus nerve stimulation: While not leading to weight loss or improvements in glucose regulation in type 2 diabetic rats. It did result in faster glucose processing in healthy rats offering promise for future type 2 diabetes prevention strategies.
🔗 Key Publications:
- Roux-en-Y gastric bypass surgery
- Ileal Transposition
- Vagus nerve stimulation
Education/Academic qualification
Neuro-endocrinology, PhD, Energy balance in Obesity: effects of bariatric surgery and vagus nerve stimulation
1-Feb-2018 → 1-Sept-2022
Award Date: 4-Dec-2024
Biomedical Sciences, MSc., University of Groningen
1-Sept-2015 → 30-Aug-2017
Honours Master, MSc., University of Groningen
1-Sept-2015 → 30-Aug-2016
Biology, BSc., University of Groningen
1-Sept-2010 → 30-Aug-2015
External positions
Jr. Scientist in vivo biology at uniQure
1-Sept-2022 → …
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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LightGBM-Based Seizure Detection Method in Pilocarpine Mouse Model of Epilepsy
Edoho, M., Partouche, N., Hoornenborg, C. W., Hoogland, T. M., Baudouin, S., Mooney, C. & Wei, L., Mar-2026, In: Algorithms. 19, 3, 14 p., 167.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile -
A Western-Style Diet Influences Ingestive Behavior and Glycemic Control in a Rat Model of Roux-en-Y Gastric Bypass Surgery
Hoornenborg, C. W., Somogyi, E., Bruggink, J. E., Boyle, C. N., Lutz, T. A., Emous, M., van Beek, A. P. & van Dijk, G., 11-Apr-2025, In: Journal of Clinical Medicine. 14, 8, 15 p., 2642.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile -
Dracaena trifasciata (Prain) Mabb leaf extract protects MIN6 pancreas-derived beta cells against the diabetic toxin streptozotocin: role of the NF-κB pathway
Hoornenborg, C. W., Qomariyah, N., González-Ponce, H. A., van Beek, A. P., Moshage, H. & van Dijk, G., 16-Apr-2025, In: Frontiers in Pharmacology. 16, 13 p., 1485952.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile -
Modified AAV5 capsid for improved brain biodistribution following direct injection in preclinical models
Kieper, S. N., Spronck, E. A., Bourajjaj, M., Morais, R. D. V. S., van der Bent, M. L., Acar Broekmans, S., van Rooijen, C., van Westen, R., Squeri, G., Brasser, G., Wartel, M., Waaijer, S. J. H., Hoornenborg, C. W., Hoogland, T. M., Porter, R. & Anggakusuma, 11-Dec-2025, In: Molecular therapy-Methods & clinical development. 33, 4, 18 p., 101642.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile -
Energy balance in obesity: Effects of bariatric surgery and vagus nerve stimulation
Hoornenborg, W., 2024, [Groningen]: University of Groningen. 180 p.Research output: Thesis › Thesis fully internal (DIV)
Open AccessFile
Activities
- 2 Organising and contributing to an event
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De Jonge Onderzoekers - Natuur & Techniek-cursus 2022
Olivier, J. (Contributor) & Hoornenborg, W. (Contributor)
20-May-2022Activity: Organising and attending an event › Organising and contributing to an event › Popular
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Universiteit van Noorderzon
Hoornenborg, W. (Contributor)
19-Aug-2019Activity: Organising and attending an event › Organising and contributing to an event › Popular
File
Datasets
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Replication Data for: Weight loss in adult male Wistar rats by Roux-en-Y gastric bypass is primarily explained by caloric intake reduction and pre-surgery body weight
Hoornenborg, C. W. (Creator), Somogyi, E. (Creator), Bruggink, J. (Creator), Boyle, C. N. (Creator), Lutz, T. A. (Creator), Emous, M. (Creator), Van Beek, A. P. (Creator), Nyakas, C. (Creator) & Van Dijk, G. (Creator), DataverseNL, 2-Apr-2024
DOI: 10.34894/s0x3ty
Dataset
Press/Media
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De Universiteit van Noorderzon
Olivier, J., Rauws, W., Hoornenborg, W., Peters, L., Weiland, S., Douwenga, W., Cabrera Arreola, A. & Scheurink, A.
12/08/2019 → 19/08/2019
4 items of Media coverage
Press/Media: Public Engagement Activities › Popular
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Docent van het jaar: Enthousiasme is het geheim
Scheurink, A. & Hoornenborg, W.
01/12/2014 → 21/01/2016
2 items of Media coverage, 1 Media contribution
Press/Media: Public Engagement Activities › Professional