European Autism Interventions - A Multicentre Study for Developing New Medications

Development and implementation of translational approaches to accelerate drug discovery for Autism Spectrum Disorders (ASD). As a principal investigator in the project, my contributions concern the development of behavioral and cognitive phenotyping battery for developing and adult mice. Several genetic mouse models for ASD have been tested and revealed distinct social and repetitive behavior trajectories. These behavioral phenotypes will now be used for the genetic mapping of loci underlying these sophisticated phenotypes relevant to ASD. Furthermore, we have implemented integrated EEG-behavioral analyses in ASD mouse models, critically important to simultaneously study neural circuit functioning during specific behavioral events.